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1. 发明授权

EP1024139B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-(6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL) ACETIC ACID DERIVATIVES 有权
标题翻译：用于生产光学活性的2-（6-（羟甲基）-1,3-二恶烷-4-基） - 衍生物
公开(公告)号：EP1024139B1
公开(公告)日：2004-05-12
申请号：EP99935066.3
申请日：1999-08-05
申请人： KANEKA CORPORATION
发明人： KIZAKI, Noriyuki , YAMADA, Yukio , YASOHARA, Yoshihiko , NISHIYAMA, Akira , MIYAZAKI, Makoto , MITSUDA, Masaru , KONDO, Takeshi , UEYAMA, Noboru , INOUE, Kenji
IPC分类号： C07D319/06 , C07C67/343 , C07C67/31
CPC分类号： C07D319/06 , C07B2200/07 , C07C67/343 , C07C253/30 , C12P7/62 , C07C69/716 , C07C255/21

2. 发明公开

EP0857790A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINO COMPOUNDS 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER AMINOVERBINDUNGEN
公开(公告)号：EP0857790A1
公开(公告)日：1998-08-12
申请号：EP96935392.9
申请日：1996-10-21
申请人： KANEKA CORPORATION
发明人： YAMADA, Yukio , IWASAKI, Akira , KIZAKI, Noriyuki , IKENAKA, Yasuhiro , OGURA, Masahiro , HASEGAWA, Junzo
IPC分类号： C12P13/00 , C12N9/10 , C12P41/00
CPC分类号： C12P13/001 , C12N9/1096 , C12P13/005 , C12P13/008 , C12P13/04 , C12P41/006 , Y10S435/83
摘要： A process for producing optically active (R)-amino compounds which comprises treating an aralkyl alkyl ketone compound (the amino receptor) coexisting with a racemic or (R)-amino compound (the amino donor) with an (R)-specific transaminase produced by a microorganism belonging to the genus Arthrobacter and thus effecting stereoselective transamination. This process makes it possible to facilitate the production in a high yield of optically active (R)-amino compounds, etc., having aryl, etc. at the 1-position which have been difficult to synthesize by the conventional techniques.
摘要翻译：一种制备光学活性（R） - 氨基化合物的方法，其包括用（R） - 特异性转氨酶处理与外消旋或（R） - 氨基化合物（氨基供体）共存的芳烷基烷基酮化合物（氨基受体）通过属于节杆菌属的微生物，从而实现立体选择性转氨酶。该方法使得可以以高产率的方式促进在1-位上具有芳基等的光学活性（R） - 氨基化合物等的生产，这些常规技术难以合成。

3. 发明公开

EP3791714A1 METHOD FOR CULTIVATING PLANTS AND COLORING ACCELERATOR FOR GRAPE BERRIES 审中-公开
公开(公告)号：EP3791714A1
公开(公告)日：2021-03-17
申请号：EP19800487.1
申请日：2019-05-07
申请人： Kaneka Corporation
发明人： SAKAMOTO, Atsushi , SHIMADA, Hiroshi , TANAKA, Shoma , NOJIRI, Masutoshi , FU, Yu , KIZAKI, Noriyuki , KITANO, Mitsuaki
IPC分类号： A01K7/06
摘要： A method for cultivating a plant includes: applying allantoin to a grapevine; and growing the grapevine in a cultivation medium. Applying the allantoin may be performed at a veraison stage of the grapevine. The allantoin may be applied to a part of the grapevine that is above the cultivation medium at a dose of about 0.05 to 5 g per grapevine, and may be applied by spraying the allantoin on leaves or fruits of the grapevine at a dose of about 0.05 to 5 g per grapevine. The grapevine may be grown at a density of about 1,500 to 10,000 plants per hectare, and about 0.1 to 13 g/m 2 of the allantoin may be applied.

4. 发明授权

EP0967271B1 NOVEL CARBONYL REDUCTASE, GENE THAT ENCODES THE SAME, AND METHOD OF UTILIZING THESE 失效
标题翻译：新羰基还原酶，基因，供他们使用此代码，方法
公开(公告)号：EP0967271B1
公开(公告)日：2004-10-20
申请号：EP97937861.9
申请日：1997-09-01
申请人： KANEKA CORPORATION
发明人： YASOHARA, Yoshihiko , KIZAKI, Noriyuki , HASEGAWA, Junzo , WADA, Masaru, Usuki-manshon 305 , SHIMIZU, Sakayu, 6-9, Tokiwayamashita-cho , KATAOKA, Michihiko, Haitsukosumo 227 , YAMAMOTO,K. Nihontabaccosangyo Kab. Hiyoshidai-ryo , KAWABATA, Hiroshi, Aburesuto Iwakura 1204 , KITA, Keiko, Godoshukusha Kosanjyutaku 3-105
IPC分类号： C12N9/02 , C12N15/53 , C12N15/63 , C12N1/21 , C12P7/62 , C12N9/04 , C12P41/00
CPC分类号： C12P7/62 , C12N9/0006 , C12P41/002
摘要： An enzyme having the activity of asymmetrically reducing a carbonyl compound to an optically active alcohol, a DNA which encodes the enzyme, a plasmid having the DNA, cells transformed by the plasmid, and a process for producing optically active alcohols with the enzyme and/or the transformed cells.

5. 发明公开

EP1416050A1 METHOD OF MODIFYING ENZYME AND OXIDOREDUCTASE VARIANT 审中-公开
标题翻译：改变酶和氧化还原酶变异体的方法
公开(公告)号：EP1416050A1
公开(公告)日：2004-05-06
申请号：EP02738904.8
申请日：2002-07-02
申请人： KANEKA CORPORATION
发明人： NAKAI, Takahisa , MORIKAWA, Souichi , KIZAKI, Noriyuki , YASOHARA, Yoshihiko
IPC分类号： C12N15/53 , C12N9/06 , C12N1/21 , C12P7/62
CPC分类号： C12N9/0006 , C12P7/62
摘要： An enzyme modifying method for converting the coenzyme-dependency of an oxidoreductase is developed. Using this method, a novel carbonyl reductase mutant capable of utilizing NADH as a coenzyme is provided. It is also intended to provide a process for enzymatically producing an optically active (S)-4-halo-3-hydroxybutyric ester by utilizing the carbonyl reductase mutant.
A method for modifying an enzyme itself so as to convert the coenzyme-dependency of a carbonyl reductase which asymmetrically reduces a carbonyl compound to produce an optically active alcohol, a carbonyl reductase having such coenzyme dependency as has been converted from NADPH to NADH which is obtained by the above method, a DNA encoding this enzyme mutant, a plasmid carrying this DNA, a transformant obtained by the transformation with this plasmid, and a process for producing an optically active alcohol by using this enzyme mutant and/or this transformant.
摘要翻译：开发了用于转化氧化还原酶的辅酶依赖性的酶修饰方法。使用该方法，提供了能够利用NADH作为辅酶的新型羰基还原酶突变体。还旨在提供通过利用羰基还原酶突变体酶促生产光学活性（S）-4-卤代-3-羟基丁酸酯的方法。一种修饰酶本身以转化羰基还原酶的辅酶依赖性的方法，该羰基还原酶不对称地还原羰基化合物以产生光学活性醇，具有从NADPH转化为NADH的这种辅酶依赖性的羰基还原酶，其获得通过上述方法，通过使用该酶突变体和/或该转化体，编码该酶突变体的DNA，携带该DNA的质粒，通过该质粒转化而获得的转化体以及用于生产光学活性醇的方法。

6. 发明公开

EP2754710A1 METHOD FOR CULTIVATING SEAWEED AND METHOD FOR PRODUCING ALGINIC ACID-CONTAINING COMPOSITION 审中-公开
标题翻译：方法培养藻类和方法生产组合物ALGININSÄUREHALTIGEN
公开(公告)号：EP2754710A1
公开(公告)日：2014-07-16
申请号：EP12829423.8
申请日：2012-09-06
申请人： Kaneka Corporation
发明人： KIZAKI, Noriyuki , FURUTA, Takeshi , MOURI, Taku , TAOKA, Naoaki
IPC分类号： C12N1/12 , A23K1/16 , A23L1/30 , A61K31/734 , A61P1/12 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , B01J20/24 , B01J20/30 , C12P7/44 , C12R1/89
CPC分类号： C12P19/04 , A23K10/10 , A23K10/30 , A23K20/163 , A23L33/10 , A23L33/105 , A23L33/21 , A61K31/734 , A61K36/05 , B01J20/24 , B01J20/3078 , B01J2220/4843 , C02F1/68 , C12N1/12 , C12P7/44 , C12R1/89 , Y02W10/37
摘要： The objective of the present invention is to provide a method for cultivating an alga having ability to produce alginic acid industrially and effectively and a method for producing an alginic acid-containing composition industrially advantageously. The method for cultivating an alga according to the present invention is characterized in comprising the step of cultivating the alga heterotrophically, wherein the alga belongs to the genus Parachlorella and has ability to produce alginic acid.
摘要翻译：本发明的目的是提供一种用于培养藻类上具有生产藻酸和工业上有效地并在藻含酸组合物生产工业上有利地方法的能力的方法。用于培养藻类的gemäß异养于本发明的方法中，包括培养藻类的步骤的特征在于，所述藻类worin属于小球藻属帕拉和具有产生藻酸的能力。

7. 发明授权

EP0987332B1 DNA encoding a polypeptide having stereoselective transaminase activity, and transformants comprising said DNA 失效
标题翻译： Deoxynukleinsäure编码具有立体选择性转氨酶活性，和含有该Deoxynukleinsäure转化的多肽
公开(公告)号：EP0987332B1
公开(公告)日：2009-08-19
申请号：EP98914111.4
申请日：1998-04-20
申请人： KANEKA CORPORATION
发明人： YAMADA, Yukio , IWASAKI, Akira , KIZAKI, Noriyuki , MATSUMOTO, Keiji , IKENAKA, Yasuhiro , OGURA, Masahiro , HASEGAWA, Junzo
IPC分类号： C12P13/04 , C12N15/54
CPC分类号： C12P13/001 , C12N9/1096
摘要： A process for efficiently producing optically active amino compounds, mainly (R)-amino compounds, at a low cost by means of a microbial enzyme; a polypeptide suitable for use in the production process and having a stereoselective transaminase activity; and a DNA coding for the polypeptide. The process is characterized by comprising causing a transaminase to act on a ketone compound as an amino acceptor in the presence of a primary amine as an amino donor to stereoselectively transfer the amino group to thus obtain an optically active amino compound. The DNA contains a base sequence coding for a polypeptide having a stereoselective transaminase activity. The polypeptide can be obtained by incubating a microorganism belonging to the genus Arthrobacter.

8. 发明公开

EP1908845A1 METHOD FOR PRODUCING OPTICALLY ACTIVE 2-(N-SUBSTITUTED AMINOMETHYL)-3-HYDROXYBUTYRIC ACID ESTER 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEM 2-（N-SUBSTITUIERTES-AMINOMETHYL）-3-HYDROXYBUTTERSÄUREESTER
公开(公告)号：EP1908845A1
公开(公告)日：2008-04-09
申请号：EP06768311.0
申请日：2006-07-19
申请人： Kaneka Corporation
发明人： YASOHARA, Yoshihiko , YANO, Miho , KAWANO, Shigeru , KIZAKI, Noriyuki
IPC分类号： C12P13/02 , C12P17/10
CPC分类号： C12P13/02 , C12P17/10
摘要： The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides an efficient method for industrially producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters, in particular such compounds having the (2S,3R) configuration, which are useful as intermediates for the production of medicinal compounds, among others.
摘要翻译：本发明涉及一种光学活性2-（N-取代氨基甲基）-3-羟基丁酸酯的制备方法，其中2-（N-取代氨基甲基）-3-氧代丁酸酯可用立体选择性的酶源处理将所述酯还原成具有（2S，3R）构型的相应的光学活性2-（N-取代氨基甲基）-3-羟基丁酸酯。本发明提供了工业上制造光学活性2-（N-取代氨基甲基）-3-羟基丁酸酯的有效方法，特别是具有（2S，3R）构型的这种化合物，其可用作生产药物的中间体化合物等。

9. 发明公开

EP2465938A1 PRODUCTION METHOD FOR ASTAXANTHIN-CONTAINING COMPOSITION 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER ASTAXANTHINHALTIGEN ZUSAMMENSETZUNG
公开(公告)号：EP2465938A1
公开(公告)日：2012-06-20
申请号：EP10808081.3
申请日：2010-08-11
申请人： Kaneka Corporation
发明人： INOUE, Hiroaki , KIZAKI, Noriyuki , NANBA, Hirokazu
IPC分类号： C12P23/00 , A23K1/16 , A23L1/30 , A61P3/00 , A61K31/01 , A61K31/122 , A61K35/74 , C12R1/01 , C12R1/645
CPC分类号： A61K31/01 , A23K20/174 , A23K20/179 , A61K31/122 , C12P23/00
摘要： The present invention relates to a method for reducing the relative ratio of 3-hydroxy-3',4'-didehydro-β,ψ-caroten-4-one (HDCO) to astaxanthin in a composition containing astaxanthin and HDCO by contacting the composition with an acidic medium having a pH of 3 or less and/or a basic medium having a pH of 9 or greater, and also relates to a method for producing an astaxanthin-containing composition which includes reducing the relative ratio of HDCO by the above method. By means of the method of the present invention, the relative ratio of HDCO, the biological function of which is not known, in an astaxanthin-containing composition can be easily reduced.
摘要翻译：本发明涉及通过使组合物与组合物接触来降低含有虾青素和HDCO的组合物中3-羟基-3'，4'-二脱氢-2，β-胡萝卜素-4-酮（HDCO）与虾青素的相对比例的方法 pH为3以下的酸性介质和/或pH为9以上的碱性介质，还涉及含有虾青素的组合物的制造方法，其包括通过上述方法降低HDCO的相对比例。通过本发明的方法，可以容易地降低含有虾青素的组合物中HDCO（其生物功能不知道）的相对比例。

10. 发明公开

EP1306438A1 NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME 有权
标题翻译：亲爱的哥伦比亚大公司，德累斯顿VERFAHREN ZU DESSEN VERWENDUNG
公开(公告)号：EP1306438A1
公开(公告)日：2003-05-02
申请号：EP01956776.7
申请日：2001-08-01
申请人： KANEKA CORPORATION
发明人： KIZAKI, Noriyuki , YASOHARA, Yoshihiko , HASEGAWA, Junzo
IPC分类号： C12N15/53 , C12N9/02 , C12N1/21 , C12P17/10
CPC分类号： C12N9/0008 , C12N9/0006 , C12P17/10 , C12P41/002
摘要： The present invention provides a novel polypeptide producing (S)-N-benzyl-3-pyrrolidinol, a DNA coding for it and a method of using them.
A polypeptide having the following physicochemical properties (1) to (5):

(1) Action: It asymmetrically reduces N-benzyl-3-pyrrolidinone to produce (S)-N-benzyl-3-pyrrolidinol with NADPH as a coenzyme;
(2) Optimum action pH: 4.5 to 5.5;
(3) Optimum action temperature: 40°C to 45°C;
(4) Molecular weight: About 29,000 as determined by gel filtration analysis, about 35,000 as determined by SDS-polyacrylamide gel electrophoresis analysis;
(5) Inhibitor: It is inhibited by the divalent copper ion.

Further, a polypeptide having the amino acid sequence shown under SEQ ID NO:1 in the sequence listing; or
a polypeptide having an amino acid sequence obtainable from the amino acid sequence shown under SEQ ID NO:1 in the sequence listing by substitution, insertion, deletion and/or addition of one or more amino acids and
having enzyme activity in asymmetrically reducing N-benzyl-3-pyrrolidinone to produce (S)-N-benzyl-3-pyrrolidinol.
摘要翻译：本发明提供了产生（S）-N-苄基-3-吡咯烷醇的新型多肽，其编码的DNA及其使用方法。具有以下物理化学性质的多肽（1）至（5）：（1）作用：不对称地还原N-苄基-3-吡咯烷酮以制备（S）-N-苄基-3-吡咯烷醇，其中NADPH作为辅酶; （2）最佳作用pH：4.5〜5.5; （3）最佳作用温度：40〜45℃; （4）分子量：通过凝胶过滤分析确定约29,000，通过SDS-聚丙烯酰胺凝胶电泳分析测定约35,000; （5）抑制剂：被二价铜离子抑制。此外，具有序列表中SEQ ID NO：1所示的氨基酸序列的多肽; 或具有通过序列表中SEQ ID NO：1所示的氨基酸序列获得的氨基酸序列的多肽，其通过取代，插入，缺失和/或添加一个或多个氨基酸并具有不对称还原N- 苄基-3-吡咯烷酮，得到（S）-N-苄基-3-吡咯烷醇。

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