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1. 发明公开

EP2997968A1 Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same 无效
标题翻译：艾森 - （III）-Hydroxidkomplexe mit aktivierten Glucosesirups und Verfahren zur Herstellung davon
公开(公告)号：EP2997968A1
公开(公告)日：2016-03-23
申请号：EP14386023.7
申请日：2014-09-22
申请人： Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K31/295 , A61K31/7004
CPC分类号： A61K33/26 , A61K31/295 , A61K31/7004 , A61K47/69
摘要： The present invention generally relates to iron (III) carbohydrate complexes and to processes for the manufacture thereof. The product obtainable according to the method of the present invention may be safely used to the general population or animals in the therapy of iron deficiency. The process of the invention includes the steps of (i) providing an aqueous solution of glucose syrup having a certain dextrose equivalent (DE), (ii) adding one or more oxidizing bleaching agents, thereby obtaining the activated glucose syrup; (iii) converting said activated glucose syrup into a complex with iron (III) hydroxide; and (iv) obtaining a complex of iron (III) hydroxide and activated glucose syrup.
摘要翻译：本发明一般涉及铁（III）碳水化合物复合物及其制备方法。根据本发明的方法可获得的产品可以安全地用于一般人群或动物治疗铁缺乏症。本发明的方法包括以下步骤：（i）提供具有一定葡萄糖当量（DE）的葡萄糖浆水溶液，（ii）加入一种或多种氧化漂白剂，从而得到活化葡萄糖浆; （iii）将所述活化的葡萄糖浆与氢氧化铁（III）转化成络合物; 和（iv）获得氢氧化铁（III）和活化葡萄糖浆的络合物。

2. 发明公开

EP2283823A1 Effervescent formulations comprising a phosphonate and methods for their preparation 有权
标题翻译： Efferveszenzformulierungen mit einem Phosphonat und Herstellungsverfahrendafür
公开(公告)号：EP2283823A1
公开(公告)日：2011-02-16
申请号：EP09009791.6
申请日：2009-07-29
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0007 , A61K9/1611 , A61K9/2009
摘要： The invention provides an effervescent pharmaceutical composition comprising a biphosphonate compound or its pharmaceutically acceptable salt, a carbonate source, an acid source, a divalent metal salt as humidity moderator and a divalent cation scavenger, wherein the molar ratio of divalent cation scavenger to humidity moderator is at least 0.8/1. This composition makes the production of effervescent formulations comprising biphosphonate compounds easier, since less stringent controls or even no control of environmental humidity conditions have to be carried out during the production of the product. Moreover, the final product is protected against the negative impact of humidity, which may induce disintegration during the shelf-life of the product.
摘要翻译：本发明提供了包含二膦酸盐化合物或其药学上可接受的盐，碳酸盐源，酸源，作为调湿剂的二价金属盐和二价阳离子清除剂的泡腾药物组合物，其中二价阳离子清除剂与湿度调节剂的摩尔比为至少0.8 / 1。该组合物使得包含双膦酸酯化合物的泡腾制剂的生产更容易，因为在产品生产期间必须进行不太严格的控制或甚至不控制环境湿度条件。此外，最终产品可以防止潮湿的负面影响，这可能在产品的保质期内引起分解。

3. 发明公开

EP3781126A1 A PHARMACEUTICAL DRY POWDER COMPOSITION FOR INHALATION COMPRISING A THYROID HORMONE 有权
公开(公告)号：EP3781126A1
公开(公告)日：2021-02-24
申请号：EP19722514.7
申请日：2019-04-10
申请人： Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K9/00 , A61K47/26 , A61K9/14 , A61K31/198

4. 发明授权

EP1856102B1 MEDICAMENTS FOR ALZHEIMER 有权
标题翻译：药物抗阿尔茨海默氏病的
公开(公告)号：EP1856102B1
公开(公告)日：2009-06-17
申请号：EP05708486.5
申请日：2005-02-28
申请人： Tseti, Ioulia
发明人： KOUROUNAKIS, Panos , DOULGKERIS, Christos , GALANAKIS, Dimitrios , KOUROUNAKIS, Angeliki
IPC分类号： C07D403/06 , C07D207/16 , C07D211/60 , A61K31/445 , A61K31/405
CPC分类号： C07D403/06 , C07D207/16 , C07D211/60
摘要： Novel multifunctional compound for the treatment or the retardation of neurodegenerative diseases e.g. Alzheimer's disease and related pathological conditions. Formula (I); wherein, R is a non-steroidal anti-inflammatory drug moiety, being selected from the category of acetic acid derivatives (such as indomethacin), propionic acid derivatives (e.g. naproxen, ketoprofen) or various other acids with anti-inflammatory action which do not belong to the Above mentioned categories, A is a CHOH group or a CH2 group or a (CH2)2 group, Y is an antioxidant moiety (cysteamine or cysteine ethyl ester) or neuroprotective moiety (2-Pyridin-3-yl-alkanol) or NGF-inducing moiety (e.g. 2-methoxy-4-methyl-phenol).

5. 发明授权

EP3034512B1 A process for producing iron (III) casein N-acetyl-aspartylated complexes and use thereof in pharmaceutical compositions 有权转让
标题翻译：生产铁（III）酪蛋白N-乙酰基 - 天冬氨酰化复合物的方法及其在药物组合物中的用途
公开(公告)号：EP3034512B1
公开(公告)日：2017-12-06
申请号：EP14386034.4
申请日：2014-12-19
申请人： Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： C07K14/47
CPC分类号： A61K47/64 , A61K33/26 , C07K14/4732
摘要： The present invention generally relates to new process for the preparation of iron (III) casein N-acetyl-aspartylated complexes. The product obtainable according to the method of the present invention may be safely used to the general population or animals in the therapy of iron deficiency. The process of the invention includes the steps of: (a) reaction of casein with N-acetyl-L-aspartyl chloride, to form N-acetyl-L-aspartylated casein, (b) subsequent reaction of the N-acetyl-L-aspartylated casein with ferric chloride; and (c) obtaining the iron (III) complex with N-acetyl-L-aspartylated casein.

6. 发明授权

EP2277546B1 Stable ready to use injectable paracetamol formulation 有权
标题翻译：稳定，准备，注射扑热息痛
公开(公告)号：EP2277546B1
公开(公告)日：2015-07-15
申请号：EP09009569.6
申请日：2009-07-23
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K9/08 , A61K47/18 , A61K47/20 , A61K47/40 , A61K47/48 , A61K31/167
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/08 , A61K47/10 , A61K47/183 , A61K47/40 , A61K47/6951

7. 发明授权

EP2283823B1 Effervescent formulations comprising a phosphonate and methods for their preparation 有权
标题翻译：与它们的膦酸酯及其制造方法Efferveszenzformulierungen
公开(公告)号：EP2283823B1
公开(公告)日：2012-07-11
申请号：EP09009791.6
申请日：2009-07-29
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0007 , A61K9/1611 , A61K9/2009

8. 发明公开

EP2389923A1 Stable ready to use injectable paracetamol formulation 有权
标题翻译： Stabile，gebrauchsfertige，injizierbare Paracetamolformulierung
公开(公告)号：EP2389923A1
公开(公告)日：2011-11-30
申请号：EP10005258.8
申请日：2010-05-19
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： Tseti, Ioulia
IPC分类号： A61K9/00 , A61K31/167 , A61K47/18 , A61K47/40 , A61K47/20
CPC分类号： A61K9/0019 , A61K31/167 , A61K47/20 , A61K47/22 , A61K47/40
摘要： The invention concerns a stable aqueous paracetamol solution for use in IV infusion comprising at least one stabilizing-dissolving compound for paracetamol in solution selected from the group consisting of cyclodextrins, at least one stabilizing compound bearing at least one thiol functional group and at least one stabilizing compound selected from the group consisting of Thiamine salts.
摘要翻译：本发明涉及一种用于IV输注的稳定的对乙酰氨基酚水溶液，其包含至少一种稳定溶解化合物，用于溶液中的对乙酰氨基酚，所述溶液选自环糊精，至少一种具有至少一个硫醇官能团的稳定化合物和至少一种稳定化选自硫胺盐的化合物。

9. 发明公开

EP4138810A1 PHARMACEUTICAL COMPOSITION COMPRISING L-TRIIODOTHYRONINE (T3) FOR USE IN THE TREATMENT OF TISSUE HYPOXEMIA AND SEPSIS 审中-实审
公开(公告)号：EP4138810A1
公开(公告)日：2023-03-01
申请号：EP21728969.3
申请日：2021-04-15
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： PANTOS, Constantinos , MOUROUZIS, Iordanis
IPC分类号： A61K31/195 , A61P43/00 , A61P29/00 , A61P31/14

10. 发明公开

EP3908272A1 L-TRIIODOTHYRONINE (T3) FOR USE IN LIMITING MICROVASCULAR OBSTRUCTION 有权
公开(公告)号：EP3908272A1
公开(公告)日：2021-11-17
申请号：EP19832974.0
申请日：2019-12-27
申请人： Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. , Tseti, Ioulia
发明人： PANTOS, Constantinos , MOUROUZIS, Iordanis
IPC分类号： A61K31/198 , A61P9/10

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