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1. 发明公开

EP0489870A1 SYSTEM AND METHOD FOR TRANSFORMING TWO DIMENSIONAL SIGNALS OF A HAND HELD SECTOR TRANSDUCER INTO THREE DIMENSIONAL SIGNALS 失效
标题翻译：方法和系统一只手将二维信号损耗的转炉在三维信号。
公开(公告)号：EP0489870A1
公开(公告)日：1992-06-17
申请号：EP90914870.0
申请日：1990-08-31
申请人： MONTEFIORE MEDICAL CENTER
发明人： ROTH, James, A.
IPC分类号： A61B8 , G01S7 , G01S15 , G06T1 , G06T15 , G06T17
CPC分类号： A61B8/483 , A61B8/08 , A61B8/0883 , G01S7/5205 , G01S15/8993 , G06T17/00
摘要： L'invention peut être utilisée afin d'obtenir des images à trois dimensions de tout objet devant être visualisé ou mesuré, y compris le corps humain. Les images à trois dimensions peuvent être utilisées afin de produire des visualisations bidimensionnelles ou à perspective à trois dimensions. Cette caractéristique facilite le calcul de la superficie ou du volume de l'objet. Un sous-système imageur ultrasonore (21, 22) produit des signaux qui représentent les images des sections de l'objet. Les signaux d'images sont stockés en tant que matrices de valeurs de pixels numériques (117). On prévoit des moyens (110) servant à dériver et à stocker des informations qui représentent la position et l'orientation du transducteur pendant l'analyse d'une section associée de l'objet. Les matrices des valeurs de pixels sont ensuite introduites dans des emplacements de mémoire de voxels.

2. 发明公开

EP0337498A2 Method for determining state of disease progression 失效
标题翻译： Verfahren zur Bestimmung des Krankheitsverlaufszustands。
公开(公告)号：EP0337498A2
公开(公告)日：1989-10-18
申请号：EP89106875.1
申请日：1989-04-17
申请人： MONTEFIORE MEDICAL CENTER
发明人： Augenlicht, Leonard H.
IPC分类号： C12Q1/68 , G01N33/574 , A61K37/02 , A61K31/70 , A61K39/395
CPC分类号： C07K16/3046 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , G01N33/57446
摘要： The present invention relates to a method for determining the state of disease progression thereby providing a means for the detection of said disease and in the risk evaluation for the development of said disease. In particular, the present invention contemplates a method for determining and monitoring the state of malignant or premalignant progression or risk of development of malignant or premalignant progression in mammalian tissue or cells. In particular, the present invention is directed to benign and malignant colon tumors and benignly and malignantly transformed colon cells. The present invention is predicated on the discovery that the abundance of specific first nucleic acids changes in response to the disease state. The present invention is also directed to recombinant second nucleic acids useful in the detection and quantification of the first nucleic acids by hybridization. The present invention also contemplates the use of polypeptides encoded by said second nucleic acids in the regression and prophylaxis of disease states.
摘要翻译：本发明涉及一种用于确定疾病进展状态的方法，从而提供用于检测所述疾病的手段和用于发展所述疾病的风险评估。特别地，本发明考虑了用于确定和监测恶性或恶化前进展状态或哺乳动物组织或细胞中恶化或恶化前进进展的风险的方法。特别地，本发明涉及良性和恶性结肠肿瘤以及良性和恶性转化的结肠细胞。本发明基于以下发现：特异性第一核酸的丰度响应于疾病状态而改变。本发明还涉及可用于通过杂交检测和定量第一核酸的重组第二核酸。本发明还考虑在回归和预防疾病状态中使用由所述第二核酸编码的多肽。

3. 发明公开

EP4256087A1 METHOD FOR PREDICTING PATIENT RESPONSE TO CD40-TARGETED THERAPIES 审中-公开
公开(公告)号：EP4256087A1
公开(公告)日：2023-10-11
申请号：EP21901456.0
申请日：2021-12-02
申请人： Albert Einstein College of Medicine , Montefiore Medical Center , Johannes Gutenberg University (JGU) Medical Center
发明人： TOMER, Yaron , FAUSTINO, Larissa C. , KAHALY, George J.
IPC分类号： C12Q1/6883 , C07K16/28 , G01N33/68

4. 发明公开

EP2790717A2 DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN 有权
标题翻译：治疗物质对胶原蛋白结合蛋白SUPPLY
公开(公告)号：EP2790717A2
公开(公告)日：2014-10-22
申请号：EP12857691.5
申请日：2012-12-14
申请人： The Board of Trustees of the University of Arkansas , Kitasato University , Montefiore Medical Center
发明人： SAKON, Joshua , PHILOMINATHAN, Sagaya, Theresa, Leena , KATIKANENI, Ranjitha , MATSUSHITA, Osamu , PONNAPAKKAM, Tulasi , KOIDE, Takaki , GENSURE, Robert, C.
IPC分类号： A61K38/16
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

5. 发明公开

EP4192479A1 DENDRITIC CELL ACTIVATING THERAPY AS AN ADJUNCT TO RADIATION THERAPY 审中-实审
公开(公告)号：EP4192479A1
公开(公告)日：2023-06-14
申请号：EP21852137.5
申请日：2021-08-05
申请人： Montefiore Medical Center
发明人： GUHA, Chandan , PANDEY, Sanjay
IPC分类号： A61K35/15 , A61K45/06 , A61N7/02

8. 发明公开

EP3706866A1 LOW ENERGY IMMUNE PRIMING FOR TREATING CANCER AND METASTASIS 审中-实审
公开(公告)号：EP3706866A1
公开(公告)日：2020-09-16
申请号：EP18876112.6
申请日：2018-11-09
申请人： Montefiore Medical Center
发明人： GUHA, Chandan , BARRY, Stephen
IPC分类号： A61N7/02 , A61B5/055 , A61B5/06 , A61B8/08 , A61K47/42 , A61K49/22 , A61N5/10

9. 发明授权

EP2790717B1 DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN 有权
公开(公告)号：EP2790717B1
公开(公告)日：2018-05-30
申请号：EP12857691.5
申请日：2012-12-14
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , Montefiore Medical Center , National University Corporation Kagawa University
发明人： SAKON, Joshua , PHILOMINATHAN, Sagaya, Theresa, Leena , KATIKANENI, Ranjitha , MATSUSHITA, Osamu , PONNAPAKKAM, Tulasi , KOIDE, Takaki , GENSURE, Robert, C. , NISHI, Nozomu
IPC分类号： A61K38/16
CPC分类号： C12N9/52 , A61K8/4913 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/99 , A61K38/00 , A61K38/179 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/193 , A61K38/27 , A61K38/29 , A61K38/30 , A61K39/3955 , A61K39/44 , A61K47/64 , A61K2039/505 , A61K2039/6031 , A61K2800/57 , A61Q7/00 , A61Q7/02 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12Y304/24003
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

10. 发明公开

EP2678686A1 ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER 有权
标题翻译：经选择性剪接的mRNA异构肿瘤转移的AS预后指标
公开(公告)号：EP2678686A1
公开(公告)日：2014-01-01
申请号：EP12749944.0
申请日：2012-02-24
申请人： Massachusetts Institute of Technology , Albert Einstein College of Medicine of Yeshiva University , Montefiore Medical Center
发明人： GERTLER, Frank, B. , BURGE, Christopher, Boyce , SHAPIRO, Irina, M. , CHENG, Wu, Albert , CONDEELIS, John, S. , OKTAY, Maja, H.
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57415
摘要： The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.

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