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1. 发明公开

EP2484774A2 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
标题翻译：多个基因表达构建体SORF和过程与多蛋白，促蛋白和蛋白水解
公开(公告)号：EP2484774A2
公开(公告)日：2012-08-08
申请号：EP12154443.1
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C12P21/06 , C07H21/02 , C12N15/00 , C12N1/18 , C07H21/04 , C12P21/02 , C07K16/00
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is an expression vector for generating one or more recombinant protein products comprising a promoter regulatory element operably linked to a single open reading frame (sORF) insert; said sORF insert comprising: (a) a first nucleic acid sequence encoding a first polypeptide, (b) a first intervening nucleic acid sequence encoding a first protein cleavage site, and (c) a second nucleic acid sequence encoding a second polypeptide; wherein said intervening nucleic acid sequence encoding said first protein cleavage site is operably positioned between said first nucleic acid sequence and said second nucleic acid sequence; and wherein said expression vector is capable of expressing a sORF polypeptide cleavable at said first protein cleavage site; wherein said first protein cleavage site comprises a self-processing cleavage site comprising a hedgehog segment or modified hedgehog segment, wherein the hedgehog segment or modified hedgehog segment permits cleavage of said sORF polypeptide but not ligation of said first polypeptide and said second polypeptide.
摘要翻译：公开的是用于产生一种或多种重组蛋白产物，其包括可操作地连接到单个开放阅读框（SORF）插入一个启动子调控元件的表达载体; 所述插入件SORF包括：（a）编码第一多肽的第一核酸序列，（b）编码第一蛋白的切割位点，以及（c）编码第二多肽的第二核酸序列的第一插入核酸序列; worin说居间编码所述第一蛋白质的切割位点的核酸序列，所述第一核酸序列和核酸之间可操作地定位在所述第二序列; 和worin所述表达载体能够表达在所述第一种蛋白质的切割位点切割SORF的多肽; worin所述第一蛋白裂解位点包含一个自加工切割位点，其包括刺猬段或修饰的刺猬段，worin刺猬段或修饰的刺猬段允许所述SORF多肽的裂解而不是所述第一多肽和第二多肽。所述的结扎。

2. 发明公开

EP2468768A3 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
标题翻译：多个基因表达构建体SORF和过程与多蛋白，促蛋白和蛋白水解
公开(公告)号：EP2468768A3
公开(公告)日：2012-10-31
申请号：EP12154514.9
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C12P21/06 , C07H21/02 , C12N15/00 , C12N1/18 , C07H21/04 , C12P21/02 , C07K16/00 , C12N15/10
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is an expression vector for expressing a recombinant protein, comprising a coding sequence for a polyprotein, wherein the polyprotein comprises at least a first and a second protein segment, wherein said protein segments are separated by a protein cleavage site therebetween, wherein the protein cleavage site comprises a self processing peptide cleavage sequence, a signal peptide cleavage sequence, or a protease cleavage sequence; and wherein said coding sequence is expressible in a host cell and is cleaved within the host cell.

3. 发明公开

EP2468881A3 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
公开(公告)号：EP2468881A3
公开(公告)日：2012-08-15
申请号：EP12154418.3
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C12N15/10 , C12N15/70 , C12N15/85 , C12N5/10 , C12P21/02 , C07K16/00
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is a method for expression of proteins of a two hybrid system, wherein said two hybrid system comprises a bait protein and a candidate prey protein, said method comprising the steps of: providing a host cell into which has been introduced an expression vector encoding a polyprotein comprising a bait protein portion and a candidate prey protein portion, said portions separated by a cleavable segment comprising a self-processing cleavage sequence, a signal peptide sequence or a protease cleavage site; and culturing the host cell under conditions which allow expression of the polyprotein and self processing or protease cleavage of the polyprotein.

4. 发明公开

EP2500361A1 Antibodies to receptor of advanced glycation end products (rage) and uses thereof 有权
标题翻译：抗体受体晚期糖化终产物（RAGE）和其用途
公开(公告)号：EP2500361A1
公开(公告)日：2012-09-19
申请号：EP12168663.8
申请日：2009-05-08
申请人： Abbott GmbH & Co. KG , Abbott Laboratories, Inc.
发明人： Gu, Jijie , Mueller, Reinhold , Ebert, Ulrich , Nimmrich, Volker , Hsieh, Chung-Ming , Wu, Zhen , Digiammarino, Enrico L. , Luo, Feng , Fox, Gerard B. , Harlan, John E. , Schmidt, Martin , Loebbert, Ralf
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61P25/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12P21/005 , Y02A50/466
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid ß and advanced glycation-end-products.
摘要翻译：本申请涉及一种结合RAGE的蛋白质的分离的蛋白，尤其是单克隆抗体，特别是CDR嫁接的，人源化抗体。具体地，本文的抗体具有抑制RAGE的结合其各种配体的能力。它们的在本申请中描述的抗体或部分是用于由RAGE病理生理配体治疗的疾病或病症为特征的或诱导的有用的，例如错折叠蛋白等淀粉样蛋白SS和高级糖化终产物。

5. 发明公开

EP2484774A3 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
标题翻译：包括sorf构建体在内的多种基因表达和使用多蛋白，前蛋白和蛋白水解的方法
公开(公告)号：EP2484774A3
公开(公告)日：2012-11-14
申请号：EP12154443.1
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C12P21/06 , C07H21/02 , C12N15/00 , C12N15/10 , C12N1/18 , C07H21/04 , C12P21/02
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is an expression vector for generating one or more recombinant protein products comprising a promoter regulatory element operably linked to a single open reading frame (sORF) insert; said sORF insert comprising: (a) a first nucleic acid sequence encoding a first polypeptide, (b) a first intervening nucleic acid sequence encoding a first protein cleavage site, and (c) a second nucleic acid sequence encoding a second polypeptide; wherein said intervening nucleic acid sequence encoding said first protein cleavage site is operably positioned between said first nucleic acid sequence and said second nucleic acid sequence; and wherein said expression vector is capable of expressing a sORF polypeptide cleavable at said first protein cleavage site; wherein said first protein cleavage site comprises a self-processing cleavage site comprising a hedgehog segment or modified hedgehog segment, wherein the hedgehog segment or modified hedgehog segment permits cleavage of said sORF polypeptide but not ligation of said first polypeptide and said second polypeptide.
摘要翻译：公开了用于产生一种或多种重组蛋白质产物的表达载体，所述重组蛋白质产物包含与单个开放阅读框（sORF）插入片段可操作连接的启动子调控元件; 所述sORF插入物包含：（a）编码第一多肽的第一核酸序列，（b）编码第一蛋白质切割位点的第一插入核酸序列，和（c）编码第二多肽的第二核酸序列; 其中所述编码所述第一蛋白质切割位点的插入核酸序列可操作地位于所述第一核酸序列和所述第二核酸序列之间; 并且其中所述表达载体能够表达在所述第一蛋白切割位点可切割的sORF多肽; 其中所述第一蛋白质裂解位点包含自我加工裂解位点，所述自我加工裂解位点包含刺猬蛋白片段或修饰的hedgehog片段，其中所述hedgehog片段或修饰的hedgehog片段允许切割所述sORF多肽但不连接所述第一多肽和所述第二多肽。

6. 发明公开

EP2468881A2 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
标题翻译：包括sorf构建体在内的多种基因表达和使用多蛋白，前蛋白和蛋白水解的方法
公开(公告)号：EP2468881A2
公开(公告)日：2012-06-27
申请号：EP12154418.3
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C12P21/06 , C07H21/02 , C12N15/00 , C12N1/18 , C07H21/04 , C07K16/00 , C12P21/02
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is a method for expression of proteins of a two hybrid system, wherein said two hybrid system comprises a bait protein and a candidate prey protein, said method comprising the steps of: providing a host cell into which has been introduced an expression vector encoding a polyprotein comprising a bait protein portion and a candidate prey protein portion, said portions separated by a cleavable segment comprising a self-processing cleavage sequence, a signal peptide sequence or a protease cleavage site; and culturing the host cell under conditions which allow expression of the polyprotein and self processing or protease cleavage of the polyprotein.
摘要翻译：公开了用于表达双杂交系统的蛋白质的方法，其中所述双杂交系统包含诱饵蛋白质和候选猎物蛋白质，所述方法包括以下步骤：提供其中引入了编码所述多蛋白包含诱饵蛋白部分和候选猎物蛋白部分，所述部分通过包含自我加工裂解序列，信号肽序列或蛋白酶裂解位点的可裂解片段分开; 并在允许多蛋白表达和自身加工或蛋白酶切割多蛋白的条件下培养宿主细胞。

7. 发明公开

EP2468768A2 Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis 审中-公开
标题翻译：多个基因表达构建体SORF和过程与多蛋白，促蛋白和蛋白水解
公开(公告)号：EP2468768A2
公开(公告)日：2012-06-27
申请号：EP12154514.9
申请日：2006-07-21
申请人： Abbott Laboratories
发明人： Carson, Gerald R. , Gion, Wendy , Salfeld, Jochen G. , Gu, Jijie , Regier, Dean A. , Kunes, Yune
IPC分类号： C07K16/00 , C12P21/02 , C12P21/06 , C07H21/02 , C12N15/00 , C12N1/18 , C07H21/04
CPC分类号： C12N15/67 , C07K16/00 , C07K2319/50 , C07K2319/92 , C12N15/1055 , C12P21/02 , C12P21/06
摘要： Disclosed is an expression vector for expressing a recombinant protein, comprising a coding sequence for a polyprotein, wherein the polyprotein comprises at least a first and a second protein segment, wherein said protein segments are separated by a protein cleavage site therebetween, wherein the protein cleavage site comprises a self processing peptide cleavage sequence, a signal peptide cleavage sequence, or a protease cleavage sequence; and wherein said coding sequence is expressible in a host cell and is cleaved within the host cell.
摘要翻译：公开的是用于表达重组蛋白，其包含一个编码序列的多蛋白，worin多蛋白包括至少一个第一和第二蛋白质片段，worin所述蛋白段通过蛋白裂解位点在其间分开，worin蛋白裂解的表达载体站点包括自处理肽裂解序列，信号肽切割序列，或蛋白酶切割序列; 和worin所述编码序列是在宿主细胞中表达和在宿主细胞内被切割。

8. 发明公开

EP2116556A1 Antibodies to receptor of advanced glycation end products (rage) and uses thereof 有权
标题翻译：抗体受体晚期糖化终产物（RAGE）和其用途
公开(公告)号：EP2116556A1
公开(公告)日：2009-11-11
申请号：EP09159779.9
申请日：2009-05-08
申请人： Abbott GmbH & Co. KG , Abbott Laboratories
发明人： Gu, Jijie , Hsieh, Chung-Ming , Wu, Zhen , Digiammarino, Enrico L. , Luo, Feng , Fox, Gerard B. , Harlan, John E. , Schmidt, Martin , Loebbert, Ralf , Mueller, Reinhold , Ebert, Ulrich , Nimmrich, Volker
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61P25/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12P21/005 , Y02A50/466
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application arc useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid β and advanced glycation-end-products.

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