专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1095040B1 NEW BENZOXAZOLES WITH PDE-INHIBITING ACTIVITY 有权
标题翻译：与PDE抑制作用NEW恶唑
公开(公告)号：EP1095040B1
公开(公告)日：2004-03-31
申请号：EP99931198.8
申请日：1999-06-26
申请人： ALTANA Pharma AG
发明人： ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BÄR, Thomas , FLOCKERZI, Dieter , SCHMIDT, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , MARTIN, Thomas
IPC分类号： C07D413/04 , C07D263/56 , A61K31/42
CPC分类号： C07D263/56 , C07D413/04
摘要： Compounds of formula (I) in which R1, R2, R3 and A have the meanings indicated in the description, are novel efficacious PDE inhibitors.

2. 发明授权

EP1075476B1 BENZIMIDAZOLE UND OXAZOLE 有权
标题翻译：苯并咪唑和恶唑
公开(公告)号：EP1075476B1
公开(公告)日：2003-06-04
申请号：EP99920814.3
申请日：1999-04-29
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , SCHMIDT,Beate , FLOCKERZI, Dieter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KILIAN, Ulrich , KLEY, Hans-Peter , BÄR, Thomas
IPC分类号： C07D413/00 , A61K31/42 , A61K31/415 , C07D405/04 , C07D413/04 , C07D413/14
CPC分类号： C07D405/04 , C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.

3. 发明授权

EP1000034B1 SUBSTITUTED 6-ALKYLPHENANTHRIDINES 失效
标题翻译：取代的6-烷基苯并噻吩
公开(公告)号：EP1000034B1
公开(公告)日：2002-09-18
申请号：EP98942571.5
申请日：1998-07-18
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D491/04
CPC分类号： C07D491/04 , C07D221/12

4. 发明授权

EP1363874B1 TRYPTASE INHIBITORS 有权
标题翻译： TRYPTASEHEMMER
公开(公告)号：EP1363874B1
公开(公告)日：2007-06-06
申请号：EP02722086.2
申请日：2002-02-16
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , BÄR, Thomas , STADLWIESER, Josef , ULRICH, Wolf-Rüdiger , DOMINIK, Andreas , BUNDSCHUH, Daniela , ZECH, Karl , SOMMERHOFF, Christian, P.
IPC分类号： C07C271/20 , A61K31/192 , A61K31/194 , A61P11/00 , C07D213/30
CPC分类号： C07C271/20
摘要： Tryptase inhibitors of the formula (I) in which M is a central building block containing two acetylene groups; A1 and A2 are carbonyl containing linking groups; K1 is B3-X1, -B3-Y1 or B3-Z1-B5-X1; K2 is B4-X2, -B4-Y2 or B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene; B5 and B6 are identical or different and are a bond of 1-2C-alkylene; X1 and X2 are identical or different and are amino, aminocarbonyl or amidino; Y1 and Y2 are imidazol-1-yl; Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3-cyclohexylene or 1,4-cyclohexylene.

5. 发明公开

EP1401809A1 TRYPTASE INHIBITORS 有权
标题翻译：类胰蛋白酶抑制剂
公开(公告)号：EP1401809A1
公开(公告)日：2004-03-31
申请号：EP02740716.2
申请日：2002-06-14
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , BÄR, Thomas , STADLWIESER, Josef , WOLLIN, Stefan-Lutz , ZECH, Karl , SOMMERHOFF, Christian P.
IPC分类号： C07D207/16 , A61K31/401 , A61P11/06 , A61P11/00
CPC分类号： C07D207/16
摘要： Compounds of formula (I) in which M, B1, B2, R1, R2, R6, R7, K1 and K2 have the meanings indicated in the description are novel active tryptase inhibitors.

6. 发明授权

EP0920426B1 NEUE THIAZOL-DERIVATE MIT PHOSPHODIESTERASE INHIBIERENDER WIRKUNG 失效
标题翻译：与磷酸二酯酶抑制效果NEW噻唑衍生物
公开(公告)号：EP0920426B1
公开(公告)日：2003-10-01
申请号：EP97940080.1
申请日：1997-08-13
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , MARTIN, Thomas , FLOCKERZI, Dieter , Schmidt, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , BÄR, Thomas , ULRICH, Wolf-Rüdiger
IPC分类号： C07D401/14 , A61K31/425
CPC分类号： C07D417/04 , C07D417/14
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and n have the meanings given in the description, are new effective bronchotherapeutic agents (phosphodiesterase IV inhibitors).

7. 发明授权

EP0828728B1 PHENYLDIHYDROBENZOFURANE 失效
公开(公告)号：EP0828728B1
公开(公告)日：2003-01-22
申请号：EP96916048.0
申请日：1996-05-11
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BÄR, Thomas , GUTTERER, Beate , FLOCKERZI, Dieter , MARTIN, Thomas , THIBAUT, Ulrich , HATZELMANN, Armin , BEUME, Rolf , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , ULRICH, Wolf-Rüdiger
IPC分类号： C07D307/94 , C07D307/86 , A61K31/34
CPC分类号： C07D307/94 , C07D307/86
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and R5 have the meanings given in the description, are new and powerful PDE inhibitors.
摘要翻译：具有式（I）的化合物（其中R1，R2，R3，R4和R5具有说明书中给出的含义）是新的和强大的PDE抑制剂。

8. 发明授权

EP0920426B9 NEUE THIAZOL-DERIVATE MIT PHOSPHODIESTERASE INHIBIERENDER WIRKUNG 失效
标题翻译：与磷酸二酯酶抑制效果NEW噻唑衍生物
公开(公告)号：EP0920426B9
公开(公告)日：2005-04-06
申请号：EP97940080.1
申请日：1997-08-13
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , MARTIN, Thomas , FLOCKERZI, Dieter , Schmidt, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , BÄR, Thomas , ULRICH, Wolf-Rüdiger
IPC分类号： C07D401/14 , A61K31/425
CPC分类号： C07D417/04 , C07D417/14
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and n have the meanings given in the description, are new effective bronchotherapeutic agents (phosphodiesterase IV inhibitors).

9. 发明公开

EP1370518A2 TRYPTASE-INHIBITORS 审中-公开
标题翻译：类胰蛋白酶抑制剂
公开(公告)号：EP1370518A2
公开(公告)日：2003-12-17
申请号：EP02724222.1
申请日：2002-03-12
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , ULRICH, Wolf-Rüdiger , BÄR, Thomas , STADLWIESER, Josef , WOLLIN, Stefan-Lutz , ZECH, Karl , SOMMERHOFF, Christian, P.
IPC分类号： C07C271/20 , A61K31/192 , A61K31/194 , A61P11/00 , C07D213/30
CPC分类号： C07C271/20
摘要： Compounds of the formula I, wherein M, A1, A2, K1 and K2 have the meanings as indicated below are tryptase inhibitors. M is a central building block containing an acetylene containing linking group. A1 and A2 are carbonyl containing linking groups K1 is -B3-X1, -B3-Y1 or B3-Z1-B5-X1, K2 is -B4-X2, -B4-Y2 or -B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene, B5 and B6 are identical or different and are a bond or 1-2C-alkylene, X1 and X2 are identical or different and are amino, aminocarbonyl or amidino, Y1 and Y2 are imidazol -1-yl, Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3,-cyclohexalene or 1,4-cyclohexylene, the salts of these compounds, and the N-oxides of the nitrogen-containing heteroalryls, heteroarylenes and heterocycloalkylenes, and their salts, where all those compounds are excluded in which, owing to the meaning of the variables, there would be a direct linkage of two hereroatoms or two carbonyl groups.
摘要翻译：其中M，A1，A2，K1和K2具有如下所示含义的式I化合物是类胰蛋白酶抑制剂。 M是含有含乙炔连接基团的中央构件。 A1和A2是含羰基连接基团，K1是-B3-X1，-B3-Y1或B3-Z1-B5-X1，K2是-B4-X2，-B4-Y2或-B4-Z2-B6-X2，B3 和B 4是相同或不同的并且是键或1-4C-亚烷基，B 5和B 6相同或不同并且是键或1-2C-亚烷基，X 1和X 2相同或不同并且是氨基，氨基羰基或脒基， Y1和Y2是咪唑-1-基，Z1和Z2相同或不同，并且是5,2-亚吡啶基，6-甲基-5,2-亚吡啶基，4,1-亚哌啶基，3,6-吲唑基，3,6 - 亚苯基，1,3-亚苯基，1,4-亚苯基，1,3-环己烯或1,4-亚环己基，这些化合物的盐以及含氮杂芳基，亚杂芳基和杂环亚烷基的N-氧化物，和它们的盐，其中排除了所有这些化合物，其中由于这些变量的含义，将存在两个下游或两个羰基的直接连接。

10. 发明公开

EP1363874A2 TRYPTASE INHIBITORS 有权
标题翻译： TRYPTASE抑制剂
公开(公告)号：EP1363874A2
公开(公告)日：2003-11-26
申请号：EP02722086.2
申请日：2002-02-16
申请人： ALTANA Pharma AG
发明人： MARTIN, Thomas , BÄR, Thomas , STADLWIESER, Josef , ULRICH, Wolf-Rüdiger , DOMINIK, Andreas , BUNDSCHUH, Daniela , ZECH, Karl , SOMMERHOFF, Christian, P.
IPC分类号： C07C271/20 , A61K31/192 , A61K31/194 , A61P11/00 , C07D213/30
CPC分类号： C07C271/20
摘要： Tryptase inhibitors of the formula (I) in which M is a central building block containing two acetylene groups; A1 and A2 are carbonyl containing linking groups; K1 is B3-X1, -B3-Y1 or B3-Z1-B5-X1; K2 is B4-X2, -B4-Y2 or B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene; B5 and B6 are identical or different and are a bond of 1-2C-alkylene; X1 and X2 are identical or different and are amino, aminocarbonyl or amidino; Y1 and Y2 are imidazol-1-yl; Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3-cyclohexylene or 1,4-cyclohexylene.
摘要翻译：式（I）的类胰蛋白酶抑制剂，其中M是含有两个乙炔基团的中心结构单元; A1和A2是含羰基的连接基团; K1是B3-X1，-B3-Y1或B3-Z1-B5-X1; K 2是B 4 -X 2，-B 4 -Y 2或B 4 -Z 2 -B 6 -X 2，B 3和B 4相同或不同并且是键或1-4C-亚烷基; B5和B6相同或不同，并且是1-2C-亚烷基的键; X1和X2相同或不同，并且是氨基，氨基羰基或脒基; Y1和Y2是咪唑-1-基; Z1和Z2相同或不同，为5,2-亚吡啶基，6-甲基-5,2-亚吡啶基，4,1-亚哌啶基，3,6-吲唑基，3,6-亚吲哚基，1,3-亚苯基，1 ，4-亚苯基，1,3-亚环己基或1,4-亚环己基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式