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1. 发明公开

EP2450048A3 Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase 审中-公开
标题翻译：组合物和方法用于基因转录的恢复通过抑制DNA甲基化和组蛋白脱乙酰基酶的
公开(公告)号：EP2450048A3
公开(公告)日：2012-08-01
申请号：EP11184450.2
申请日：2002-04-19
申请人： SuperGen, Inc.
发明人： Dimartino, Jorge
IPC分类号： A61K38/00 , A61K31/335 , A01N43/02 , A01N43/16 , C07H19/06 , C07H19/09
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/205 , A61K31/335 , A61K31/7072 , A61K38/09 , A61K38/12 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/208 , A61K38/212 , A61K38/215 , A61K38/217 , A61K38/31 , A61K2300/00
摘要： Compositions and methods are provided for treating diseases associated with aberrant slicing of gene expression such as cancer by re-establishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.

2. 发明公开

EP2450048A2 Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase 审中-公开
标题翻译：组合物和方法用于基因转录的恢复通过抑制DNA甲基化和组蛋白脱乙酰基酶的
公开(公告)号：EP2450048A2
公开(公告)日：2012-05-09
申请号：EP11184450.2
申请日：2002-04-19
申请人： SuperGen, Inc.
发明人： Dimartino, Jorge
IPC分类号： A61K38/00 , A61K31/335 , A01N43/02 , A01N43/16 , C07H19/06 , C07H19/09
CPC分类号： A61K45/06 , A61K31/165 , A61K31/19 , A61K31/205 , A61K31/335 , A61K31/7072 , A61K38/09 , A61K38/12 , A61K38/1816 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/208 , A61K38/212 , A61K38/215 , A61K38/217 , A61K38/31 , A61K2300/00
摘要： Compositions and methods are provided for treating diseases associated with aberrant slicing of gene expression such as cancer by re-establishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
摘要翻译：提供了用于治疗与基因表达的异常切片相关的疾病的组合物和方法：通过重新建立的基因表达，通过抑制DNA低甲基化和组蛋白脱乙酰酶的如癌症。该方法包括：从所述疾病的患者施用患有一个治疗有效量的DNA甲基化抑制剂：如半胱氨酸类似物：如地西他滨，在与有效量的组蛋白脱乙酰酶抑制剂的组合：如异羟肟酸，环肽，苯甲酰胺，丁酸和depudecin。

3. 发明公开

EP2174938A1 Quinoline derivatives for modulating DNA methylation 审中-公开
标题翻译： Quinoline zur Modulation der DNA-Methylierung
公开(公告)号：EP2174938A1
公开(公告)日：2010-04-14
申请号：EP10000636.0
申请日：2007-10-12
申请人： SuperGen, Inc.
发明人： Phiasivongsa, Pasit , Redkar, Sanjeev , Gamage, Swarna , Brooke, Darby , Denny, William , Bearss, David, J. , Vankayalapati, Hariprasad
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于DNA甲基化的调节，例如通过选择性抑制DNA甲基转移酶DNMT1有效抑制胞嘧啶在C-5位甲基化。提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

4. 发明公开

EP1663259A4 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 审中-公开
标题翻译：组合物和治疗癌症的方法
公开(公告)号：EP1663259A4
公开(公告)日：2009-07-29
申请号：EP04778072
申请日：2004-07-13
申请人： SUPERGEN INC
发明人： RUBINFELD JOSEPH
IPC分类号： A61K31/7072 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/192 , A61K31/40 , A61K31/706 , A61K45/06 , A61P35/00 , C07K16/00 , C12N15/11
CPC分类号： A61K31/706 , A61K31/16 , A61K2300/00

5. 发明公开

EP1572075A4 METHOD FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL KINASE ACTIVITY 审中-公开
标题翻译：法疾病治疗与异常激酶活性
公开(公告)号：EP1572075A4
公开(公告)日：2008-03-12
申请号：EP03710881
申请日：2003-02-06
申请人： SUPERGEN INC
发明人： LYONS JOHN , RUBINFELD JOSEPH
IPC分类号： A61K31/00 , A61K31/706 , A61K31/7068 , A61K31/57 , A61K39/395 , A61K45/06 , A61P11/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/08
CPC分类号： A61K31/7068 , A61K31/00 , A61K31/706 , A61K45/06

6. 发明授权

EP1056459B1 TREATMENT OF HIV INFECTIONS 有权
标题翻译：治疗HIV感染
公开(公告)号：EP1056459B1
公开(公告)日：2006-05-03
申请号：EP99906918.0
申请日：1999-02-11
申请人： Supergen, Inc.
发明人： WRENN, Simeon, M., Jr.
IPC分类号： A61K31/55 , A61K31/52 , A61P31/18
CPC分类号： A61K31/7076 , A61K31/00 , A61K31/7056 , A61K38/13 , A61K47/6849 , A61K2039/505 , C07K16/28
摘要： Disclosed is a method of treating an HIV-infected host including administering to the host a therapeutic agent that is cytotoxic or cytostatic with respect to CD4+ T cells, but has reduced cytotoxic or cytostatic activity with respect to T lymphocyte stem cells, in a CD4+ T cell cytotoxic or cytostatic effective amount. Also disclosed is a method of treating an HIV-infected host including administering highly active antiretroviral therapy; and coadministering to the host a therapeutic agent that is cytotoxic or cytostatic with respect to CD4+ T cells, but has reduced cytotoxic or cytostatic activity with respect to T lymphocyte stem cells, in a CD4+ T cell cytotoxic or cytostatic effective amount. Also disclosed is a method of ex vivo or in vitro treatment of blood derived cells, bone marrow transplants, or other organ transplants including treating the blood derived cells, bone marrow transplants, or other organ transplants with a therapeutic agent that is cytotoxic or cytostatic with respect to CD4+ T cells, but has reduced cytotoxic or cytostatic activity with respect to T lymphocyte stem cells in a CD4+ T cell cytotoxic or cytostatic effective amount. Kits and compositions useful in the practice of the invention are also disclosed.

7. 发明公开

EP1461056A4 METHOD FOR PREPARING AND USING POLYOXYETHYLATED CASTOR OIL IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：过程在药物组合物的制备和聚氧乙烯蓖麻油的使用
公开(公告)号：EP1461056A4
公开(公告)日：2006-01-25
申请号：EP02786816
申请日：2002-11-26
申请人： SUPERGEN INC
发明人： JOSHI-HANGAL RAJASHREE , RUBINFELD JOSEPH , REDKAR SANJEEV , GORE ASHOK Y
IPC分类号： A61K9/08 , A61K9/00 , A61K31/337 , A61K36/47 , A61K47/10 , A61K47/22 , A61K47/34 , A61K47/44 , A61K47/46 , A61P35/00
CPC分类号： A61K47/44 , A61K9/0019 , A61K31/337

8. 发明公开

EP1572075A3 METHOD FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL KINASE ACTIVITY 审中-公开
标题翻译：一种治疗与异常激酶活性有关的疾病的方法
公开(公告)号：EP1572075A3
公开(公告)日：2005-12-07
申请号：EP03710881.8
申请日：2003-02-06
申请人： Supergen, Inc.
发明人： LYONS, John , RUBINFELD, Joseph
IPC分类号： A61K39/00 , A61K39/395 , A61K31/57

9. 发明公开

EP1549312A1 SEQUENTIAL THERAPY COMPRISING A 20(S)-CAMPTOTHECIN AND AN ANTHRACYCLINE 审中-公开
标题翻译：与20（S） - 喜树碱与蒽环类抗生素顺序处理
公开(公告)号：EP1549312A1
公开(公告)日：2005-07-06
申请号：EP03738982.2
申请日：2003-05-28
申请人： SuperGen, Inc.
发明人： RUBINFELD, Joseph
IPC分类号： A61K31/4745
CPC分类号： A61K31/70 , A61K45/06
摘要： A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation. The method comprises: administering to the patient an anthracycline for a period of time during which a 20(S)-camptothecin is not present in a pharmacologically active form in patient's blood, and administering a 20(S)-camptothecin to the patient.

10. 发明公开

EP1485102A2 SEQUENTIAL THERAPY COMPRISING A 20(S)-CAMPTOTHECIN COMPOUND AND A PYRIMIDINE BASE ANALOG 审中-公开
标题翻译：序贯疗法与20（S） - 喜树碱化合物的嘧啶碱基类似物
公开(公告)号：EP1485102A2
公开(公告)日：2004-12-15
申请号：EP03707767.4
申请日：2003-02-06
申请人： SuperGen, Inc.
发明人： RUBINFELD, Joseph , METTINGER, Karl, L. , LYONS, John , ROMEL, Lawrence, A.
IPC分类号： A61K31/545 , A61K31/47
CPC分类号： A61K31/513 , A61K31/4745 , A61K31/7072 , A61K2300/00
摘要： A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation, the method comprising: administering to the patient a 20(S)-camptothecin compound for a period of time during which a pyrimidine base analog is not being administered to the patient; and administering a pyrimidine base analog to the patient.

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