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1. 发明授权

EP1528917B1 DOSAGE FORM COMPRISING HIGH DOSE HIGH SOLUBLE ACTIVE INGREDIENT AS MODIFIED RELEASE AND LOW DOSE ACTIVE INGREDIENT AS IMMEDIATE RELEASE 有权转让
标题翻译：随着水溶性活跃在缓释制剂在瞬间RELEASING制剂高剂量和中其他活动低剂量药物剂型
公开(公告)号：EP1528917B1
公开(公告)日：2013-06-19
申请号：EP03758649.2
申请日：2003-08-01
申请人： Torrent Pharmaceuticals Ltd
发明人： VAYA, Navin , KARAN, Rajesh, Singh , NADKARNI, Sunil, Sadanand , GUPTA, Vinod, Kumar
IPC分类号： A61K9/22 , A61K9/24 , A61K31/22 , A61K31/53 , A61K31/4439 , A61K31/4025 , A61K31/455 , A61K31/19 , A61K31/155
CPC分类号： A61K9/209 , A61K9/2077 , A61K9/2081 , A61K31/155 , A61K31/19 , A61K31/22 , A61K31/4025 , A61K31/455 , A61K31/53

2. 发明公开

EP2178835A1 NOVEL SUBSTITUTED PIPERIDONES AS HSP INDUCERS 审中-公开
标题翻译：新的取代的哌啶酮AS HSP INDUCTORS
公开(公告)号：EP2178835A1
公开(公告)日：2010-04-28
申请号：EP08789905.0
申请日：2008-06-24
申请人： Torrent Pharmaceuticals Ltd
发明人： KUMAR, Prabhat , MOHANAN, Anookh , ARGADE, Navnath , HADOLE, Chakradhar , MANDHARE, Appaji , GUPTA, Ramesh , DESHPANDE, Shailesh , JAMADARKHANA, Prashant , JOSHI, Poonam
IPC分类号： C07D211/74 , C07D401/06 , C07D409/06 , C07D413/06 , A61K31/45 , A61P9/10 , A61P25/28
CPC分类号： C07D401/06 , C07D211/74 , C07D409/06 , C07D413/06
摘要： The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

3. 发明公开

EP2061766A2 NOVEL COMPOUNDS 有权
标题翻译：新化合物
公开(公告)号：EP2061766A2
公开(公告)日：2009-05-27
申请号：EP08772567.7
申请日：2008-06-02
申请人： Torrent Pharmaceuticals Ltd
发明人： CHHIPA, Laxmikant Torrent Research Center , ZAMBAD, Shitalkumar Pukharaj Torrent Research Center , GUPTA, Ramesh Torrent Research Center , TULI, Davinder Torrent Research Center , KASUNDRA, Ashok Torrent Research Center , MUNSHI, Siralee Torrent Research Center , SIDDIQUI, M. Amir Torrent Research Center , BHATTAMISRA, Subrat Kumar Torrent Research Center , DUTT, C. Torrent Research Center , CHAUTHAIWALE, Vijay Torrent Research Center
IPC分类号： C07D231/14 , C07D403/06 , A61K31/4155 , A61P3/04
CPC分类号： C07D403/06 , C07D231/12 , C07D231/14 , C07D231/18 , C07D403/10 , C07D403/12 , C07D409/04 , C07D413/06
摘要： The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3 R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.
摘要翻译：本发明公开了新颖的甲状腺样化合物，其中R 1，R 2，R 3，R 4和Z如说明书中所定义，其制备方法，含有此类化合物的组合物以及此类化合物和组合物作为药物的用途。此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着消除了甲状腺毒性效应。本发明还涉及式（I）化合物在制备用于治疗各种疾病如肥胖症，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

4. 发明授权

EP1080081B1 BENZOFUROXAN DERIVATIVES AND THEIR USE IN TREATING ANGINA PECTORIS 有权
标题翻译： Benzofuroxan及其用于治疗心绞痛
公开(公告)号：EP1080081B1
公开(公告)日：2004-06-30
申请号：EP99918219.9
申请日：1999-05-17
申请人： Torrent Pharmaceuticals Ltd
发明人： SANKARANARAYANAN, Alangudi B-7, swastik park,
IPC分类号： C07D271/12 , C07D413/12 , C07D493/04 , A61K31/41 , A61K31/44
CPC分类号： A61K31/4245 , C07D271/12

5. 发明公开

EP1243581A1 Pyridinium compounds useful for the treatment of AGE-related diseases 有权
标题翻译： Pyridiniumverbindungen zur Behandlung von AGE-relatierten Krankheiten
公开(公告)号：EP1243581A1
公开(公告)日：2002-09-25
申请号：EP01201057.5
申请日：2001-03-21
申请人： Torrent Pharmaceuticals Ltd
发明人： Sankaranarayanan, Alangudi
IPC分类号： C07D213/82 , C07D213/78 , C07D213/80 , C07D405/06 , C07D409/06 , C07D401/06 , A61K31/444 , A61P9/10 , A61P17/00 , A61P5/50
CPC分类号： C07D213/78 , C07D213/80 , C07D213/82 , C07D401/06 , C07D405/06 , C07D409/06
摘要： The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, or pharmaceutically acceptable salts thereof.
The invention also discloses, method for preparation of the novel compounds of the series and pharmaceutical composition comprising one or more of these compounds. The invention further discloses a method of treatment of a diabetic patient by administering the compounds either singly or in combination with drugs for antidiabetic therapy.
摘要翻译：本发明公开了通过破坏预先形成的AGE，可用于治疗糖尿病和衰老相关血管并发症的新颖化合物，包括肾脏疾病，神经损伤，动脉粥样硬化，视网膜病变，皮肤病学和牙齿变色，或其药学上可接受的盐。本发明还公开了制备该系列新化合物的方法和包含一种或多种这些化合物的药物组合物。本发明还公开了一种通过单独给药或与用于抗糖尿病治疗的药物组合施用化合物来治疗糖尿病患者的方法。

6. 发明授权

EP2231613B1 MONTELUKAST BENZHYDRYL PIPERAZINE SALTS AND PROCESS FOR PREPARATION THEREOF 有权
标题翻译：孟鲁司特二苯甲基哌嗪的盐类和工艺及其
公开(公告)号：EP2231613B1
公开(公告)日：2011-10-12
申请号：EP09719393.2
申请日：2009-01-05
申请人： Torrent Pharmaceuticals Ltd.
发明人： SHIMPI, Nitin, Ashok , LAKKAD, Mahendra, Gordhanbhai , NADKARNI, Sunil, Sadanand , A.V.V., Srinivasa, Rao
IPC分类号： C07D215/18 , C07D295/02 , C07D295/06
CPC分类号： C07D215/18 , C07D295/02 , C07D295/06
摘要： The invention relates to Benzhydryl piperazine salts of [R-(E)] -1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(1 -hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic acid represented by the formula (III). Furthermore, the invention relates to the use of Benzhydryl piperazine salts of [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic acid represented by the formula (III) for the preparation of substantially pure [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl] -3 -[2-(1-hydroxy-1- methylethyl) phenyl] propyl] thio] methyl] cyclopropane acetic acid or its alkali, salts and pharmaceutical composition comprising the same.

7. 发明公开

EP2101771A2 STABLE LERCANIDIPINE FORMULATION 审中-公开
标题翻译：稳定的LERCANIDIPINE配方
公开(公告)号：EP2101771A2
公开(公告)日：2009-09-23
申请号：EP07870544.9
申请日：2007-12-05
申请人： Torrent Pharmaceuticals Ltd
发明人： GUNUPATI, Jyothi, Lakshmi , NANDA, Nagesh
IPC分类号： A61K31/4422 , A61K9/28
CPC分类号： A61K31/4422 , A61K9/1611 , A61K9/1652 , A61K9/2009 , A61K9/2054 , A61K9/2059 , A61K9/2853 , A61K9/2866
摘要： The present invention relates to stable solid oral dosage form of lercanidipine by using a process of preparation of adsorbates. The invention further relates to lercanidipine adsorbates that are obtainable by said process, as well as pharmaceutical formulations prepared while employing said lercanidipine adsorbates.
摘要翻译：本发明涉及利用制备吸附物的方法的乐卡地平稳定的固体口服剂型。本发明进一步涉及可通过所述方法获得的乐卡地平吸附物，以及在使用所述乐卡地平吸附物时制备的药物制剂。

8. 发明授权

EP1146865B1 PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF DEXTRO- AND LAEVO- ISOMERS OF SOTALOL 有权
标题翻译：药物组合物含索他洛尔葡萄糖和左旋异构体的组合
公开(公告)号：EP1146865B1
公开(公告)日：2003-05-28
申请号：EP99902781.6
申请日：1999-02-22
申请人： Torrent Pharmaceuticals Ltd
发明人： SANKARANARAYANAN, Alangudi
IPC分类号： A61K31/18
CPC分类号： A61K31/18
摘要： The invention discloses a safer Antiarrhythmic drug with controlled Beta Adrenergic activity which comprises a combination of dextro- and laevo- rotatory isomers of sotalol as active ingredients in which the range of ratio of said dextro- and laevo- isomer is from 1.5:1 to 3.5:1, pharmaceutical compositions with said combination as active ingredients and its preparation and use of the said combination in the treatment of cardiac ailments in mammals including human being.

9. 发明公开

EP1304101A1 Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications 审中-公开
标题翻译： Zusammensetzung enthaltend Pyridinderivate und deren kosmetische und therapeutische Anwendung
公开(公告)号：EP1304101A1
公开(公告)日：2003-04-23
申请号：EP01204295.8
申请日：2001-11-12
申请人： Torrent Pharmaceuticals Ltd
发明人： Sankaranarayanan, Alangudi
IPC分类号： A61K7/48 , A61K31/44 , A61P17/00
CPC分类号： A61Q17/00 , A61K8/4926 , A61K2800/522 , A61Q19/08
摘要： The invention discloses a new class of compounds particularly pyridinium derivatives, which have been found to exhibit triple function of a free radical scavenger (antioxidant), AGE breaker and AGE inhibitor, and cosmetic composition comprising these compounds contained in a cosmetically acceptable carrier. The invention also discloses a method of cosmetic application by applying such composition. The invention further discloses a pharmaceutical composition, comprising said compounds useful in scavenging free radicals from the body cells of a mammal, a method of scavenging free radicals from the body cells of a mammal and a method of treating of diseases caused by accumulation of free radicals in the body cells of a mammal by administering a composition made with the compounds of the invention. The invention in addition, also discloses composition and method for inhibiting AGE in a mammal by use of the compounds of the same group.
摘要翻译：本发明公开了一类已发现自由基清除剂（抗氧化剂），AGE破坏剂和AGE抑制剂三重功能的化合物，特别是吡啶衍生物，以及含有化妆品组合物的化妆品组合物。本发明还公开了通过应用这种组合物的化妆品应用的方法。本发明还公开了一种药物组合物，其包含可用于从哺乳动物的体细胞中清除自由基的所述化合物，从哺乳动物的身体细胞中清除自由基的方法和治疗由自由基积累引起的疾病的方法通过施用本发明化合物制成的组合物在哺乳动物的体细胞中。本发明还公开了通过使用相同组的化合物来抑制哺乳动物中的AGE的组合物和方法。

10. 发明授权

EP2753302B1 PHARMACEUTICAL COMPOSITION OF TAPENTADOL 有权
公开(公告)号：EP2753302B1
公开(公告)日：2018-11-28
申请号：EP12751609.4
申请日：2012-07-19
申请人： Torrent Pharmaceuticals Ltd.
发明人： NADKARNI, Sunil, Sadanand , ABRAHAM, Jaya , KHATRI, Kapil , MITTAL, Vipul
IPC分类号： A61K9/00 , A61K31/137 , A61K47/10 , A61K47/36 , A61K47/38
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/137 , A61K47/10 , A61K47/18
摘要： The present invention relates to a pharmaceutical composition of tapentadol for nasal administration. Present invention also relates to the process of preparation of pharmaceutical composition of tapentadol for nasal administration and its use in the treatment of pain.

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