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1. 发明公开

EP1957443A2 VERFAHREN ZUR HERSTELLUNG VON SULFONAMIDEN 审中-公开
公开(公告)号：EP1957443A2
公开(公告)日：2008-08-20
申请号：EP06830101.9
申请日：2006-11-23
申请人： BASF SE
发明人： SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik , RACK, Michael , MAYER, Guido , PLESCHKE, Axel
IPC分类号： C07C303/38 , C07C311/51 , C07C201/12 , C07C205/58 , C07C303/40
CPC分类号： C07C303/38 , C07C201/12 , C07C303/40 , C07C311/51 , C07C205/58
摘要： The invention relates to methods for producing sulfonamides of formula I, wherein the variables have the designations cited in the description, by reacting m-nitro-benzoic acid chlorides of formula II with aminosulfons of formula III, under the influence of B equivalents of base IV. Said method is characterised in that, during step a) the aminosulfon of formula III is reacted with B1 equivalents of base IV, and during step b), the reaction mixture resulting from step a) is reacted with m-nitro-benzoic acid chlorides of formula II and B2 equivalents of base IV; B, B1 and B2 having the designations cited in the description.
摘要翻译：本发明涉及制备式I磺酰胺的方法，其中这些变量在本说明书中引用的名称是通过式B的间硝基 - 苯甲酰氯与式III的氨基砜在B当量的碱IV的影响下反应。所述方法的特征在于，在步骤a）期间，式III的氨基磺与B1当量的碱IV反应，并且在步骤b）期间，将由步骤a）得到的反应混合物与间硝基苯甲酸氯化物碱基IV的式Ⅱ和B2当量; B，B1和B2具有说明书中引用的标号。

2. 发明公开

EP2200978A1 VERFAHREN ZUR HERSTELUNG VON SULFONSÄUREDIAMIDEN 审中-公开
标题翻译： VERFAHREN ZUR HERSTELUNG VONSULFONSÄUREDIAMIDEN
公开(公告)号：EP2200978A1
公开(公告)日：2010-06-30
申请号：EP08838788.1
申请日：2008-10-10
申请人： BASF SE
发明人： PLESCHKE, Axel , SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik
IPC分类号： C07C303/34 , C07C307/06 , C07D239/54
CPC分类号： C07C303/34 , A01N43/54 , C07C307/06 , C07C381/00 , C07D239/54
摘要： The present invention relates to a method for producing sulfonic acid amines of the general formula (I) R1R2N-S(O)2-NH2 (I), where R1 and R2 are independent of each other and stand for a primary alkyl radical having 1 to 8 C atoms, a secondary alkyl radical having 3 to 8 C atoms, or a cycloalkyl radical having 5 to 8 C atoms, or, together with the nitrogen atom, form a 5- to 8-member saturated nitrogen heterocyclic compound that can comprise, in addition to the nitrogen atom, an additional hetero atom, selected from O and S, as a ring member, wherein the nitrogen heterocyclic compound is unsubstituted, or can comprise 1, 2, 3, or 4 alkyl groups each having 1 to 4 C atoms as substituents. The method comprises the following steps: i) conversion of a secondary amine of the formula (II) R1R2NH (II), where R1 and R2 have the meaning indicated above, having sulfuryl chloride in an inert, particularly aromatic, solvent in the presence of a tertiary amine, to form a sulfamoyl chloride of the formula (III) R1R2N-S(O)2-CI (III), where R1 and R2 have the meaning indicated above, and ii) conversion of the sulfamoyl chloride of the formula (III) obtained in step i) using ammonia, wherein in step ii) the sulfamoyl chloride of the formula (III) is used in the form of the solution obtained in step i) in the inert, particularly aromatic, solvent.
摘要翻译：本发明涉及通式（I）R 1 R 2 N-S（O）2 -NH 2（I）的磺酸胺的制备方法，其中R 1和R 2彼此独立并且代表具有1 具有3至8个C原子的仲烷基或具有5至8个C原子的环烷基，或者与该氮原子一起形成5至8元饱和氮杂环化合物，该化合物可包含除了氮原子之外，还可以包含选自O和S的另外的杂原子作为环成员，其中氮杂环化合物是未取代的，或者可以包含1,2,3或4个各自具有1至4个 C原子作为取代基。该方法包括以下步骤：i）将式（II）的仲胺在惰性溶剂，特别是芳香溶剂存在下转化其中R1和R2具有上述含义的式IIR2NH（II）形成式（III）R 1 R 2 N-S（O）2 -Cl（III）的氨磺酰氯，其中R 1和R 2具有上述含义，和ii）将式其中在步骤ii）中，式（III）的氨磺酰氯以在步骤i）中获得的溶液形式在惰性溶剂，特别是芳香溶剂中使用。

3. 发明公开

EP2081914A2 KRISTALLINE FORM VON 2-CHLOR-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORMETHYL)-1-(2H)-PYRIMIDINYL]-4-FLUOR-N-[[METHYL-(1-METHYLETHYL)AMINO]SULFONYL]BENZAMID 有权
标题翻译： [[甲基 - 2-氯-5- [3,6-二氢-3-甲基-2,6-二氧-4-（三氟甲基）-1（2H） - 嘧啶基] -4-氟-N的结晶形式 - （1-甲基乙基）氨基]磺酰基]苯甲酰胺
公开(公告)号：EP2081914A2
公开(公告)日：2009-07-29
申请号：EP07821246.1
申请日：2007-10-12
申请人： BASF SE
发明人： SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik , ERK, Peter , SAXELL, Heidi Emilia , HAMPRECHT, Gerhard , SEITZ, Werner , MAYER, Guido , WOLF, Bernd , COX, Gerhard , MICHEL, Alfred , ZAGAR, Cyrill , REINHARD, Robert , SIEVERNICH, Bernd
IPC分类号： C07D239/54 , A01N43/48
CPC分类号： C07D239/54
摘要： The present invention relates to a crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)amino]sulphonyl]benzamide. The invention also relates to a method for preparing this crystalline form and to formulations for crop protection which comprise this crystalline form of the phenyluracil.

4. 发明公开

EP1893586A1 VERFAHREN ZUR HERSTELLUNG VON 1-ALKYL-3-PHENYLURACILEN 有权
公开(公告)号：EP1893586A1
公开(公告)日：2008-03-05
申请号：EP06755248.9
申请日：2006-05-18
申请人： BASF SE
发明人： GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , SCHMIDT, Thomas , WEVERS, Jan Hendrik , ZECH, Helmut , HÄBERLE, Rudolf
IPC分类号： C07D239/54
CPC分类号： C07D239/54
摘要： The invention relates to a method for production of 1-alkyl-3- phenyluracils of formula (I), where the variables R1 to R7 have the meanings given in the description, whereby 3-phenyluracils of formula (II) and alkylating agents of formula (III) are reacted together, characterised in that during the complete reaction the pH is maintained in the range of 1 to 6 by portioned addition of base.
摘要翻译：本发明涉及制备式（I）的1-烷基-3-苯基尿嘧啶的方法，其中变量R 1至R 7具有说明书中给出的含义，由此式（II）的3-苯基尿嘧啶和式（III）一起反应，其特征在于在完全反应期间，通过分批加入碱将pH保持在1至6的范围内。

5. 发明授权

EP2079714B1 HYDRATE DES 2-CHLOR-5-Ý3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORMETHYL)-1-(2H)-PYRIMIDINYL¨-4-FLUOR-N-ÝÝMETHYL-(1-METHYLETHYL)AMINO¨SULFONYL¨BENZAMIDS 有权
标题翻译：（2H） - 嘧啶-2-基）-4-氟-N-甲基 - （1-甲基 - 甲基乙基）AMINO¨SULFONYL¨BENZAMIDS
公开(公告)号：EP2079714B1
公开(公告)日：2012-09-26
申请号：EP07821247.9
申请日：2007-10-12
申请人： BASF SE
发明人： SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik , ERK, Peter , SAXELL, Heidi Emilia , HAMPRECHT, Gerhard , SEITZ, Werner , MAYER, Guido , WOLF, Bernd , COX, Gerhard , MICHEL, Alfred , ZAGAR, Cyrill , REINHARD, Robert , SIEVERNICH, Bernd
IPC分类号： A01N43/54 , A01N43/48 , C07D239/54
CPC分类号： C07D239/54 , A01N43/54

6. 发明授权

EP1948609B1 PROCESS FOR THE PREPARATION OF PYRIDYLCARBOXYLIC AMIDES AND ESTERS 有权
标题翻译：制备吡啶羧酸酰胺和酯的方法
公开(公告)号：EP1948609B1
公开(公告)日：2010-03-10
申请号：EP06807578.7
申请日：2006-10-26
申请人： BASF SE
发明人： BRINK, Monika , KNELL, Marcus , WEVERS, Jan Hendrik
IPC分类号： C07D213/81 , C07D213/79
CPC分类号： C07D213/803 , C07D213/79 , C07D213/81
摘要： The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110°C to 160°C; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.
摘要翻译：本发明涉及制备其中Hal，X和R1具有权利要求1中给出的含义的式（I）吡啶基羧酸酰胺和酯I的方法，其包括以下步骤：（a）加热基本上由三氯甲基吡啶 II，其中Hal具有给定含义的式（II）和1.0-1.5当量浓硫酸，其特征在于将液体形式的三氯甲基吡啶II在110℃至160℃的温度下加入到浓硫酸中 C; 和（b）任选在溶剂和/或碱存在下，使步骤（a）中获得的中间体产物与胺或醇III，其中X和R1具有给定含义的HXR1反应。

7. 发明公开

EP2079714A1 HYDRATE DES 2-CHLOR-5-Ý3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORMETHYL)-1-(2H)-PYRIMIDINYL¨-4-FLUOR-N-ÝÝMETHYL-(1-METHYLETHYL)AMINO¨SULFONYL¨BENZAMIDS 有权
标题翻译：作者水合物2-氯-5-Ý3,6二氢-3-甲基-2,6-二氧-4-（三氟甲基）-1（2H） - 嘧啶-4-氟-N-ÝÝMETHYL-（1- 甲基乙基）AMINO¨SULFONYL¨BENZAMIDS
公开(公告)号：EP2079714A1
公开(公告)日：2009-07-22
申请号：EP07821247.9
申请日：2007-10-12
申请人： BASF SE
发明人： SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik , ERK, Peter , SAXELL, Heidi Emilia , HAMPRECHT, Gerhard , SEITZ, Werner , MAYER, Guido , WOLF, Bernd , COX, Gerhard , MICHEL, Alfred , ZAGAR, Cyrill , REINHARD, Robert , SIEVERNICH, Bernd
IPC分类号： C07D239/54 , A01N43/48
CPC分类号： C07D239/54 , A01N43/54
摘要： The present invention relates to hydrates of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)amino]sulphonyl]benzamide. The invention also relates to a method for preparing these hydrates, and to formulations for crop protection which comprise hydrates of the phenyluracil I.

8. 发明授权

EP2081914B1 KRISTALLINE FORM VON 2-CHLOR-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO-4-(TRIFLUORMETHYL)-1-(2H)-PYRIMIDINYL]-4-FLUOR-N-[[METHYL-(1-METHYLETHYL)AMINO]SULFONYL]BENZAMID 有权
标题翻译： [[甲基 - 2-氯-5- [3,6-二氢-3-甲基-2,6-二氧-4-（三氟甲基）-1（2H） - 嘧啶基] -4-氟-N的结晶形式 - （1-甲基乙基）氨基]磺酰基]苯甲酰胺
公开(公告)号：EP2081914B1
公开(公告)日：2011-03-02
申请号：EP07821246.1
申请日：2007-10-12
申请人： BASF SE
发明人： SCHMIDT, Thomas , GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , WEVERS, Jan Hendrik , ERK, Peter , SAXELL, Heidi Emilia , HAMPRECHT, Gerhard , SEITZ, Werner , MAYER, Guido , WOLF, Bernd , COX, Gerhard , MICHEL, Alfred , ZAGAR, Cyrill , REINHARD, Robert , SIEVERNICH, Bernd
IPC分类号： C07D239/54 , A01N43/48
CPC分类号： C07D239/54
摘要： The present invention relates to a crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)amino]sulphonyl]benzamide. The invention also relates to a method for preparing this crystalline form and to formulations for crop protection which comprise this crystalline form of the phenyluracil.

9. 发明授权

EP1893586B1 VERFAHREN ZUR HERSTELLUNG VON 1-ALKYL-3-PHENYLURACILEN 有权
标题翻译：用于生产1-烷基3-苯基
公开(公告)号：EP1893586B1
公开(公告)日：2008-09-17
申请号：EP06755248.9
申请日：2006-05-18
申请人： BASF SE
发明人： GEBHARDT, Joachim , LÖHR, Sandra , KEIL, Michael , SCHMIDT, Thomas , WEVERS, Jan Hendrik , ZECH, Helmut , HÄBERLE, Rudolf
IPC分类号： C07D239/54
CPC分类号： C07D239/54
摘要： The invention relates to a method for production of 1-alkyl-3- phenyluracils of formula (I), where the variables R1 to R7 have the meanings given in the description, whereby 3-phenyluracils of formula (II) and alkylating agents of formula (III) are reacted together, characterised in that during the complete reaction the pH is maintained in the range of 1 to 6 by portioned addition of base.

10. 发明公开

EP1948609A1 PROCESS FOR THE PREPARATION OF PYRIDYLCARBOXYLIC AMIDES AND ESTERS 有权
标题翻译：用于生产酯和PYRIDYLCARBONSÄUREAMIDEN
公开(公告)号：EP1948609A1
公开(公告)日：2008-07-30
申请号：EP06807578.7
申请日：2006-10-26
申请人： BASF SE
发明人： BRINK, Monika , KNELL, Marcus , WEVERS, Jan Hendrik
IPC分类号： C07D213/81 , C07D213/79
CPC分类号： C07D213/803 , C07D213/79 , C07D213/81
摘要： The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110°C to 160°C; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.

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