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2. 发明公开

EP1167389A1 Antibodies against the protein SEMP1, methods for their production and uses thereof 有权
标题翻译：针对蛋白质的抗体SEMP1，它们的制备方法，以及它们的应用
公开(公告)号：EP1167389A1
公开(公告)日：2002-01-02
申请号：EP01114743.6
申请日：2001-06-22
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Hoevel, Thorsten , Koch, Stefan , Kubbies, Manfred , Mundigl, Olaf , Rüger, Petra
IPC分类号： C07K16/18 , A61K39/395 , C12N5/16
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/28 , C07K2317/34 , C12N2799/026 , C12N2799/027
摘要： Antibody binding to the SEMP1 antigen and characterized in that said antibody binds to SEMP1 in a manner equivalent to an antibody selected from the group of antibodies DSM ACC2458, DSM ACC2459, DSM ACC2461, and DSM ACC2463 is useful for cancer diagnosis and therapy.
摘要翻译：抗体结合至抗原SEMP1并且在特征的所述抗体结合在选自抗体的DSM ACC2458，DSM ACC2459，DSM ACC2461和DSM ACC2463是癌症的诊断和治疗有用的选择的抗体的方式相当于SEMP1到。

3. 发明公开

EP2272873A2 Antibodies against insulin-like growth factor I receptor and uses thereof 有权
标题翻译： Reikeptor und deren Verwendungen
公开(公告)号：EP2272873A2
公开(公告)日：2011-01-12
申请号：EP10180710.5
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C07K16/28 , C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is of IgG1 isotype, b) shows a ratio of IC 50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1,c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phosphorylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, andd) shows no IGF-IR stimulating activity measured as IGF-IR phosphorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-1R per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.
摘要翻译：与IGF-1R结合并抑制IGF-I和IGF-II与IGF-1R结合的抗体，其特征在于所述抗体是a）是IgG1同种型，b）显示IC 50的抑制值 IGF-I与IGF-1R的结合抑制IGF-II与IGF-1R的结合为1:3至3：1，c）在5nM IGF-1R磷酸化浓度下抑制至少80％在使用3T3细胞的细胞磷酸化测定中，当与没有所述抗体的这种测定相比时，在含有0.5％热灭活胎牛血清（FCS）的培养基中，每个细胞提供40万至600,000分子IGF-1R，并且d）显示没有IGF-1R刺激在细胞磷酸化测定中，使用3T3细胞，在含有0.5％热灭活的胎牛血清（FCS）的培养基中，每细胞提供40,000至600,000分子IGF-1R，在10μM浓度下作为IGF-1R磷酸化测量活性。没有所述抗体的测定在抗肿瘤治疗中具有改善的性质。

4. 发明公开

EP2243835A2 Antibodies against insulin-like growth factor I receptor and uses thereof 审中-公开
标题翻译： Antikörpergegen insulinartigen Wachstumsfaktor-1-Rezeptor und deren Verwendung
公开(公告)号：EP2243835A2
公开(公告)日：2010-10-27
申请号：EP10167052.9
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is of IgG1 isotype, b) shows a ratio of IC 50 values of inhibition of the binding of IGF-1 to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1,c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phosphorylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, andd) shows no IGF-IR stimulating activity measured as IGF-IR phosphorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-1R per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.
摘要翻译：与IGF-1R结合并抑制IGF-I和IGF-II与IGF-1R结合的抗体，其特征在于所述抗体是a）是IgG1同种型，b）显示IC 50的抑制值 IGF-1与IGF-IR的结合抑制IGF-II与IGF-IR的结合为1:3至3：1，c）在5nM IGF-1R磷酸化浓度下抑制至少80％在使用3T3细胞的细胞磷酸化测定中，当与没有所述抗体的这种测定相比时，在含有0.5％热灭活胎牛血清（FCS）的培养基中，每个细胞提供40万至600,000分子IGF-1R，并且d）显示没有IGF-1R刺激在细胞磷酸化测定中，使用3T3细胞，在含有0.5％热灭活的胎牛血清（FCS）的培养基中，每细胞提供40,000至600,000分子IGF-1R，在10μM浓度下作为IGF-1R磷酸化测量活性。没有所述抗体的测定在抗肿瘤治疗中具有改善的性质。

5. 发明授权

EP1959014B9 Antibodies against insulin-like growth factor I receptor and uses thereof 有权转让
标题翻译：针对胰岛素样生长因子-I受体及其使用的抗体
公开(公告)号：EP1959014B9
公开(公告)日：2011-12-28
申请号：EP08007731.6
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C07K16/28 , C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73

6. 发明公开

EP2272873A3 Antibodies against insulin-like growth factor I receptor and uses thereof 有权
标题翻译：针对胰岛素样生长因子-I受体及其用途抗体
公开(公告)号：EP2272873A3
公开(公告)日：2011-09-28
申请号：EP10180710.5
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is of IgG1 isotype, b) shows a ratio of IC 50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1,c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phosphorylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, andd) shows no IGF-IR stimulating activity measured as IGF-IR phosphorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-1R per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.

7. 发明授权

EP1959014B1 Antibodies against insulin-like growth factor I receptor and uses thereof 有权转让
标题翻译：针对胰岛素样生长因子-I受体及其使用的抗体
公开(公告)号：EP1959014B1
公开(公告)日：2011-03-23
申请号：EP08007731.6
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C07K16/28 , C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73

8. 发明授权

EP2272873B1 Antibodies against human insulin-like growth factor I receptor and uses thereof 有权
标题翻译：抗体与人胰岛素样生长因子-I受体及其应用
公开(公告)号：EP2272873B1
公开(公告)日：2015-01-28
申请号：EP10180710.5
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , Van de Winkel, Jan , Van Vugt, Martine
IPC分类号： C12N15/13 , C12N5/16 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73

9. 发明公开

EP2243835A3 Antibodies against insulin-like growth factor I receptor and uses thereof 审中-公开
标题翻译：针对胰岛素样生长因子-1受体抗体，其使用
公开(公告)号：EP2243835A3
公开(公告)日：2010-11-10
申请号：EP10167052.9
申请日：2004-07-09
申请人： F. Hoffmann-La Roche AG
发明人： Graus, Yvo , Kopetzki, Erhard , Kuenkele, Klaus-Peter , Mundigl, Olaf , Parren, Paul , Rebers, Frank , Schumacher, Ralf , van de Winkel, Jan , van Vugt, Martine
IPC分类号： C12N15/13 , C12N5/16 , A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is of IgG1 isotype, b) shows a ratio of IC 50 values of inhibition of the binding of IGF-1 to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1,c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phosphorylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, andd) shows no IGF-IR stimulating activity measured as IGF-IR phosphorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-1R per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.

10. 发明授权

EP1167389B1 Antibodies against the protein SEMP1, methods for their production and uses thereof 有权
标题翻译：针对蛋白质的抗体SEMP1，它们的制备方法，以及它们的应用
公开(公告)号：EP1167389B1
公开(公告)日：2007-07-11
申请号：EP01114743.6
申请日：2001-06-22
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Hoevel, Thorsten , Koch, Stefan , Kubbies, Manfred , Mundigl, Olaf , Rüger, Petra
IPC分类号： C07K16/18 , A61K39/395 , C12N5/16
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/28 , C07K2317/34 , C12N2799/026 , C12N2799/027

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