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1. 发明公开

EP2738247A1 MICROORGANISM HAVING CARBON DIOXIDE FIXATION PATHWAY INTRODUCED THEREINTO 有权
标题翻译：枸橼酸多巴胺
公开(公告)号：EP2738247A1
公开(公告)日：2014-06-04
申请号：EP12819719.1
申请日：2012-07-27
申请人： Mitsui Chemicals, Inc.
发明人： FUJII, Ryota , SHIRAI, Tomokazu , ARAKI, Tadashi , AMANO, Koh , MATSUMOTO, Yoshiko , TATENO, Toshihiro , TAKEBAYASHI, Nozomi , MORISHIGE, Takashi , TAKAHASHI, Hitoshi , WADA, Mitsufumi , SHIMIZU, Hiroshi , FURUSAWA, Chikara , HIRASAWA, Takashi , HIDESAKI, Tomonori , ENDO, Ayako , JÜRGEN-LOHMANN, Dominik Lukas , MADHAVAN, Anjali , CHONG, SU SUN
IPC分类号： C12N1/21 , C12P7/04 , C12P7/28 , C12P19/32 , C12N15/09
CPC分类号： C12P19/40 , C12N1/20 , C12N9/0006 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/28 , C12P13/14 , C12P19/32 , C12Y101/0106 , C12Y101/01081 , C12Y401/01047 , C12Y401/03024 , C12Y602/01009
摘要： An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
摘要翻译：提供了能够使用二氧化碳有效地合成乙酰辅酶A的乙酰辅酶A生产微生物和使用其的物质制备方法。一种乙酰辅酶A生产微生物，其包括通过赋予选自苹果酸硫激酶，苹果酰辅酶A裂解酶，乙醛酸卡巴肼，2-羟基-3-氧代丙酸酯还原酶中的至少一种酶活性而获得的乙酰辅酶A生产循环，和羟丙酮酸还原酶。

2. 发明授权

EP1806401B1 DNA ENCODING NOVEL ENZYME HAVING D-SERINE SYNTHASE ACTIVITY, METHOD OF PRODUCING THE ENZYME AND METHOD OF PRODUCING D-SERINE BY USING THE SAME 有权
标题翻译：用于d SERIN合酶编码DNA，PROCESS FOR生产该酶及其制造方法D-SERIN THEREOF使用一种新的酶
公开(公告)号：EP1806401B1
公开(公告)日：2013-07-31
申请号：EP05793824.3
申请日：2005-10-07
申请人： Mitsui Chemicals, Inc.
发明人： ARAKI, Tadashi , HIDESAKI, Tomonori , WATANABE, Seiichi , NISHIDA, Keita , NAGAHARA, Kiyoteru , KOITO, Mitsuo
IPC分类号： C12N15/09 , C12P13/06
CPC分类号： C12P13/06 , C12N9/1014
摘要： This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

3. 发明授权

EP2806026B1 METHOD FOR PRODUCING 1,5-PENTAMETHYLENEDIAMINE, MUTANT LYSINE DECARBOXYLASE, METHOD FOR PRODUCING 1,5-PENTAMETHYLENE DIISOCYANATE AND METHOD FOR PRODUCING POLYISOCYANATE COMPOSITION 有权
公开(公告)号：EP2806026B1
公开(公告)日：2018-12-26
申请号：EP13738315.4
申请日：2013-01-17
申请人： Mitsui Chemicals, Inc.
发明人： MOCHIZUKI, Daisuke , ARAKI, Tadashi , NATSUJI, Akiko , SAKAI, Tomomi , HIDESAKI, Tomonori
IPC分类号： C12N9/88 , C07C263/10 , C07C263/14 , C12P13/00
CPC分类号： C12P13/001 , C07C209/68 , C07C263/10 , C12N9/88 , C12P13/00 , C12Y401/01018 , C07C211/09 , C07C265/14
摘要： A mutant lysine decarboxylase is produced by replacing at least one of the amino-acids in the amino acid sequence shown in sequence ID No.4 of the sequence listing with another amino-acid.

4. 发明公开

EP2338979A1 BACTERIUM CAPABLE OF PRODUCING LACTIC ACID, AND METHOD FOR PRODUCING LACTIC ACID 审中-公开
标题翻译： MILCHSÄUREPRODUZIERENDESBAKTERIUM UND VERFAHREN ZURMILCHSÄUREPRODUKTION
公开(公告)号：EP2338979A1
公开(公告)日：2011-06-29
申请号：EP09814542.8
申请日：2009-09-11
申请人： Mitsui Chemicals, Inc.
发明人： WADA, Mitsufumi , TAKAHASHI, Katsuyuki , MORISHIGE, Takashi , MIYAZAWA, Daisuke , TAKAHASHI, Hitoshi , MOCHIZUKI, Daisuke , ARAKI, Tadashi
IPC分类号： C12N1/21 , C12N15/09 , C12P7/56
CPC分类号： C12P7/56 , C12N9/0006 , C12N9/0069 , C12P41/002
摘要： The present invention provides: a lactic acid-producing Escherichia coli including an enzymatic activity of at least one NAD-dependent lactate dehydrogenase and an enzymatic activity of at least one NAD-independent lactate oxidoreductase, both of which are enhanced so as to decompose one of D-lactic acid or L-lactic acid and to produce the other one of D-lactic acid or L-lactic acid; and a lactic acid production method using the lactic acid-producing Escherichia coli.
摘要翻译：本发明提供：具有至少一种NAD依赖性乳酸脱氢酶的酶活性和至少一种不依赖于NAD的乳酸氧化还原酶的酶活性的乳酸生产性大肠杆菌，两者都被增强以分解其中之一 D-乳酸或L-乳酸，并生成D-乳酸或L-乳酸中的另一种; 以及使用产乳酸的大肠杆菌的乳酸的制造方法。

5. 发明公开

EP2336295A1 METHOD FOR PRODUCING LACTIC ACID FROM PLANT-DERIVED RAW MATERIAL, AND LACTIC-ACID-PRODUCING BACTERIUM 有权
标题翻译：用于生产乳酸从植物原料，牛奶酸工业细菌
公开(公告)号：EP2336295A1
公开(公告)日：2011-06-22
申请号：EP09814543.6
申请日：2009-09-11
申请人： Mitsui Chemicals, Inc.
发明人： MORISHIGE, Takashi , TAKAHASHI, Katsuyuki , TAKAHASHI, Hitoshi , WADA, Mitsufumi , MOCHIZUKI, Daisuke , MIYAZAWA, Daisuke , ARAKI, Tadashi
IPC分类号： C12N1/21 , C12N15/09 , C12P7/56
CPC分类号： C12P7/56 , C12N1/20 , C12N9/1205 , C12N9/2451
摘要： The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producing Escherichia coli comprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing Escherichia coli.

6. 发明授权

EP1178051B1 PROCESS FOR SELECTIVELY PRODUCING 1-PHOSPHORYLATED SUGAR DERIVATIVE ANOMER AND PROCESS FOR PRODUCING NUCLEOSIDE 有权
标题翻译： PROCESS用于生产核苷A 1磷酸化的端基异构体ZUCKERDERIVATIV的选择性生产和工艺
公开(公告)号：EP1178051B1
公开(公告)日：2008-05-28
申请号：EP01904386.8
申请日：2001-02-13
申请人： Mitsui Chemicals, Inc.
发明人： KOMATSU, Hironori , AWANO, Hirokazu , FUKAZAWA, Nobuyuki , ITO, Kiyoshi , IKEDA, Ichirou , ARAKI, Tadashi , NAKAMURA, Takeshi , ASANO, Tamotsu , FUJIWARA, Junya , ANDO, Tomoyuki , TSUCHIYA, Katsutoshi , MARUYAMA, Kyoko , UMETANI, Hideki , YAMAUCHI, Takahiro , MIYAKE, Hitoki
IPC分类号： C07F9/655 , C07H1/02 , C07H19/20 , C07H19/12 , C07H19/19 , C07H19/23 , C07H13/08 , C07H11/04 , C12P19/38 , C07H1/04
CPC分类号： C07H19/10 , C07H19/00 , C07H19/20
摘要： A mixture of 1-phosphorylated sugar derivative anomers is phosphorolyzed and isomerized to thereby crystallize one of the anomers. Thus, the equilibrium is shifted and a desired isomer alone is selectively produced. From the 1-phosphorylated sugar derivative thus obtained and a base, a nucleoside is produced at a high stereoselectivity and a high yield under the action of a nucleoside phosphorylase. Thus, a process for anomer-selectively producing a 1-phosphorylated sugar derivative and a process for producing a nucleoside are provided.

7. 发明公开

EP3623472A1 RECOMBINANT MICROORGANISM, PRODUCTION METHOD OF PYRIDOXAMINE, OR SALT THEREOF, USING RECOMBINANT MICROORGANISM, AND PRODUCTION METHOD OF PYRIDOXAL, OR SALT THEREOF, USING RECOMBINANT MICROORGANISM 审中-公开
公开(公告)号：EP3623472A1
公开(公告)日：2020-03-18
申请号：EP18798161.8
申请日：2018-05-11
申请人： Mitsui Chemicals, Inc. , Renascience Co., Ltd.
发明人： TATENO, Toshihiro , YOKOTA, Motoi , HIDESAKI, Tomonori , ARAKI, Tadashi , SHINDO, Atsunori , MATSUMOTO, Yoshiko , MIYATA, Toshio , HONJO, Masaru
IPC分类号： C12N15/09 , C12N1/21 , C12P17/12
摘要： A recombinant microorganism includes a gene encoding a pyridoxine dehydrogenase, a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid regeneration enzyme having an enzymatic activity of regenerating an amino acid consumed by the pyridoxamine synthetase, in which at least two of the gene encoding the pyridoxine dehydrogenase, the gene encoding the pyridoxamine synthetase, or the gene encoding the amino acid regeneration enzyme, are introduced from outside of a bacterial cell, or are endogenous to the bacterial cell and have an enhanced expression. In addition, a recombinant microorganism into which a gene encoding a pyridoxine dehydrogenase is introduced is provided.

8. 发明授权

EP2336295B1 METHOD FOR PRODUCING LACTIC ACID FROM PLANT-DERIVED RAW MATERIAL, AND LACTIC-ACID-PRODUCING BACTERIUM 有权
标题翻译：从植物来源的原料生产乳酸的方法和产酸乳酸的细菌
公开(公告)号：EP2336295B1
公开(公告)日：2018-01-24
申请号：EP09814543.6
申请日：2009-09-11
申请人： Mitsui Chemicals, Inc.
发明人： MORISHIGE, Takashi , TAKAHASHI, Katsuyuki , TAKAHASHI, Hitoshi , WADA, Mitsufumi , MOCHIZUKI, Daisuke , MIYAZAWA, Daisuke , ARAKI, Tadashi
IPC分类号： C12N1/21 , C12N15/09 , C12P7/56 , C12P41/00 , C12N9/04
CPC分类号： C12P7/56 , C12N1/20 , C12N9/1205 , C12N9/2451
摘要： The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producing Escherichia coli comprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing Escherichia coli.

9. 发明公开

EP2426210A1 PROCESS FOR PRODUCTION OF 3-MERCAPTOPROPIONIC ACID OR SALT THEREOF 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON 3-MERCAPTOPROPIONSÄUREODER EINEM SALZ DARAUS
公开(公告)号：EP2426210A1
公开(公告)日：2012-03-07
申请号：EP10769529.8
申请日：2010-04-30
申请人： Mitsui Chemicals, Inc.
发明人： ARAKI, Tadashi , FURUYA, Masayuki , HAYASHI, Hidetoshi
IPC分类号： C12P11/00 , C12N15/09
CPC分类号： C12P11/00 , C08G75/28 , C12Y305/01004 , C12Y402/01084
摘要： The present invention provides is a method for producing 3-mercaptopropionic acid from 3-mercaptopropionamide or a salt thereof with the use of an amidase. The method enables the production of 3-mercaptopropionic acid on an industrial scale through an enzymatic reaction.
摘要翻译：本发明提供了使用酰胺酶从3-巯基丙酰胺或其盐生产3-巯基丙酸的方法。该方法能够通过酶反应在工业规模生产3-巯基丙酸。

10. 发明公开

EP1338654A1 PROCESS FOR PRODUCING NUCLEOSIDE COMPOUND 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER NUKLEOSIDVERBINDUNG
公开(公告)号：EP1338654A1
公开(公告)日：2003-08-27
申请号：EP01980986.2
申请日：2001-11-06
申请人： Mitsui Chemicals, Inc.
发明人： ARAKI, Tadashi , IKEDA, Ichiro , TAKAHASHI, Katsuyuki , ITO, Kiyoshi , ASANO, Tamotsu , NIKUMARU, Seiya , NAKAMURA, Takeshi , ISHIBASHI, Hiroki , NAGAHARA, Kiyoteru , FUKUIRI, Yasushi
IPC分类号： C12P19/38
CPC分类号： C12P19/38
摘要： In reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in an aqueous reaction medium in the presence-of a metal cation to produce a nucleoside compound, the timing or method of addition of at least one of these components to the aqueous reaction medium is varied; thereby, a nucleoside compound can be produced at a high yield efficiently without inviting the high viscosity or solidification of the reaction mixture, even when the above components are used in such amounts that the reaction mixture becomes highly viscous or is solidified when the components are used without the above variation of the addition timing or method. Thus, there can be provided a process for producing a nucleoside compound, which comprises a step of reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in the presence of nucleoside phosphorylase activity, which gives a nucleoside compound at an improved conversion, and which has wide applicability.
摘要翻译：在金属阳离子存在下，在水性反应介质中使戊糖-1-磷酸与核酸碱基或核酸碱基类似物反应以产生核苷化合物，添加这些中的至少一种的时间或方法改变水性反应介质的组分; 因此，即使当使用上述成分使得当使用组分时反应混合物变得高粘稠或固化的量，可以高效率地生产核苷化合物而不引起反应混合物的高粘度或固化而没有上述添加时间或方法的变化。因此，可以提供一种制备核苷化合物的方法，其包括在核苷磷酸化酶活性存在下使戊糖-1-磷酸与核酸碱基或核酸碱基类似物反应的步骤，得到核苷化合物改进后，具有广泛的适用性。

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