专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2963421A1 Process for diagnosis of neurodegenerative diseases 审中-公开
标题翻译： Verfahren zur诊断神经退行性病变Erkrankungen
公开(公告)号：EP2963421A1
公开(公告)日：2016-01-06
申请号：EP14175677.5
申请日：2014-07-03
申请人： SeNostic GmbH
发明人： SeNostic GmbH
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N1/04 , G01N1/286 , G01N21/6428 , G01N2021/6439 , G01N2800/2828 , G06F19/00 , G06F19/10 , G06F19/18 , Y02A90/26
摘要： The invention provides an analytical process for analysing the presence of at least one aggregated conformation prion protein in a sample of body fluid or a sample of tissue and uses the dependency of the amplification of the aggregated conformation on the shear-force intensity applied to the native conformation prion protein, which is also dependent on the specific seed present in the admixture with native conformation prion protein, for specifically analysing for the presence of an aggregated conformation prion protein in the sample. The process of the invention contains the step of determining the content of aggregated conformation prion protein generated in admixture with the sample to be analysed using one shear-force intensity, preferably using least at two different shear-force intensities and the step of comparing data on these contents of generated prion protein having an aggregated conformation with data on the content of aggregated prion protein that is pre-determined, each at the same shear-force intensity for a mixture of the same native conformation prion protein with a reference sample as a seed.
摘要翻译：本发明提供了一种分析方法，用于分析体液或组织样品中至少一种聚集的构象朊病毒蛋白的存在，并且使用聚集构象的扩增对应用于天然的剪切力强度的依赖性构象朊病毒蛋白也依赖于与天然构象朊病毒蛋白混合物中存在的特定种子，用于特异性分析样品中聚集的构象朊病毒蛋白的存在。本发明的方法包括以下步骤：使用一种剪切力强度，优选使用至少两种不同的剪切力强度来确定与待分析样品混合产生的聚集构象朊病毒蛋白的含量，以及将数据进行比较生成的朊病毒蛋白的内含物具有聚集构象，其中预先确定了聚集的朊病毒蛋白质含量的数据，每种化合物的相同剪切力强度用于相同天然构象朊病毒蛋白与参照样品作为种子的混合物。

2. 发明授权

EP2675555B1 METHOD FOR PRODUCTION AND ANALYSIS OF PRIONS 有权转让
标题翻译：生产和分析PR的方法
公开(公告)号：EP2675555B1
公开(公告)日：2017-09-20
申请号：EP12703832.1
申请日：2012-02-15
申请人： SeNostic GmbH
发明人： LÜHRS, Thorsten , DELUWEIT, Felix
IPC分类号： C07K14/47 , B01F7/00 , B01F7/28 , B01F11/02 , B01F13/08 , B01F15/00
CPC分类号： B01F11/0225 , B01F7/00008 , B01F7/00541 , B01F7/008 , B01F11/0258 , B01F13/0836 , B01F13/0845 , B01F15/00006 , B01F15/00389 , B01F15/00707 , B01F15/0072 , B01F2215/0073 , B01F2215/0427 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01F2215/0481 , C07K14/47

3. 发明公开

EP3164716A1 PROCESS FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES 有权转让
标题翻译：神经退行性疾病的诊断过程
公开(公告)号：EP3164716A1
公开(公告)日：2017-05-10
申请号：EP15742188.4
申请日：2015-07-01
申请人： SeNostic GmbH
发明人： LÜHRS, Thorsten
IPC分类号： G01N33/68 , G06F19/00
摘要： The invention provides an analytical process for analysing the presence of at least one aggregated conformation prion protein in a sample of body fluid or a sample of tissue and uses the dependency of the amplification of the aggregated conformation on the shear-force intensity applied to the native conformation prion protein, which is also dependent on the specific seed present in the admixture with native conformation prion protein, for specifically analysing for the presence of an aggregated conformation prion protein in the sample. The process of the invention contains the step of determining the content of aggregated conformation prion protein generated in admixture with the sample to be analysed using one shear-force intensity, preferably using least at two different shear-force intensities and the step of comparing data on these contents of generated prion protein having an aggregated conformation with data on the content of aggregated prion protein that is pre-determined, each at the same shear-force intensity for a mixture of the same native conformation prion protein with a reference sample as a seed.
摘要翻译：本发明提供了用于分析体液样品或组织样品中至少一种聚集构象朊病毒蛋白的存在的分析过程，并且使用聚集构象的扩增依赖于施加于天然材料的剪切力强度构象朊蛋白，其也依赖于存在于与天然构象朊病毒蛋白混合物中的特定种子，用于特异性分析样品中聚集构象朊病毒蛋白的存在。本发明的方法包括使用一个剪切力强度确定与待分析样品混合产生的聚集构象朊病毒蛋白质的含量的步骤，优选至少在两个不同剪切力强度下进行测定以及比较所产生的朊病毒蛋白质的内容物具有聚集构象和关于预先确定的聚集的朊病毒蛋白质的含量的数据，每种情况在相同天然构象朊病毒蛋白质与作为种子的参照样品的混合物的相同剪切力强度下。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式