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    • 3. 发明公开
    • METHOD FOR INCREASING LONGEVITY OF A HUMAN BEING AND ANIMALS
    • 方法延伸出的人与动物的生命
    • EP1880733A4
    • 2009-08-12
    • EP05745412
    • 2005-04-25
    • GENKIN DMITRY DMITRIEVICHTETS VIKTOR VENIAMINOVICH
    • TETS GEORGY VIKTOROVICH
    • A61K38/47A61K39/44A61P43/00
    • C12N9/22A61K38/00C07K16/44C12Y301/21001
    • The invention relates to medicine and veterinary science and can be used for increasing longevity and retarding unhealthy manifestations brought by ageing. It is an object of the present invention to provide an effective method for increasing longevity and retarding unhealthy manifestations brought by ageing of human beings and animals without directly affecting the genetic apparatus of the ageing cells, in particular, reduction of sexual activity and reproductive ability, climacteric, changes in glucose tolerance, reduction of cognitive and mnestic functions, reduction of stress resistivity, development of organ and tissue sclerosis. According to the invention an agent that inactivates extracellular blood DNA is administered into the system circulation of blood; the extracellular blood DNA inactivating agent can be embodied in the form of an extracellular blood DNA destroying agent; said extracellular blood DNA destroying agent can be embodied in the form of an DNAse enzyme; the extracellular blood DNA inactivating agent can also be embodied in the form of an extracellular blood DNA binding agent; the extracellular blood DNA binding agent can be embodied in the form of anti-DNA antibodies; the extracellular blood DNA inactivating agent can be administered in the form of an agent that alters the chemical composition and/or conformation and/or polymery of the extracellular blood DNA without destroying it; the extracellular blood DNA inactivating agent can also be embodied in the form of an agent that stimulates the synthesis and/or activity of endogenous biopolymers, which bind or destroy or alter the chemical composition and/or conformation and/or polymery of the extracellular blood DNA without destroying it.
    • 5. 发明公开
    • METHOD FOR TREATING ONCOLOGICAL DISEASES
    • VERFAHREN ZUR BEHANDLUNG VON ONKOLOGISCHEN ERKRANKUNGEN
    • EP1655036A4
    • 2009-06-17
    • EP04748955
    • 2004-07-01
    • GENKIN DMITRY DMITRIEVICHTETS VIKTOR VENIAMINOVICH
    • GENKIN DMITRY DMITRIEVICHTETS VIKTOR VENIAMINOVICHTETS GEORGY VIKTOROVICH
    • A61K38/43A61K38/44A61K38/46A61K39/395A61P35/00
    • A61K39/0011A61K38/465A61K38/48A61K2039/505A61K2039/53C07K16/44C12Y301/21001A61K2300/00
    • The invention relates to medicine and veterinary science and can be used for treating mainly solid tumors. The inventive method for treating oncological diseases consisting in injecting a blood extracellular DNA destroying agent into a systemic blood circulation. Said blood extracellular DNA destroying agent can be embodied in the form of a DNAse enzyme, in particular a bovine pancreatic DNAse which is parenterally injected in doses ranging from of 50 000 Kunz units to 250 000 000 Kunz units a day every day during 5-360 days or in the form of a recombinant human DNAse. In addition, a blood extracellular DNA binding agent embodied in the form of anti-DNA antibodies can be injected into a systemic blood circulation. In addition a modified agent which modifies the chemical composition and/or conformation and/or polymery and/or an association with proteins and/or lipids and/or ribonucleic acids of the blood extracellular DNA. Said modifying agent can be embodied in the form of a enzyme-ribonuclease. An extracellular ribonuclease of a Serratia Mercenses bacterium can be used in the form of said agents.
    • 本发明涉及医学和兽医学,可用于主要治疗实体瘤。 本发明的治疗肿瘤疾病的方法包括将血细胞外DNA破坏剂注射到全身血液循环中。 所述血细胞外DNA破坏剂可以以DNA酶的形式体现,特别是牛胰腺DNA酶,其在5-360天期间每天每天以50000Kunz单位至2500000000Kunz单位的剂量肠胃外注射 天或以重组人DNAse的形式存在。 此外,以抗DNA抗体形式体现的血细胞外DNA结合剂可以注射到全身血液循环中。 另外还包括改变化学组成和/或构象和/或聚合和/或与血细胞外DNA的蛋白质和/或脂质和/或核糖核酸的缔合的修饰剂。 所述修饰剂可以以酶 - 核糖核酸酶的形式体现。 可以以所述药剂的形式使用粘质沙雷氏菌细菌的胞外核糖核酸酶。
    • 8. 发明公开
    • METHOD FOR TREATING RECURRING SKIN AND MUCOUS MEMBRANE DISEASES CAUSED BY HSV-1 AND HSV-2
    • 方法用于治疗由HSV-1和HSV-2引起RECURRING皮肤和粘膜疾病
    • EP3006020A4
    • 2017-02-15
    • EP14806838
    • 2014-06-06
    • TETS VIKTOR VENIAMINOVICHTETS GEORGY VIKTOROVICH
    • TETS VIKTOR VENIAMINOVICHTETS GEORGY VIKTOROVICH
    • A61K9/02A61K9/06A61K9/10A61K31/63A61P31/22
    • A61K31/63A61K9/0014A61K9/0034A61K9/02A61K9/06A61K9/10
    • The invention relates to medicine and specifically to methods for treating recurring forms of diseases related to the family of herpes viruses. A method for treating recurring diseases of the skin and mucous membranes caused by HSV-1 and HSV-2 involves applying a preparation to an affected area, said preparation including a base containing 0.5% or 1% of an active substance, namely a (2,6-dichlorophenyl)amide salt of carbopentoxysulfanilic acid of general formula (I): where X is Na, K, NH 4 ; the preparation is applied twice daily for 3-5 days and, should prodromes appear, a second course of treatment is carried out, in which the preparation is applied 1-2 times daily for 2-3 days; the base containing the active substance can be in the form of a cream, an ointment, a gel, a suspension, suppositories, a patch or a film. Carrying out the second course of treatment provides a sharp increase in therapeutic efficacy, even to the extent of preventing relapse over a prolonged period of observation as a result of the effect of the preparation, upon reuse, on the viruses persisting in nerve cells.
    • 本发明涉及医学和专门用于处理有关家庭的疱疹病毒疾病的复发形式的方法。 一种用于治疗皮肤的重复疾病和粘膜由HSV-1和HSV-2引起的方法包括在受影响的区域施加的制剂,该制剂包含含有0.5%或活性物质的1%时,基体即(2 ,6-二氯苯基)(I)通式carbopentoxysulfanilic酸的酰胺盐:其中X为Na,K,NH 4; 所述制剂3-5天每天施用两次,并且,shoulderstand前驱症状出现,治疗的第二过程中进行,其中所述制剂每天1-2次的应用2-3天; 含有活性物质的碱可以是乳膏,软膏,凝胶,悬浮液,栓剂,贴剂或膜的形式。 进行处理的第二个疗程提供治疗功效的急剧增加,甚至防止复发整个观察长期作为制剂的效果的结果,在重复使用,对病毒在神经细胞中持续的程度。