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1. 发明公开

EP1930034A1 An integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权转让
标题翻译：集成Zentrifugalpumpoxygenator用于去除气泡和排气体外生命保障系统的血液体外生命支持的系统和方法
公开(公告)号：EP1930034A1
公开(公告)日：2008-06-11
申请号：EP07106451.3
申请日：2007-04-18
申请人： Levitronix LLC , University of Maryland, Baltimore
发明人： Gellman, Barry N. , Wu, Zhongjun , Koert, Andrew , Zhang, Juntao
IPC分类号： A61M1/16 , A61M1/10
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： The invention relates to an integrated centrifugal blood pump-oxygenator (1) comprising a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further comprises an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to an gas outlet (13) and a blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) by the rotational body (8) from the blood inlet (4) to the blood outlet (5). According to the invention, the rotational body (8) is magnetically journalled in a contact free manner with respect to the rotor-housing (9). The invention is also related to an extracorporeal life support system (1000) and a method of de-bubbling and priming a extracorporeal life support system (1000) in accordance with the present invention.
摘要翻译：本发明涉及到集成离心血液泵充氧（1），包括壳体（2）具有顶部（3），其具有血液入口（4），血液出口（5）和进气口（6），和一个底部（7）具有一个旋转体（8）在转子 - 壳体被可旋转地布置（9）的底部（7）。集成离心血液泵充氧（1）还包括在所述壳体（2），在操作状态下氧worin（12）被从气体入口转移在内部（11）提供充氧膜（10）（6）通过充氧器膜（10），以在气体出口（13）和血液（14）是通过从血液入口由转动体（8）泵送血液（14）带入与充氧膜（10）直接接触的（4）血液出口（5）。。根据本发明，旋转体（8）被磁性地相对于所述转子 - 壳体（9）在轴颈一个接触的方式。因此，本发明涉及上体外生命支持系统（1000）和脱泡的方法和涂刷在雅舞蹈体外生命支持系统（1000）与本发明。

2. 发明公开

EP1825873A2 A pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 审中-公开
标题翻译：一个泵流入套管，一个泵流出套管和一个血液管理系统
公开(公告)号：EP1825873A2
公开(公告)日：2007-08-29
申请号：EP06125595.6
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Richardson, J. Scott , Gellman, Barry N. , Koert, Andrew , Dasse, Kurt
IPC分类号： A61M1/36 , A61M25/00
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and / or from an associated vessel to an external blood handling system. Said pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and /or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及一种从心脏（2）和/或从相关血管向外部血液处理系统提供血液导管的泵流入套管（1）。所述泵流入套管包括主体（3），所述主体（3）包括基本上轴向延伸的流入腔（4），所述流入腔具有用于将流入腔（4）附接到所述血液处理系统的远端（5）并具有用于将血液从心脏（2）和/或从相关血管引入流入内腔（4）的近端（6），其中至少一个突出部（7）设置在近端 - （6）以使心肌偏转而不侵入所述流入内腔（4），其中所述泵流入套管的所述主体（3）包括加强件装置（8）。本发明还涉及根据本发明的泵流出套管（19）和包括泵流入套管和泵流出套管的血液管理系统。

3. 发明公开

EP1825872A2 A pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 审中-公开
标题翻译：一个泵流入套管，一个泵流出套管和一个血液管理系统
公开(公告)号：EP1825872A2
公开(公告)日：2007-08-29
申请号：EP06125598.0
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Gellman, Barry N. , Richardson, J. Scott , Marks, John , Koert, Andrew
IPC分类号： A61M1/10 , A61M1/36 , A61M25/00
CPC分类号： A61M25/007 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M2025/0076 , A61M2025/0078 , A61M2027/004
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and / or from an associated vessel to an external blood handling system, said pump-inflow-cannula (1) comprising a body (3), encompassing an inflow-lumen (4), extending essentially axially along a center-line (5), having a distal-end (6) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (7) for an introduction of blood from the heart (2) and / or from the associated vessel into the inflow-lumen (4). At the proximal-end (7) at least one angled-hole (8), extending around a longitudinal hole-axis (9) is provided, and said hole-axis (9) includes a presettable hole-angle (α) with the center-line (5) of the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula (1) comprises a reinforcement-means (10). The invention is also related to a pump-outflow-cannula (23) and to a blood managing system comprising a pump-inflow-cannula (1) and a pump-outflow-cannula (23) in accordance with the present invention.
摘要翻译：本发明涉及一种从心脏（2）和/或从相关血管向外部血液处理系统提供血液导管的泵流入套管（1），所述泵流入套管（1）包括主体包括流入内腔（4），所述流入内腔基本上沿着中心线（5）轴向延伸，具有用于将所述流入内腔（4）附接到所述血液处理系统的远端（6），以及具有用于将血液从心脏（2）和/或从相关脉管引入流入内腔（4）的近端（7）。在近端（7）处设置至少一个围绕纵向孔轴线（9）延伸的倾斜孔（8），并且所述孔轴线（9）包括可预设的孔角度（4）的中心线（5），其中所述泵流入套管（1）的所述主体（3）包括加强装置（10）。本发明还涉及根据本发明的泵流出套管（23）和包括泵流入套管（1）和泵流出套管（23）的血液管理系统。

4. 发明公开

EP1990067A2 A pump-outflow-cannula and a blood managing system 审中-公开
标题翻译： Perfusionskanüle和Blut-Managementsystem
公开(公告)号：EP1990067A2
公开(公告)日：2008-11-12
申请号：EP08161529.6
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Gellman, Barry N. , Richardson, J. Scott , Marks, John , Koert, Andrew
IPC分类号： A61M1/36
CPC分类号： A61M25/007 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M2025/0076 , A61M2025/0078 , A61M2027/004
摘要： The invention relates to a pump-outflow-cannula (23) providing a blood conduit from an external blood handling system to a heart (2) and / or to an associated vessel, said pump-outflow-cannula (23) comprising a body (24) encompassing an essentially axially extending outflow-lumen (25) having a distal-end (26) for an introduction of blood from said blood management system into the outflow-lumen (25), and having a proximal-end (27) for an attachment of the outflow-lumen (25) to the heart (2) and / or to the associated vessel. According to the invention, said body (24) of the pump-outflow-cannula (23) comprises a reinforcement-means (28).The invention is also related to a blood managing system comprising a pump-outflow-cannula (23) in accordance with the present invention.
摘要翻译：本发明涉及提供从外部血液处理系统到心脏（2）和/或相关血管的血液导管的泵 - 流出 - 插管（23），所述泵 - 流出 - 插管（23）包括主体 24）包括具有远端（26）的基本上轴向延伸的流出腔（25），用于将血液从所述血液管理系统引入流出腔（25），并且具有近端（27），用于流出腔（25）与心脏（2）和/或相关血管的连接。根据本发明，泵流出套管（23）的所述主体（24）包括加强装置（28）。本发明还涉及一种血液管理系统，其包括泵 - 流出 - 插管（23）根据本发明。

5. 发明公开

EP1825872A3 A pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 审中-公开
标题翻译：引流插管灌注插管和血液管理系统
公开(公告)号：EP1825872A3
公开(公告)日：2007-10-03
申请号：EP06125598.0
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Gellman, Barry N. , Richardson, J. Scott , Marks, John , Koert, Andrew
IPC分类号： A61M1/10 , A61M1/36 , A61M25/00
CPC分类号： A61M25/007 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M2025/0076 , A61M2025/0078 , A61M2027/004
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and / or from an associated vessel to an external blood handling system, said pump-inflow-cannula (1) comprising a body (3), encompassing an inflow-lumen (4), extending essentially axially along a center-line (5), having a distal-end (6) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (7) for an introduction of blood from the heart (2) and / or from the associated vessel into the inflow-lumen (4). At the proximal-end (7) at least one angled-hole (8), extending around a longitudinal hole-axis (9) is provided, and said hole-axis (9) includes a presettable hole-angle (α) with the center-line (5) of the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula (1) comprises a reinforcement-means (10). The invention is also related to a pump-outflow-cannula (23) and to a blood managing system comprising a pump-inflow-cannula (1) and a pump-outflow-cannula (23) in accordance with the present invention.

6. 发明公开

EP1990067A3 A pump-outflow-cannula and a blood managing system 审中-公开
标题翻译：灌注插管和血液管理系统
公开(公告)号：EP1990067A3
公开(公告)日：2010-12-15
申请号：EP08161529.6
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Gellman, Barry N. , Richardson, J. Scott , Marks, John , Koert, Andrew
IPC分类号： A61M1/10 , A61M1/36 , A61M25/00
CPC分类号： A61M25/007 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M2025/0076 , A61M2025/0078 , A61M2027/004
摘要： The invention relates to a pump-outflow-cannula (23) providing a blood conduit from an external blood handling system to a heart (2) and / or to an associated vessel, said pump-outflow-cannula (23) comprising a body (24) encompassing an essentially axially extending outflow-lumen (25) having a distal-end (26) for an introduction of blood from said blood management system into the outflow-lumen (25), and having a proximal-end (27) for an attachment of the outflow-lumen (25) to the heart (2) and / or to the associated vessel. According to the invention, said body (24) of the pump-outflow-cannula (23) comprises a reinforcement-means (28).The invention is also related to a blood managing system comprising a pump-outflow-cannula (23) in accordance with the present invention.

7. 发明公开

EP1825873A3 A pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 审中-公开
标题翻译： Drainagekanule，Perfusionskanüle和Blut-Managementsystem
公开(公告)号：EP1825873A3
公开(公告)日：2007-09-26
申请号：EP06125595.6
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Richardson, J. Scott , Gellman, Barry N. , Koert, Andrew , Dasse, Kurt
IPC分类号： A61M1/36 , A61M25/00
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and / or from an associated vessel to an external blood handling system. Said pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and /or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及提供从心脏（2）和/或从相关血管到外部血液处理系统的血液导管的泵流入套管（1）。所述泵入流套管包括主体（3），其包围基本上轴向延伸的流入腔（4），其具有用于将流入腔（4）附接到所述血液处理系统的远端（5）并且具有近端（6），用于将来自心脏（2）和/或从相关血管的血液引入流入腔（4）中，其中至少一个突起（7）设置在近端 - 端部（6）使心脏肌肉偏转进入流入腔（4），其中所述泵流入套管的所述主体（3）包括加强装置（8）。本发明还涉及一种泵 - 流出 - 插管（19）和一种血液管理系统，其包括根据本发明的泵流入套管和泵 - 流出 - 套管。

8. 发明公开

EP1990066A3 A pump-outflow-cannula and a blood managing system 有权转让
标题翻译：泵出流量套管和血液管理系统
公开(公告)号：EP1990066A3
公开(公告)日：2010-12-15
申请号：EP08161283.0
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Richardson, J. Scott , Gellman, Barry N. , Koert, Andrew , Dasse, Kurt
IPC分类号： A61M1/36 , A61M25/00
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-outflow-cannula (19) providing a blood conduit from an external blood handling system to a heart (2) and / or to an associated vessel. The pump-outflow-cannula (19) comprises a body (20) encompassing an essentially axially extending outflow-lumen (21) having a distal-end (22) for an introduction of blood from said blood management system into the outflow-lumen (21), and having a proximal-end (23) for an attachment of the outflow-lumen (21) to the heart (2) and / or to the associated vessel. According to the invention, said body (20) of the pump-outflow-cannula comprises a reinforcement-means (24).The invention is also related to a blood managing system comprising a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及从外部血液处理系统到心脏（2）和/或相关血管提供血液导管的泵流出套管（19）。泵流出套管（19）包括主体（20），主体（20）包含基本上轴向延伸的流出内腔（21），该流出内腔具有用于将血液从所述血液管理系统引入流出内腔的远端（21），并具有用于将流出腔（21）附接到心脏（2）和/或相关血管的近端（23）。根据本发明，泵 - 流出套管的所述主体（20）包括加强装置（24）。本发明还涉及包括根据本发明的泵 - 流出套管的血液管理系统。

9. 发明公开

EP1990066A2 A pump-outflow-cannula and a blood managing system 有权转让
标题翻译： Perfusionskanüle和Blut-Managementsystem
公开(公告)号：EP1990066A2
公开(公告)日：2008-11-12
申请号：EP08161283.0
申请日：2006-12-07
申请人： Levitronix LLC
发明人： Richardson, J. Scott , Gellman, Barry N. , Koert, Andrew , Dasse, Kurt
IPC分类号： A61M1/36
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-outflow-cannula (19) providing a blood conduit from an external blood handling system to a heart (2) and / or to an associated vessel. The pump-outflow-cannula (19) comprises a body (20) encompassing an essentially axially extending outflow-lumen (21) having a distal-end (22) for an introduction of blood from said blood management system into the outflow-lumen (21), and having a proximal-end (23) for an attachment of the outflow-lumen (21) to the heart (2) and / or to the associated vessel. According to the invention, said body (20) of the pump-outflow-cannula comprises a reinforcement-means (24).The invention is also related to a blood managing system comprising a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及提供从外部血液处理系统到心脏（2）和/或相关血管的血液导管的泵 - 流出 - 插管（19）。泵 - 流出 - 套管（19）包括主体（20），其包围具有远端（22）的基本上轴向延伸的流出腔（21），用于将血液从所述血液管理系统引入流出腔并且具有用于将流出腔（21）附接到心脏（2）和/或相关联的血管的近端（23）。根据本发明，泵流出套管的所述主体（20）包括加强装置（24）。本发明还涉及包括根据本发明的泵 - 流出 - 套管的血液管理系统。

10. 发明公开

EP1839601A1 Self-expanding cannula 审中-公开
标题翻译： SelbstexpandierendeKanüle
公开(公告)号：EP1839601A1
公开(公告)日：2007-10-03
申请号：EP06117504.8
申请日：2006-07-19
申请人： Levitronix LLC
发明人： Gellman, Barry N.
IPC分类号： A61B17/34 , A61M25/06 , A61M25/00
CPC分类号： A61B17/3439 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/122 , A61M1/3659 , A61M25/005 , A61M25/007 , A61M25/04 , A61M25/0662 , A61M2025/0024
摘要： The invention relates to a self-expanding cannula (1), in particular a self- expanding cardiac cannula, providing a conduit through a skin (3) between an inside of a corpus (2) and an outside of the corpus (2) for attachment to an extracorporeal fluid handling system (4), in particular to a blood handling system (4). The body (100) of the self-expanding cannula (1) is constructed from a braided-wire (150), so that the self-expanding cannula (1) is capable of expanding from a closed diameter (D1) to an opened diameter (D2). The invention is also related to a catheter-sheath (8) and a catheter-sheath assembly (800) as well as to a method for applying and positioning a self-expanding cannula (1), and a catheter-sheath-assembly (800) in accordance with the present invention.
摘要翻译：本发明涉及一种自膨胀套管（1），特别是一种自扩张式心脏插管，提供穿过一个语料库（2）的内部和语料库（2）的外部之间的皮肤（3）的导管，用于附着到体外流体处理系统（4），特别是血液处理系统（4）。自膨胀套管（1）的主体（100）由编织线（150）构成，使得自膨胀套管（1）能够从闭合直径（D1）扩展到开口直径（D2）。本发明还涉及导管鞘（8）和导管鞘组件（800）以及用于施加和定位自膨胀插管（1）的方法，以及导管鞘组件（800））根据本发明。

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