专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2776554A4 SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) 有权
标题翻译：系统和用于进行扩增救援多重聚合酶链式反应法（PCR）
公开(公告)号：EP2776554A4
公开(公告)日：2015-09-23
申请号：EP12848324
申请日：2012-11-12
申请人： ICUBATE INC
发明人： BERTRAND JEFF , HAN JIAN
IPC分类号： C12M1/40 , B01L3/00 , B01L3/02 , B01L7/00 , C12Q1/68 , G01N35/00 , G01N35/10
CPC分类号： G01N35/00029 , B01L3/021 , B01L3/502 , B01L7/52 , B01L2200/10 , B01L2400/0487 , B01L2400/0644 , C12Q1/6848 , C12Q1/686 , G01N35/10 , G01N35/1011 , G01N35/1081 , G01N2035/00158 , G01N2035/00801 , G01N2035/00851
摘要： Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data. The control element is further configured to analyze the test data received from the reader and to produce an output indicative of a comparison of the test data to predefined data.

2. 发明公开

EP2430177A1 APPARATUS FOR PERFORMING AMPLICON RESCUE MULTIPLEX PCR 有权
标题翻译：用于进行AMPLICON RESCUE MULTIPLEX PCR的装置
公开(公告)号：EP2430177A1
公开(公告)日：2012-03-21
申请号：EP10775636.3
申请日：2010-05-14
申请人： Icubate, Inc.
发明人： BERTRAND, Jeff , HAN, Jian
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01L3/0217 , B01L3/502 , B01L2200/10 , G01N35/10 , G01N35/1011 , G01N35/1081
摘要： A cassette for performing multiplex PCR is described. The cassette allows for the automated amplification and detection of multiple nucleic acid targets while limiting contamination. The device facilitates a two-amplification, two-primer PCR protocol which results in highly specific, highly sensitive and semi-quantitative amplification of multiple nucleic acid targets. The cassette contains a cavity, a base with a plurality of chambers, a movable pipette for the transfer of reagents and a detection area. The cassettes are single use, disposable devices which may be loaded with reagents needed for the detection of multiple targets. The cassettes may be used in a hospital or clinical setting to quickly screen clinical samples and detect the presence of infectious agents.
摘要翻译：描述了用于执行多重PCR的盒。该盒允许自动扩增和检测多个核酸目标，同时限制污染。该装置有利于双扩增双引物PCR方案，其导致多个核酸靶标的高度特异性，高度灵敏和半定量扩增。该盒包含腔体，具有多个腔室的基座，用于转移试剂的可移动移液管和检测区域。盒是单次使用的一次性装置，其可装载用于检测多个目标所需的试剂。这些盒子可用于医院或临床环境中以快速筛选临床样品并检测传染物的存在。

3. 发明公开

EP2776554A1 SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) 有权
标题翻译：系统和用于进行扩增救援多重聚合酶链式反应法（PCR）
公开(公告)号：EP2776554A1
公开(公告)日：2014-09-17
申请号：EP12848324.5
申请日：2012-11-12
申请人： Icubate, Inc.
发明人： BERTRAND, Jeff , HAN, Jian
IPC分类号： C12M1/40
CPC分类号： G01N35/00029 , B01L3/021 , B01L3/502 , B01L7/52 , B01L2200/10 , B01L2400/0487 , B01L2400/0644 , C12Q1/6848 , C12Q1/686 , G01N35/10 , G01N35/1011 , G01N35/1081 , G01N2035/00158 , G01N2035/00366 , G01N2035/00801 , G01N2035/00851
摘要： Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data. The control element is further configured to analyze the test data received from the reader and to produce an output indicative of a comparison of the test data to predefined data.

4. 发明公开

EP3517971A1 SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) 无效
公开(公告)号：EP3517971A1
公开(公告)日：2019-07-31
申请号：EP19164708.0
申请日：2012-11-12
申请人： Icubate, Inc.
发明人： EWING, Phillip , BERTRAND, Jeff , HAN, Jian
IPC分类号： G01N35/00 , B01L7/00 , C12Q1/686
摘要： The present disclosure generally pertains to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). The system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

5. 发明授权

EP2776554B1 SYSTEMS AND METHODS FOR PERFORMING AMPLICON RESCUE MULTIPLEX POLYMERASE CHAIN REACTION (PCR) 有权
公开(公告)号：EP2776554B1
公开(公告)日：2019-03-27
申请号：EP12848324.5
申请日：2012-11-12
申请人： Icubate, Inc.
发明人： BERTRAND, Jeff , HAN, Jian , EWING, Phillip
IPC分类号： C12M1/40 , B01L3/00 , B01L3/02 , B01L7/00 , C12Q1/68 , G01N35/00 , G01N35/10 , C12Q1/686

6. 发明公开

EP3453767A1 APPARATUS FOR PERFORMING AMPLICON RESCUE MULTIPLEX PCR 无效
公开(公告)号：EP3453767A1
公开(公告)日：2019-03-13
申请号：EP18195976.8
申请日：2010-05-14
申请人： Icubate, Inc.
发明人： BERTRAND, Jeff , HAN, Jian
IPC分类号： C12P19/34 , B01L3/00
摘要： The present disclosure is a cassette for PCR amplification and detection of DNA amplicons, the cassette having a cassette pipette which may be moved vertically and horizontally within the cassette, at least one reagent chamber, and at least one detector, such as a microarray, for the detection of DNA amplified during the PCR amplification steps.

7. 发明授权

EP2430177B1 APPARATUS FOR PERFORMING AMPLICON RESCUE MULTIPLEX PCR 有权
公开(公告)号：EP2430177B1
公开(公告)日：2018-09-26
申请号：EP10775636.3
申请日：2010-05-14
申请人： Icubate, Inc.
发明人： BERTRAND, Jeff , HAN, Jian
IPC分类号： C12P19/34 , B01L3/00
CPC分类号： B01L7/52 , B01L3/0217 , B01L3/502 , B01L2200/10 , G01N35/10 , G01N35/1011 , G01N35/1081
摘要： A cassette for performing multiplex PCR is described. The cassette allows for the automated amplification and detection of multiple nucleic acid targets while limiting contamination. The device facilitates a two-amplification, two-primer PCR protocol which results in highly specific, highly sensitive and semi-quantitative amplification of multiple nucleic acid targets. The cassette contains a cavity, a base with a plurality of chambers, a movable pipette for the transfer of reagents and a detection area. The cassettes are single use, disposable devices which may be loaded with reagents needed for the detection of multiple targets. The cassettes may be used in a hospital or clinical setting to quickly screen clinical samples and detect the presence of infectious agents.

8. 发明公开

EP2430177A4 APPARATUS FOR PERFORMING AMPLICON RESCUE MULTIPLEX PCR 有权
标题翻译：进行ARM-PCR的装置
公开(公告)号：EP2430177A4
公开(公告)日：2013-07-24
申请号：EP10775636
申请日：2010-05-14
申请人： ICUBATE INC
发明人： BERTRAND JEFF , HAN JIAN
IPC分类号： C12P19/34 , B01L3/00
CPC分类号： B01L7/52 , B01L3/0217 , B01L3/502 , B01L2200/10 , G01N35/10 , G01N35/1011 , G01N35/1081
摘要： A cassette for performing multiplex PCR is described. The cassette allows for the automated amplification and detection of multiple nucleic acid targets while limiting contamination. The device facilitates a two-amplification, two-primer PCR protocol which results in highly specific, highly sensitive and semi-quantitative amplification of multiple nucleic acid targets. The cassette contains a cavity, a base with a plurality of chambers, a movable pipette for the transfer of reagents and a detection area. The cassettes are single use, disposable devices which may be loaded with reagents needed for the detection of multiple targets. The cassettes may be used in a hospital or clinical setting to quickly screen clinical samples and detect the presence of infectious agents.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式