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1. 发明公开

EP3738649A1 IMPLANTABLE MEDICAL DEVICE COMPRISING AN ANCHORING DEVICE 审中-公开
公开(公告)号：EP3738649A1
公开(公告)日：2020-11-18
申请号：EP19187483.3
申请日：2019-07-22
申请人： BIOTRONIK SE & Co. KG
发明人： Hughes, Devan , Whittington, R. Hollis , Muessig, Dirk , Kibler, Andrew B. , Suwito, Wantjinarjo , Austin, Eric
IPC分类号： A61N1/375 , A61N1/372
摘要： An implantable medical device (1) comprises a housing (10) having a proximal end (101) and a distal end (100), an electrode device (11) arranged in the region of the distal end (100), and an anchoring device (2) fixedly attached to the housing (10) in the region of the distal end (100). The anchoring device (2) comprises at least one anchoring member (20) having a preshaped first configuration, the at least one anchoring member (20) being deflectable from the preshaped first configuration into a strained second configuration for placement of the implantable medical device (1) on an object. The at least one anchoring member (20) comprises a tip section (21) and a connection section (22) extending in between the tip section (21) and the distal end (100) of the housing (10), wherein at least in the preshaped first configuration the tip section (21) comprises a straight portion (212) adjoining the connection section (22) at a transition location (211) by forming a bend in between the straight portion (212) and the connection section (22).

2. 发明授权

EP3085414B1 DEVICE FOR SELECTIVE NERVE STIMULATION 有权
公开(公告)号：EP3085414B1
公开(公告)日：2020-03-18
申请号：EP16164037.0
申请日：2016-04-06
申请人： BIOTRONIK SE & Co. KG
发明人： Baru, Marcelo , Kibler, Andrew B.
IPC分类号： A61N1/36

3. 发明公开

EP3085414A1 DEVICE AND METHOD FOR SELECTIVE NERVE STIMULATION 有权
标题翻译： VORRICHTUNG UND VERFAHREN ZUR SELEKTIVEN NERVENSTIMULATION
公开(公告)号：EP3085414A1
公开(公告)日：2016-10-26
申请号：EP16164037.0
申请日：2016-04-06
申请人： BIOTRONIK SE & Co. KG
发明人： Baru, Marcelo , Kibler, Andrew B.
IPC分类号： A61N1/36
摘要： The invention concerns an implantable pulse generator (106) that is connected or can be connected to a stimulation lead (100) having a plurality of stimulation electrodes (102, 104) for delivery of stimulation pulses. The implantable pulse generator (106) comprises at least one stimulation unit (36, 38, 40, 42, 44, 46) that is configured to generate electric stimulation pulses for nerve stimulation. The implantable pulse generator (106) further comprises a control unit (50) that is configured to trigger delivery of generated electric stimulation pulses via selected electrodes of the plurality of stimulation electrodes (102, 104) wherein said electric stimulation pulses form a pulse train comprising:
i) an initial selective-arrest phase for the large-diameter fibers in the vicinity of selected electrodes;
ii) followed by a phase where a charge-balanced alternating current (AC) is applied between the same or other selected electrodes;
iii) and where such AC is briefly unbalanced to effectively deliver nerve stimulation therapy pulses, returning to charge-balanced operation in between therapy pulses.
摘要翻译：本发明涉及可植入脉冲发生器（106），其可连接或可连接到具有用于传送刺激脉冲的多个刺激电极（102,104）的刺激引线（100）。可植入脉冲发生器（106）包括被配置成产生用于神经刺激的电刺激脉冲的至少一个刺激单元（36,38,40,42,44,46）。可植入脉冲发生器（106）还包括控制单元（50），其被配置为通过所述多个刺激电极（102,104）中的选定电极触发产生的电刺激脉冲的传送，其中所述电刺激脉冲形成脉冲串，包括：i）所选电极附近的大直径纤维的初始选择性抑制阶段; ii）之后是在相同或其它选择的电极之间施加电荷平衡交流电（AC）的相位; iii）并且其中这种AC短暂地不平衡以有效地递送神经刺激治疗脉冲，在治疗脉冲之间返回到电荷平衡操作。

4. 发明公开

EP3669935A1 CAPACITOR-DISCHARGE COMMUNICATION SCHEME FOR AN IMPLANTABLE MEDICAL SYSTEM 有权
公开(公告)号：EP3669935A1
公开(公告)日：2020-06-24
申请号：EP19154497.2
申请日：2019-01-30
申请人： BIOTRONIK SE & Co. KG
发明人： Baru, Marcelo , Taff, Brian M. , Kibler, Andrew B.
IPC分类号： A61N1/375 , A61N1/372 , A61N1/362 , A61B5/00 , H04B13/00 , A61N1/36
摘要： The present disclosure relates to an implantable medical system (1) for intra-body communication, comprising: an implantable first device (2) comprising a plurality of capacitors (102), wherein the first device (2) is configured to discharge said capacitors (102) in an encoded sequence to generate a signal (S), and particularly an implantable second device (3), wherein the second device (3) is configured to receive said signal (S) and to use the information contained in said signal (S) for performing a function.

5. 发明公开

EP3260167A1 IMPLANTABLE LEADLESS PACEMAKER WITH ATRIAL-VENTRICULAR SYNCHRONIZED PACING 有权
公开(公告)号：EP3260167A1
公开(公告)日：2017-12-27
申请号：EP17177623.0
申请日：2017-06-23
申请人： BIOTRONIK SE & Co. KG
发明人： Müssig, Dirk , Kibler, Andrew B. , Stotts, Larry
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/3622 , A61N1/365 , A61N1/36514 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37205 , A61N1/3756
摘要： The invention is related to an implantable leadless pacemaker (iLP) for a human or animal heart, wherein the iLP comprises a housing, at least two electrode poles for picking up electrical potentials and/or delivering electrical stimulation, a stimulation control unit in connection with the electrode poles, a sensing unit, wherein the sensing unit is in connection with at least one electrode pole a signal processing unit in connection with the sensing unit a signal evaluation unit in connection with the signal processing unit and/or the sensing unit an energy source, wherein the iLP is configured to be anchored within a first heart chamber, and the sensing unit is configured to sense electrical potentials via the at least two electrode poles, wherein the sensing unit is further configured to sense a first signal associated with an activity of the first heart chamber, and the stimulation control unit is configured to deliver electrical stimulation in the first heart chamber via the at least two electrode poles, wherein the sensing unit is configured to sense a second signal associated with an activity of a second heart chamber, wherein the second heart chamber is different from the first heart chamber.

6. 发明公开

EP3037128A1 IMPLANTABLE PULSE GENERATOR SYSTEM FOR VAGAL NERVE STIMULATION 有权
标题翻译：植物筋膜刺激物
公开(公告)号：EP3037128A1
公开(公告)日：2016-06-29
申请号：EP15199207.0
申请日：2015-12-10
申请人： BIOTRONIK SE & Co. KG
发明人： Lian, Jie , Kraiter, Lauren , Fryer, Alan , Kibler, Andrew B. , Müssig, Dirk , Stotts, Larry , Dabney, Warren , von Arx, Jeffrey A.
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： The invention refers to an implantable pulse generator system that comprises a stimulation unit for generating a delivery of vagal nerve stimulation pulses, an activity sensor for determining an exertion level of a user and generating a metabolic demand-representing signal, at least one autonomic tone sensor for determining an autonomic status of a user and generating an autonomic status-representing signal, and a control unit that is connected to the stimulation unit, the activity sensor and the autonomic tone sensor, and that is adapted to control the stimulation unit depending on both, the metabolic demand-representing signal and the autonomic status-representing signal.
摘要翻译：本发明涉及一种植入式脉冲发生器系统，其包括用于产生输送迷走神经刺激脉冲的刺激单元，用于确定使用者的运动水平并产生代谢需求代表信号的活动传感器，至少一个自主音调传感器用于确定用户的自主状态并产生自主状态表示信号;以及控制单元，其连接到所述刺激单元，所述活动传感器和所述自主音调传感器，并且适于根据两者来控制所述刺激单元，代谢需求代表信号和自主状态表示信号。

7. 发明公开

EP3623004A1 INTERLEAVED MULTI-CONTACT NEUROMODULATION THERAPY WITH REDUCED ENERGY 审中-公开
公开(公告)号：EP3623004A1
公开(公告)日：2020-03-18
申请号：EP18208288.3
申请日：2018-11-26
申请人： BIOTRONIK SE & Co. KG
发明人： Kibler, Andrew B. , Slee, Sean , Riahi, Pamela Shamsie Victoria
IPC分类号： A61N1/36 , A61N1/05
摘要： The present invention relates to a medical device (1) for generating electrical stimulation of a patient (P), comprising: a pulse generator (2) configured to generate current pulses for electrical stimulation of the patient (P), and at least one electrode lead (3) configured to be connected to the pulse generator (2) and comprising a plurality of electrode contacts (E1...E8) for delivering said current pulses to tissue (S) of the patient (P), wherein the pulse generator (2) is configured to repeatedly deliver a current pulse (CP) between two electrodes (E1, E3) forming a first group (G1) of electrode contacts of said plurality of electrode contacts, wherein the pulse generator (2) is further configured to deliver a charge balancing current pulse (AP) after each current pulse (CP) between said electrodes (E1, E3) of the first group (G1) such that the respective current pulse (CP) is separated from the succeeding charge balancing current pulse (AP) by an inter pulse interval (II), wherein the respective current pulse (CP) comprises an amplitude that has the same absolute magnitude (A) than the succeeding charge balancing current pulse (AP), but is of opposite sign, and wherein the pulse generator (2) is configured to deliver between each current pulse (CP) and the succeeding charge balancing current pulse (AP) a current pulse (CP) delivered between two further electrodes (E2, E4) forming a second group (G2) of electrode contacts of said plurality of electrode contacts. Furthermore, the invention relates to a corresponding method.

8. 发明授权

EP3037128B1 IMPLANTABLE PULSE GENERATOR SYSTEM FOR VAGAL NERVE STIMULATION 有权
公开(公告)号：EP3037128B1
公开(公告)日：2019-03-13
申请号：EP15199207.0
申请日：2015-12-10
申请人： BIOTRONIK SE & Co. KG
发明人： Lian, Jie , Kraiter, Lauren , Fryer, Alan , Kibler, Andrew B. , Müssig, Dirk , Stotts, Larry , Dabney, Warren , von Arx, Jeffrey A.
IPC分类号： A61N1/36 , A61N1/05

9. 发明公开

EP3381507A1 MULTI-ELECTRODE STIMULATION THERAPY WITH REDUCED ENERGY 审中-实审
公开(公告)号：EP3381507A1
公开(公告)日：2018-10-03
申请号：EP18161378.7
申请日：2018-03-13
申请人： BIOTRONIK SE & Co. KG
发明人： Kibler, Andrew B. , Baru, Marcelo , Müssig, Dirk
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0529 , A61N1/025 , A61N1/0551 , A61N1/3605 , A61N1/36062 , A61N1/36142 , A61N1/36164 , A61N1/36171
摘要： The invention describes a device (100) for neurostimulation, comprising a number N of electrodes. N is equal or larger than 3, wherein the device (100) is configured to deliver via each electrode therapeutic electric phases of amplitudes I 1 , I2,..I N , with a frequency f and after each therapeutic electric phase a number of N-1 charge balancing electric phases. The charge balancing electric phases of the respective electrode each have a polarity that is opposite the polarity of the preceding therapeutic electric phase of the respective electrode. The device is configured to return for each electrode the current of each therapeutic electric phase in the other N-l electrodes.

10. 发明公开

EP3530315A1 A MEDICAL IMPLANT SYSTEM FOR RECAPTURING/EXPLANTING AN IMPLANT 审中-公开
公开(公告)号：EP3530315A1
公开(公告)日：2019-08-28
申请号：EP18171581.4
申请日：2018-05-09
申请人： BIOTRONIK SE & Co. KG
发明人： Taff, Brian M. , Kibler, Andrew B. , Whittington, R. Hollis , Muessig, Dirk , Stotts, Larry
IPC分类号： A61N1/372 , A61B17/22 , A61N1/05
摘要： The disclosure relates to a medical implant system (1), comprising: an implant (2) that is implantable into a patient, and a catheter (3) configured for explanting the implant (2). The catheter (3) and/or the implant (2) is configured to measure a distance (D) between a tip (30) of the catheter (3) and the implant (2). The system (1) is configured to generate an output signal indicative of said distance (D). In another embodiment, the system (1) comprises a sensor element (22) which is configured to measure at least one physical quantity indicative of a local anatomical environment of the implant (2). Also, methods for recapturing and/or explanting an implanted implant (2) are provided.

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