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1. 发明公开

EP0937457A1 REMEDIES FOR ALLERGIC DERMATITIS 失效
标题翻译： ARZNEIMITTEL GEGEN ALLERGISCHE DERMATITIS
公开(公告)号：EP0937457A1
公开(公告)日：1999-08-25
申请号：EP97935880.1
申请日：1997-08-25
申请人： Kyoto Pharmaceutical Industries, Ltd.
发明人： SHIRAHASE, Hiroaki , YOSHIMI, Akihisa , NAKAMURA, Shohei , KANDA, Mamoru , FUKATA, Fumio
IPC分类号： A61K31/35
CPC分类号： C07D311/24 , A61K31/352 , Y10S514/886
摘要： A therapeutic agent for allergic dermatitis caused by type IV allergic reaction, which contains diethyl L-lysylcromoglycate of the formula
or a nontoxic salt thereof as an active ingredient. This therapeutic agent for allergic dermatitis is effective for the treatment of allergic dermatitis caused by type IV allergic reaction, such as contact dermatitis mainly induced by type IV allergic reaction and atopic dermatitis induced by type I and type IV allergic reactions.
摘要翻译：由IV型过敏反应引起的过敏性皮炎的治疗剂，其包含式CHEM的L-赖氨酰色甘酸二乙酯或其无毒盐作为活性成分。这种过敏性皮炎治疗剂对于治疗由IV型过敏反应引起的过敏性皮炎，如主要由IV型过敏反应引起的接触性皮炎和I型和IV型过敏反应引起的特应性皮炎是有效的。

2. 发明公开

EP0916338A1 ANTIRHEUMATIC AGENT 失效
标题翻译： ANTIRHEUMATIKUM
公开(公告)号：EP0916338A1
公开(公告)日：1999-05-19
申请号：EP97924362.3
申请日：1997-06-06
申请人： Kyoto Pharmaceutical Industries, Ltd.
发明人： SHIRAHASE, Hiroaki , YOSHIMI, Akihisa , FUKATA, Fumio , OKUNISHI, Hideki , KOBAYASHI, Yuta
IPC分类号： A61K31/35
CPC分类号： A61K31/352 , A61K31/35 , C07D311/24 , Y10S514/825
摘要： An antirheumatic agent comprising diethyl L-lysylcromoglycate of the following formula
or a nontoxic salt thereof as an active ingredient. This compound has an anti-inflammatory action and immunomodulating action, is absorbed by oral administration to be delivered efficiently to local sites, and is associated with fewer side effects, so that it serves well as an antirheumatic agent that can be administered orally.
摘要翻译：一种抗风湿剂，其包含下列化学式的L-赖氨酰色甘酸二乙酯或其无毒盐作为活性成分。该化合物具有抗炎作用和免疫调节作用，通过口服吸收被有效地递送至局部位置，并且与副作用较少相关，使其作为口服给药的抗风湿剂起作用。

3. 发明公开

EP1040826A1 MEDICINAL USE OF CROMOGLYCIC ACID COMPOUNDS 审中-公开
标题翻译：药物用于牛血清酸化合物
公开(公告)号：EP1040826A1
公开(公告)日：2000-10-04
申请号：EP98956002.4
申请日：1998-11-30
申请人： Kyoto Pharmaceutical Industries, Ltd.
发明人： SHIRAHASE, Hiroaki , YOSHIMI, Akihisa , NAKAMURA, Shohei , KANDA, Mamoru , FUKATA, Fumio
IPC分类号： A61K31/35
CPC分类号： C07D311/24 , A61K31/352
摘要： The cromoglycic acid compound of the formula (I)
has an antirheumatic action, an antiinflammatory action and an immunomodulating action. This compound is effective for the inhibition of the symptoms of chronic rheumatoid arthritis and is associated with fewer side effects. Therefore, the antirheumatic agent of the present invention can be used beneficially for the treatment of rheumatoid arthritis. In addition, this compound has anti-type I and anti-type IV allergic activities. Therefore, the compound can be used beneficially mainly for the treatment of allergic dermatitis, in which a type IV allergic reaction is involved, such as contact dermatitis, in which a type IV allergic reaction is involved, atopic dermatitis, in which type I and type IV allergic reactions are involved and the like.
摘要翻译：式（I）的色甘酸化合物具有抗风湿作用，抗炎作用和免疫调节作用。该化合物对抑制慢性类风湿性关节炎症状是有效的，并且副作用较少。因此，本发明的抗风湿剂可有益地用于治疗类风湿性关节炎。此外，该化合物还具有抗I型和抗IV型过敏活性。因此，该化合物主要用于治疗其中涉及IV型过敏反应的过敏性皮炎，如涉及IV型过敏反应的接触性皮炎，特应性皮炎，其中I型和I型 IV涉及过敏反应等。

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