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1. 发明公开

EP2550984A1 BLOOD PURIFICATION DEVICE 有权
标题翻译： BLUTREINIGUNGSVORRICHTUNG
公开(公告)号：EP2550984A1
公开(公告)日：2013-01-30
申请号：EP11759506.6
申请日：2011-03-24
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , TOYODA, Masahiro
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/1601 , A61M1/1613 , A61M1/3431 , A61M1/3434 , A61M1/3441 , A61M1/3455 , A61M1/3462 , A61M1/3465 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M2205/3327 , A61M2205/3334 , A61M2205/3351 , A61M2230/207
摘要： [object]
Disclosed is a blood purification apparatus capable of preventing excess concentration in blood circulating extracorporeally during online HDF or online HF performing a pre-substitution.
[Solution]
The blood purification apparatus is equipped with a dialyzer 1, an arterial blood circuit 2 in which a blood pump 4 has been disposed, a venous blood circuit 3, a dialysate introduction line L1 that introduces a dialysate to the dialyzer 1, a dialysate discharge line L2 that discharges the dialysate from the dialyzer 1, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2, wherein a control device 11 is provided capable of estimating or measuring the concentration of blood in a dilution channel section A; on the arterial blood circuit 2 that includes the fluid channel spanning from the connection site of the substitution line L3 to the dialyzer 1, and that controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.
摘要翻译：本发明公开了一种血液净化装置，其能够防止在在线HDF或在线HF中进行预取代的体外血液循环过度集中。 [解决方案]血液净化装置配备有透析器1，配置有血液泵4的动脉血液回路2，静脉血液回路3，将透析液引入透析器1的透析液导入管线L1，从透析器1排出透析液的透析液排出管线L2，将替代管线L3中流通的透析液供给到动脉血液回路2的替代管路L3和替代泵9，其中提供能够估计或测量稀释通道部分A中的血液浓度; 在包括从替代线L3的连接部分到透析器1的流体通道的动脉血液回路2上，并且基于估计或测量的血液浓度来控制由替代泵9提供的透析液的体积。

2. 发明公开

EP2535065A1 DIALYZER 有权
标题翻译： DIALYSEGERÄT
公开(公告)号：EP2535065A1
公开(公告)日：2012-12-19
申请号：EP11742208.9
申请日：2011-02-08
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , TANAKA, Kensaku
IPC分类号： A61M1/14
CPC分类号： A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3646 , A61M1/3649
摘要： An object of the present invention is to provide a dialysis apparatus which can prevent the generation of excessive positive pressure in the flow route between the blood pump and the dialysate infusing pump although there would be caused an error in the flow rate of the blood pump and the dialysate infusing pump during the blood-returning process. According to the present invention, there is provided a dialysis apparatus comprising a dialysate infusing line, one end of which being connected to the dialysate introducing line or the dialysate discharging line, the other end-side being branched out at a branch point into two flow routes respectively having a first branch end and a second branch end, the first branch end being able to be connected to the arterial blood circuit or the venous blood circuit, and the second branch end being able to be connected to the tip end of the arterial blood circuit during the blood-returning process, and a dialysate infusing pump arranged on the dialysate infusing line at a connection-side of the dialysate infusing line relative to the dialysate introducing line or the dialysate discharging line from the branch point for supplying the dialysate of the dialysate introducing line or the dialysate discharging line to the first branch end and the second branch end.
摘要翻译：本发明的目的是提供一种能够防止在血液泵和透析液输注泵之间的流路中产生过大的正压的透析装置，但是会引起血液泵的流量的误差，血液回流过程中的透析液注入泵。根据本发明，提供了一种透析装置，其包括透析液输注线，其一端与透析液导入管线或透析液排出管线连接，另一端侧在分支点分支成两流分别具有第一分支端和第二分支端的路径，第一分支端能够连接到动脉血液回路或静脉血液回路，并且第二分支端能够连接到动脉的末端血液返回过程中的血液循环，以及配置在透析液输注管线上的透析液输注管道上的透析液输注管线相对于透析液引入管线或透析液排出管路的透析液输注管线，透析液引入管线或透析液排出管线到第一分支端和第二分支端。

3. 发明公开

EP3299048A1 BLOOD PURIFICATION DEVICE 有权
标题翻译：血液净化装置
公开(公告)号：EP3299048A1
公开(公告)日：2018-03-28
申请号：EP16796556.5
申请日：2016-05-19
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , AKITA, Kunihiko , TOYODA, Masahiro
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61M1/3624 , A61M1/3627 , A61M1/3638 , A61M1/3643 , A61M1/3661 , A61M39/281 , A61M2205/07 , A61M2205/3331 , A61M2205/3344 , A61M2205/3375 , A61M2205/3379
摘要： The present invention provides a blood purification apparatus capable of assuredly preventing the blood of a patient from being extracorporeally circulated through a blood circuit with a puncture needle being inappropriately stuck in an access vessel. A blood purification apparatus according to the present invention includes a blood circuit (1) through which blood of a patient extracorporeally circulate, and a dialyzer (2) that purifies the blood flowing in the blood circuit (1). The apparatus further includes a pressure-change-producing device capable of applying a positive pressure or a negative pressure to distal portions of the blood circuit (1) while an arterial puncture needle (a) and a venous puncture needle (b) are yet to be connected to the blood circuit (1), a pressure-change-detecting device capable of detecting pressure changes in the distal portions of the blood circuit (1) that occur when the distal portions of the blood circuit (1) that are under the positive pressure or the negative pressure applied by the pressure-change-producing device are connected to the arterial puncture needle (a) and the venous puncture needle (b) that are stuck in the patient, and an evaluation device (11) capable of evaluating a state of sticking of the arterial puncture needle (a) and the venous puncture needle (b) on the basis of the pressure changes detected by the pressure-change-detecting device.
摘要翻译：本发明提供一种血液净化装置，其能够可靠地防止患者的血液在穿刺针不适当地卡在进入血管中的情况下通过血液回路体外循环。本发明的血液净化装置具备使体外循环的患者的血液循环的血液回路（1）和净化在血液回路（1）中流动的血液的透析器（2）。该装置还包括能够在动脉穿刺针（a）和静脉穿刺针（b）尚未到达时向血液回路（1）的远端部分施加正压力或负压力的压力变化产生装置与血液回路（1）连接;压力变化检测装置，能够检测在血液回路（1）的远端部分处于血液回路（1）下方时发生的血液回路将由压力变化产生装置施加的正压或负压连接到卡在患者体内的动脉穿刺针（a）和静脉穿刺针（b）;以及评估装置（11），其能够评估基于由压力变化检测装置检测到的压力变化来确定动脉穿刺针（a）和静脉穿刺针（b）的粘附状态。

4. 发明授权

EP3351275B1 BLOOD PURIFICATION APPARATUS 有权
公开(公告)号：EP3351275B1
公开(公告)日：2020-06-24
申请号：EP16855406.1
申请日：2016-10-12
申请人： Nikkiso Company Limited
发明人： ISHIZAKI, Fumihiko , HASEGAWA, Shinya , OBATA, Yuki
IPC分类号： A61M1/16

5. 发明公开

EP3351275A1 BLOOD PURIFICATION APPARATUS 有权
公开(公告)号：EP3351275A1
公开(公告)日：2018-07-25
申请号：EP16855406.1
申请日：2016-10-12
申请人： Nikkiso Company Limited
发明人： ISHIZAKI, Fumihiko , HASEGAWA, Shinya , OBATA, Yuki
IPC分类号： A61M1/16
摘要： To provide a blood purification apparatus in which the hot-water-disinfection time can be optimized with consideration for environmental conditions. A blood purification apparatus provided with a dialyzer 2 for giving dialysis treatment to a patient, and with a tube for introducing dialysate into or discharging drain liquid from the dialyzer 2. The apparatus includes a thermistor 9 that is capable of detecting an environmental condition at a time of a hot-water-disinfection process in which the tube is disinfected with hot water or a parameter regarding the environmental condition, and an estimating device 11 that estimates a hot-water-disinfection time required for the hot-water disinfection of the tube in accordance with the environmental condition or the parameter regarding the environmental condition detected by thermistor 9.

6. 发明公开

EP3287159A1 BLOOD PURIFICATION APPARATUS 有权
标题翻译：血液净化装置
公开(公告)号：EP3287159A1
公开(公告)日：2018-02-28
申请号：EP16783201.3
申请日：2016-04-20
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , FURUHASHI, Tomohiro , TAKEUCHI, Satoshi
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/301 , A61M1/30 , A61M1/3626 , A61M1/3638 , A61M1/3639 , A61M1/3644 , A61M2205/18 , A61M2205/3306 , A61M2205/3331 , A61M2205/3341 , A61M2205/3365 , A61M2230/207
摘要： To provide a blood purification apparatus employing a single-needle double-pump method and being capable of automatically discharging a priming solution that has undergone substitution from a blood circuit during blood removal. A blood purification apparatus includes a blood circuit 1 to which an only puncture needle 3 is connectable, a dialyzer 2 that purifies blood flowing in the blood circuit 1, a first blood pump 5, a second blood pump 6, and a control device 17 that allows the blood of a patient to be extracorporeally circulated through the blood circuit 1 by causing the first blood pump 5 and the second blood pump 6 to alternately undergo normal rotation. During blood removal, the control device 17 operates to substitute a priming solution in the blood circuit 1 with the blood of the patient and to discharge the priming solution having undergone the substitution from the blood circuit 1 by causing the first blood pump 5 to undergo normal rotation and the second blood pump 6 to undergo reverse rotation.
摘要翻译：本发明提供一种血液净化装置，该血液净化装置采用单针双泵方式，能够自动地排出在取血时从血液回路进行置换的预充液。血液净化装置具有能够连接唯一的穿刺针3的血液回路1，净化在血液回路1中流动的血液的透析器2，第一血液泵5，第二血液泵6以及控制装置17，通过使第一血液泵5和第二血液泵6交替进行正常旋转，从而使患者的血液通过血液回路1进行体外循环。在除血过程中，控制装置17通过使血液回路1中的预充液与患者的血液置换，使第一血液泵5正常地排出经过血液回路1的置换的预备溶液旋转，第二血液泵6反转。

7. 发明授权

EP2535065B1 DIALYZER 有权
标题翻译：透析器
公开(公告)号：EP2535065B1
公开(公告)日：2017-07-19
申请号：EP11742208.9
申请日：2011-02-08
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , TANAKA, Kensaku
IPC分类号： A61M1/14 , A61M1/34 , A61M1/36
CPC分类号： A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3646 , A61M1/3649

8. 发明授权

EP2550984B1 BLOOD PURIFICATION DEVICE 有权
标题翻译：血液清洗设备
公开(公告)号：EP2550984B1
公开(公告)日：2016-06-01
申请号：EP11759506.6
申请日：2011-03-24
申请人： Nikkiso Company Limited
发明人： HASEGAWA, Shinya , TOYODA, Masahiro
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/1601 , A61M1/1613 , A61M1/3431 , A61M1/3434 , A61M1/3441 , A61M1/3455 , A61M1/3462 , A61M1/3465 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M2205/3327 , A61M2205/3334 , A61M2205/3351 , A61M2230/207

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