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1. 发明公开

EP0467782A1 Myocardial infarction immunoassay 失效
标题翻译： Herzinfarkt免疫分析。
公开(公告)号：EP0467782A1
公开(公告)日：1992-01-22
申请号：EP91401996.3
申请日：1991-07-17
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Shah, Vipin D. , Yen, Shing-Erh , Anchin, Gerald M.
IPC分类号： G01N33/573 , C12Q1/50
CPC分类号： G01N33/573 , C07K16/40
摘要： Methods and reagents for determining the lapse of time since an acute disease event, such as the occurrence of a myocardial infarction, are presented. A serum or plasma sample is assayed to determine the concentration of two analyte sets. From these measurements, the time of the acute event can be more accurately determined. Novel antibodies, labeled and insolubilized derivatives of these antibodies, labeled proteins, and kits containing one or more of these reagents are also described.
摘要翻译：提出了用于确定急性疾病事件之后的时间流逝的方法和试剂，例如心肌梗死的发生。测定血清或血浆样品以确定两个分析物组的浓度。从这些测量可以更准确地确定急性事件的时间。还描述了这些抗体的新型抗体，标记和不溶性衍生物，标记的蛋白质和含有一种或多种这些试剂的试剂盒。

2. 发明公开

EP0384130A2 Myocardial infarction immunoassay 失效
标题翻译：心脏攻击免疫。
公开(公告)号：EP0384130A2
公开(公告)日：1990-08-29
申请号：EP90101237.7
申请日：1990-01-22
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Shah, Vipin D. , Yen, Shing-Erh , Anchin, Gerald M.
IPC分类号： G01N33/573 , C12P21/08 , C12N5/18
CPC分类号： C12N9/0006 , C07K14/47 , C07K16/18 , C07K16/40 , G01N33/573 , Y10S436/811 , Y10S436/815
摘要： Methods and reagents for determining the lapse of time since an acute disease event, such as the occurrence of a myocardial infarction, are presented. A serum or plasma sample is assayed to determine the concentration of two analyte sets. From these measurements, the time of the acute event can be more accurately determined. Novel antibodies, labeled and insolubilized derivatives of these antibodies, labeled proteins, and kits containing one or more of these reagents are also described.

3. 发明公开

EP0304628A3 Immunoassay for CK-MM isoenzymes 失效
标题翻译：免疫测定CK-MM同工酶
公开(公告)号：EP0304628A3
公开(公告)日：1991-07-17
申请号：EP88111778.2
申请日：1988-07-21
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Shah, Vipin D. , Yen, Shing-Erh , Anchin, Gerald M.
IPC分类号： G01N33/573
CPC分类号： C12N9/0006 , C07K14/47 , C07K16/18 , C07K16/40 , G01N33/573 , Y10S436/811 , Y10S436/815
摘要： Methods and reagents for early detection of myocardial infarction determine the level of CK-MM A and the level of the combined CK-MM A and CK-MM B in in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MM A ) antibodies, anti-(CK-MM B ) antibodies, anti-(CK-MM (A+B) ) antibodies, labeled and insolubilized derivatives of these antibodies, labeled MM A , and kits containing one or more of these reagents are also described.
摘要翻译：用于早期检测心肌梗塞的方法和试剂确定血清样品中CK-MMA的水平和联合的CK-MMA和CK-MMB的水平。从这些测量结果可以更准确地确定急性期的时间。新的抗（CK-MMA）抗体，抗（CK-MMB）抗体，抗（CK-MM（A + B））抗体，这些抗体的标记和不溶化衍生物，标记的MMA和含有一种或多种也描述了这些试剂。

4. 发明公开

EP0384130A3 Myocardial infarction immunoassay 失效
标题翻译：心肌梗塞免疫测定
公开(公告)号：EP0384130A3
公开(公告)日：1991-05-29
申请号：EP90101237.7
申请日：1990-01-22
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Shah, Vipin D. , Yen, Shing-Erh , Anchin, Gerald M.
IPC分类号： G01N33/573 , C12P21/08 , C12N5/18
CPC分类号： C12N9/0006 , C07K14/47 , C07K16/18 , C07K16/40 , G01N33/573 , Y10S436/811 , Y10S436/815
摘要： Methods and reagents for determining the lapse of time since an acute disease event, such as the occurrence of a myocardial infarction, are presented. A serum or plasma sample is assayed to determine the concentration of two analyte sets. From these measurements, the time of the acute event can be more accurately determined. Novel antibodies, labeled and insolubilized derivatives of these antibodies, labeled proteins, and kits containing one or more of these reagents are also described.
摘要翻译：介绍了用于确定自急性疾病事件（例如心肌梗塞的发生）以来的时间流逝的方法和试剂。测定血清或血浆样品以确定两种分析物组的浓度。通过这些测量，可以更准确地确定急性事件的时间。还描述了新抗体，这些抗体的标记和不溶化衍生物，标记的蛋白质和含有一种或多种这些试剂的试剂盒。

5. 发明公开

EP0304628A2 Immunoassay for CK-MM isoenzymes 失效
标题翻译：免疫测定CK-MM同工酶。
公开(公告)号：EP0304628A2
公开(公告)日：1989-03-01
申请号：EP88111778.2
申请日：1988-07-21
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Shah, Vipin D. , Yen, Shing-Erh , Anchin, Gerald M.
IPC分类号： G01N33/573
CPC分类号： C12N9/0006 , C07K14/47 , C07K16/18 , C07K16/40 , G01N33/573 , Y10S436/811 , Y10S436/815
摘要： Methods and reagents for early detection of myocardial infarction determine the level of CK-MM A and the level of the combined CK-MM A and CK-MM B in in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MM A ) antibodies, anti-(CK-MM B ) antibodies, anti-(CK-MM (A+B) ) antibodies, labeled and insolubilized derivatives of these antibodies, labeled MM A , and kits containing one or more of these reagents are also described.
摘要翻译：用于早期检测心肌梗死的方法和试剂测定血清样品中CK-MMA的水平和组合的CK-MMA和CK-MMB的水平。从这些测量可以更精确地确定急性期的时间。新型抗（CK-MMA）抗体，抗（CK-MMB）抗体，抗（CK-MM（A + B））抗体，这些抗体的标记和不溶性衍生物，标记的MMA和含有一种或多种的这些试剂也被描述。

6. 发明公开

EP0281251A3 A method for preparing a fecal sample composition for immunoassay testing 失效
标题翻译：一种用于免疫测试的FECAL样品组合物的制备方法
公开(公告)号：EP0281251A3
公开(公告)日：1988-09-28
申请号：EP88300924
申请日：1988-02-03
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Grow, Michael A. , Shah, Vipin D.
IPC分类号： G01N33/53 , G01N33/72 , A61B10/00
CPC分类号： G01N33/725 , A61B10/0038 , A61B2050/0064 , G01N33/528 , G01N33/721 , G01N33/726 , Y10S436/815 , Y10S436/825 , Y10T436/10 , Y10T436/107497 , Y10T436/25375
摘要： A method for preparing a fecal sample for immunoassay testing comprising the steps of dispersing a sample of from 1 to less than 10 wt.% of a stool sample in an aqueous fecal test solution formulated with one or more preservatives, analyte stabilizing agents and endogenous interference reducing agents. The fecal solids are then permitted to settle to form a liquid phase substantially free from fecal solids, and the clarified liquid phase is removed to provide a test sample free from fecal solids. The fecal test solutions contain suitable stool stabilizers such as buffers and antimicrobial agents, analyte protecting agents such as proteolytic, reductive or oxidative enzyme inhibitors, endogenous assay interfering enzyme inhibitors such as a reducing agent, and non-specific binding inhibitors such as animal proteins. The stool sample should be fresh or be fresh frozen and thawed immediately before dispersion in the buffer solution. The sample is suitable for any solid-phase immunoassay determination of a fecal sample analyte. A method for determining analyte in a stool sample comprises conjugating anti-analyte antibody adhered to a insoluble support with analyte in the clarified sample, and determining the presence and extent of such conjugation. For determining human hemoglobin in a sample of human stool, the aqueous fecal test solution preferably contains a proteinase inhibitor, formaldehyde and an animal albumin.

7. 发明公开

EP0281251A2 A method for preparing a fecal sample composition for immunoassay testing 失效
标题翻译： Verfahren zur Zubereitung einerfäkalenProbenzusammensetzungfürimmunologischeNachprüfung。
公开(公告)号：EP0281251A2
公开(公告)日：1988-09-07
申请号：EP88300924.3
申请日：1988-02-03
申请人： INTERNATIONAL IMMUNOASSAY LABORATORIES, INC.
发明人： Grow, Michael A. , Shah, Vipin D.
IPC分类号： G01N33/53
CPC分类号： G01N33/725 , A61B10/0038 , A61B2050/0064 , G01N33/528 , G01N33/721 , G01N33/726 , Y10S436/815 , Y10S436/825 , Y10T436/10 , Y10T436/107497 , Y10T436/25375
摘要： A method for preparing a fecal sample for immunoassay testing comprising the steps of dispersing a sample of from 1 to less than 10 wt.% of a stool sample in an aqueous fecal test solution formulated with one or more preservatives, analyte stabilizing agents and endogenous interference reducing agents. The fecal solids are then permitted to settle to form a liquid phase substantially free from fecal solids, and the clarified liquid phase is removed to provide a test sample free from fecal solids. The fecal test solutions contain suitable stool stabilizers such as buffers and antimicrobial agents, analyte protecting agents such as proteolytic, reductive or oxidative enzyme inhibitors, endogenous assay interfering enzyme inhibitors such as a reducing agent, and non-specific binding inhibitors such as animal proteins. The stool sample should be fresh or be fresh frozen and thawed immediately before dispersion in the buffer solution. The sample is suitable for any solid-phase immunoassay determination of a fecal sample analyte.
A method for determining analyte in a stool sample comprises conjugating anti-analyte antibody adhered to a insoluble support with analyte in the clarified sample, and determining the presence and extent of such conjugation. For determining human hemoglobin in a sample of human stool, the aqueous fecal test solution preferably contains a proteinase inhibitor, formaldehyde and an animal albumin.
摘要翻译：一种制备用于免疫测定试验的粪便样品的方法，包括以下步骤：将1至少于10重量％的粪便样品的样品分散在用一种或多种防腐剂，分析物稳定剂和内源性干扰物配制的水性粪便试验溶液中还原剂。然后允许粪便固体沉降以形成基本上不含粪便固体的液相，并除去澄清的液相以提供不含粪便固体的测试样品。粪便测试溶液含有合适的粪便稳定剂如缓冲剂和抗微生物剂，分析物保护剂如蛋白水解酶，还原酶或氧化酶抑制剂，内源性测定干扰酶抑制剂如还原剂和非特异性结合抑制剂如动物蛋白质。粪便样品应该是新鲜的，或者在分散在缓冲溶液中之前立即冷冻和解冻。样品适用于粪便样品分析物的任何固相免疫测定。用于测定粪便样品中的分析物的方法包括将附着于不溶性载体的抗分析物抗体与澄清样品中的分析物缀合，并确定这种缀合的存在和程度。为了测定人粪便样品中的人血红蛋白，粪便测试溶液优选含有蛋白酶抑制剂，甲醛和动物白蛋白。

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