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1. 发明公开

EP2609954A3 An interactive apparatus and method for real-time profiling of inhalation efforts 有权转让
标题翻译：用于实时分析吸入努力的交互装置和方法
公开(公告)号：EP2609954A3
公开(公告)日：2018-01-10
申请号：EP13161157.6
申请日：2009-06-19
申请人： MannKind Corporation
发明人： Overfield, Dennis , Sahi, Carl R. , Adamo, Benoit , Kinsey, P. Spencer , McLean, Scott , Polidoro, John M. , Smutney, Chad C.
IPC分类号： A61M15/00 , A61B5/087 , A61M16/00 , G09B23/28
CPC分类号： A61M15/0065 , A61B5/087 , A61M15/0021 , A61M15/0025 , A61M15/008 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2206/10 , A61M2209/086 , A61M2230/40 , G06F19/00 , G09B23/28
摘要： A sensor system (1000) for a dry powder inhaler (900) comprising:a detachable device (1000) configured to attach to the dry powder inhaler (900), the detachable device (1000) including at least one sensor (1202) configured to detect in real time at least one signal generated by the dry powder inhaler (900) during an inhalation maneuver.
摘要翻译： 1。一种用于干粉吸入器（900）的传感器系统（1000），包括：可拆卸装置（1000），该可拆卸装置构造成附接到干粉吸入器（900），所述可拆卸装置（1000）包括至少一个传感器（1202）在吸气操作期间实时检测由干粉吸入器（900）产生的至少一个信号。

2. 发明授权

EP2570147B1 A dry powder inhaler and system for drug delivery 有权转让
标题翻译：干粉吸入器和药物输送系统
公开(公告)号：EP2570147B1
公开(公告)日：2017-10-18
申请号：EP12170549.5
申请日：2009-06-12
申请人： MannKind Corporation
发明人： Smutney, Chad C. , Mann, Alfred , Kinsey, P. Spencer , Sahi, Carl R. , Adamo, Benoit , Polidoro, John M. , McLean, Scott , Overfield, Dennis , Bryant, Anthony , He, Tom
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20

3. 发明公开

EP2570147A2 A dry powder inhaler and system for drug delivery 有权转让
标题翻译：干粉吸入器和药物输送系统
公开(公告)号：EP2570147A2
公开(公告)日：2013-03-20
申请号：EP12170549.5
申请日：2009-06-12
申请人： MannKind Corporation
发明人： Smutney, Chad C. , Mann, Alfred , Kinsey, P. Spencer , Sahi, Carl R. , Adamo, Benoit , Polidoro, John M. , McLean, Scott , Overfield, Dennis , Bryant, Anthony , He, Tom
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A dry powder inhaler (100) comprises a chamber (150) for containing a powder and a housing (120) in which the chamber (150) is mounted. The housing (120) defines first (118,124) and second flow paths (140) leading from outside the inhaler (100) to a mouthpiece (130), the first flow path (118,124) allowing air to flow through the chamber (150) and the second flow path (140) allowing air to bypass the chamber. The first (118,124) and second (140) paths are configured so that in use airflow bypassing the chamber (150) is directed to impinge upon airflow exiting the chamber (150) for deagglomerating powder particles as they exit the chamber (150). The chamber (150) may contain a cohesive powder e.g. a diketopiperazine, and the powder may contain insulin or another medicament.
摘要翻译：干粉吸入器（100）包括用于容纳粉末的腔室（150）和安装腔室（150）的壳体（120）。壳体（120）限定从吸入器（100）外部通向嘴部（130）的第一流动路径（118,124）和第二流动路径（140），第一流动路径（118,124）允许空气流过腔室（150），并且第二流动路径（140）允许空气绕过腔室。第一（118,124）和第二（140）路径被构造成使得在使用中绕过腔室（150）的气流被引导冲击离开腔室（150）的气流，以在粉末颗粒离开腔室（150）时解聚集粉末颗粒。腔室（150）可以含有粘结粉末，例如，二酮哌嗪，粉末可以含有胰岛素或其他药物。

4. 发明公开

EP2567723A1 A dry powder inhaler and system for drug delivery 有权转让
标题翻译：干粉吸入器和药物输送系统
公开(公告)号：EP2567723A1
公开(公告)日：2013-03-13
申请号：EP12170583.4
申请日：2009-06-12
申请人： MannKind Corporation
发明人： Smutney, Chad C. , Mann, Alfred , Kinsey, P. Spencer , Sahi, Carl R. , Adamo, Benoit , Polidoro, John M. , McLean, Scott , Overfield, Dennis , Bryant, Anthony , He, Tom
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath powered dry powder inhaler configured to deliver particles to the pulmonary circulation of a subject comprises a chamber for containing the particles and a mouthpiece. Portions of the inhaler define a flow path leading from at least one inlet (119) to said chamber through said chamber and through at least one outlet (127) from said chamber to the mouthpiece. The at least one inlet and the at least one outlet are further configured so that air from the at least one inlet is directed across said at least one outlet and controls exit from the chamber of powder entrained within the flow. In embodiments the at least one inlet (119), the at least one outlet (127) and the chamber are configured so that in use air entering the chamber circulates within the chamber for promoting entrainment and lifting of a powder in the chamber. In these embodiments the inlet may define a first direction for air entry into the chamber, the outlet may define a second direction generally perpendicular to the first direction for air and powder leaving the chamber, and the inlet (119), outlet (127) and chamber may be configured so that in use air within the chamber circulates about an axis directed generally perpendicular to the first and generally perpendicular to the second direction. The chamber may contain a cohesive powder e.g. a diketopiperazine, and the powder may contain insulin or another medicament.
摘要翻译：构造成将颗粒递送至受试者的肺循环的呼吸动力干粉吸入器包括用于容纳颗粒和吸口的腔室。吸入器的部分限定了从至少一个入口（119）通过所述腔室通过所述腔室并且通过至少一个出口（127）从所述腔室到达吹口的流动路径。所述至少一个入口和所述至少一个出口进一步构造成使得来自所述至少一个入口的空气被引导穿过所述至少一个出口并且控制从所述流动内夹带的粉末室的出口。在实施例中，至少一个入口（119），至少一个出口（127）和腔室被构造成使得在使用中进入腔室的空气在腔室内循环以促进腔室中粉末的夹带和提升。在这些实施例中，入口可限定空气进入腔室的第一方向，出口可限定大致垂直于第一方向的第二方向，以使空气和粉末离开腔室，并且入口（119），出口（127）和腔室可构造成使得在使用中腔室内的空气围绕大致垂直于第一方向且大致垂直于第二方向的轴线循环。该室可以含有粘结粉末，例如，二酮哌嗪，粉末可以含有胰岛素或其他药物。

5. 发明公开

EP2676695A3 Apparatus, system and method for measuring resistance of an inhaler 审中-公开
标题翻译： Vorrichtung，系统和Verfahren zur Messung des Widerstandes eines吸入器
公开(公告)号：EP2676695A3
公开(公告)日：2017-03-01
申请号：EP13185426.7
申请日：2010-03-11
申请人： MannKind Corporation
发明人： Adamo, Benoit , McLean, Scott , Smutney, Chad C. , Polidoro, John M. , Sahi, Carl R.
IPC分类号： A61M15/00 , A62B27/00
CPC分类号： G01N7/00 , A61M15/00 , A61M15/0065 , A61M16/0003 , A61M16/0057 , A61M16/10 , A61M16/201 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/3334 , A61M2209/02 , G01F1/00 , G01L13/00
摘要： Abstract: The present disclosure relates to a device (10) and method for measuring the resistance of inhalers (20) to air flow. In particular, the device and method can be used to measure the resistance to air flow of dry powder inhalers (20), which are used for pulmonary drug delivery. The device (10) has a pair of chambers (12, 18) to mount and enclose an inhaler (20) within. Each chamber (12, 18) has a respective valve. The device (10) has further a pressure controller (22), a flow controller (24) and pressure and flow sensors and microprocessors configured to control opening and closing of the valves and to detect and analyze the corresponding signals.
摘要翻译：摘要：本发明涉及一种用于测量吸入器（20）对气流的阻力的装置（10）和方法。特别地，该装置和方法可用于测量用于肺部药物递送的干粉吸入器（20）的气流阻力。装置（10）具有一对安装和封闭吸入器（20）的腔室（12,18）。每个室（12,18）具有相应的阀。装置（10）还具有压力控制器（22），流量控制器（24）和压力和流量传感器和微处理器，其被配置为控制阀的打开和关闭并检测和分析对应的信号。

6. 发明公开

EP2676695A2 Apparatus, system and method for measuring resistance of an inhaler 审中-公开
标题翻译：装置，系统和方法，用于测量的吸入器的电阻
公开(公告)号：EP2676695A2
公开(公告)日：2013-12-25
申请号：EP13185426.7
申请日：2010-03-11
申请人： MannKind Corporation
发明人： Adamo, Benoit , McLean, Scott , Smutney, Chad C. , Polidoro, John M. , Sahi, Carl R.
IPC分类号： A61M15/00 , A62B27/00
CPC分类号： G01N7/00 , A61M15/00 , A61M15/0065 , A61M16/0003 , A61M16/0057 , A61M16/10 , A61M16/201 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/3334 , A61M2209/02 , G01F1/00 , G01L13/00
摘要： Abstract: The present disclosure relates to a device (10) and method for measuring the resistance of inhalers (20) to air flow. In particular, the device and method can be used to measure the resistance to air flow of dry powder inhalers (20), which are used for pulmonary drug delivery. The device (10) has a pair of chambers (12, 18) to mount and enclose an inhaler (20) within. Each chamber (12, 18) has a respective valve. The device (10) has further a pressure controller (22), a flow controller (24) and pressure and flow sensors and microprocessors configured to control opening and closing of the valves and to detect and analyze the corresponding signals.

7. 发明公开

EP2570147A3 A dry powder inhaler and system for drug delivery 有权转让
标题翻译： Trockenpulverinhalator和系统zur Wirkstofffreisetzung
公开(公告)号：EP2570147A3
公开(公告)日：2013-07-10
申请号：EP12170549.5
申请日：2009-06-12
申请人： MannKind Corporation
发明人： Smutney, Chad C. , Mann, Alfred , Kinsey, P. Spencer , Sahi, Carl R. , Adamo, Benoit , Polidoro, John M. , McLean, Scott , Overfield, Dennis , Bryant, Anthony , He, Tom
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A dry powder inhaler (100) comprises a chamber (150) for containing a powder and a housing (120) in which the chamber (150) is mounted. The housing (120) defines first (118,124) and second flow paths (140) leading from outside the inhaler (100) to a mouthpiece (130), the first flow path (118,124) allowing air to flow through the chamber (150) and the second flow path (140) allowing air to bypass the chamber. The first (118,124) and second (140) paths are configured so that in use airflow bypassing the chamber (150) is directed to impinge upon airflow exiting the chamber (150) for deagglomerating powder particles as they exit the chamber (150). The chamber (150) may contain a cohesive powder e.g. a diketopiperazine, and the powder may contain insulin or another medicament.
摘要翻译：干粉吸入器（100）包括用于容纳粉末的室（150）和其中安装有室（150）的壳体（120）。壳体（120）限定从吸入器（100）的外部到吸嘴（130）的第一流动路径（118,124）和第二流动路径（140），第一流动路径（118,124）允许空气流过腔室（150）和所述第二流路（140）允许空气绕过所述室。第一（118,124）和第二（140）路径被构造成使得在使用中，旁路室（150）的气流被引导以撞击离开室（150）的气流，以在粉末颗粒离开室（150）时解散聚集。腔室（150）可以包含粘性粉末，例如，二酮哌嗪，并且粉末可以含有胰岛素或其它药物。

8. 发明公开

EP2609954A2 An interactive apparatus and method for real-time profiling of inhalation efforts 有权转让
标题翻译：一个互动的装置和方法吸入研究的实时分析
公开(公告)号：EP2609954A2
公开(公告)日：2013-07-03
申请号：EP13161157.6
申请日：2009-06-19
申请人： MannKind Corporation
发明人： Overfield, Dennis , Sahi, Carl R. , Adamo, Benoit , Kinsey, P. Spencer , McLean, Scott , Polidoro, John M. , Smutney, Chad C.
IPC分类号： A61M15/00 , A61B5/087 , A61M16/00
CPC分类号： A61M15/0065 , A61B5/087 , A61M15/0021 , A61M15/0025 , A61M15/008 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2206/10 , A61M2209/086 , A61M2230/40 , G06F19/00 , G09B23/28
摘要： A sensor system (1000) for a dry powder inhaler (900) comprising:a detachable device (1000) configured to attach to the dry powder inhaler (900), the detachable device (1000) including at least one sensor (1202) configured to detect in real time at least one signal generated by the dry powder inhaler (900) during an inhalation maneuver.
摘要翻译：一种传感器系统（1000），用于干粉吸入器（900），包括：配置一个可拆卸装置（1000）附连到被配置为干粉吸入器（900），所述可拆卸装置（1000）包括至少一个传感器（1202）实时检测吸入操纵期间由干粉吸入器（900）产生的至少一个信号。

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