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1. 发明公开

EP1615034A4 FIXING AGENTS, METHOD OF FIXING SUBSTANCE WITH THE SAME, AND SUBSTRATE HAVING SUBSTANCE FIXED THERETO WITH THE SAME 审中-公开
标题翻译：固定剂，方法用于固定物质和基质与事实固定化物
公开(公告)号：EP1615034A4
公开(公告)日：2010-11-24
申请号：EP04724403
申请日：2004-03-30
申请人： RIKAGAKU KENKYUSHO
发明人： ITO YOSHIHIRO , HASUDA HIROKAZU , KONNO TOMOHIRO , ISHIHARA KAZUHIKO , YAMAUCHI TETSUYA
IPC分类号： G01N33/547 , C12M1/34 , C12M1/40 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54393

2. 发明公开

EP1041160A4 METHODS FOR DETECTING MUTATION IN BASE SEQUENCE 失效
标题翻译：方法的突变对基序列检测
公开(公告)号：EP1041160A4
公开(公告)日：2003-05-28
申请号：EP98935298
申请日：1998-07-30
申请人： RIKAGAKU KENKYUSHO , HAYASHIZAKI YOSHIHIDE
发明人： HAYASHIZAKI Y
IPC分类号： C12Q1/68 , C12M1/32 , C12N15/11 , G01N33/58
CPC分类号： C12Q1/6827 , C12Q2565/501 , C12Q2563/131 , C12Q2521/514 , C12Q2563/119 , C12Q2525/107
摘要： A method for detecting a mutated nucleic acid and/or DNA fragment which comprises hybridizing a nucleic acid fragment, etc. immobilized on a plate with another nucleic acid fragment, etc. to be examined in the presence of the mutation, binding the thus formed inappropriate base pair to a substance capable of binding specifically to the inappropriate base pair, such as labeled Mut S, and then detecting and identifying the fragment to which the above substance has been bound; a method which comprises treating, in place of the above substance capable of binding specifically to the inappropriate pair, an inappropriate base pair formed between hybridized fragments with a substance capable of specifically recognizing and cleaving the inappropriate base pair, thus cleaving or removing the hybridized fragment starting with the inappropriate base pair, labeling the fragment remaining on a plate after the cleavage or removal, and then detecting and identifying the thus labeled fragment; and substances capable of binding specifically to an inappropriate base pair such as GFP-labeled Mut S. Thus, structural mutations in two or more genes can be detected in parallel. In particular, structural mutations can be detected while monitoring the extent of expression simultaneously.

3. 发明公开

EP0939130A4 RNA POLYMERASE 失效
标题翻译：聚合酶
公开(公告)号：EP0939130A4
公开(公告)日：2002-09-18
申请号：EP98929851
申请日：1998-07-06
申请人： RIKAGAKU KENKYUSHO , NIPPON GENE CO LTD , HAYASHIZAKI YOSHIHIDE
发明人： HAYASHIZAKI YOSHIHIDE , WATAHIKI MASANORI
IPC分类号： C12N15/09 , C12N1/21 , C12N9/12 , C12N15/54 , C12Q1/68 , C12R1/19 , C12P19/34
CPC分类号： C12N9/1247 , C12N9/1252
摘要： An RNA polymerase comprising a wild type RNA polymerase with at least one amino acid modified so as to have a higher ability of incorporating 3'-deoxyribonucleotide or a derivative thereof than that of the corresponding wild type RNA polymerase. Specifically, for example, an RNA polymerase comprising a wild type RNA polymerase wherein at least one amino acid present in the nucleotide bonding site, for example, phenylalanine, is substituted by tyrosine. The RNA polymerase has little or no bias of incorporation between ribonucleotide and 3'-deoxyribonucleotide, between ribonucleotides having different bases, and between deoxyribonucleotides having different bases.

4. 发明公开

EP0967219A4 COMPOUNDS HAVING ENERGY TRANSFER FUNCTION AND METHOD FOR DNA BASE SEQUENCING BY USING THE SAME 失效
标题翻译：具有能量传递函数和DNA碱基测序使用这些化合物的方法LINKS
公开(公告)号：EP0967219A4
公开(公告)日：2002-09-11
申请号：EP98931037
申请日：1998-07-10
申请人： RIKAGAKU KENKYUSHO , WAKO PURE CHEMICAL INDUSTIES L , HAYASHIZAKI YOSHIHIDE
发明人： HAYASHIZAKI YOSHIHIDE
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q2565/1015 , C12Q2521/119
摘要： Compounds having two reporters capable of serving as a donor and an acceptor in energy transfer, for example, a fluorescent group together with a 2',3'-deoxyribonucleotide residue or a 3'-deoxyribonucleotide residue. These compounds can serve as a terminator in the chain terminator method. These two reporters are located at a sufficient interval for inducing energy transfer. A method for DNA base sequencing by the chain terminator method wherein the chain termination reaction is effected with the use of the above terminators. Compounds having two reporters capable of serving as a donor and an acceptor in energy transfer and being usable as primers or initiators in a method for DNA base sequencing with the use of the chain terminator method and a method for DNA base sequencing with the use of these compounds.

5. 发明授权

EP0723273B1 Multilayer film structure for soft X-ray optical elements 失效
标题翻译：在软X射线的光学元件的多层结构
公开(公告)号：EP0723273B1
公开(公告)日：2002-05-22
申请号：EP96100700.2
申请日：1996-01-18
申请人： RIKAGAKU KENKYUSHO
发明人： Kumagai, Hiroshi, c/o Rikagaku Kenkyusho , Toyoda, Kouichi, c/o Rikagaku Kenkyusho
IPC分类号： G21K1/06
CPC分类号： B82Y10/00 , G21K1/062 , G21K2201/061 , Y10T428/24942

6. 发明授权

EP0780936B1 Wavelength selecting method in wavelength tunable laser and wavelength selectable laser oscillator in wavelength tunable laser 失效
标题翻译：在可调谐激光器和可选择激光振荡器，在波长可调激光器中用于波长选择的方法
公开(公告)号：EP0780936B1
公开(公告)日：2002-03-27
申请号：EP96120284.3
申请日：1996-12-17
申请人： RIKAGAKU KENKYUSHO
发明人： Wada, Satoshi , Akagawa, Kazuyuki , Tashiro, Hideo
IPC分类号： H01S3/106
CPC分类号： H01S3/1068 , G02F1/116

7. 发明公开

EP0873754A4 AMINO ACID COMPOSITIONS 失效
标题翻译： AMINOSÄURENZUSAMMENSETZUNGEN
公开(公告)号：EP0873754A4
公开(公告)日：1999-03-24
申请号：EP97900113
申请日：1997-01-09
申请人： RIKAGAKU KENKYUSHO , MEIJI MILK PROD CO LTD
发明人： ABE TAKASHI , TSUCHITA HIROSHI , IIDA KOJI
IPC分类号： A61K31/415 , A61K38/48 , A61K31/195 , A61K31/395 , A61K31/40
CPC分类号： A61K31/415 , A61K31/40 , A61K31/195 , A61K2300/00
摘要： Amino acid compositions containing the following amino acids each in the molar proportion as specified below: proline (12.6 - 23.4), alanine (8.4 - 15.6), glycine (13.3 - 24.9), valine (8.2 - 15.4), threonine (5.0 - 9.4), leucine (4.3 - 8.1), histidine (1.8 - 11.9), serine (1.7 - 3.3), lysine (6.0 - 11.2), isoleucine (3.1 - 5.9), glutamic acid (2.2 - 10.4), arginine (2.4 - 4.6), phenylalanine (2.6 - 5.0), tyrosine (4.2 - 7.8) and trypsin (1.5 - 2.9). These compositions are efficacious in supplementing amino acids in blood reduced in association with hard exercise and suppressing changes in blood amino acid levels, thus improving motor functions, relieving fatigue after exercise, and facilitating the recovery from fatigue.
摘要翻译：包含以下摩尔比的以下氨基酸的氨基酸组合物：脯氨酸（12.6至23.4），丙氨酸（8.4至15.6），甘氨酸（13.3至24.9），缬氨酸（8.2至15.4），苏氨酸（5.0至9.4），亮氨酸（4.3至8.1），组氨酸（1.8至11.9），丝氨酸（1.7至3.3），赖氨酸（6.0至11.2），异亮氨酸（3.1至5.9），谷氨酸（2.2至10.4），精氨酸（2.4至4.6）苯丙氨酸（2.6〜5.0），酪氨酸（4.2〜7.8）和胰蛋白酶（1.5〜2.9）。该组合物补充了在锻炼期间减少的血液氨基酸，并且显示出改善运动功能的效果，减少运动后的疲劳并帮助恢复疲劳。

8. 发明公开

EP0780936A3 Wavelength selecting method in wavelength tunable laser and wavelength selectable laser oscillator in wavelength tunable laser 失效
标题翻译：一种用于波长选择的激光方法Wellenlängeabstimmbaren
公开(公告)号：EP0780936A3
公开(公告)日：1998-01-28
申请号：EP96120284.3
申请日：1996-12-17
申请人： RIKAGAKU KENKYUSHO
发明人： Wada, Satoshi , Akagawa, Kazuyuki , Tashiro, Hideo
IPC分类号： H01S3/106
CPC分类号： H01S3/1068 , G02F1/116
摘要： An object of the present invention is to electrically tuned control an oscillating wavelength of a laser at high rate and in good reproducibility without providing any mechanically movable section in the laser resonator. To achieve the object, provided is a laser oscillator comprising a laser resonator composed of a mirror on the output side and a total reflection mirror, a Ti:Al 2 O 3 laser crystal disposed in the laser resonator, an acousto-optic crystal disposed in the laser resonator and to which are inputted the outputting light rays from the Ti:Al 2 O 3 laser crystal, a piezoelectric element mounted on the acousto-optic crystal to input acoustic waves thereto, and a diffraction light ray correcting prism disposed in the laser resonator and for correcting an angle of deflection of the diffraction light rays outputted from the acousto-optic crystal.

9. 发明公开

EP0723273A2 Multilayer film structure for soft X-ray optical elements 失效
标题翻译：元素生物科学
公开(公告)号：EP0723273A2
公开(公告)日：1996-07-24
申请号：EP96100700.2
申请日：1996-01-18
申请人： RIKAGAKU KENKYUSHO
发明人： Kumagai, Hiroshi, c/o Rikagaku Kenkyusho , Toyoda, Kouichi, c/o Rikagaku Kenkyusho
IPC分类号： G21K1/06
CPC分类号： B82Y10/00 , G21K1/062 , G21K2201/061 , Y10T428/24942
摘要： In order to provide a multilayer film structure for soft X-ray optical elements in which a high reflectivity can be attained in even a soft X-ray wavelength region of a wavelength of 10 nm or less including the wavelength range of water window zone, in a multilayer film structure for soft X-ray optical elements wherein a first thin film, being a different type of a second thin film, and the second thin film are piled up in layers to form a multilayer film, at least one of the aforesaid first thin film and the aforesaid second thin film is made to be an oxide thin film.
摘要翻译：为了提供即使在包括水窗区域的波长范围的10nm以下的波长的软X射线波长区域也能够获得高反射率的软X射线光学元件的多层膜结构，用于软X射线光学元件的多层膜结构，其中作为不同类型的第二薄膜的第一薄膜和第二薄膜堆叠成层以形成多层膜，至少一个上述第一薄膜将薄膜和上述第二薄膜制成氧化物薄膜。

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