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1. 发明公开

EP3083981A1 MICROBE IDENTIFICATION BY MASS SPECTROMETRY AND INFRARED SPECTROMETRY 有权转让
标题翻译：生殖鉴定质谱，红外光谱
公开(公告)号：EP3083981A1
公开(公告)日：2016-10-26
申请号：EP14796748.3
申请日：2014-11-10
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus
IPC分类号： C12Q1/04 , G01N33/68
摘要： The invention relates to a method for identifying unknown microbes in a sample, wherein a mass spectrometric determination termination down to the taxonomic level of the genus or species is supplemented by a detailed determination of a lower taxonomic level or variety by means of infrared spectrometry, using restricted reference libraries of infrared spectra. These libraries can be genus-specific, containing only infrared spectra of microbes of one genus, or species-specific, containing only infrared spectra of microbes of one species. In so doing, a robust mass spectrometric identification of the species of unknown microbes is advantageously supplemented with a detailed analysis of the subspecies and varieties by means of infrared spectrometry, primarily in order to identify medically important varieties such as pathovars like EHEC and EPEC, and antibiotic-resistant microbes like MRSA.

2. 发明公开

EP2647029A1 DEPOSITION AID FOR THE MANUAL DEPOSITION OF MASS SPECTROMETRIC SAMPLES 有权转让
标题翻译：分离有助于为MASS样品手工分离
公开(公告)号：EP2647029A1
公开(公告)日：2013-10-09
申请号：EP11790591.9
申请日：2011-11-23
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , WELLER, Ulrich
IPC分类号： H01J49/04 , B01L99/00 , G01N35/00 , G01N33/68
CPC分类号： H01J49/0413 , B01L3/545 , B01L9/523 , B01L99/00 , B01L2300/0645 , B01L2300/0829 , G01N1/28 , G01N2001/045 , H01J49/0418
摘要： The invention concerns the reduction of the risk of an incorrect assignment of samples to sample sites during the manual deposition of samples for ionization by laser desorption (for example MALDI or LDCI). The invention offers a method wherein a sample support with several sample sites is provided, at least one sample site is selected, and the selected sample site is highlighted, at least in contrast to neighboring not selected sample sites, in a way which the human eye can perceive.

3. 发明授权

EP3094739B1 MASS SPECTROMETRIC RESISTANCE DETERMINATION BY MEASURING METABOLISM 有权转让
公开(公告)号：EP3094739B1
公开(公告)日：2018-10-24
申请号：EP15700451.6
申请日：2015-01-14
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , SPARBIER, Katrin
IPC分类号： C12Q1/18 , G01N33/68 , C12Q1/04
CPC分类号： C12Q1/18 , C12Q1/04 , G01N33/6851
摘要： The invention relates to a mass spectrometric method to determine microbial resistances to antibiotics. The decrease or modification of specific nutrient components by microbes, and thus the metabolism of the microbes, is determined mass spectrometrically in culture media containing antibiotics. Hence it is not the microbes which are introduced into the mass spectrometric analysis, but the culture medium. The special nutrient components which are subject to the mass spectrometric observation are indicators for the metabolism exhibited by the microbes in the culture in the presence of antibiotics, and are thus indicators for their susceptibility or resistance.

4. 发明授权

EP3083981B1 MICROBE IDENTIFICATION BY MASS SPECTROMETRY AND INFRARED SPECTROMETRY 有权转让
标题翻译：非洲红十字国际委员会
公开(公告)号：EP3083981B1
公开(公告)日：2017-03-01
申请号：EP14796748.3
申请日：2014-11-10
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus
IPC分类号： C12Q1/04 , G01N33/68
摘要： The invention relates to a method for identifying unknown microbes in a sample, wherein a mass spectrometric determination termination down to the taxonomic level of the genus or species is supplemented by a detailed determination of a lower taxonomic level or variety by means of infrared spectrometry, using restricted reference libraries of infrared spectra. These libraries can be genus-specific, containing only infrared spectra of microbes of one genus, or species-specific, containing only infrared spectra of microbes of one species. In so doing, a robust mass spectrometric identification of the species of unknown microbes is advantageously supplemented with a detailed analysis of the subspecies and varieties by means of infrared spectrometry, primarily in order to identify medically important varieties such as pathovars like EHEC and EPEC, and antibiotic-resistant microbes like MRSA.
摘要翻译：本发明涉及一种用于鉴定样品中未知微生物的方法，其中通过红外光谱法通过红外光谱法详细测定较低分类水平或品种来补充至属或物种分类级别的质谱测定终止，使用限制红外光谱参考库。这些文库可以属于属，仅含有一个属的微生物或物种特异性的微生物的红外光谱，其仅包含一种微生物的红外光谱。在这样做的过程中，通过红外光谱法有利地补充了亚种和品种的详细分析，主要是为了鉴定医学上重要的品种，如EHEC和EPEC等病原体，以及抗生素抗性微生物如MRSA。

5. 发明授权

EP2601304B1 MASS SPECTROMETRIC DIAGNOSIS OF SEPSIS WITHOUT BLOOD CULTURE 有权转让
公开(公告)号：EP2601304B1
公开(公告)日：2020-11-04
申请号：EP11749128.2
申请日：2011-07-29
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , PUSCH, Wolfgang , MAIER, Thomas , MICHELMANN, Karsten , FRANZEN, Jochen
IPC分类号： C12Q1/04 , G01N33/68 , C12M1/34 , C12M3/00

6. 发明公开

EP3094739A1 MASS SPECTROMETRIC RESISTANCE DETERMINATION BY MEASURING METABOLISM 有权转让
标题翻译：代表性物品
公开(公告)号：EP3094739A1
公开(公告)日：2016-11-23
申请号：EP15700451.6
申请日：2015-01-14
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , SPARBIER, Katrin
IPC分类号： C12Q1/18 , G01N33/68 , C12Q1/04
CPC分类号： C12Q1/18 , C12Q1/04 , G01N33/6851
摘要： The invention relates to a mass spectrometric method to determine microbial resistances to antibiotics. The decrease or modification of specific nutrient components by microbes, and thus the metabolism of the microbes, is determined mass spectrometrically in culture media containing antibiotics. Hence it is not the microbes which are introduced into the mass spectrometric analysis, but the culture medium. The special nutrient components which are subject to the mass spectrometric observation are indicators for the metabolism exhibited by the microbes in the culture in the presence of antibiotics, and are thus indicators for their susceptibility or resistance.
摘要翻译：本发明涉及确定抗生素耐药性的质谱法。在含有抗生素的培养基中，通过质谱法测定微生物对特定营养成分的减少或改变，从而微生物的代谢。因此，不是引入质谱分析的微生物，而是培养基。进行质谱观察的特殊营养成分是在抗生素存在下由培养物中的微生物表现的代谢指标，因此是其敏感性或耐药性的指标。

7. 发明授权

EP2647029B1 DEPOSITION AID FOR THE MANUAL DEPOSITION OF MASS SPECTROMETRIC SAMPLES 有权转让
标题翻译：分离有助于为MASS样品手工分离
公开(公告)号：EP2647029B1
公开(公告)日：2015-04-15
申请号：EP11790591.9
申请日：2011-11-23
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , WELLER, Ulrich
IPC分类号： H01J49/04 , B01L99/00 , G01N35/00 , G01N33/68 , G01N1/04 , G01N1/28
CPC分类号： H01J49/0413 , B01L3/545 , B01L9/523 , B01L99/00 , B01L2300/0645 , B01L2300/0829 , G01N1/28 , G01N2001/045 , H01J49/0418
摘要： The invention concerns the reduction of the risk of an incorrect assignment of samples to sample sites during the manual deposition of samples for ionization by laser desorption (for example MALDI or LDCI). The invention offers a method wherein a sample support with several sample sites is provided, at least one sample site is selected, and the selected sample site is highlighted, at least in contrast to neighboring not selected sample sites, in a way which the human eye can perceive.

8. 发明公开

EP2580598A1 MASS SPECTROMETRIC MEASUREMENT OF -LACTAMASE RESISTANCES 有权转让
标题翻译：质谱法测定乳糖酶抗性
公开(公告)号：EP2580598A1
公开(公告)日：2013-04-17
申请号：EP11728209.5
申请日：2011-06-10
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus , MICHELMANN, Karsten , SPARBIER, Katrin
IPC分类号： G01N33/94 , G01N33/68 , C12Q1/34
CPC分类号： C12Q1/18 , C12Q1/34 , G01N33/6851 , G01N2333/986 , G01N2800/26 , G01N2800/44
摘要： The invention relates to the determination of resistances of microorganisms which produce beta-lactamases, in particular "extended spectrum beta-lactamases" (ESBL). The invention provides a method whereby the microbial resistance can be measured very simply and quickly by means of the catalytic effect of the microbially produced beta-lactamases on beta-lactam antibiotics, which consists in a hydrolytic cleavage of the beta-lactam ring. The method determines the resistance of the bacteria a few hours after a suitable substrate, either a beta-lactam antibiotic or a customized beta-lactam derivative, has been added to a suspension of the microbes, by direct mass spectrometric measurement of the substrate breakdown caused by the beta-lactamases.
摘要翻译：本发明涉及确定产生β-内酰胺酶的微生物，特别是“扩展谱β-内酰胺酶”（ESBL）的抗性。本发明提供了一种通过微生物产生的β-内酰胺酶对β-内酰胺抗生素的催化作用非常简单和快速地测量微生物抗性的方法，其中β-内酰胺抗生素包括β-内酰胺环的水解裂解。该方法通过直接质谱测量所引起的底物分解，在合适的底物（β-内酰胺抗生素或定制的β-内酰胺衍生物）已经添加至微生物悬浮液后几小时测定细菌的抗性由β-内酰胺酶决定。

9. 发明授权

EP3083981B2 MICROBE IDENTIFICATION BY MASS SPECTROMETRY AND INFRARED SPECTROMETRY 有权转让
公开(公告)号：EP3083981B2
公开(公告)日：2019-12-25
申请号：EP14796748.3
申请日：2014-11-10
申请人： Bruker Daltonik GmbH
发明人： KOSTRZEWA, Markus
IPC分类号： C12Q1/04 , G01N33/68

10. 发明授权

EP2880450B1 DETECTION OF MIXTURES IN MASS-SPECTROMETRIC MICROBE IDENTIFICATION 有权转让
标题翻译：质谱法检测混合物中微量元素的鉴定
公开(公告)号：EP2880450B1
公开(公告)日：2017-11-29
申请号：EP13742213.5
申请日：2013-07-25
申请人： Bruker Daltonik GmbH
发明人： FRANZEN, Jochen , KLEPEL, Stefan , KOSTRZEWA, Markus , MAIER, Thomas
IPC分类号： G01N33/68
CPC分类号： C12Q1/04 , G01N33/6848 , G01N2560/00 , G06F19/18

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