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1. 发明公开

EP3558373A1 NANOPARTICLES FOR USE FOR TREATING A NEURONAL DISORDER 审中-实审
公开(公告)号：EP3558373A1
公开(公告)日：2019-10-30
申请号：EP17826215.0
申请日：2017-12-19
申请人： Nanobiotix
发明人： MEYRE, Marie-Edith , POTTIER, Agnès , LEVY, Laurent
IPC分类号： A61K41/00 , A61P25/00 , A61N2/00 , A61N1/36 , A61N1/04

2. 发明授权

EP2790682B1 NANOPARTICLES COMPRISING METALLIC AND HAFNIUM OXIDE MATERIALS, PREPARATION AND USES THEREOF 无效
公开(公告)号：EP2790682B1
公开(公告)日：2019-03-20
申请号：EP12806026.6
申请日：2012-12-17
申请人： Nanobiotix
发明人： POTTIER, Agnès , LEVY, Laurent , MEYRE, Marie-Edith
IPC分类号： A61K9/51 , A61K33/24 , A61P35/00

3. 发明公开

EP3302419A1 NANOPARTICLES FOR USE AS A THERAPEUTIC VACCINE 审中-实审
标题翻译：用作治疗性疫苗的纳米颗粒
公开(公告)号：EP3302419A1
公开(公告)日：2018-04-11
申请号：EP16727391.1
申请日：2016-05-27
申请人： Nanobiotix
发明人： MARILL, Julie , POTTIER, Agnès , LEVY, Laurent
IPC分类号： A61K9/00 , A61N5/10 , A61K9/51 , A61K33/24
CPC分类号： A61K33/24 , A61K9/0009 , A61K9/5115 , A61K38/19 , A61K39/0011 , A61K41/0038 , A61K45/06 , A61K2039/55555 , A61K2039/70 , A61N2005/1098 , A61P35/04 , A61K2300/00
摘要： The present invention relates to the field of human health and more particularly concerns nanoparticles for use as a therapeutic vaccine in the context of radiotherapy in a subject suffering of a cancer, in particular of a metastatic cancer or of a liquid cancer.

4. 发明公开

EP3010552A1 COMPOSITIONS AND METHODS FOR USE IN ONCOLOGY 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG IN DER ONKOLOGIE
公开(公告)号：EP3010552A1
公开(公告)日：2016-04-27
申请号：EP14731952.9
申请日：2014-06-19
申请人： Nanobiotix
发明人： POUL, Laurence , LEVY, Laurent , BERJAUD, Céline , GERMAIN, Matthieu , POTTIER, Agnès
IPC分类号： A61K49/04 , A61K9/08 , A61K9/51
CPC分类号： A61K49/04 , A61K9/0024 , A61K9/06 , A61K49/0423 , A61K49/0457 , A61P35/00
摘要： The present invention relates to compositions and methods for use in medical diagnostic and patient monitoring, typically in the context of therapy, in particular in the context of oncology to optimize tumor bed local irradiation. It more particularly relates to a biocompatible gel comprising nanoparticle and/or nanoparticles aggregates, wherein i) the density of each nanoparticle and of each nanoparticle aggregate is of at least 7 g/cm3, the nanoparticle or nanoparticles of the aggregate comprising an inorganic material comprising at least one metal element having an atomic number Z of at least 25, more preferably of at least 40, each of said nanoparticle and of said nanoparticle aggregate being covered with a biocompatible coating; ii) the nanoparticles and/or nanoparticle aggregate concentration is of at least about 1% (w/w); and iii) the apparent viscosity at 2 s−1 of the gel comprising nanoparticles and/or nanoparticle aggregates, is between about 0.1 Pa·s and about 1000 Pa·s when measured between 20° C. and 37° C.
摘要翻译：本发明涉及用于医学诊断和患者监测的组合物和方法，通常在治疗的上下文中，特别是在肿瘤学优化肿瘤床局部照射的背景下。更具体地涉及包含纳米颗粒和/或纳米颗粒聚集体的生物相容性凝胶，其中i）每个纳米颗粒和每个纳米颗粒聚集体的密度为至少7g / cm 3，所述聚集体的纳米颗粒或纳米颗粒包含无机材料，其包含至少一种原子序数Z为至少25，更优选至少为40的金属元素，所述纳米颗粒和所述纳米颗粒聚集体中的每一个被生物相容性涂层覆盖; ii）纳米颗粒和/或纳米颗粒聚集体浓度为至少约1％（w / w）; 和iii）当在20℃和37℃之间测量时，包含纳米颗粒和/或纳米颗粒聚集体的凝胶在2s -1处的表观粘度为约0.1Pa·s至约1000Pa·s。

5. 发明公开

EP4255488A1 POROUS, HIGH-Z AND CARBON-FREE PARTICLES AS RADIOENHANCERS 审中-实审
公开(公告)号：EP4255488A1
公开(公告)日：2023-10-11
申请号：EP21816086.9
申请日：2021-11-30
申请人： Nanobiotix
发明人： LEVY, Laurent , BERJAUD, Céline , MADEIRA, Alexandra , MARILL, Julie , MEYRE, Marie-Edith
IPC分类号： A61K41/00 , A61N5/10 , A61P35/00 , B82Y5/00

6. 发明公开

EP4157457A1 NANOPARTICLES, IONIZING RADIATION AND INNOVATIVE THERAPEUTIC COMBINATIONS THEREOF 审中-实审
公开(公告)号：EP4157457A1
公开(公告)日：2023-04-05
申请号：EP21727885.2
申请日：2021-05-25
申请人： Nanobiotix
发明人： BORGHI, Elsa , LEVY, Laurent
IPC分类号： A61P35/00 , A61K33/242 , A61K41/00

7. 发明公开

EP3229781A1 PHARMACEUTICAL COMPOSITION, PREPARATION AND USES THEREOF 审中-公开
标题翻译：药物组合物，制剂和用途
公开(公告)号：EP3229781A1
公开(公告)日：2017-10-18
申请号：EP15800773.2
申请日：2015-11-24
申请人： Nanobiotix
发明人： MEYRE, Marie-Edith , POTTIER, Agnès , LEVY, Laurent
IPC分类号： A61K9/127 , A61K9/14 , A61K9/51 , A61K31/704
CPC分类号： A61K9/127 , A61K9/14 , A61K9/51 , A61K31/704
摘要： The present invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle and of (ii) at least one pharmaceutical compound, to be administered to a subject in need of such a pharmaceutical compound, wherein the nanoparticle potentiates the pharmaceutical compound efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm, its absolute surface charge value is of at least 10 mV (|10 mV|), and its Young modulus is less than 100 kPa. The invention also relates to such a composition for use for administering the pharmaceutical compound in a subject in need thereof, wherein the at least one nanoparticle and the at least one pharmaceutical compound are to be administered in the subject between more than 5 minutes and about 72 hours one from each other.
摘要翻译：本发明涉及药物组合物，其包含（i）至少一种生物相容性纳米颗粒和（ii）至少一种药物化合物的组合，以待施用于需要这种药物化合物的受试者，其中纳米颗粒增强药物复合效率。生物相容性纳米粒子的最长尺寸典型地在约4nm与约500nm之间，其绝对表面电荷值为至少10mV（| 10mV |），并且其杨氏模量小于100kPa。本发明还涉及用于在有需要的受试者中施用药物化合物的组合物，其中所述至少一种纳米颗粒和所述至少一种药物化合物将在受试者中施用超过5分钟至约72 小时彼此。

8. 发明授权

EP2451481B1 METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF 有权
标题翻译：金属纳米粒子，其生产和使用
公开(公告)号：EP2451481B1
公开(公告)日：2017-01-25
申请号：EP10729917.4
申请日：2010-07-09
申请人： Nanobiotix
发明人： LEVY, Laurent , POTTIER, Agnès , POUL, Laurence , MAGGIORELLA, Laurence
IPC分类号： A61K41/00 , A61P35/00
CPC分类号： A61K41/0038 , A61N5/10 , A61N2005/1098
摘要： The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.

9. 发明授权

EP2670393B8 METHOD OF MONITORING THE RELEASE FROM LIPOSOMES OF A PRODUCT OF INTEREST USING SUPERPARAMAGNETIC NANOPARTICLES. 有权
标题翻译：利用超磁性纳米颗粒监测产品利尿素释放的方法。
公开(公告)号：EP2670393B8
公开(公告)日：2016-10-05
申请号：EP12701899.2
申请日：2012-01-31
申请人： Nanobiotix , Centre National de la Recherche Scientifique , Université de Bordeaux
发明人： POTTIER, Agnès , LEVY, Laurent , MEYRE, Marie-Edith , GERMAIN, Matthieu , LORENZATO, Cyril , MOONEN, Chrit , SMIRNOV, Pierre
IPC分类号： A61K41/00 , A61K9/127 , A61K49/18 , A61K9/51 , A61K31/704
CPC分类号： A61K49/1812 , A61K9/0009 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K9/5094 , A61K9/5115 , A61K31/704 , A61K41/0028 , G01N24/088 , G01R33/5601

10. 发明授权

EP2300054B1 INORGANIC NANOPARTICLES OF HIGH DENSITY TO DESTROY CELLS IN-VIVO 有权
标题翻译：用高密度无机纳米微粒在体内细胞，破坏
公开(公告)号：EP2300054B1
公开(公告)日：2016-09-07
申请号：EP09757595.5
申请日：2009-06-04
申请人： Nanobiotix
发明人： LEVY, Laurent , POTTIER, Agnès , ROUET, Annabelle , MARILL, Julie , DEVAUX, Corinne , GERMAIN, Matthieu
IPC分类号： B82Y5/00 , A61K41/00 , A61P35/00
CPC分类号： A61K41/0038 , B82Y5/00 , Y10S977/904

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