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1. 发明授权

EP0532451B1 Transdermal drug delivery device 失效
标题翻译：用于透皮应用
公开(公告)号：EP0532451B1
公开(公告)日：1996-01-17
申请号：EP92630083.1
申请日：1992-09-10
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/303

2. 发明授权

EP0497727B1 Electrolytic dispensing device 失效
标题翻译：电解捐助。
公开(公告)号：EP0497727B1
公开(公告)日：1995-06-21
申请号：EP92630012.0
申请日：1992-01-30
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155
CPC分类号： A61M5/155

3. 发明公开

EP0481601A2 Liquid material dispenser 失效
标题翻译： Abgabevorrichtungfürflüssiges材料。
公开(公告)号：EP0481601A2
公开(公告)日：1992-04-22
申请号：EP91308396.0
申请日：1991-09-13
申请人： S.I. SCIENTIFIC INNOVATIONS LTD.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155 , A61M5/148
CPC分类号： A61M5/155 , A61M2005/14204 , B05B11/0045 , Y10S128/12
摘要： A liquid material dispenser includes a rigid housing (2) having a flexible partition defining first and second compartments (4, 6) on opposite sides of the partition, and an electrolytic cell (22) in the first compartment (4) capable of generating a gas when energized by a source of electric current in order to expand the first compartment (4) and thereby to contract the second compartment (6). The second compartment (6) contains the liquid material which is dispensed via a discharge opening (8) in accordance with the rate of generation of the gas.
摘要翻译：液体材料分配器包括具有柔性分隔物的刚性壳体（2），该柔性分隔物限定在隔板的相对侧上的第一和第二隔室（4,6），以及第一隔室（4）中的电解池（22），其能够产生为了扩大第一隔室（4）并由此使第二隔室（6）收缩，通过电流源通电时的气体。第二隔室（6）包含根据气体产生速率通过排放口（8）分配的液体材料。

4. 发明公开

EP0385916A3 Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate. 失效
标题翻译：用于分配特定用于以预定速率递送药物的液体的装置和方法
公开(公告)号：EP0385916A3
公开(公告)日：1990-12-19
申请号：EP90630047.0
申请日：1990-02-22
申请人： S.I. SCIENTIFIC INNOVATIONS LTD.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155
CPC分类号： A61M5/155 , A61M5/172 , A61M2005/14204
摘要： A device for dispensing a liquid, particularly a medicament, at a predetermined rate, comprises a container (2) including a displaceable partition (4) to define a first expansible-contractible chamber (2a) on one side for receiving the liquid (6) to be dispensed, and a second expansible-contractible chamber (26) on the opposite side for receiving an electrolytic cell (8). The electrolytic cell has electrodes (8a) and an electrolyte (8b) capable of generating, upon the energization of the electrodes (8a), a gas under pressure to thereby displace the displaceable partition (4) and to force the liquid (6) out from the first chamber (2a) in accordance with the rate of energization of the electrodes (8a).

5. 发明授权

EP0481601B1 Liquid material dispenser 失效
标题翻译：分配器液体材料
公开(公告)号：EP0481601B1
公开(公告)日：1995-12-13
申请号：EP91308396.0
申请日：1991-09-13
申请人： S.I. SCIENTIFIC INNOVATIONS LTD.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155 , A61M5/148
CPC分类号： A61M5/155 , A61M2005/14204 , B05B11/0045 , Y10S128/12

6. 发明公开

EP0681497A1 TRANSCUTANEOUS DRUG DELIVERY APPLICATOR 失效
标题翻译： APPLICATOR经皮给药的药物。
公开(公告)号：EP0681497A1
公开(公告)日：1995-11-15
申请号：EP94907823.0
申请日：1994-01-14
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd. , FRIEDMAN, Mark, M.
IPC分类号： A61N1
CPC分类号： A61N1/044 , A61N1/0448
摘要： This is a transcutaenous iontophoretic drug applicator, which includes an array of reservoirs (10) which are electrically insulated from one another, some of which contain the drug to be administered. The applicator further includes a partially electrically conducting layer (12), preferably formed of two portions, each segment corresponding to an electrode (14), which overlies and contacts the reservoirs (10), and electrodes (14) which overlay and contact the partially electrically conducting layer (12). An electrical power source (16) supplies power to the electrodes (14) and causes the drug to be pushed out of the reservoirs (10) and into the skin (11). The applicator is designed to keep the local current flux below threshold irritation and burn levels regardless of variations in electrical skin resistance.

7. 发明公开

EP0532451A1 Transdermal drug delivery device 失效
标题翻译： Einrichtung zur transdermalen Wirkstoffabgabe。
公开(公告)号：EP0532451A1
公开(公告)日：1993-03-17
申请号：EP92630083.1
申请日：1992-09-10
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/303
摘要： A transdermal drug delivery device (2) includes anode and cathode electrodes (11,12) supported on a base member (10) in spaced relation to each other to define a gap therebetween, a gel (13) containing a liquid drug to be delivered covering the gap and in contact with both of the electrodes (11,12), and a liquid permeable sheet (14) covering the gel (13) containing the liquid to be delivered.
摘要翻译：透皮药物输送装置（2）包括负责彼此隔开关系的基底构件（10）上的阳极和阴极电极（11,12），以在它们之间形成间隙，凝胶（13）含有待输送的液体药物覆盖间隙并与两个电极（11,12）接触;以及覆盖含有待输送液体的凝胶（13）的透液性片（14）。

8. 发明公开

EP0497727A1 Electrolytic dispensing device 失效
标题翻译： Elektrolytischer Spender。
公开(公告)号：EP0497727A1
公开(公告)日：1992-08-05
申请号：EP92630012.0
申请日：1992-01-30
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155
CPC分类号： A61M5/155
摘要： An electrolytic dispensing device includes a first contractible chamber (C1) for receiving a liquid to be dispensed, and a second contractible chamber (C2) for receiving a gas to control the rate of dispensing of the liquid from the first chamber. An electolytic cell (10) generates a gas which is fed to the second chamber to dispense liquid from the first chamber in accordance with the electrical current conducted through the electrolytic cell. The electrolytic cell includes a partition (18) of an ion-permeable, but gas-impermeable, material separating its two electrodes (12,14). The partition is effective to permit gas generated at one electrode to be fed to the second chamber, and to block from the second chamber gas generated at the other electrode, and thereby to prevent the formation of a hazardous mixture of gases.
摘要翻译：电解分配装置包括用于接收待分配液体的第一收缩室（C1）和用于接收气体以控制来自第一室的液体分配速率的第二收缩室（C2）。电解池（10）产生供给第二室的气体，以便根据通过电解池传导的电流从第一室分配液体。电解池包括分离其两个电极（12,14）的离子可透过但不透气的材料的隔板（18）。该分隔是有效的，以允许在一个电极处产生的气体被供给到第二室，并且阻止在另一个电极处产生的第二室气体，从而防止形成有害的气体混合物。

9. 发明授权

EP0681497B1 TRANSCUTANEOUS DRUG DELIVERY APPLICATOR 失效
标题翻译： APPLICATOR经皮给药的药物
公开(公告)号：EP0681497B1
公开(公告)日：2001-06-20
申请号：EP94907823.2
申请日：1994-01-14
申请人： S.I. SCIENTIFIC INNOVATIONS LTD.
发明人： GROSS, Joseph
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448
摘要： This is a transcutaenous iontophoretic drug applicator, which includes an array of reservoirs (10) which are electrically insulated from one another, some of which contain the drug to be administered. The applicator further includes a partially electrically conducting layer (12), preferably formed of two portions, each segment corresponding to an electrode (14), which overlies and contacts the reservoirs (10), and electrodes (14) which overlay and contact the partially electrically conducting layer (12). An electrical power source (16) supplies power to the electrodes (14) and causes the drug to be pushed out of the reservoirs (10) and into the skin (11). The applicator is designed to keep the local current flux below threshold irritation and burn levels regardless of variations in electrical skin resistance.

10. 发明授权

EP0494042B1 Liquid delivery device particularly useful for delivering drugs 失效
标题翻译：液体分配器用于药物输送
公开(公告)号：EP0494042B1
公开(公告)日：1997-06-18
申请号：EP91630120.3
申请日：1991-12-30
申请人： S.I. SCIENTIFIC INNOVATIONS Ltd.
发明人： Gross, Joseph , Zucker, Shlomo
IPC分类号： A61M5/155
CPC分类号： B05B9/0844 , A61M5/155 , A61M5/16881 , B05B11/0045

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