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1. 发明公开

EP0275933A3 Pressure control apparatus 失效
标题翻译：压力控制装置和装置，用于通过使用其进行提取，色谱分离和分离
公开(公告)号：EP0275933A3
公开(公告)日：1991-01-09
申请号：EP88100485.7
申请日：1988-01-15
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio , Kashiwazaki, Hiromi , Sugawara, Michiaki , Hondo, Toshinobu
IPC分类号： G01N30/32 , G05D16/20
CPC分类号： B01D11/0203 , B01D11/028 , G01N30/02 , G01N30/32 , G01N30/74 , G01N30/80 , G01N2030/062 , G01N2030/085 , G05D16/2013 , Y10T137/7761 , B01D15/40
摘要： A pressure control apparatus is used in an apparatus for effecting extraction, chromatographic separation, and fractionation. The pressure control apparatus is intended to reduce the amount of a fluid stagnating in a valve, and is arranged to cyclically open and close the valve, thereby controlling the level of pressure. An apparatus for effecting extraction, chromatographic separation, and fractionation is designed to perform in an on-line manner the extraction of soluble components contained in a sample as well as the separation and fractionation of the components. A chromatography is connected to a downstream side of a supercritical fluid extraction device, and the aforesaid pressure control apparatus is used as back-pressure regulators (9, 18) for the chromatography and the extraction device. An extraction fluid and an elution fluid which are used in a mobile phase may be a common fluid (Fig. 1) or separate fluids (Fig. 10). At the time of extraction, the soluble components of the sample within an extraction vessel (6) is extracted by a supercritical fluid, and is delivered to an adsorption column (14). The supercritical fluid is converted into a gas by reducing the pressure within the adsorption column and thus the solubility of the fluid is lowered so that the resultant extract is adsorbed by an adsorbent packed in this column. At the time of chromatographic separation, the pressure within the adsorption column (14) is maintained at a critical pressure or higher and thus an extract is eluted by the supercritical fluid and is delivered to a separation column (16), in which the extract is separated into individual components. Then, when the pressure within the adsorption column is reduced, the supercritical fluid is gasified and the result components are collected as fractions.

2. 发明公开

EP0294312A1 Split stream flow cell 失效
标题翻译： DurchflussküvettemitStrömungsspaltung。
公开(公告)号：EP0294312A1
公开(公告)日：1988-12-07
申请号：EP88710013.9
申请日：1988-06-06
申请人： JASCO CORPORATION
发明人： Imahashi, Toru , Maruyama, Naoyuki , Konishi, Hideki , Saito, Muneo
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N30/34 , G01N30/74 , G01N2021/0346 , G01N2021/0382 , G01N2030/746
摘要： The present invention relates to a split stream flow cell which is used for a UV detector of liquid chromatography and in which a UV light for detecting absorption of the light is transmitted through a sample solution flowing in the cell. It is an object of the present invention to reduce the influences of both the flow effect and the liquid lens effect without cell volume being made too large. To this end, a split stream flow cell of the present invention comprises a split flow channel (12) which passes through a cell block (10) and which has a central portion communicating with an inlet channel (18), both ends communicating with an outlet channel (38), and both sides symmetrical with respect to the central portion, the diameter thereof being increased from a given position in the central portion toward both ends.
摘要翻译：本发明涉及一种用于液相色谱的紫外检测器的分流式流动池，其中用于检测光的吸收的紫外光透射通过在该池中流动的样品溶液。本发明的目的是减小流动效应和液体透镜效应两者对细胞体积过大的影响。为此，本发明的分流流动池包括通过电池块（10）并且具有与入口通道（18）连通的中心部分的分流通道（12），两端与出口通道（38），并且两侧相对于中心部分对称，其直径从中心部分中的给定位置向两端增加。

3. 发明授权

EP0438184B1 Apparatus for effecting extraction 失效
标题翻译： Extraktionsvorrichtung。
公开(公告)号：EP0438184B1
公开(公告)日：1994-10-05
申请号：EP91104018.6
申请日：1988-01-15
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio , Kashiwazaki, Hiromi , Sugawara, Michiaki , Hondo, Toshinobu
IPC分类号： G01N30/32 , G01N30/28
CPC分类号： B01D11/0203 , B01D11/028 , G01N30/02 , G01N30/32 , G01N30/74 , G01N30/80 , G01N2030/062 , G01N2030/085 , G05D16/2013 , Y10T137/7761 , B01D15/40
摘要： A pressure control apparatus is used in an apparatus for effecting extraction, chromatographic separation, and fractionation. The pressure control apparatus is intended to reduce the amount of a fluid stagnating in a valve, and is arranged to cyclically open and close the valve, thereby controlling the level of pressure. An apparatus for effecting extraction, chromatographic separation, and fractionation is designed to perform in an on-line manner the extraction of soluble components contained in a sample as well as the separation and fractionation of the components. A chromatography is connected to a downstream side of a supercritical fluid extraction device, and the aforesaid pressure control apparatus is used as back-pressure regulators (9, 18) for the chromatography and the extraction device. An extraction fluid and an elution fluid which are used in a mobile phase may be a common fluid (Fig. 1) or separate fluids (Fig. 10). At the time of extraction, the soluble components of the sample within an extraction vessel (6) is extracted by a supercritical fluid, and is delivered to an adsorption column (14). The supercritical fluid is converted into a gas by reducing the pressure within the adsorption column and thus the solubility of the fluid is lowered so that the resultant extract is adsorbed by an adsorbent packed in this column. At the time of chromatographic separation, the pressure within the adsorption column (14) is maintained at a critical pressure or higher and thus an extract is eluted by the supercritical fluid and is delivered to a separation column (16), in which the extract is separated into individual components. Then, when the pressure within the adsorption column is reduced, the supercritical fluid is gasified and the result components are collected as fractions.

4. 发明公开

EP0438184A1 Apparatus for effecting extraction 失效
标题翻译： Extraktionsvorrichtung。
公开(公告)号：EP0438184A1
公开(公告)日：1991-07-24
申请号：EP91104018.6
申请日：1988-01-15
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio , Kashiwazaki, Hiromi , Sugawara, Michiaki , Hondo, Toshinobu
IPC分类号： G01N30/32 , G01N30/28
CPC分类号： B01D11/0203 , B01D11/028 , G01N30/02 , G01N30/32 , G01N30/74 , G01N30/80 , G01N2030/062 , G01N2030/085 , G05D16/2013 , Y10T137/7761 , B01D15/40
摘要： A pressure control apparatus (13,22) is used in an apparatus for effecting extraction (6), chromatographic (16) separation, and fractionation (24). The pressure control apparatus (13,22) is intended to reduce the amount of a fluid stagnating in a valve (11,20), and is arranged to cyclically open and close the valve (11,20), thereby controlling the level of pressure. An apparatus for effecting extraction, chromatographic separation, and fractionation is designed to perform in an on-line manner the extraction of soluble components contained in a sample as well as the separation and fractionation of the components. A chromatography (16) is connected to a downstream side of a supercritical fluid extraction device (6), and the aforesaid pressure control apparatus is used as back-pressure regulators (9, 18) for the chromatography (16) and the extraction device (6). An extraction fluid (1) and an elution fluid (1) which are used in a mobile phase may be a common fluid (Fig. 1) or separate fluids (Fig. 10). At the time of extraction, the soluble components of the sample within an extraction vessel (6) is extracted by a supercritical fluid (1), and is delivered to an adsorption column (14). The supercritical fluid is converted into a gas by reducing the pressure within the adsorption column and thus the solubility of the fluid is lowered so that the resultant extract is adsorbed by an adsorbent packed in this column. At the time of chromatographic separation, the pressure within the adsorption column (14) is maintained at a critical pressure or higher and thus an extract is eluted by the supercritical fluid and is delivered to a separation column (15), in which the extract is separated into individual components. Then, when the pressure within the adsorption column (14) is reduced, the supercritical fluid is gasified and the result components are collected as fractions.
摘要翻译：在用于进行萃取（6），色谱（16）分离和分馏（24）的装置中使用压力控制装置（13,22）。压力控制装置（13,22）旨在减少滞留在阀（11,20）中的流体的量，并被设置为循环地打开和关闭阀（11,20），由此控制压力水平。用于进行提取，色谱分离和分级分离的装置被设计为以在线方式提取样品中所含的可溶性组分以及组分的分离和分级。色谱法（16）连接到超临界流体萃取装置（6）的下游侧，上述压力控制装置用作色谱法（16）和提取装置（16）的背压调节器（9,18） 6）。在流动相中使用的萃取流体（1）和洗脱液（1）可以是普通流体（图1）或单独的流体（图10）。在提取时，提取容器（6）内的样品的可溶成分被超临界流体（1）提取，并被输送到吸附塔（14）。通过降低吸附塔内的压力将超临界流体转化为气体，从而降低流体的溶解度，使得所得萃取物被填充在该塔中的吸附剂吸附。在色谱分离时，吸附塔（14）内的压力保持在临界压力或更高的水平，因此萃取物被超临界流体洗脱并输送到分离塔（15），其中提取物分成单个组件。然后，当吸附塔（14）内的压力降低时，将超临界流体气化，并将结果组分作为馏分收集。

5. 发明公开

EP0309380A3 Recycle chromatograph with supercritical fluid 失效
标题翻译：具有超临界流体的回收色谱
公开(公告)号：EP0309380A3
公开(公告)日：1990-02-14
申请号：EP88710032.9
申请日：1988-09-26
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio
IPC分类号： B01D15/08
CPC分类号： B01D15/40 , B01D15/1814 , G01N30/02
摘要： It is an object to provide a recycle chromatograph with supercritical fluid mobile phase for separating a sample into components by recycling a mobile phase which includes modifier solvent for the purpose of taking a desired component. It is structured in such a manner that a recycling pump (10), a column (14), a detector (16), and a three-way valve (18) are connected in a sequential order as described above to form a closed loop which acts as a recycle flow line. A back-pressure regulator (20) is connected to the remainder port (C) of this three-way valve (18), and a mobile phase supplying device (30, 38, 30A, 38A, 48) for supplying the mobile phase under a predetermined pressure is connected to a flow line between the three-way valve (18) and the recycling pump (10). By means of this mobile phase supplying device and the recycle closed loop (the column pressure drop Δ p)/(column plate number) can be reduced, whereupon the column effective plate number can be increased. Thus, a sufficient resolution rate for fractionating a component can be obtained after appropriate recycling times. Furthermore, by combining the mobile phase supplying device (30, 38, 30A, 38A, 48) and the back-pressure regulator (20), the internal pressures in the column and the detector can be kept above the critical pressure even if unnecessary components are being removed or a necessary component is being fractionated. As a result of which fractionation can be performed.

6. 发明公开

EP0275933A2 Pressure control apparatus 失效
标题翻译： Druckregelapparat。
公开(公告)号：EP0275933A2
公开(公告)日：1988-07-27
申请号：EP88100485.7
申请日：1988-01-15
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio , Kashiwazaki, Hiromi , Sugawara, Michiaki , Hondo, Toshinobu
IPC分类号： G01N30/32 , G05D16/20
CPC分类号： B01D11/0203 , B01D11/028 , G01N30/02 , G01N30/32 , G01N30/74 , G01N30/80 , G01N2030/062 , G01N2030/085 , G05D16/2013 , Y10T137/7761 , B01D15/40
摘要： A pressure control apparatus is used in an apparatus for effecting extraction, chromatographic separation, and fractionation. The pressure control apparatus is intended to reduce the amount of a fluid stagnating in a valve, and is arranged to cyclically open and close the valve, thereby controlling the level of pressure. An apparatus for effecting extraction, chromatographic separation, and fractionation is designed to perform in an on-line manner the extraction of soluble components contained in a sample as well as the separation and fractionation of the components. A chromatography is connected to a downstream side of a supercritical fluid extraction device, and the aforesaid pressure control apparatus is used as back-pressure regulators (9, 18) for the chromatography and the extraction device. An extraction fluid and an elution fluid which are used in a mobile phase may be a common fluid (Fig. 1) or separate fluids (Fig. 10). At the time of extraction, the soluble components of the sample within an extraction vessel (6) is extracted by a supercritical fluid, and is delivered to an adsorption column (14). The supercritical fluid is converted into a gas by reducing the pressure within the adsorption column and thus the solubility of the fluid is lowered so that the resultant extract is adsorbed by an adsorbent packed in this column. At the time of chromatographic separation, the pressure within the adsorption column (14) is maintained at a critical pressure or higher and thus an extract is eluted by the supercritical fluid and is delivered to a separation column (16), in which the extract is separated into individual components. Then, when the pressure within the adsorption column is reduced, the supercritical fluid is gasified and the result components are collected as fractions.
摘要翻译：在用于进行萃取，色谱分离和分馏的装置中使用压力控制装置。压力控制装置旨在减少滞留在阀中的流体的量，并且被设置为循环地打开和关闭阀，从而控制压力水平。用于进行提取，色谱分离和分级分离的装置被设计为以在线方式提取样品中所含的可溶性组分以及组分的分离和分级。色谱法连接到超临界流体萃取装置的下游侧，并且上述压力控制装置用作色谱法和提取装置的背压调节器（9,18）。在流动相中使用的萃取流体和洗脱液可以是常见的流体（图1）或单独的流体（图10）。在提取时，提取容器（6）内的样品的可溶组分通过超临界流体萃取，并被输送到吸附塔（14）。通过降低吸附塔内的压力将超临界流体转化为气体，从而降低流体的溶解度，使得所得萃取物被填充在该塔中的吸附剂吸附。在色谱分离时，吸附塔（14）内的压力保持在临界压力或更高的水平，因此萃取物被超临界流体洗脱并被输送到分离塔（16），其中提取物分成单个组件。然后，当吸附塔内的压力降低时，将超临界流体气化，并将结果成分作为馏分收集。

7. 发明授权

EP0294312B1 Split stream flow cell 失效
标题翻译：分流流动池
公开(公告)号：EP0294312B1
公开(公告)日：1993-04-28
申请号：EP88710013.9
申请日：1988-06-06
申请人： JASCO CORPORATION
发明人： Imahashi, Toru , Maruyama, Naoyuki , Konishi, Hideki , Saito, Muneo
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N30/34 , G01N30/74 , G01N2021/0346 , G01N2021/0382 , G01N2030/746

8. 发明授权

EP0275933B1 Pressure control apparatus 失效
标题翻译：压力控制设备。
公开(公告)号：EP0275933B1
公开(公告)日：1994-07-27
申请号：EP88100485.7
申请日：1988-01-15
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio , Kashiwazaki, Hiromi , Sugawara, Michiaki , Hondo, Toshinobu
IPC分类号： G01N30/32 , G05D16/20
CPC分类号： B01D11/0203 , B01D11/028 , G01N30/02 , G01N30/32 , G01N30/74 , G01N30/80 , G01N2030/062 , G01N2030/085 , G05D16/2013 , Y10T137/7761 , B01D15/40
摘要： A pressure control apparatus is used in an apparatus for effecting extraction, chromatographic separation, and fractionation. The pressure control apparatus is intended to reduce the amount of a fluid stagnating in a valve, and is arranged to cyclically open and close the valve, thereby controlling the level of pressure. An apparatus for effecting extraction, chromatographic separation, and fractionation is designed to perform in an on-line manner the extraction of soluble components contained in a sample as well as the separation and fractionation of the components. A chromatography is connected to a downstream side of a supercritical fluid extraction device, and the aforesaid pressure control apparatus is used as back-pressure regulators (9, 18) for the chromatography and the extraction device. An extraction fluid and an elution fluid which are used in a mobile phase may be a common fluid (Fig. 1) or separate fluids (Fig. 10). At the time of extraction, the soluble components of the sample within an extraction vessel (6) is extracted by a supercritical fluid, and is delivered to an adsorption column (14). The supercritical fluid is converted into a gas by reducing the pressure within the adsorption column and thus the solubility of the fluid is lowered so that the resultant extract is adsorbed by an adsorbent packed in this column. At the time of chromatographic separation, the pressure within the adsorption column (14) is maintained at a critical pressure or higher and thus an extract is eluted by the supercritical fluid and is delivered to a separation column (16), in which the extract is separated into individual components. Then, when the pressure within the adsorption column is reduced, the supercritical fluid is gasified and the result components are collected as fractions.

9. 发明授权

EP0309380B1 Recycle chromatograph with supercritical fluid 失效
标题翻译：具有超临界流体的回收色谱
公开(公告)号：EP0309380B1
公开(公告)日：1992-11-25
申请号：EP88710032.9
申请日：1988-09-26
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio
IPC分类号： B01D15/08
CPC分类号： B01D15/40 , B01D15/1814 , G01N30/02

10. 发明公开

EP0309380A2 Recycle chromatograph with supercritical fluid 失效
标题翻译： Umlaufchromatograph mitüberkritischem流体。
公开(公告)号：EP0309380A2
公开(公告)日：1989-03-29
申请号：EP88710032.9
申请日：1988-09-26
申请人： JASCO CORPORATION
发明人： Saito, Muneo , Yamauchi, Yoshio
IPC分类号： B01D15/08
CPC分类号： B01D15/40 , B01D15/1814 , G01N30/02
摘要： It is an object to provide a recycle chromatograph with supercritical fluid mobile phase for separating a sample into components by recycling a mobile phase which includes modifier solvent for the purpose of taking a desired component.
It is structured in such a manner that a recycling pump (10), a column (14), a detector (16), and a three-way valve (18) are connected in a sequential order as described above to form a closed loop which acts as a recycle flow line. A back-pressure regulator (20) is connected to the remainder port (C) of this three-way valve (18), and a mobile phase supplying device (30, 38, 30A, 38A, 48) for supplying the mobile phase under a predetermined pressure is connected to a flow line between the three-way valve (18) and the recycling pump (10).
By means of this mobile phase supplying device and the recycle closed loop (the column pressure drop Δ p)/(column plate number) can be reduced, whereupon the column effective plate number can be increased. Thus, a sufficient resolution rate for fractionating a component can be obtained after appropriate recycling times.
Furthermore, by combining the mobile phase supplying device (30, 38, 30A, 38A, 48) and the back-pressure regulator (20), the internal pressures in the column and the detector can be kept above the critical pressure even if unnecessary components are being removed or a necessary component is being fractionated. As a result of which fractionation can be performed.
摘要翻译：本发明的目的是提供一种具有超临界流体流动相的再循环色谱仪，用于通过循环包含改性剂溶剂的流动相将样品分离成组分，以获得所需组分。以如上所述的顺序连接回收泵（10），塔（14），检测器（16）和三通阀（18）的结构，形成闭环其充当循环流动线。背压调节器（20）连接到该三通阀（18）的剩余端口（C），以及流动相供应装置（30,38,30A，38A，48）预定压力连接到三通阀（18）和回收泵（10）之间的流动管线。通过该流动相供给装置和再循环闭环（柱压降DELTA p）/（塔板数）可以减少，从而可以增加柱有效板数。因此，在适当的回收时间之后，可以获得用于分馏成分的足够的分离率。此外，通过组合流动相供给装置（30,38,30A，38A，48）和背压调节器（20），即使不需要的组分，也可以将柱和检测器中的内部压力保持在临界压力以上正在被去除或必要的组件被分馏。结果可以进行分馏。

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