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1. 发明公开

EP4297760A1 METHODS OF ISOLATING EXOSOMES 审中-实审
公开(公告)号：EP4297760A1
公开(公告)日：2024-01-03
申请号：EP22760349.5
申请日：2022-02-23
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： MARSH, Spencer , PRIDHAM, Kevin J. , JOURDAN, Linda Jane , GOURDIE, Robert G.
IPC分类号： A61K35/20 , A61K38/17 , B01D61/58 , C07K14/47

3. 发明公开

EP3852868A1 TREATMENT PLANNING SYSTEM FOR IMMUNOTHERAPY ENHANCEMENT VIA NON-THERMAL ABLATION 审中-公开
公开(公告)号：EP3852868A1
公开(公告)日：2021-07-28
申请号：EP19861489.3
申请日：2019-09-18
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： DAVALOS, Rafael V. , WHITE, Natalie
IPC分类号： A61N1/32 , A61N1/00 , A61N1/18

4. 发明公开

EP3639852A1 LIVE ATTENUATED CHIMERIC PORCINE CIRCOVIRUS VACCINE 审中-实审
公开(公告)号：EP3639852A1
公开(公告)日：2020-04-22
申请号：EP19209400.1
申请日：2011-03-16
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： MENG, Xiang-Jin , BEACH, Nathan , RAMAMOORTHY, Sheela
IPC分类号： A61K39/12
摘要： The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).

5. 发明授权

EP1969692B1 LOCATION DETERMINATION OF POWER SYSTEM DISTURBANCES BASED ON FREQUENCY RESPONSES OF THE SYSTEM 有权
公开(公告)号：EP1969692B1
公开(公告)日：2020-03-11
申请号：EP06838659.8
申请日：2006-11-30
申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
发明人： GARNDER, Robert, Matthew , ZHONG, Zhian , LIU, Yilu
IPC分类号： H02J3/08 , H02J3/38

6. 发明公开

EP3388515A1 CHIMERIC INFECTIOUS DNA CLONES OF PORCINE CIRCOVIRUS AND USES THEREOF 审中-实审
公开(公告)号：EP3388515A1
公开(公告)日：2018-10-17
申请号：EP18175133.0
申请日：2002-12-11
申请人： Virginia Tech Intellectual Properties, Inc. , Iowa State University Research Foundation, Inc.
发明人： MENG, Xiang-Jin , FENAUX, Martijn , HALBUR, Patrick G.
IPC分类号： C12N7/00 , C12N7/04 , A61K39/12 , C12N15/34
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to an immunogenic polypeptide product which is obtainable by expressing infectious chimeric DNA clones of porcine circovirus (PCV). The present invention also relates to corresponding vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone is constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position.

7. 发明公开

EP3235384A1 COMPOSITION FOR ANIMAL CONSUMPTION 有权
标题翻译：动物消费的组成
公开(公告)号：EP3235384A1
公开(公告)日：2017-10-25
申请号：EP17157986.5
申请日：2004-11-24
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： GROSS, Kathy , PAETAU-ROBINSON, Inke , SAKER, Korinn, E.
IPC分类号： A23K20/158 , A23K50/40
CPC分类号： A23K50/40 , A23K20/147 , A23K20/158 , A23K20/174 , A23K20/22 , A23K20/24 , A23K50/00
摘要： A composition suitable for animal treats, toys or nutritional supplements comprises:a fat content of about 8% by weight to about 35% by weight on a dry matter basis, a protein content of about 35% by weight to about 75% by weight on a dry matter basis, a carbohydrate content of less than 30% by weight on a dry matter basis, omega-3 polyunsaturated fatty acids; and omega-6 polyunsaturated fatty acids; wherein the weight ratio of the omega-6 polyunsaturated fatty acids to the omega-3 polyunsaturated fatty acids is from about 0.3:1 to about 5:1.
The composition comprises omega-3 polyunsaturated fatty acids having less than 20 carbon atoms in a concentration of from about 0.9% to about 1.2% by weight of the composition; omega-3 polyunsaturated fatty acids having greater than 20 carbon atoms in a concentration of from about 4.2% to about 6.0% by weight of the composition; omega-6 polyunsaturated fatty acids having less than 20 carbon atoms in a concentration of from about 1.9% to about 4.8% by weight of the composition; and omega-6 polyunsaturated fatty acids having greater than 20 carbon atoms in a concentration of from about 1.0% to about 1.3% by weight of the composition, all on a dry matter basis.
摘要翻译：适用于动物处理，玩具或营养补充剂的组合物包含：基于干物质的脂肪含量为约8重量％至约35重量％，蛋白质含量为约35重量％至约75重量％基于干物质，基于干物质的小于30重量％的碳水化合物含量，ω-3多不饱和脂肪酸; 和ω-6多不饱和脂肪酸; 其中ω-6多不饱和脂肪酸与ω-3多不饱和脂肪酸的重量比为约0.3:1至约5:1。该组合物包含浓度为组合物重量的约0.9％至约1.2％的具有少于20个碳原子的ω-3多不饱和脂肪酸; 具有大于20个碳原子的ω-3多不饱和脂肪酸，其浓度为组合物重量的约4.2％至约6.0％; 具有少于20个碳原子的ω-6多不饱和脂肪酸，其浓度为组合物重量的约1.9％至约4.8％; 和具有大于20个碳原子的ω-6多不饱和脂肪酸，其浓度为组合物重量的约1.0％至约1.3％，全部以干物质为基础。

8. 发明授权

EP2772140B1 Composition for reducing MAP kinase activity in an animal 有权
标题翻译： Zenamensetzung zur Verringerung der MAP-Kinaseaktivitätin Tieren
公开(公告)号：EP2772140B1
公开(公告)日：2017-04-05
申请号：EP14170652.3
申请日：2004-11-24
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Gross, Kathy , Paetau-Robinson, Inke , Saker, Korinn, E.
IPC分类号： A23K20/158 , A23K20/147 , A23K50/40
CPC分类号： A23K50/40 , A23K20/147 , A23K20/158 , A23K20/174 , A23K20/22 , A23K20/24 , A23K50/00

9. 发明公开

EP2866943A1 FLOTATION MACHINE ROTOR 有权
标题翻译：浮动机器转子
公开(公告)号：EP2866943A1
公开(公告)日：2015-05-06
申请号：EP13810045.8
申请日：2013-05-08
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： YOON, Roe-Hoan , LUTTRELL, Gerald , RAGAB, Saad , TELIONIS, Demetri , SAID, Abdel-Halim , MISKOVIC, Sanja , NOBLE, Aaron , YANG, Yihong
IPC分类号： B03D1/16
CPC分类号： B03D1/20 , B01F3/04539 , B01F7/00241 , B01F2003/04546 , B01F2003/04567
摘要： A rotor for flotation machines or flotation cells of flotation machines includes blades that are configured to provide improved bubble flow and bubble generation performance while also reducing the power requirements for rotating the rotor to generate bubble flow within a tank of a flotation cell used to generate froth. Embodiments of the rotor may also be configured to be smaller than conventional rotor designs, which may help reduce the costs of manufacturing the rotor or flotation machines using such embodiments of the rotor.
摘要翻译：用于浮选机的浮选机或浮选单元的转子包括叶片，所述叶片构造成提供改进的气泡流动和气泡生成性能，同时还降低旋转转子以在用于产生泡沫的浮选槽的槽内产生气泡流动的功率要求。转子的实施例还可以构造成比常规转子设计小，这可以有助于降低使用转子的这种实施例制造转子或浮选机的成本。

10. 发明公开

EP2851428A3 Porcine torque teno virus vaccines and diagnosis 失效
标题翻译：猪扭矩特诺病毒疫苗和诊断
公开(公告)号：EP2851428A3
公开(公告)日：2015-04-29
申请号：EP14180718.0
申请日：2010-08-23
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Meng, Xiang-Jin , Huang, Yaowei
IPC分类号： C12N15/34 , C12N15/63 , A61K39/12 , C12Q1/68 , G01N33/569 , C07K14/01
CPC分类号： G01N33/56983 , A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/14034 , C12Q1/701 , G01N2333/01 , G01N2333/085 , G01N2469/20
摘要： The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1 a-VA, PTTV1 b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.

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