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1. 发明公开

EP2835135A2 Means and methods for treating pseudomonas infection 审中-公开
标题翻译：治疗假单胞菌感染的手段和方法
公开(公告)号：EP2835135A2
公开(公告)日：2015-02-11
申请号：EP14172834.5
申请日：2014-06-17
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： Grossmann, Tom N. , Ottmann, Christian , Glas, Adrian , Bier, David
IPC分类号： A61K38/16 , A61P31/04
CPC分类号： A61K38/164
摘要： The present invention relates to a peptide or depsipeptide of formula (I)

(Y) k X 1 YZ 1 X 2 Z 2 (Y) m (I),

wherein X 1 is an α-amino acid residue or an α-hydroxy acid residue of formula (IIa)

-A-CR 1 R 2 -CO- (IIa),

X 2 is an α-amino acid residue or an α-hydroxy acid residue of formula (IIb)

-A-CR 3 R 4 -CO- (IIb),

wherein A is NH or O; R 1 and R 3 are independently selected from H, halogen such as F, substituted or unsubstituted C 1 to C 4 alkyl such as methyl, substituted or unsubstituted aryl and substituted or unsubstituted arylalkyl, aryl being a 5- or 6-membered ring with 0, 1, 2 or 3 heteroatoms, heteroatoms being selected from O, N and S, alkyl in said arylalkyl being C 1 to C 4 alkyl, said alkyl in said arylalkyl optionally being substituted, the term "substituted", when relating to R 1 and R 3 , providing for, as valence permits, 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F; R 2 and R 4 together are chosen to be substituted or unsubstituted n-alk-1,ω-diyl or substituted or unsubstituted n-alken-1,ω-diyl, ω being an integer number selected from 6, 7, 8, 9, 10, 11, 12, 13 and 14, the term "substituted", when relating to R 2 and R 4 , providing for 1 or 2, in case of the substituents being halogen 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F and C 1 to C 4 alkyl such as methyl, said C 1 to C 4 alkyl in turn optionally being substituted with, as valence permits, 1, 2, 3, 4, 5, 6, 7 or 8 substituents, said substituents being chosen from halogen such as F, and the double bond in said n-alken-1,ω-diyl being at any one of positions 1, 2, 3, 4,... and (ω-1); each occurrence of Y is independently selected to be an α-amino acid or α-hydroxy acid; k is an integer number selected from 0, 1, 2, 3, 4, 5, 6 and 7; m is an integer number selected from 1, 2, 3 and 4; Z 1 is a polar or negatively charged α-amino acid or α-hydroxy acid; and Z 2 is a an aliphatic hydrophobic α-amino acid or α-hydroxy acid; the N-terminus of said peptide or depsipeptide is free; protected, preferably acetylated; or conjugated, preferably to a cell-penetrating peptide or a lipid; and the C-terminus of said peptide or depsipeptide is free; protected, preferably amidated; or conjugated, preferably to a cell-penetrating peptide or a lipid.
摘要翻译：本发明涉及式（I）（Y）kX1YZ1X2Z2（Y）m（I）的肽或缩肽，其中X1是式（IIa）-A- （IIb）-A-CR 3 R 4 -CO-（IIb）的α-氨基酸残基或α-羟基酸残基，其中A是NH或O; R1和R3独立地选自H，卤素如F，取代或未取代的C1至C4烷基如甲基，取代或未取代的芳基和取代或未取代的芳基烷基，芳基为与0,1或2元连接的5元或6元环， 2或3个杂原子，杂原子选自O，N和S，所述芳基烷基中的烷基为C 1 -C 4烷基，所述芳基烷基中的所述烷基任选被取代，当涉及R 1和R 3时，术语“取代的” 作为化合价允许有1,2,3,4,5,6,7或8个取代基，所述取代基选自卤素如F; R2和R4一起被选择为取代或未取代的n-烷基-1，ω-二基或取代或未取代的n-链烯-1，ω-二基，ω是选自6,7,8,9,10的整数，11,12,13和14中，当涉及R2和R4时，术语“取代的”提供1或2，在取代基为卤素1,2,3,4,5,6,7或8的情况下取代基，所述取代基选自卤素如F和C1-C4烷基如甲基，所述C1-C4烷基进而任选地被1,2,3或4个取代基取代， 8个取代基，所述取代基选自卤素如F，并且所述正链烯-1，ω-二基中的双键位于1,2,3,4，...和（ω-1））; 每次出现的Y独立地选择为α-氨基酸或α-羟基酸; k是选自0,1,2,3,4,5,6和7的整数; m是选自1,2,3和4的整数; Z1是极性或带负电荷的α-氨基酸或α-羟基酸; Z2是脂肪族疏水性α-氨基酸或α-羟基酸; 所述肽或缩肽的N-末端是游离的; 保护的，优选乙酰化的; 或缀合的，优选地与细胞穿透肽或脂质偶联; 并且所述肽或缩肽的C末端是游离的; 受保护的，优选酰胺化的; 或缀合的，优选地与细胞穿透肽或脂质缀合。

2. 发明公开

EP1599497A2 CRYSTAL STRUCTURE OF THE TERNARY COMPELEX OF 14-3-3, FUSICOCCIN, AND PLASMA MEMBRANE ATPASE AND METHODS FOR DESIGNING NEW HERBICIDES 有权
标题翻译： 14-3-3，fusicoccin和质膜ATP酶和方法的三元复合物的晶体结构来设计新型除草剂
公开(公告)号：EP1599497A2
公开(公告)日：2005-11-30
申请号：EP04714780.6
申请日：2004-02-26
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： WITTINGHOFER, Alfred , WÜRTELE, Martin , OECKING, Claudia , JELICH-OTTMANN, Christian
IPC分类号： C07K14/415 , C12N15/29 , A01H5/00
CPC分类号： C07K14/415 , C07K2299/00
摘要： The present invention relates to a crystal of a ternary complex composed of the protein 14-3-3, a ligand thereof and a fragment of Plasma Membrane ATPase (PMA) comprising the coordinates of table 4 or coordinates which differ from the coordinates of table 4 by a root mean square deviation of the C-alpha atoms of less than 3 Angstrom, wherein (a) protein 14-3-3 consists of the amino acid sequence of SEQ ID NO: 1 or of the sequence of a species homolog; (b) the ligand is Fusicoccin; (c) PMA is a C-terminal peptide of up to 15 amino acid residues in 'length; comprising the amino acid sequence of SEQ ID NO: 2 or comprising the sequence of a species homolog. Moreover, the invention also relates to methods for obtaining crystals of 14-3-3 in ternary complex and to methods relating to the determination of said 14-3-3 crystal coordinates. In addition, the present invention relates to computer modeling of crystal coordinates, to methods for developing a ligand binding to the complex of protein 14-3-3 and PMA and to methods for identifying a potential ligand to the complex of 14-3-3 and PMA. Furthermore, the present invention relates to a method for identifying and selecting a protein or protein complex with increased affinity to a ligand, to nucleic acid molecules encoding PMA or 14-3-3 with decreased affinity to a ligand and to methods of generating transgenic plants encoding PMA or 14-3-3 with decreased affinity to said ligand. Finally, the present invention relates to a device for developing a ligand for the complex of PMA and 14-3-3 and to the use of said device.

3. 发明授权

EP0971692B1 SPEZIFISCHE MAGNETOSOMEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG 失效
标题翻译：具体磁预兆，制造方法相同，它们的用途
公开(公告)号：EP0971692B1
公开(公告)日：2003-03-05
申请号：EP98919046.7
申请日：1998-03-06
申请人： MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： BÄUERLEIN, Edmund , SCHÜLER, Dirk , RESZKA, Regina , PÄUSER, Sabine
IPC分类号： A61K9/00
CPC分类号： A61K49/1812 , A61K33/26 , A61K41/0004 , A61K41/0052 , A61K48/00 , A61N2/06 , C12N15/88

4. 发明授权

EP0839205B1 LEBERSPEZIFISCHER ADENOVIRUS-EXPRESSIONSVEKTOR 失效
标题翻译：肝特异性腺病毒表达载体
公开(公告)号：EP0839205B1
公开(公告)日：2000-02-02
申请号：EP96923829.4
申请日：1996-07-08
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： SANDIG, Volker , LÖSER, Peter , STRAUSS, Michael
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2710/10351 , C12N2730/10122 , C12N2830/008
摘要： The invention concerns an adenovirus vector for liver-specific gene therapy. Areas of application include, in medicine, the treatment of genetic defects and tumour diseases of the liver, and molecular biology. The vector according to the invention is characterized in that a therapeutic gene which is coupled to a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancer-less minimal promoter and is optionally surrounded by SAR elements is inserted in the adenovirus genome.

5. 发明公开

EP0941466A2 VERFAHREN UND ANORDNUNG ZUM BESTIMMEN VORGEGEBENER EIGENSCHAFTEN VON ZIELPARTIKELN EINES PROBENMEDIUMS 失效
标题翻译：方法和系统用于确定样本介质的目标颗粒受控性能
公开(公告)号：EP0941466A2
公开(公告)日：1999-09-15
申请号：EP97952809.0
申请日：1997-11-26
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin , EVOTEC BioSystems Aktiengesellschaft
发明人： SEIDEL, Claus , BRAND, Leif , GÜNTHER, Rolf
IPC分类号： C12M1 , G01N15 , G01N21
CPC分类号： G01N15/0211 , C12M41/46 , G01N15/02 , G01N21/6408 , G01N2015/0222
摘要： The method or device expand the field of application of fluorescent correlation spectroscopy. The device has a confocal optical structure, a pulsed laser (20) for excitation and components for detection (8) and evaluation (27) of measuring signals for time-correlated single photon counting. The data is registered in such a way that for each detected photon, detection time is recorded in microseconds while fluorescence delay time is recorded in nanoseconds. This maximum information on each detected photon is used to assign parameters determined by time-correlated single photon counting to each detected photon and create correlation functions for the determined parameters arising therefrom. Correlation functions of parameters or selective correlation functions, e.g. for fluorescence burning life, are thus obtained. The method or device can also be used to detect individual molecules and to calculate correlation functions only for those signal segments which are assigned to the individually existing particles, thereby enabling improvement of the signal-to-noise ratio in extremely diluted solutions.

6. 发明授权

EP0695417B1 ULTRASCHALLMESSGERÄT MIT EINEM RESONATORKAMMERKÖRPER UND AUSSEN ANGEORDNETEN ELEKTRO-AKUSTISCHEN WANDLERN 失效
标题翻译： WITH A谐振腔超声仪表和向外排列电声换能
公开(公告)号：EP0695417B1
公开(公告)日：1999-06-30
申请号：EP94915101.3
申请日：1994-04-22
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： BUCKIN, Vitaly , DE MAEYER, Leo , FUNCK, Theodor
IPC分类号： G01H13/00
CPC分类号： G01H13/00 , G01N29/036 , G01N2291/102
摘要： Ultrasonic resonators consist of a resonator chamber body (11) and one or several electro-acoustic transducers (13, 14). The resonator body is made of a non-piezoelectric material; it forms a resonance cavity for receiving a sample. This resonance cavity is designed so that a resonance wave field of stationary linear acoustic waves is formed between the acoustically excited inner walls. The electro-acoustic transducers are acoustically coupled to the outside of the resonator chamber body in a fixed, removable or movable manner.

7. 发明公开

EP0731173A2 Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge 失效
标题翻译： Verfahren zum direkten Nachweisen wenigerNucleinsäurestränge
公开(公告)号：EP0731173A2
公开(公告)日：1996-09-11
申请号：EP95119546.0
申请日：1995-12-12
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： Eigen, Manfred, Prof.Dr. , Rigler, Rudolf, Dr.
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： C12Q1/6816 , C12Q2565/107 , C12Q2561/113 , C12Q2537/143
摘要： Ein Verfahren zum direkten Nachweisen weniger, vorzugsweise einzelner Nucleinsäurestränge einer bestimmten Zielsequenz (10) in einer Untersuchungslösung umfaßt die folgenden Schritte:

a) Bereitstellen einer Testlösung mit einem Gemisch (11) unterschiedlicher, kurzer Primer (12, 13, 14), die jeweils eine zu einem Abschnitt (a, b, c) der Zielsequenz (10) komplementäre, sogenannte Antisense-Sequenz (a', b', c') aufweisen und mit einem oder mehreren Farbstoffmolekülen markiert sind,
b) Mischen der Testlösung mit der Untersuchungslösung und Inkubieren dieser gemischten Lösung (15) unter Hybridisierung der Primer (12, 13, 14) mit den nachzuweisenden Nucleinsäuresträngen zulassenden Randbedingungen, und dann
c) Identifizieren der Zielsequenz (10) in der inkubierten Lösung (15) mit einer Apparatur (20) für optische Analysen, die dazu ausgelegt ist, wenige, vorzugsweise einen der nachzuweisenden Nucleinsäurestränge, an die bzw. den ein oder mehrere Primer (12, 13, 14) hybridisiert ist bzw. sind, vor dem Hintergrund der nicht hybridisierten Primer (12, 13, 14) zu diskriminieren.
摘要翻译：直接检测少数，尤其是单一的核酸链靶序列（10）包括：（a）制备测试溶液。 contg。混合的不同的短引物（12-14），其各自具有与（10）的片段互补并用≥1个荧光染料标记的反义序列; （b）孵化该测试溶液。和杂交条件下的样品; （c）使用能够区分与引物杂交的（10）和非杂交引物的背景的光学分析系统鉴定（10）。还有一种类似的方法，使用一个长的引物，用许多荧光染料摩尔标记。并与（实际）整个靶序列互补。

8. 发明授权

EP0637398B1 EINRICHTUNG ZUR OPTISCHEN ABTASTUNG EINES AUFZEICHNUNGSTRÄGERS, INSBESONDERE EINER PHOSPHORSPEICHERPLATTE 失效
标题翻译：装置用于光学扫描的记录介质上，特别是荧光粉DISK
公开(公告)号：EP0637398B1
公开(公告)日：1996-07-03
申请号：EP93911506.9
申请日：1993-04-26
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： SCHRÖDER, Rasmus , BURMESTER, Christoph
IPC分类号： G11B7/12 , G11B7/00 , G11C13/04 , H01J37/22 , G06K7/10
CPC分类号： H01J37/224 , G06K7/10 , G11B7/0033 , G11B7/123 , G11C13/04
摘要： Device for the optical scanning of a recording medium, especially a phosphor storage plate (12), with a scanning head (10) which can move in relation to the recording medium and contains an imaging system in the form of an extended rotation-ellipsoidal mirror (14). The ellipsoidal mirror (14) has an inlet (16) and an outlet aperture (18) at opposite ends. A scanning laser beam (30) impinges obliquely on the storage plate (12) moving past the inlet aperture (16). A reverse-tapering chamber (20) and a photodetector (24) are connected to the outlet aperture (18).

9. 发明授权

EP0621965B1 PC-GESTEUERTER DIRECT-DIGITAL-SYNTHESIZER 失效
公开(公告)号：EP0621965B1
公开(公告)日：1996-04-03
申请号：EP93902217.4
申请日：1993-01-15
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： FUNCK, Theodor , BUCKIN, Vitali
IPC分类号： G06F1/03
CPC分类号： G06F1/0328
摘要： A direct digital synthesiser (DDS) (1) or digitally operating function generator contains one or more channels (A, B, ...), each with a phase increment register, and is controlled by a computer installation (2) (e.g. a PC) via the transmission of information bits to the DDS (1) by the computer installation (2). Each phase increment register has a given bit width and a stored phase P in operation at all times. A phase increment Q with a given bit length is added by specific process steps which prevents overflow. During control, a hardware protocol (4) with a multiplexer ensures that the information bits transmitted by the computer installation (2) to the DDS (1) are effective as either address or data bits.

10. 发明授权

EP0432241B1 PROBENKOPF FÜR DIE KERNRESONANZ-GANZKÖRPER-TOMOGRAPHIE ODER DIE ORTSABHÄNGIGE IN-VIVO KERNRESONANZ-SPEKTROSKOPIE 失效
标题翻译：样品头核磁共振全身CT或局部主体体内核磁共振光谱。
公开(公告)号：EP0432241B1
公开(公告)日：1995-09-06
申请号：EP90909336.1
申请日：1990-06-23
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin
发明人： BRUNNER, Hermann , HAUSSER, Karl, Hermann , VEITH, Werner
IPC分类号： G01R33/34
CPC分类号： G01R33/34053 , G01R33/34007 , G01R33/34046 , G01R33/34061 , G01R33/343 , G01R33/3628
摘要： The invention concerns a probe head (50) for whole-body nuclear-resonance tomography or local in vivo nuclear-resonance spectroscopy, comprising a high-frequency coil (51) with a series of inductive sections in the form of metal strips (53-60) disposed alternately with capacitative sections in the form of gaps (61-68) along the line of the high-frequency current (I1) in such a way that the lines of force (72) of the magnetic field (H1) generated by the high-frequency coil (51) run parallel to an axis (74) defined by the high-frequency coil (51). The high-frequency coil (51) forms, together with an outer wall (52), a single unit. The number of inductive and capacitative sections is chosen so that it lies just below the limiting value at which a transition occurs in the distribution of the lines of force (71) of the high-frequency electric field (E1) generated by the high-frequency coil (51), the transition being from a first distribution (75), in which between each section (55) and the axis (74) there is a plane (76) in which the strength of the high-frequency electric field (E1) is zero, to a second distribution, in which the strength of the high-frequency electric field (E1), irrespective of the number of inductive sections, is substantially rotationally symmetrical about the axis and increases linearly from the axis towards the high-frequency coil.

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