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1. 发明授权

EP1956093B1 von Willebrand Factor (vWF)-cleaving protease 有权
标题翻译：血管性血友病因子（vWF - ） - 分裂蛋白酶
公开(公告)号：EP1956093B1
公开(公告)日：2011-09-21
申请号：EP08156811.5
申请日：2002-04-25
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Soejima, Kenji , Mimura, Noriko , Maeda, Hiroaki , Nozaki, Chikateru , Hamamoto, Takayoshi , Nakagaki, Tomohiro
IPC分类号： C12N15/57 , C12N9/50 , C12P21/00
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421

2. 发明公开

EP2157178A1 Antibody against von Willebrand Factor cleaving enzyme and assay system using the same 审中-公开
标题翻译： Antikörpergegen das Willebrand-Faktor-Spaltungssystems und Testsystem damit
公开(公告)号：EP2157178A1
公开(公告)日：2010-02-24
申请号：EP09163352.9
申请日：2003-09-25
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Soejima, Kenji , Mimura, Noriko , Maeda, Hiroaki , Nozaki, Chikateru , Hamamoto, Takayoshi , Nakagaki, Tomohiro
IPC分类号： C12N15/02
CPC分类号： C12N9/6489 , C07K16/40
摘要： It is intended to provide an antibody showing immunoreactivity selectively to ADAMTS-13 and applications of this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Alternatively, it is intended to provide a process for producing and use of a modified ADAMTS-13 molecule partially deleted aiming at the application in pharmaceutical products. An antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunized and sensitized with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; a process for producing an antibody comprising a step of immunizing and sensitizing a warm-blooded animal with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; use of the above-described antibody including a method of detecting and purifying ADAMTS-13; and a modified ADAMTS-13 molecule partially deleted are provided.
摘要翻译：旨在提供一种抗体，显示对ADAMTS-13的免疫反应性和该抗体在ADAMTS-13自身抗体阳性患者的表位分析或诊断中的应用。或者，旨在提供一种制备和使用针对在药物产品中应用的部分缺失的修饰的ADAMTS-13分子的方法。对于ADAMTS-13特异的抗体，其可从用含有部分或全部ADAMTS-13氨基酸序列的多肽免疫并致敏的温血动物获得; 一种制备抗体的方法，包括用含有部分或全部ADAMTS-13氨基酸序列的多肽对温血动物进行免疫和敏化的步骤; 使用上述抗体，包括检测和纯化ADAMTS-13的方法; 并提供部分缺失的修饰的ADAMTS-13分子。

3. 发明公开

EP1156064A2 Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma 失效
标题翻译： Gegen Katze-Krankheite chimaerischer Katze-Maus-Antikörper和杂交杂交瘤
公开(公告)号：EP1156064A2
公开(公告)日：2001-11-21
申请号：EP01118802.6
申请日：1990-08-10
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Ono, Yoichi, Shinki Appartment 101 , Tokiyoshi, Sachio
IPC分类号： C07K16/46 , C12N15/13 , C12N5/20 , G01N33/50
CPC分类号： C12N5/166 , C07K16/00 , C07K16/081 , C07K16/462 , C07K2317/24 , C07K2319/00
摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.
摘要翻译：该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3'位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。

4. 发明公开

EP0327000A3 Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效
标题翻译：编码抗HIV抗体变异区域的基因片段，使用该抗体的抗HIV抗体及其制备方法
公开(公告)号：EP0327000A3
公开(公告)日：1990-05-30
申请号：EP89101583.6
申请日：1989-01-30
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Tokiyoshi, Sachio , Matsushita, Shuzo , Hattori, Toshio , Takatsuki, Kiyoshi
IPC分类号： C12N15/13 , A61K39/395 , C12N5/10 , C12P21/08
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.

5. 发明公开

EP0327000A2 Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效
标题翻译：编码由这些嵌合抗-HIV抗体和它们的制备方法表示的抗HIV抗体的可变区基因片段。
公开(公告)号：EP0327000A2
公开(公告)日：1989-08-09
申请号：EP89101583.6
申请日：1989-01-30
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Tokiyoshi, Sachio , Matsushita, Shuzo , Hattori, Toshio , Takatsuki, Kiyoshi
IPC分类号： C12N15/13 , A61K39/395 , C12N5/10 , C12P21/08
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.
摘要翻译：描述的是新颖的，其包括来自人抗体和小鼠单克隆抗体的可变区的恒定区的嵌合抗 - 人免疫缺陷病毒（HIV）抗体，基因片段编码嵌合抗-HIV抗体的H和L链的可变区，其有效用于具有HIV中和活性，其中一个检查基因片段掺入转化体，从那里过表达嵌合抗HIV抗体和用于制备它们的方法的嵌合抗-HIV抗体的表达。本发明显示抗HIV中和活性的和嵌合的抗HIV抗体可用于无副作用由HIV引起的诊断，治疗和预防获得性免疫缺陷综合症的（AIDS）有用：如过敏性休克或血清病。

6. 发明授权

EP0361182B1 Recombinant Marek's disease virus, process for preparing the same and vaccine containing the same 失效
标题翻译：重组马立克氏病病毒，其制备方法和疫苗。
公开(公告)号：EP0361182B1
公开(公告)日：1994-01-19
申请号：EP89116679.5
申请日：1989-09-08
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Sakaguchi, Masashi , Maeda, Hiroaki , Yamamoto, Michitaka , Miyazaki, Junichi Higashimachi Minami-jutaku 3-101
IPC分类号： C12N15/86 , C12N15/85 , A61K39/255
CPC分类号： C12N15/86 , A61K39/12 , A61K39/255 , C07K14/005 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343

7. 发明授权

EP0327000B1 Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效
标题翻译：编码抗HIV抗体变异区域的基因片段，使用该抗体的抗HIV抗体及其制备方法
公开(公告)号：EP0327000B1
公开(公告)日：1993-07-28
申请号：EP89101583.6
申请日：1989-01-30
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Tokiyoshi, Sachio , Matsushita, Shuzo , Hattori, Toshio , Takatsuki, Kiyoshi
IPC分类号： C12N15/13 , A61K39/395 , C12N5/10 , C12P21/08
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24

8. 发明公开

EP0417486A1 Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin 失效
标题翻译： Katze-Maus-Heterohybridoma und Genfragment，dasfürdie Konstant-Region von Katze-Immunoglobulin codiert。
公开(公告)号：EP0417486A1
公开(公告)日：1991-03-20
申请号：EP90115426.0
申请日：1990-08-10
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Ono, Yoichi , Tokiyoshi, Sachio
IPC分类号： C07K13/00 , C12N15/13 , C12N5/20 , C12P21/08
CPC分类号： C12N5/166 , C07K16/00 , C07K16/081 , C07K16/462 , C07K2317/24 , C07K2319/00
摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3′ site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.
摘要翻译：该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3分钟位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。

9. 发明公开

EP0361182A1 Recombinant Marek's disease virus, process for preparing the same and vaccine containing the same 失效
标题翻译： Rekombinantes Marek-Krankheitsvirus，Verfahren zu seiner Herstellung，und Vakzine。
公开(公告)号：EP0361182A1
公开(公告)日：1990-04-04
申请号：EP89116679.5
申请日：1989-09-08
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Sakaguchi, Masashi , Maeda, Hiroaki , Yamamoto, Michitaka , Miyazaki, Junichi Higashimachi Minami-jutaku 3-101
IPC分类号： C12N15/86 , C12N15/85 , A61K39/255
CPC分类号： C12N15/86 , A61K39/12 , A61K39/255 , C07K14/005 , C12N2710/16322 , C12N2710/16334 , C12N2710/16343
摘要： A recombinant Marek's disease is described which comprises a Marek's disease virus genome and a DNA fragment incorporated therein, said DNA fragment containing
a promoter derived from an animal cell or an animal virus and a structural gene coding for an exogenous protein. Furthermore a process for preparing said recombinant virus is described which comprises
preparing a gene fragment wherein a structural gene coding for an exogenous gene is located downstream of a promoter derived from an animal cell or an animal virus, incorporating said gene fragment into theBamHI - H fragment of a gene of a Marek's disease virus type I, and incorporating said fragment into a Marek's disease virus type I genome. Finally a multivalent live vaccine for birds is described which contains the above recombinant virus.
摘要翻译：描述了重组马立克氏病，其包含马立克氏病病毒基因组和其中掺入的DNA片段，所述DNA片段含有源自动物细胞或动物病毒的启动子和编码外源蛋白质的结构基因。此外，描述了制备所述重组病毒的方法，其包括制备基因片段，其中编码外源基因的结构基因位于来源于动物细胞或动物病毒的启动子的下游，将所述基因片段并入BHIHI-H片段的马立克氏病病毒I型的基因，并将所述片段并入马立克氏病病毒I型基因组。最后描述了含有上述重组病毒的鸟类多价活疫苗。

10. 发明授权

EP2180045B1 Novel protein highly producing recombinant animal cell, method for preparing the same and method for mass-producing protein using the same 有权
标题翻译：新的重组动物细胞具有高蛋白质生产，其制造方法，以及用于蛋白质大量生产这样的方法
公开(公告)号：EP2180045B1
公开(公告)日：2015-12-23
申请号：EP09013237.4
申请日：2004-10-21
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： Matsuyama, Reiko , Maeda, Hiroaki , Shirahama, Hitomi , Imamura, Takayuki , Kamachi, Yasuharu
IPC分类号： C12N5/10 , C07K14/745 , C12N15/12 , C07K14/46 , C12P21/02 , C12N15/85 , C12N15/866
CPC分类号： C12P21/02 , C12N2510/02

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