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1. 发明公开

EP1753517A2 VERFAHREN ZUR HERSTELLUNG VON CHEMISCHEN UND PHARMAZEUTISCHEN PRODUKTEN MIT INTEGRIERTER MEHRSÄULEN-CHROMATOGRAPHIE 有权转让
标题翻译：工艺为化工和医药产品，集成了更多的柱层析研制
公开(公告)号：EP1753517A2
公开(公告)日：2007-02-21
申请号：EP05742674.4
申请日：2005-05-14
申请人： Bayer Technology Services GmbH
发明人： STRUBE, Jochen , KLATT, Karsten-Ulrich , NOETH, Gerhard , GREIFENBERG, Joern , BÖCKER, Sebastian , KANSY, Heinz , JÄHN, Peter , JUSTEN, Berthold
IPC分类号： B01D15/00
CPC分类号： F16K27/003 , B01D15/1842 , F16B11/00 , F16D1/068 , F16D3/387 , F16D2001/062 , G01N30/42 , Y10T137/7062
摘要： The invention relates to a chromatographic method for material separation in the production of chemicals such as chiral pharmaceuticals, isomers or biomolecules on a large and small scale, based on simulated moving bed technology (SMB). The invention especially relates to a method for material separation using a simulated moving bed method whereby a product mixture to be separated and the eluant are continuously fed to a column switching system consisting of more than one chromatography column connected in series and filled with an adsorbing agent, and at least one extract flow containing a separated component and a raffinate flow containing at least one other component are continuously removed in different locations of the column switching system, and whereby a relative movement between a liquid, mobile phase consisting of the product mixture and the eluant and the adsorbing agent in the solid phase is generated by sequentially opening liquid feed and removal positions along the column. The method according to the invention is characterized in that only an eluant feed pump and an eluant compensation reservoir but no circulation pump is used in the circuit.
摘要翻译：在一个处理以提取从混合物手性药剂，异构体或生物分子，将产物从混合物中通过模拟移动床技术双重流色谱法分离。在一个处理以提取从混合物手性药剂，异构体或生物分子，将产物从混合物中通过模拟移动床技术双重流色谱法分离。在这个过程中现有技术的5-泵装置是由一个4泵装置代替。该方法使用一个单一的洗脱液流量恒定进料泵和一个单一的洗脱液补偿容器和没有循环泵。该组件采用在电路色谱不超过四个泵。现有技术排出泵，提取或精制放电是通过调节阀代替。洗脱液不纯的在电路中的自动放电是由在线检测和调节器阀促进。所作的回收物流和相关联的冗余的测量结果是由数据比较增加，增加了体积流量控制的精度。独立权利要求中包括了：（1）与主板，一个阀壳，以及一控制单元壳体，其中，所述控制系统位于一个内部气动腔室中的模块化阀系统; 和（2）一个相称的生产过程。

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