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1. 发明公开

EP4339203A1 BECLIN1-TARGETED STAPLED PEPTIDE AND PHARMACEUTICAL COMPOSITION 审中-实审
公开(公告)号：EP4339203A1
公开(公告)日：2024-03-20
申请号：EP22806815.1
申请日：2022-05-11
申请人： Shenzhen Research Institute Of The Hong Kong Polytechnic University , Fudan University
发明人： ZHAO, Yanxiang , QIU, Xianxiu , ZHANG, Xiaozhe , LI, Na , WANG, Renxiao
IPC分类号： C07K7/08 , A61K38/10 , A61P35/00
摘要： Disclosed are a Beclin 1-targeting stapled peptide and a pharmaceutical composition. The stapled peptide comprises an amino acid sequence at least 66.7% identical to amino acid residues 191-205 of Beclin 1, an amino acid residue E195 and an amino acid residue N202 in the stapled peptide are connected by a hydrocarbon staple to stabilize the α-helical structure of the stapled peptide. The hydrocarbon staple is located at a position in the stapled peptide closer to the Beclin1 coiled coil domain-stapled peptide binding interface, which can enhance the binding affinity of the stapled peptide to Beclin 1 by 10-30 fold. Compared to other autophagy inducers like rapamycin and Tat-Beclin 1 peptide, the optimized stapled peptide of the present disclosure shows the unique profile of not only inducing autophagy but also significantly enhancing the endolysosomal degradation of cell surface oncogenic receptors EGFR and HER2 in HER2-positive cancer cells.

3. 发明公开

EP3776219A1 CLIENT-SERVER ARCHITECTURE FOR MULTICORE COMPUTER SYSTEM TO REALIZE SINGLE-CORE-EQUIVALENT VIEW 审中-公开
公开(公告)号：EP3776219A1
公开(公告)日：2021-02-17
申请号：EP19826315.4
申请日：2019-06-14
申请人： The Hong Kong Polytechnic University
发明人： WANG, Qixin , WANG, Zhu
IPC分类号： G06F12/08

4. 发明公开

EP3735415A1 NOVEL ANTIBIOTICS AND METHODS OF USING THEM 审中-公开
公开(公告)号：EP3735415A1
公开(公告)日：2020-11-11
申请号：EP18898907.3
申请日：2018-12-20
申请人： Versitech Limited , The Hong Kong Polytechnic University
发明人： LI, Xuechen , JIN, Kang , CHEN, Sheng , PO, Kathy Hiu Laam
IPC分类号： C07K7/06 , C07K7/56 , A61K38/00 , A61K38/08 , A61P31/04 , A61P31/10 , A61P31/12

5. 发明公开

EP3274298A1 METHODS AND CATALYSTS FOR GREEN BIODIESEL PRODUCTION FROM UNREFINED LOW GRADE FEEDSTOCK 有权
标题翻译：无定形低品位原料生产绿色生物柴油的方法和催化剂
公开(公告)号：EP3274298A1
公开(公告)日：2018-01-31
申请号：EP16767847.3
申请日：2016-03-23
申请人： The Hong Kong Polytechnic University
发明人： YUNG, Ka Fu , WONG, Wing Tak , KWONG, Tsz Lung
IPC分类号： C01G49/00 , C01G9/00 , B01J23/80 , B01J37/08 , C11C3/10
CPC分类号： B01J23/80 , B01J23/005 , B01J35/0013 , B01J35/002 , B01J35/023 , B01J35/026 , B01J35/1014 , B01J35/1038 , B01J35/1042 , B01J35/1057 , B01J35/1061 , B01J37/0018 , B01J37/03 , B01J37/04 , B01J37/086 , C01G49/0063 , C01P2002/32 , C01P2002/72 , C01P2002/77 , C01P2002/82 , C01P2002/85 , C01P2004/03 , C01P2004/04 , C01P2004/64 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C01P2006/17 , C07C67/02 , C07C67/03 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C11C3/003 , Y02E50/13 , C07C69/52 , C07C69/24
摘要： This invention provides a catalyst comprising a new form of ZnFe2O4 spinel nanoparticles, and a method for preparing same. The catalyst is useful for catalyzing the esterification of fatty acids or transesterification of triglycerides, wherein the reaction rate and conversion can be enhanced by free fatty acids.

6. 发明授权

EP2744125B1 SIGNAL TRANSMITTING METHOD, SIGNAL RECEIVING METHOD, PASSIVE OPTICAL NETWORK DEVICE AND SYSTEM 有权
标题翻译： SIGNALÜBERTRAGUNGSVERFAHREN，SIGNALEMPFANGSVERFAHREN，被动OPTISCHE NETZWERKVORRICHTUNG系统DAFÜR
公开(公告)号：EP2744125B1
公开(公告)日：2017-06-21
申请号：EP11864796.5
申请日：2011-09-15
申请人： Huawei Technologies Co., Ltd. , The Hong Kong Polytechnic University
发明人： ZHOU, Lei , WEI, Guo , LV, Chao , WANG, Dawei , LIU, Botao
IPC分类号： H04B10/00 , H04B10/2587 , H04B10/63 , H04B10/61 , H04B10/27 , H04B10/532 , H04J14/02
CPC分类号： H04B10/27 , H04B10/532 , H04B10/614 , H04B10/6151 , H04J14/02

7. 发明授权

EP2506456B1 SIGNAL RECEPTION DEVICE AND METHOD BASED ON MICROWAVE PHOTON TECHNOLOGY 有权转让
标题翻译：微波技术为基础的光子接收装置与方法
公开(公告)号：EP2506456B1
公开(公告)日：2015-03-18
申请号：EP11750208.8
申请日：2011-04-20
申请人： Huawei Technologies Co., Ltd. , The Hong Kong Polytechnic University
发明人： WAN, Wentong , LI, Kun , DONG, Limin , YANG, Yanfu , LV, Chao
IPC分类号： H04B1/40 , H04B10/2575 , H04B10/90 , H04B1/28 , H04B10/60
CPC分类号： H04B10/60 , H04B1/28 , H04B10/2575 , H04B10/90

8. 发明授权

EP2188259B1 QUINOLINE DERIVATIVES AS ANTI-CANCER AGENTS 有权
标题翻译： ALS CHINOLINDERIVATE ANTIKREBSMITTEL
公开(公告)号：EP2188259B1
公开(公告)日：2013-11-06
申请号：EP08784083.1
申请日：2008-08-21
申请人： The Hong Kong Polytechnic University
发明人： CHAN, Albert Sun-chi , TANG, Johnny Cheuk-on , LAM, Kim-hung , CHUI, Chung-hin , KOK, Stanton Hon-lung , CHAN, Sau Hing , CHEUNG, Filly , FERRARA, Roberto Gambari , CHENG, Chor Hing
IPC分类号： C07D215/26 , A61K31/438 , A61P35/00
CPC分类号： C07D215/06 , A61K31/438 , A61K31/47 , A61K31/4709 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/26

9. 发明公开

EP2436358A1 RECOVERING SYSTEM FOR TRAINING USER TO MOVE HANDS 有权
标题翻译： GENESUNGSSYSTEM ZUM手工制作EINES BENUTZERS
公开(公告)号：EP2436358A1
公开(公告)日：2012-04-04
申请号：EP10780074.0
申请日：2010-05-26
申请人： The Hong Kong Polytechnic University
发明人： TONG, Kai Yu , HO, Sie Kit , CHAN, Tai Wai David , CHEN, Mo , ZHOU, Hongfu , PANG, Man Kit Peter
IPC分类号： A61H1/02 , A63B23/16
CPC分类号： B25J9/0006 , A61H1/0285 , A61H1/0288 , A61H2201/0157 , A61H2201/0192 , A61H2201/123 , A61H2201/1261 , A61H2201/1638 , A61H2201/165 , A61H2201/1676 , A61H2201/5007 , A61H2201/5025 , A61H2201/5061 , A61H2201/5064 , A61H2230/605 , A63B21/00181 , A63B21/4019 , A63B21/4021 , A63B21/4035 , A63B21/4047 , A63B23/14 , A63B23/16 , A63B24/0006 , A63B71/0622 , A63B2071/0627 , A63B2071/0647 , A63B2220/10 , A63B2220/51 , A63B2230/605
摘要： A recovering system (10) for training a user to move hands includes a platform (24) connected to the hands and multiple finger components (71) operatively connected to the platform (24). Each finger component (71) includes a motor (12), a proximal follow-up component (13) which is applied to a metacarpophalangeal joint and includes a proximal guide rail (14) operatively connected to the motor (12), and a middle follow-up component (16) which is applied to a near knuckle and includes a middle guide rail (17) operatively connected to the proximal follow-up component (13). The knuckle indicator (22) of the proximal guide rail (14) corresponds to the first virtual center (30). The knuckle indicator (25) of the middle guide rail (17) corresponds to the second virtual center (31). The knuckles (22, 25) are aligned to the virtual centers (30, 31) so that when the proximal follow-up component (13) and the middle follow-up component (16) are activated by the motor (12), the movement of the fingers can be controlled, and the rotation axis of the fingers can be kept being around each virtual center (30, 31).
摘要翻译：用于训练用户移动手的恢复系统（10）包括连接到手的平台（24）和可操作地连接到平台（24）的多个手指部件（71）。每个指状部件（71）包括马达（12），近端随动部件（13），其被施加到掌指关节并且包括可操作地连接到马达（12）的近侧导轨（14）跟随部件（16），其被施加到近关节并且包括可操作地连接到近侧跟随部件（13）的中间导轨（17）。近侧导轨（14）的关节指示器（22）对应于第一虚拟中心（30）。中间导轨（17）的转向节指示器（25）对应于第二虚拟中心（31）。指关节（22,25）与虚拟中心（30,31）对准，使得当近侧跟踪部件（13）和中间随动部件（16）被马达（12）激活时，可以控制手指的移动，并且可以将手指的旋转轴保持在每个虚拟中心（30,31）周围。

10. 发明公开

EP2411040A1 Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents 有权
标题翻译：精氨酸酶的定点聚乙二醇化及其作为抗癌剂和抗病毒剂的用途
公开(公告)号：EP2411040A1
公开(公告)日：2012-02-01
申请号：EP10769236.0
申请日：2010-03-26
申请人： The Hong Kong Polytechnic University
发明人： LEUNG, Thomas, Yun-Chung , LO, Thomas, Wai-Hung
IPC分类号： A61K38/43 , A61P35/00 , A61P31/00
CPC分类号： C12N9/78 , A61K38/00 , A61K47/60 , C12Y305/03001
摘要： Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys
45 of the enzyme and
Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys
161 of the enzyme.
摘要翻译：单聚乙二醇化精氨酸酶缀合物及其生产方法。单聚乙二醇化精氨酸酶在分子量上是均匀的，并显示出治疗癌症和病毒感染的治疗效果。生产这种精氨酸酶缀合物的方法具有对编码精氨酸酶的基因进行遗传修饰的主要步骤，使得PEG部分可以在预定的特定预定位点附着于酶。这是通过除去不希望的位点上的PEG连接氨基酸残基，同时保持（或者如果需要，添加）在期望的酶位点处的氨基酸残基。如此产生的两种示例性单聚乙二醇化精氨酸酶缀合物是其中聚乙二醇（PEG）部分是位点特异性共价结合至酶和Caldovelox精氨酸酶（BCA）的Cys45的人精氨酸酶I（HAI），其中聚乙二醇（PEG）部分是位点特异性共价键合到酶的Cys161。

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