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1. 发明公开

EP2655605A1 MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING LIPIDS 无效
标题翻译：生物脂质体修饰的光合微生物
公开(公告)号：EP2655605A1
公开(公告)日：2013-10-30
申请号：EP11804899.0
申请日：2011-12-19
申请人： Matrix Genetics, LLC
发明人： ROBERTS, James , CROSS, Fred , KAISER, Brett K.
IPC分类号： C12N9/02 , C12P7/64
CPC分类号： C12P7/6436 , C12N9/0008 , C12N15/74 , C12N15/8242 , C12N15/8247 , C12P7/6409 , C12Y102/0108
摘要： This disclosure describes genetically modified photosynthetic microorganisms,
e.g ., Cyanobacteria, that overexpress an acyl-acyl carrier protein reductase (acyl-ACP reductase). These microorganisms may optionally overexpress one or more fatty acid synthesis proteins such as ACP and ACCase, and/or one or more polypeptides associated with glycogen breakdown. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism. The modified photosynthetic microorganisms provided herein are capable of producing increased amounts of lipids such as fatty acids or wax esters and/or synthesizing triglycerides.
摘要翻译：本公开描述了过表达酰基 - 酰基载体蛋白还原酶（酰基-ACP还原酶）的基因修饰的光合微生物，例如蓝细菌。这些微生物可以任选地过表达一种或多种脂肪酸合成蛋白，例如ACP和ACCase，和/或一种或多种与糖原分解相关的多肽。还包括光合微生物，其包含糖原生物合成或储存途径中的突变或缺失，与野生型光合微生物相比，其在减少的氮条件下积累减少量的糖原。本文提供的修饰的光合微生物能够产生增加量的脂质，例如脂肪酸或蜡酯和/或合成甘油三酯。

2. 发明公开

EP2655592A2 MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING LIPIDS 无效
标题翻译：改进的光合微生物用于产生脂质
公开(公告)号：EP2655592A2
公开(公告)日：2013-10-30
申请号：EP11804900.6
申请日：2011-12-19
申请人： Matrix Genetics, LLC
发明人： ROBERTS, James , CROSS, Fred , MCCORMICK, Margaret Mary , MUNOZ, Ernesto Javier , KAISER, Brett K. , CARLETON, Michael
IPC分类号： C12N1/00
CPC分类号： C12N15/82 , C07K14/195 , C12N9/1029 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/90 , C12N9/93 , C12P7/64 , Y02P20/52
摘要： This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that overexpress an acyl carrier protein (ACP), an acyl-ACP synthase (Aas), or both, optionally in combination with one or more overexpressed or exogenous lipid biosynthesis proteins, and/or one or more overexpressed or exogenous glycogen breakdown proteins. Exemplary biosynthesis proteins include diacyglycerol acyltransferases, thioesterases, phosphatidate phosphatases, phospholipases, triacylglycerol (TAG) hydrolases, fatty acyl-CoA synthetases, and/or acetyl-CoA carboxylases, including combinations thereof. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism. The modified photosynthetic microorganisms provided herein are capable of producing increased amounts of lipids such as fatty acids and/or synthesizing triglycerides.

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