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1. 发明授权

EP3270383B1 SELF-ALIGNING RADIOISOTOPE ELUTION SYSTEM 有权转让
公开(公告)号：EP3270383B1
公开(公告)日：2019-08-28
申请号：EP17183074.8
申请日：2007-10-03
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： HORTON, Duane , SPETH, Andrew
IPC分类号： G21F5/018 , G21G4/08 , G21H5/02

2. 发明授权

EP2663523B1 PROCESS AND APPARATUS FOR TREATING A GAS STREAM 有权转让
公开(公告)号：EP2663523B1
公开(公告)日：2018-10-10
申请号：EP12702647.4
申请日：2012-01-11
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： BARBOSA, Luis
IPC分类号： C01B3/08 , C01B5/00 , G21C9/00 , G21C9/06 , G21C19/46 , G21G1/00
CPC分类号： B01J10/00 , B01D53/46 , C01B3/08 , C01B5/00 , G21C9/00 , G21C9/06 , G21C19/46 , G21G1/001 , G21G2001/0036 , Y02E60/36 , Y02W30/883
摘要： A process of treating hydrogen gas liberated from the acid or alkaline dissolution of a metal is provided. The process comprises a step of passing the liberated hydrogen gas through a reactor containing an oxidizing agent for oxidation of the hydrogen gas into water, followed by a step of regenerating the oxidizing agent. Also provided is an apparatus for carrying out the process, the apparatus comprising a reactor containing the oxidizing agent, wherein the reactor is at least partially immersed in an alumina bath.

3. 发明授权

EP3101659B1 SELF-ALIGNING RADIOISOTOPE ELUTION SYSTEM 有权
公开(公告)号：EP3101659B1
公开(公告)日：2017-07-26
申请号：EP16180032.1
申请日：2007-10-03
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： Horton, Duane , Speth, Andrew
IPC分类号： G21F5/018 , G21G4/08 , G21G1/00
CPC分类号： G21F5/12 , G21F3/00 , G21F5/015 , G21F5/018 , G21F5/06 , G21G1/0005 , G21G4/08 , G21H5/02

4. 发明授权

EP2993669B1 PURIFICATION APPARATUS FOR MO-99 有权转让
标题翻译： REINIGUNGSVORRICHTUNGFÜRMO-99
公开(公告)号：EP2993669B1
公开(公告)日：2017-02-01
申请号：EP15185983.2
申请日：2011-08-02
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： BARBOSA, Luis A.M.M.
IPC分类号： G21G1/00
CPC分类号： C22B34/34 , G21G1/001 , G21G2001/0036
摘要： A process for purifying Mo-99 from an acidic solution obtained by dissolving an irradiated solid target comprising uranium in an acidic medium, or from an acidic solution comprising uranium and which has previously been irradiated in a nuclear reactor, or from an acidic solution comprising uranium and which has been used as reactor fuel in a homogeneous reactor, the process comprising contacting the acidic solution with an adsorbent comprising a zirconium oxide, zirconium hydroxide, zirconium alkoxide, zirconium halide and/or zirconium oxide halide, and eluting the Mo-99 from the adsorbent using a solution of a strong base, the eluate then being subjected to a subsequent purification process involving an alkaline-based Mo-99 chromatographic recovery step on an anion exchange material. Also provided is apparatus for carrying out the process.
摘要翻译：从酸性溶液中提取Mo-99的方法，该酸性溶液通过将包含铀的照射固体靶在酸性介质中或从包含铀的酸性溶液中溶解并预先在核反应器中照射的酸性溶液或由包含铀的酸性溶液并且其已经在均相反应器中用作反应堆燃料，该方法包括使酸性溶液与包含氧化锆，氢氧化锆，烷氧基锆，卤化锆和/或氧化锆卤化物的吸附剂接触，并将Mo-99从吸附剂使用强碱溶液，然后将洗脱液进行在阴离子交换材料上进行碱性Mo-99色谱回收步骤的随后纯化过程。还提供了用于执行该过程的装置。

5. 发明授权

EP2074633B8 SELF-ALIGNING RADIOISOTOPE ELUTION SYSTEM 有权转让
标题翻译：自调心放射性同位素洗脱系统
公开(公告)号：EP2074633B8
公开(公告)日：2016-09-21
申请号：EP07852540.9
申请日：2007-10-03
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： HORTON, Duane, L. , SPETH, Andrew, D.
IPC分类号： G21F5/018 , G21G4/08 , G21H5/02
CPC分类号： G21F5/12 , G21F3/00 , G21F5/015 , G21F5/018 , G21F5/06 , G21G1/0005 , G21G4/08 , G21H5/02

6. 发明授权

EP3014628B8 PROCESS OF GENERATING GERMANIUM-68 有权转让
公开(公告)号：EP3014628B8
公开(公告)日：2018-06-06
申请号：EP14742078.0
申请日：2014-06-26
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： UHLAND, Dr. William C. , PIPES, Dr. David Wayne , PERRIGO, Melissa Dianne
IPC分类号： G21G1/00 , G21G1/10
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0094 , H05H6/00
摘要： The present disclosure generally relates to a new process for generating germanium-68 from an irradiated target body. The process includes irradiation of the target body followed by various extraction techniques to generate the germanium-68.

7. 发明公开

EP3258913A1 MODIFIED DOCETAXEL LIPOSOME FORMULATIONS AND USES THEREOF 审中-公开
标题翻译：改性的多西紫杉醇脂制剂及其用途
公开(公告)号：EP3258913A1
公开(公告)日：2017-12-27
申请号：EP16710529.5
申请日：2016-02-17
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： MCGHEE, William , BLACKLEDGE, James , GRAPPERHAUS, Margaret , ROCHON, Louise S. , DEVARAKONDA, Krishna
IPC分类号： A61K9/00 , A61K9/127 , A61K31/337
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K47/12 , A61K47/24 , A61K47/28
摘要： The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG- lipid, and a taxane, The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2'-O position with a heterocyciyl-(C
2-5 alkanoic acid), The present invention also provides liposomal compositions for the treatment of cancer comprising administering to a patient, in need thereof a liposome, wherein the liposome comprises: a phosphatidylcholine lipid; a sterol; a PEG-lipid; and a taxane or a pharmaceutically acceptable salt thereof; wherein the taxane is docetaxel esterified at the 2'-O-position with a heterocyclyl-(C
2-5 alkanoic acid); and wherein upon administration of the liposomal composition to the patient, the plasma concentration of docetaxel remain above an efficacy threshold of 0,2 μΜ for at least 5 hours.

8. 发明公开

EP3424876A1 PROCESS FOR TREATING A GAS STREAM 有权转让
公开(公告)号：EP3424876A1
公开(公告)日：2019-01-09
申请号：EP18189206.8
申请日：2012-01-11
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： BARBOSA, Luis
IPC分类号： C01B3/08 , C01B5/00 , G21C19/46 , G21G1/00
摘要： A process of treating hydrogen gas liberated from the acid or alkaline dissolution of a metal is provided. The process comprises a step of passing the liberated hydrogen gas through a reactor containing an oxidising agent for oxidation of the hydrogen gas into water, followed by a step of regenerating the oxidising agent, wherein the oxidising agent comprises a metal oxide finely dispersed on an inert carrier and/or diluted with an inert, thermally-conductive diluent.

9. 发明公开

EP3270383A1 SELF-ALIGNING RADIOISOTOPE ELUTION SYSTEM 有权转让
标题翻译：自对准放射性同位素排放系统
公开(公告)号：EP3270383A1
公开(公告)日：2018-01-17
申请号：EP17183074.8
申请日：2007-10-03
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： HORTON, Duane , SPETH, Andrew
IPC分类号： G21F5/018 , G21G4/08 , G21H5/02
CPC分类号： G21F5/12 , G21F3/00 , G21F5/015 , G21F5/018 , G21F5/06 , G21G1/0005 , G21G4/08 , G21H5/02
摘要： A radioisotope elution system including a radioisotope generator having an alignment structure. The alignment structure may be configured to interface with a complementary alignment structure of an auxiliary radiation shield assembly.
摘要翻译：包括具有对准结构的放射性同位素发生器的放射性同位素洗脱系统。对准结构可以被配置为与辅助辐射屏蔽组件的互补对准结构对接。

10. 发明授权

EP2625695B1 PROCESS FOR EXTRACTING CS-137 FROM AN ACIDIC SOLUTION 有权转让
标题翻译：从酸性溶液中提取CS-137的方法
公开(公告)号：EP2625695B1
公开(公告)日：2017-07-19
申请号：EP11773620.7
申请日：2011-10-06
申请人： Mallinckrodt Nuclear Medicine LLC
发明人： BARBOSA, Luis, A.M.M.
IPC分类号： G21G1/08 , G21G1/00
CPC分类号： G21G1/001 , B01D15/08 , B01D24/007 , B01J20/0211 , B01J20/0218 , C02F1/281 , C02F1/62 , G21F9/12 , G21G1/08 , G21G2001/0036 , G21G2001/0068
摘要： A process for extracting Cs-137 from i) an acidic solution obtained by dissolving an irradiated solid target comprising uranium, ii) an acidic solution comprising uranium which has previously been irradiated in a nuclear reactor, or iii) an acidic solution comprising uranium which has been used as reactor fuel in a homogeneous reactor, the acidic solution i), ii) or iii) having been treated to harvest Mo-99, wherein the process comprises contacting the treated acidic solution with an adsorbent comprising ammonium molybdophosphate (AMP). In an embodiment, the AMP is combined with an organic or inorganic polymeric support, for example AMP synthesised within hollow aluminosilicate microspheres (AMP-C).
摘要翻译：一种从ⅰ）酸性溶液中提取铯-137的方法，该酸性溶液是通过溶解包含铀的经辐射的固体目标，ii）预先在核反应堆中照射的包含铀的酸性溶液，或者iii）包含铀的酸性溶液，在均相反应器中用作反应器燃料，酸性溶液i），ii）或iii）已经处理以收集Mo-99，其中所述方法包括使处理过的酸性溶液与包含钼磷酸铵（AMP）的吸附剂接触。在一个实施方案中，AMP与有机或无机聚合物载体（例如在中空硅铝酸盐微球（AMP-C）内合成的AMP）组合。

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