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    • 1. 发明公开
    • AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER
    • MIKROKALORIMETER ZUR AUTOMATICHCHEN同位素测定仪
    • EP3144666A1
    • 2017-03-22
    • EP16191045.0
    • 2009-12-01
    • Malvern Instruments Incorporated.,
    • BROGA, MartinPRICE, Philip E.SMITH, Stephen
    • G01N25/48
    • An isothermal titration micro calorimetry (ITC) system (300), comprising: a microcalorimeter (20), an automatic pipette assembly (30), a pipette translation unit (310) and a wash station.. The microcalorimeter (20) has a sample cell (50) and a reference cell (40), the sample cell (50) accessible via a sample cell stem (180) and the reference cell accessible via a reference cell stem (170). The automatic pipette assembly (30) comprise a syringe (200) with a titration needle (210) arranged to be inserted into the sample cell (50) for supplying titrant and a fill port (500) at an upper section of the syringe (200), providing fluidic contact with the syringe cavity when the plunger (230) is positioned above the fill port (500). The pipette assembly (30) also comprises an activator (220) for driving a plunger (230) in the syringe (200). The pipette translation unit (310) comprises a pipette arm (380) that is supported for rotation about an axis (A), supports the pipette assembly (30) at its other end and is further arranged to move the pipette assembly vertically. The pipette translation unit (310) is arranged to place the pipette assembly (30) in position for titration, washing and filling operations. The wash station is for the titrant needle (210).
    • 一种等温滴定微量热法(ITC)系统(300),包括:微量热计(20),自动移液管组件(30),移液管转换单元(310)和洗涤台。微量热计(20) 细胞(50)和参照细胞(40),所述样品池(50)可通过样品池干(180)和可通过参考细胞干(170)接近的参比细胞接近。 自动移液管组件(30)包括具有滴定针(210)的注射器(200),其被布置成插入到用于在注射器(200)的上部供应滴定剂和填充口(500)的样品池中 ),当柱塞(230)位于填充口(500)上方时,提供与注射器腔的流体接触。 移液管组件(30)还包括用于驱动注射器(200)中的柱塞(230)的活化器(220)。 移液管平移单元(310)包括用于围绕轴线(A)旋转的移液管臂(380),在其另一端支撑移液管组件(30),并且进一步布置成垂直移动移液管组件。 移液管平移单元(310)布置成将移液管组件(30)放置在适当位置用于滴定,洗涤和填充操作。 洗涤站用于滴定针(210)。
    • 2. 发明授权
    • AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER APPARATUS
    • 自动等温滴定微量器具
    • EP2352993B1
    • 2017-03-08
    • EP09830940.4
    • 2009-12-01
    • Malvern Instruments Incorporated
    • BROGA, MartinPRICE, Phillip E.SMITH, Stephen
    • G01N25/48
    • G01N25/4873B01L3/02G01K17/006G01N1/14G01N25/20G01N25/48G01N25/4813G01N25/4866G01N35/00584G01N35/0092G01N35/1002
    • An isothermal titration micro calorimetry (ITC) system (300), comprising: a microcalorimeter (20), an automatic pipette assembly (30), a pipette translation unit (310) and a wash station.. The microcalorimeter (20) has a sample cell (50) and a reference cell (40), the sample cell (50) accessible via a sample cell stem (180) and the reference cell accessible via a reference cell stem (170). The automatic pipette assembly (30) comprise a syringe (200) with a titration needle (210) arranged to be inserted into the sample cell (50) for supplying titrant and a fill port (500) at an upper section of the syringe (200), providing fluidic contact with the syringe cavity when the plunger (230) is positioned above the fill port (500). The pipette assembly (30) also comprises an activator (220) for driving a plunger (230) in the syringe (200). The pipette translation unit (310) comprises a pipette arm (380) that is supported for rotation about an axis (A), supports the pipette assembly (30) at its other end and is further arranged to move the pipette assembly vertically. The pipette translation unit (310) is arranged to place the pipette assembly (30) in position for titration, washing and filling operations. The wash station is for the titrant needle (210).
    • 自动等温滴定微量热仪(ITC)系统包含一台含有样品池和参比池的微量热仪,样品池可通过样品池进入,参比池可通过参比池进入。 该系统进一步包括自动移液管组件,该自动移液管组件包括带有滴定针的注射器,该滴定针布置成插入到用于供应滴定剂的样品池中,移液器组件包括用于驱动注射器中的柱塞的激活器,支撑移液管组件的移液管平移单元和 被设置为将移液管放置在用于滴定,清洗和填充操作的位置,用于滴定剂针的清洗站以及细胞制备单元,该细胞制备单元被布置为当移液管被放置在除了移液器之外的另一位置时执行用于替换样品池中的样品液体的操作 滴定的位置。