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1. 发明授权

EP1664016B9 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗疼痛的治疗药物
公开(公告)号：EP1664016B9
公开(公告)日：2009-07-08
申请号：EP04784627.4
申请日：2004-09-21
申请人： EURO-CELTIQUE S.A.
发明人： SUN, Qun
IPC分类号： C07D401/04 , C07D417/14 , C07D413/14 , A61K31/44 , A61K31/41 , A61K31/495
CPC分类号： C07D213/80 , C07D213/81
摘要： The present invention discloses a compound of formula: where Ar1, Ar2, X, Z1, Z2, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Pyridylene Compound”); compositions comprising an effective amount of a Pyridylene Compound; and methods for treating or preventing pain or other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Pyridylene Compound.
摘要翻译：本发明公开了下式的化合物：其中Ar1，Ar2，X，Z1，Z2，R3和m如本文所公开的，或其药学上可接受的盐（“亚磷酰基化合物”）; 包含有效量的吡啶基化合物的组合物; 以及用于治疗或预防动物疼痛或其他病症的方法，其包括向有需要的动物施用有效量的吡啶基化合物。

2. 发明授权

EP1664041B1 PHENYL-CARBOXAMIDE COMPOUNDS USEFUL FOR TREATING PAIN 有权
标题翻译：疼痛SUITABLEPHENYLCARBONSÄUREAMIDVERBINDUNGEN的治疗
公开(公告)号：EP1664041B1
公开(公告)日：2008-07-02
申请号：EP04784626.6
申请日：2004-09-21
申请人： EURO-CELTIQUE S.A.
发明人： SUN, Qun
IPC分类号： C07D417/04 , C07D213/06
CPC分类号： C07D417/12 , C07D213/56
摘要： The present invention discloses compounds of formula: (I) (II) where Ar1, Ar2, X, R1, R2, R3, m, and n are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Phenylene Compound”); compositions comprising an effective amount of a Phenylene Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Phenylene Compound.

3. 发明授权

EP1631285B1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 无效
标题翻译：疼痛合适的治疗剂的治疗
公开(公告)号：EP1631285B1
公开(公告)日：2007-08-08
申请号：EP04776652.2
申请日：2004-06-14
申请人： Euro-Celtique S.A.
发明人： KYLE, Donald, J. , SUN, Qun , TAFESSE, Laykea
IPC分类号： A61K31/44 , A61K31/495 , C07D213/02 , C07D401/02 , A61P25/00
CPC分类号： C07D211/78 , C07D213/02 , C07D401/02 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A compound of formula: wherein Ar1, Ar2, V, X, R3, R4, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a 'Cyclo(hetero)alkenyl Compound'); compositions comprising an effective amount of a Cyclo(hetero)alkenyl Compound; and methods for treating or preventing, e.g., pain, UI, an ulcer, IBD, or IBS in an animal, comprising administering to an animal in need thereof an effective amount of a Cyclo(hetero)alkenyl Compound are disclosed herein.

4. 发明公开

EP1648880A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗疼痛的治疗药物
公开(公告)号：EP1648880A1
公开(公告)日：2006-04-26
申请号：EP04779721.2
申请日：2004-07-30
申请人： Euro-Celtique S.A.
发明人： KYLE, Donald, J. , SUN, Qun
IPC分类号： C07D401/04 , A61K31/495 , A61P1/04 , A61P13/02
CPC分类号： C07D401/04 , C07D213/74 , C07D213/85
摘要： Compounds of formulae (I) and (II) where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a '3-substituted Pyridyl Compound'), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.
摘要翻译：其中X是S或O和Ar 2，R 1，R 2，R 3，R 8，n，m和t的式（I）和（II）化合物或其药学上可接受的盐（'3-取代的吡啶基化合物'），包含有效量的3-取代的吡啶基化合物的组合物，以及用于治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾症，帕金森病，帕金森病，焦虑症，癫痫症，中风，惊厥，瘙痒症状，精神病，认知障碍，记忆缺陷，脑功能受限，亨廷顿舞蹈症，肌萎缩侧索硬化症，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症在动物中给予有需要的动物有效量的本发明公开的3-取代的吡啶基化合物。

5. 发明公开

EP1648879A1 HETEROARYL-TETRAHYDROPIPERIDYL COMPOUNDS USEFUL FOR TREATING OR PREVENTING PAIN 有权
标题翻译：杂芳基TETRAHYDROPYRIDYLVERBINDUNGEN介入治疗或疼痛的预防是合适的
公开(公告)号：EP1648879A1
公开(公告)日：2006-04-26
申请号：EP04779122.3
申请日：2004-07-23
申请人： Euro-Celtique S.A.
发明人： SUN, Qun , WEN, Kate 50 Guang Lan Rd.
IPC分类号： C07D401/04 , C07D417/14 , A61K31/4545 , A61P29/00 , A61P13/00
CPC分类号： A61K31/444 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A compound of formula (I): where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a 'Tetrahydropiperidyl Compound'); compositions comprising an effective amount of a Tetrahydropiperidyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Tetrahydropiperidyl Compound are disclosed herein.

6. 发明公开

EP1648878A1 PIPERIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
标题翻译：哌啶和药物组合物含
公开(公告)号：EP1648878A1
公开(公告)日：2006-04-26
申请号：EP04779120.7
申请日：2004-07-23
申请人： Euro-Celtique S.A.
发明人： SUN, Qun , WEN, Kate , ZHOU, Xiaoming
IPC分类号： C07D401/04 , C07D417/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.

7. 发明公开

EP1583763A1 BENZOAZOLYPIPERAZINE DERIVATIVES HAVING MGLUR1- AND MGLUR5-ANTAGONISTIC ACTIVITY 有权
标题翻译：具有MGLUR1-和MGLUR5-拮抗活性的苯并氮杂哌嗪衍生物
公开(公告)号：EP1583763A1
公开(公告)日：2005-10-12
申请号：EP03814351.7
申请日：2003-12-22
申请人： Euro-Celtique S.A.
发明人： SUN, Qun , TAFESSE, Laykea , VICTORY, Sam
IPC分类号： C07D417/12 , C07D413/12 , C07D403/12 , C07D401/12 , A61K31/495 , A61P29/00 , A61P13/00
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula (I) wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson’s disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington’s chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of Benzoazolylpiperazine Compound are disclosed.
摘要翻译：其中Ar 1，A，R 3，x和m如本文所公开且Ar 2为苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并唑基哌嗪化合物”）的组合物，苯并唑基哌嗪化合物，以及治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性病症，帕金森病，帕金森病，焦虑症，癫痫症，中风，惊厥，瘙痒症状，精神病，认知障碍，记忆公开了在动物中施用有效量的苯并唑基哌嗪化合物，包括向有需要的动物给药，包括给予有效量的苯并唑基哌嗪化合物，其中所述化合物包含有效量的苯并咪唑基哌嗪化合物或其药学可接受的盐。

8. 发明公开

EP1532119A2 ARYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译：芳基取代的苯并咪唑及其作为钠通道阻滞剂
公开(公告)号：EP1532119A2
公开(公告)日：2005-05-25
申请号：EP03772101.6
申请日：2003-07-31
申请人： Euro-Celtique S.A.
发明人： SUN, Qun , ZHOU, Xiaoming , KYLE, Donald, J.
IPC分类号： C07D235/00
CPC分类号： C07D403/06 , C07D235/08 , C07D235/12
摘要： This invention relates aryl substituted benzimidazoles of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

9. 发明公开

EP2067776A1 Piperidine compounds and pharmaceutical compositions containing them 审中-公开
标题翻译： Pi ten ten en ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten ten
公开(公告)号：EP2067776A1
公开(公告)日：2009-06-10
申请号：EP09156594.5
申请日：2004-07-23
申请人： EURO-CELTIQUE S.A.
发明人： SUN, Qun , ZHOU, Xiaoming , WEN, Kate
IPC分类号： C07D401/04 , C07D417/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In embodiment, the Piperidine Compound has the formula:

and pharmaceutically acceptable salts thereof, wherein Ar 1 , Ar 2 , X, R 3 , R 4 , and m are as disclosed herein.
摘要翻译：哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。在实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar 1，Ar 2，X，R 3，R 4和m如本文所公开。

10. 发明授权

EP1379246B1 NOCICEPTIN ANALOGS 有权
标题翻译：孤啡肽类似物
公开(公告)号：EP1379246B1
公开(公告)日：2008-10-08
申请号：EP02764236.2
申请日：2002-04-18
申请人： EURO-CELTIQUE S.A.
发明人： SUN, Qun , GOEHRING, R., Richard , KYLE, Donald , CHEN, Zhengming , VICTORY, Sam , WHITEHEAD, John
IPC分类号： A61K31/44 , A61K31/48 , A61K31/415 , A61K31/445 , C07D211/04 , C07D211/06 , C07D235/24 , C07D413/04 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , A61P25/04
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of formula (I), (II), (III) or (IV), wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.

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