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1. 发明公开

EP2922842A2 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 无效
标题翻译：化合物作为磷酸二酯酶10A型抑制剂
公开(公告)号：EP2922842A2
公开(公告)日：2015-09-30
申请号：EP13798625.3
申请日：2013-11-25
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co KG
发明人： GENESTE, Hervé , TURNER, Sean , OCHSE, Michael , DRESCHER, Karla , BLACK, Lawrence A. , JANTOS, Katja , JAKOB, Clarissa
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/4427 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders wherein Y
1 and Y
2 are adjacent atoms in Het
1 , which are independently selected from the group consisting of carbon and nitrogen; k is 0, 1, 2 or 3; Het
1 is a bivalent monocyclic 5- or 6-membered heteroaromatic radical, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-R
a as ring members, or a bivalent fused bicyclic 8-, 9- or 10-membered heteroaromatic radical, having 1, 2, 3 or 4 heteroatoms or heteroatom moieties selected from O, S, N and N-R
a as ring members; Het
2 is inter alia monocyclic 5- or 6-membered hetaryl, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-R
1a as ring members, Cyc is inter alia optionally substituted monocyclic 5- or 6-membered hetaryl or optionally substituted fused 8-, 9- or 10-membered bicyclic hetaryl; Ar is optionally substituted phenylene or optionally substituted bivalent 6-membered hetaryl; R is attached to a carbon atom of Het
1 and inter alia - halogen, C
1 -C
6 -alkyl, C
2 -C
6 -alkenyl, C
2 -C
6 -alkynyl, C
1 -C
6 -alkoxy, C
1 -C
6 -fluoroalkyl, C
1 -C
6 -fluoroalkoxy, C
3 -C
6 -cycloalkyl etc.

2. 发明公开

EP3350187A1 SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE 审中-公开
公开(公告)号：EP3350187A1
公开(公告)日：2018-07-25
申请号：EP16763869.1
申请日：2016-09-14
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
发明人： DINGES, Jürgen , MOELLER, Achim , OCHSE, Michael , SCHMIDT, Martin , SCHULZ, Michael , TURNER, Sean , VAN DER KAM, Elizabeth Louise , VASUDEVAN, Anil
IPC分类号： C07D498/04 , C07D513/04 , A61K31/4985 , A61P1/04 , A61P25/30
CPC分类号： C07D498/04 , C07D513/04
摘要： and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

3. 发明授权

EP2922842B1 INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 无效
标题翻译： VERBINDUNGEN ALS磷酸二酯酶类型10A-HEMMER
公开(公告)号：EP2922842B1
公开(公告)日：2017-06-14
申请号：EP13798625.3
申请日：2013-11-25
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co KG
发明人： GENESTE, Hervé , TURNER, Sean , OCHSE, Michael , DRESCHER, Karla , BLACK, Lawrence A. , JANTOS, Katja , JAKOB, Clarissa
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/4427 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04

4. 发明公开

EP2776418A1 INHIBITORS OF PHOSPHODIESTERASE TYPE 10A 有权
标题翻译： HEMMER DER PHOSPHODIESTERASE TYP 10A
公开(公告)号：EP2776418A1
公开(公告)日：2014-09-17
申请号：EP12784578.2
申请日：2012-11-08
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , TURNER, Sean , BEHL, Berthold , LAPLANCHE, Loic , DINGES, Jürgen , JAKOB, Clarissa , BLACK, Lawrence A. , JANTOS, Katja.
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/519 , A61P25/00
CPC分类号： C07D519/00 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to novel compounds of the formula (I) which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders. wherein Q is O or S, X
1 is N or CH, X
2 is N or C-R
7 ; X
3 is O, S, -X
4 =C(R
8 )-, where C(R
8 ) is bound to the carbon atom which carries R
2 , or -X
5 =C(R
9 )-, where X
5 is bound to the carbon atom which carries R
2 ; X
4 is N or C-R
9 ; X
5 is N; Het is selected from optionally substituted phenyl, monocyclic hetaryl and fused bicyclic hetaryl; R
1 is selected inter alia from hydrogen, halogen, OH, C
1 -C
4 -alkyl, trimethylsilyl, C
1 -C
4 -alkylsulfanyl, C
1 -C
4 -alkoxy-C
1 -C
4 -alkyl, C
1 -C
4 - alkoxy, C
1 -C
4 -alkoxy-C
1 -C
4 -alkoxy, the moiety Y
1 -Cyc
1 ; R
2 is selected inter alia from hydrogen, halogen, OH, C
1 -C
4 -alkyl, trimethylsilyl, C
1 -C
4 -alkoxy-C
1 -C
4 -alkyl, C
1 -C
4 -alkoxy, C
1 -C
4 - alkoxy-C
1 -C
4 -alkoxy, C
2 -C
4 -alkenyloxy, etc; A represents one of the following groups A
1 , A
2 , A
3 , A
4 or A
5 : where * indicates the points of attachment to Het and to the nitrogen atom, respectively; and where R
3 to R
9 , R
3e , R
3f , A', Y
1 and Cyc
1 are defined in the claims.
摘要翻译：本发明涉及式I的新型化合物，其为10A型磷酸二酯酶的抑制剂及其用于制备药物的用途，因此其适用于治疗或控制选自神经障碍和精神疾病的医学病症，用于改善与这些疾病相关的症状和降低这种疾病的风险。其中Q是O或S，X 1是N或CH，X 2是N或C-R 7; X3是O，S-X4 = C（R8） - ，其中C（R8）与携带R2的碳原子结合，或-X5 = C（R9） - ，其中X5与携带R2的碳原子结合 ; X4是N或C-R9; X5是N; Het选自任选取代的苯基，单环杂芳基和稠合双环杂芳基; R1特别是选自氢，卤素，OH，C 1 -C 4 - 烷基，三甲基甲硅烷基，C 1 -C 4烷基硫烷基，C 1 -C 4 - 烷氧基-C 1 -C 4烷基，C 1 -C 4 - 烷氧基，C 1 -C 4烷氧基 - C1-C4-烷氧基，Y1-Cyc1部分; R2特别是选自氢，卤素，OH，C 1 -C 4 - 烷基，三甲基甲硅烷基，C 1 -C 4 - 烷氧基-C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷氧基-C 1 -C 4烷氧基， C2-C4-烯氧基等; A代表以下组A1，A2，A3，A4或A5：其中*表示分别与Het和氮原子相连的点; 并且在权利要求中定义R3至R9，R3e，R3f，A'，Y1和Cyc1。

5. 发明公开

EP3341369A1 FUSED HETEROCYCLIC COMPOUNDS AS S1P MODULATORS 审中-公开
公开(公告)号：EP3341369A1
公开(公告)日：2018-07-04
申请号：EP16757262.7
申请日：2016-08-26
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
发明人： LANGE, Udo , OCHSE, Michael , VAN DER KAM, Elizabeth , VAN BERGEIJK, Jeroen , TURNER, Sean , OELLIEN, Frank , WALLESER, Patrick , AMBERG, Wilhelm , HORNBERGER, Wilfried , GENESTE, Herve , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

6. 发明授权

EP2776418B1 INHIBITORS OF PHOSPHODIESTERASE TYPE 10A 有权
标题翻译：作者型磷酸二酯酶抑制剂10A
公开(公告)号：EP2776418B1
公开(公告)日：2017-01-04
申请号：EP12784578.2
申请日：2012-11-08
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , TURNER, Sean , BEHL, Berthold , LAPLANCHE, Loic , DINGES, Jürgen , JAKOB, Clarissa , BLACK, Lawrence A. , JANTOS, Katja.
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/519 , A61P25/00
CPC分类号： C07D519/00 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04

7. 发明公开

EP4255896A1 SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS 审中-实审
公开(公告)号：EP4255896A1
公开(公告)日：2023-10-11
申请号：EP21823828.5
申请日：2021-11-30
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： AMBERG, Willie , BACKFISCH, Gisela , BODIÉ, Karen , HEMPEL, Katja , LAPLANCHE, Loic , MEZLER, Mario , OCHSE, Michael , TURNER, Sean , VAN BERGEIJK, Jeroen , VAN DER KAM, Elizabeth
IPC分类号： C07D265/36 , A61P25/00 , A61K31/5386

8. 发明公开

EP2603487A1 PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开
标题翻译：表鬼臼毒胺衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：EP2603487A1
公开(公告)日：2013-06-19
申请号：EP11748621.7
申请日：2011-08-12
申请人： Abbott GmbH & Co. KG , AbbVie Inc.
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , POHLKI, Frauke , TURNER, Sean , HUTCHINS, Charles
IPC分类号： C07C311/04 , C07C311/05 , C07C311/10 , C07D205/04 , C07D207/08 , C07D211/22 , C07D231/18 , C07D233/84 , C07D207/267 , C07D295/03 , A61K31/18 , A61K31/415 , A61K31/4164 , A61P25/28 , A61P25/18
CPC分类号： C07C311/06 , C07C311/04 , C07C311/05 , C07C311/10 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D207/08 , C07D207/267 , C07D231/18 , C07D233/42 , C07D233/84 , C07D295/135 , C07D401/12 , C07D403/12
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
摘要翻译：本发明涉及式（I）的苯烷基胺衍生物或其生理学耐受的盐。本发明涉及包含这种苯烷基胺衍生物的药物组合物，以及这种苯烷基胺衍生物用于治疗目的的用途。苯烷基胺衍生物是GlyT1抑制剂。

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