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1. 发明公开

EP0652219A1 New extractive process for the recovery of naturally occurring macrolides 失效转让
标题翻译： Extraktives Verfahren zur Gewinnung vonnatürlichenMakroliden。
公开(公告)号：EP0652219A1
公开(公告)日：1995-05-10
申请号：EP94308107.5
申请日：1994-11-03
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： Gletsos, Constantine
IPC分类号： C07D498/18 , C12P17/18
CPC分类号： C07D498/18 , C12P17/188 , C12P19/445
摘要： This invention concerns a process for separating a macrolide from acidic, basic and non-polar neutral impurities present in a macrolide containing solution which comprises one or more of the following processes in any order:

a. a solution of said macrolide in a water-immiscible solvent is extracted with aqueous base to substantially remove all acidic impurities;
b. a solution of said macrolide in a water-immiscible solvent is extracted with aqueous acid to substantially remove all basic impurities;
c. a solution of said macrolide is subjected to one or more of the following in order to remove non-polar neutral impurities:

(i) extraction with a non-aromatic hydrocarbon solvent in which the macrolide is insoluble,
(ii) treatment with a sufficient quantity of a miscible macrolide non-solvent to cause the macrolide to become insoluble in the resulting solvent mixture and thus separate from the solution whereby the macrolide can be separated from the solvent mixture,
(iii) triturate with a macrolide crystallizing solvent.
摘要翻译：本发明涉及一种将大环内酯与含有大环内酯的溶液中存在的含有大环内酯的溶液中的酸性，碱性和非极性中性杂质分离的方法，该方法包括以下任一顺序的一种或多种以下方法：a。所述大环内酯在与水不混溶的溶剂中的溶液用碱水溶液萃取以基本上除去所有酸性杂质; 湾所述大环内酯在与水不混溶的溶剂中的溶液用酸水溶液萃取以基本上除去所有碱性杂质; C。对所述大环内酯类的溶液进行以下一种或多种以除去非极性中性杂质：（i）用大环内酯不溶性的非芳族烃溶剂萃取，（ii）以足够量处理的混溶性大环内酯非溶剂，以使大环内酯在所得溶剂混合物中变得不溶，从而与溶液分离，由此大环内酯可以与溶剂混合物分离，（iii）用大环内酯结晶溶剂研磨。

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