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1. 发明公开

EP2167104A1 BIFUNCTIONAL SYNTHETIC MOLECULES 审中-公开
标题翻译：双功能合成分子
公开(公告)号：EP2167104A1
公开(公告)日：2010-03-31
申请号：EP08768535.0
申请日：2008-06-17
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , PATEL, Kanu , ZHU, Zhen , QIAO, Lixin
IPC分类号： A61K31/74 , A01N61/00
CPC分类号： C07D213/80 , C07C69/612 , C07C233/87 , C07C2601/14 , C07D207/16 , C07D217/26 , C07D233/06 , C07D233/24 , C07D233/50 , C07D417/04
摘要： The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.

2. 发明公开

EP1791506A2 METHODS OF DEVICE-ASSISTED DRUG DELIVERY 审中-公开
标题翻译：程序的设备辅助药物管理局
公开(公告)号：EP1791506A2
公开(公告)日：2007-06-06
申请号：EP05798886.7
申请日：2005-09-20
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , Patel, Kanu
IPC分类号： A61F13/00
CPC分类号： A61K9/0021
摘要： This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstructive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.

3. 发明公开

EP3624770A1 TRANSDERMALLY-DELIVERED COMBINATION DRUG THERAPY FOR PAIN 审中-公开
公开(公告)号：EP3624770A1
公开(公告)日：2020-03-25
申请号：EP18727554.0
申请日：2018-05-09
申请人： BioChemics, Inc. , Masiz, John, J.
发明人： VARADI, Gyula , CARTER, Stephen, G. , MASIZ, John, J. , ZHU, Zhen
IPC分类号： A61K9/00 , A61K31/192 , A61K31/195

4. 发明授权

EP2352543B1 METHODS AND COMPOSITIONS FOR TATTOO REMOVAL 有权
公开(公告)号：EP2352543B1
公开(公告)日：2019-04-03
申请号：EP09764427.2
申请日：2009-12-04
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L. , STEPHENS, Laura , MASIZ, John, J. , DONABEDIAN, David, H.
IPC分类号： A61M37/00 , A61K8/18 , A61Q19/02 , A61N5/06 , A61K8/49 , A61Q1/14 , A61K8/67 , A61K8/02 , A61B18/20 , A61N1/32 , A61B17/00 , A61B18/00

5. 发明授权

EP2373346B1 IBUPROFEN FOR TOPICAL ADMINISTRATION 有权
公开(公告)号：EP2373346B1
公开(公告)日：2019-06-12
申请号：EP09792433.6
申请日：2009-09-10
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane
IPC分类号： A61K47/32

6. 发明公开

EP2352543A2 METHODS AND COMPOSITIONS FOR TATTOO REMOVAL 审中-公开
标题翻译：方法和组合物拆卸TATTOOS
公开(公告)号：EP2352543A2
公开(公告)日：2011-08-10
申请号：EP09764427.2
申请日：2009-12-04
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L. , STEPHENS, Laura , MASIZ, John, J. , DONABEDIAN, David, H.
IPC分类号： A61M37/00 , A61K8/18 , A61Q19/00
CPC分类号： A61K8/4926 , A61B18/203 , A61B2017/00769 , A61B2018/00452 , A61B2018/0047 , A61K8/0208 , A61K8/26 , A61K8/342 , A61K8/498 , A61K8/585 , A61K8/678 , A61K8/73 , A61K8/922 , A61K2800/51 , A61K2800/74 , A61K2800/81 , A61K2800/91 , A61M37/0092 , A61N1/325 , A61N5/062 , A61Q1/145 , A61Q19/02
摘要： Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.

7. 发明公开

EP2968125A1 TOPICAL FORMULATIONS AND METHODS FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的局部制剂和方法
公开(公告)号：EP2968125A1
公开(公告)日：2016-01-20
申请号：EP14726240.6
申请日：2014-03-14
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , VARADI, Gyula
IPC分类号： A61K9/00
CPC分类号： A61K31/198 , A61K9/0004 , A61K9/0014 , A61K31/047 , A61K31/05 , A61K31/192 , A61K31/195 , A61K31/4174 , A61K31/455 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Disclosed are topical formulations for delivery of an active ingredient to a patient. The formulation comprises components including: an active ingredient; a vasoactive agent; and a chelator, wherein the components are selected so that none of the other components is sequestered by the chelator. In some embodiments, the formulation comprises an osmolarity that is greater than about 345 milliOsmoles/liter (345 mOsM). In some embodiments, the formulation further comprises an osmolyte, wherein the osmolyte does not include an ion with a valency higher than monovalency. In some embodiments, the osmolyte in the formulation comprises an osmolarity that is greater than about 290 milliOsmoles/liter (290 mOsM). Also disclosed are methods for using the formulations, and components thereof, kits comprising the components of the formulation, and methods for manufacturing a medicament comprising components of the formulations.
摘要翻译：公开了用于将活性成分递送给患者的局部制剂。该制剂包含的组分包括：活性成分; 血管活性剂; 和螯合剂，其中选择组分使得其他组分不被螯合剂螯合。在一些实施方案中，制剂包含大于约345毫渗透率/升（345mOsM）的同渗容摩。在一些实施方案中，所述制剂还包含渗压剂，其中所述渗压剂不包含价态高于一价的离子。在一些实施方案中，制剂中的渗压剂包含大于约290毫摩尔/升（290mOsM）的同渗容摩。还公开了使用所述制剂及其组分的方法，包含所述制剂组分的试剂盒以及制备包含所述制剂组分的药物的方法。

8. 发明公开

EP2373346A2 IBUPROFEN FOR TOPICAL ADMINISTRATION 审中-公开
标题翻译： IBUPROFEN ZUR TOPISCHEN VERABREICHUNG
公开(公告)号：EP2373346A2
公开(公告)日：2011-10-12
申请号：EP09792433.6
申请日：2009-09-10
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane
IPC分类号： A61K47/32
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸））的制备。通过在药学上可接受的溶剂存在下，溶解游离酸形式的布洛芬或制备游离酸形式的布洛芬的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。

9. 发明公开

EP2307001A1 CONTROL OF BLOOD VESSEL PHYSIOLOGY TO TREAT SKIN DISORDERS 审中-公开
标题翻译：型血管生理学皮肤疾病的治疗控制
公开(公告)号：EP2307001A1
公开(公告)日：2011-04-13
申请号：EP09763660.9
申请日：2009-06-11
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , MASIZ, John, J. , STEPHENS, Laura , ZHU, Zhen , PATEL, Kanu , DONABEDIAN, David, H.
IPC分类号： A61K31/198 , A61K31/455 , A61K41/00 , A61P17/00
CPC分类号： A61K41/0028 , A61K9/0014 , A61K31/137 , A61K31/17 , A61K31/198 , A61K31/295 , A61K31/401 , A61K31/4164 , A61K31/4166 , A61K31/425 , A61K31/455 , A61K31/522 , A61K36/14 , A61K36/16 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/62 , A61K36/734 , A61K36/752 , A61K36/88 , A61K36/886 , A61K36/8969 , A61K36/9068 , A61M37/00 , A61N5/062 , A61N7/00
摘要： In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.

10. 发明公开

EP2207536A1 TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT 审中-公开
标题翻译：发出透皮WITH A渗压和介质血管活性ACTIVE
公开(公告)号：EP2207536A1
公开(公告)日：2010-07-21
申请号：EP09740777.9
申请日：2009-09-22
申请人： BioChemics, Inc.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , MASIZ, John, J.
IPC分类号： A61K9/70 , A61K47/02
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

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