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1. 发明公开

EP3123172A1 BIOASSAY SYSTEM AND METHOD FOR DETECTING ANALYTES IN BODY FLUIDS 有权
标题翻译：生物多样性系统VERFAHREN ZUM NACHWEIS VON分析在KÖRPERFLÜSSIGKEITEN
公开(公告)号：EP3123172A1
公开(公告)日：2017-02-01
申请号：EP15717699.1
申请日：2015-03-20
申请人： Instrumentation Laboratory Company
发明人： KERIMO, Josef , ZENG, Hansong , SCHARLACK, Ron , BLANKENSTEIN, Gert
IPC分类号： G01N33/543 , G01N21/00 , G01N33/58
CPC分类号： G01N33/54373 , G01N21/658 , G01N21/7743 , G01N33/54346 , G01N33/588
摘要： A bioserisor platform is configured with upconverting nanoparticles on the surface of a resonant grating structure with enhanced sensitivity. The grating structure is illuminated with a light beam at one of its resonance modes to form a strong evanescent field at the surface and used for high sensitivity assays. The strong evanescent field triggers the upconverting nanoparticles to generate enhanced and localized emission on the grating surface, with lower background and lower auto-fluorescence from the grating substrate. This leads to improved performance in detecting analytes in bioassays.
摘要翻译：生物传感器平台被配置为具有增强的灵敏度的谐振光栅结构的表面上的上转换纳米颗粒。光栅结构以其共振模式之一的光束照射，以在表面形成强烈的消逝场，并用于高灵敏度测定。强衰减场触发上变频纳米粒子，以在光栅表面产生增强和局部发射，具有较低的背景和较低的光栅衬底的自发荧光。这导致在生物测定中检测分析物方面的改进性能。

2. 发明公开

EP3497027A1 REAGENT COMPONENT DISPENSING CAPS FOR REAGENT CONTAINERS USED IN AUTOMATED CLINICAL ANALYZERS 有权
公开(公告)号：EP3497027A1
公开(公告)日：2019-06-19
申请号：EP17757953.9
申请日：2017-08-07
申请人： Instrumentation Laboratory Company
发明人： BLANKENSTEIN, Gert , ZENG, Hansong
IPC分类号： B65D51/28 , B65D81/32 , G01N35/10

3. 发明公开

EP3458839A1 EVANESCENT HEMOLYSIS DETECTION 审中-实审
公开(公告)号：EP3458839A1
公开(公告)日：2019-03-27
申请号：EP17725130.3
申请日：2017-05-15
申请人： Instrumentation Laboratory Company
发明人： SCHONBRUN, Ethan , BLANKENSTEIN, Gert , KERIMO, Josef , ZENG, Hansong
IPC分类号： G01N21/552 , G01N33/49

4. 发明公开

EP3137878A1 METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION 审中-实审
标题翻译： VERFAHREN UND SYSTEMEFÜRBLUTGERINNUNGSTESTS VERSORGUNGSORT DURCH OPTISCHE DETEKTION
公开(公告)号：EP3137878A1
公开(公告)日：2017-03-08
申请号：EP15720890.1
申请日：2015-04-27
申请人： Instrumentation Laboratory Company
发明人： KERIMO, Josef , ZENG, Hansong , SCHARLACK, Ron , BLANKENSTEIN, Gert
IPC分类号： G01N21/53 , G01N33/49 , G01N21/59
CPC分类号： G01N21/534 , G01N21/59 , G01N21/6408 , G01N21/6486 , G01N21/65 , G01N33/4905 , G01N2201/062 , G01N2201/0636
摘要： This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference (78), a sample handling structure (88), a light source (96) and an optical detection unit (94). The standard optical reference (78), such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure (88), such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference (78). During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit (94). The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.
摘要翻译：本发明涉及一种用于进行浊度测定的光学系统和方法。血液或血浆凝固，包括标准光学参考，样品处理结构，光源和光学检测单元。标准光学参考，例如荧光团掺杂的玻璃，在受控的光学条件下提供恒定的光学信号。样品处理结构，如具有反应室的微流体系统，可放置在标准光学参考下方或上方。在操作过程中，凝固血浆/血液会改变其光吸收和反射特性，导致到达光学读取单元的光信号的变化。光信号的变化，如荧光信号，表示浊度变化过程的动力学，如血浆/血液凝固过程。本发明用于光学系统进行浊度测定，包括光度测定系统，荧光系统，拉曼光谱系统等。

5. 发明公开

EP4406654A3 SPATIAL SEPARATION OF PARTICLES IN A PARTICLE CONTAINING SOLUTION FOR BIOMEDICAL SENSING AND DETECTION 审中-实审
公开(公告)号：EP4406654A3
公开(公告)日：2024-10-23
申请号：EP24179423.9
申请日：2016-01-11
申请人： Instrumentation Laboratory Company
发明人： ZENG, Hansong , BLANKENSTEIN, Gert
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/064720130101 , B01L2300/081620130101 , B01L2300/086420130101 , B01L2400/043620130101 , B01L2400/043920130101 , G01N33/49
摘要： A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.

6. 发明公开

EP4406654A2 SPATIAL SEPARATION OF PARTICLES IN A PARTICLE CONTAINING SOLUTION FOR BIOMEDICAL SENSING AND DETECTION 审中-实审
公开(公告)号：EP4406654A2
公开(公告)日：2024-07-31
申请号：EP24179423.9
申请日：2016-01-11
申请人： Instrumentation Laboratory Company
发明人： ZENG, Hansong , BLANKENSTEIN, Gert
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/064720130101 , B01L2300/081620130101 , B01L2300/086420130101 , B01L2400/043620130101 , B01L2400/043920130101 , G01N33/49
摘要： A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.

7. 发明公开

EP3497035A1 DUAL CHAMBER REAGENT MIXING CONTAINER 有权
公开(公告)号：EP3497035A1
公开(公告)日：2019-06-19
申请号：EP17757952.1
申请日：2017-08-07
申请人： Instrumentation Laboratory Company
发明人： BLANKENSTEIN, Gert , ZENG, Hansong
IPC分类号： B65D81/32 , B65D25/08

8. 发明公开

EP3245001A1 SPATIAL SEPARATION OF PARTICLES IN A PARTICLE CONTAINING SOLUTION FOR BIOMEDICAL SENSING AND DETECTION 有权
标题翻译：粒子在含生物医学传感和检测的解决方案中的空间分离
公开(公告)号：EP3245001A1
公开(公告)日：2017-11-22
申请号：EP16703385.1
申请日：2016-01-11
申请人： Instrumentation Laboratory Company
发明人： ZENG, Hansong , BLANKENSTEIN, Gert
IPC分类号： B01L3/00
CPC分类号： G01N33/49 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/06 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2400/0436 , B01L2400/0439 , G01N1/4077
摘要： A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.

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