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1. 发明授权

EP2998395B1 METHOD FOR PRODUCING LACTASE-CONTAINING COMPOSITIONS 有权
公开(公告)号：EP2998395B1
公开(公告)日：2019-04-10
申请号：EP14798365.4
申请日：2014-05-12
申请人： Godo Shusei Co., Ltd.
发明人： YOSHIKAWA, Jun , SHIOTA, Kazuma
IPC分类号： C12N9/38 , A23C9/12 , C12N9/50

2. 发明公开

EP3187582A1 LACTASE SOLUTION AND MILK USING SAME 审中-公开
标题翻译：乳糖溶液和牛奶使用相同
公开(公告)号：EP3187582A1
公开(公告)日：2017-07-05
申请号：EP15836159.2
申请日：2015-08-26
申请人： Godo Shusei Co., Ltd.
发明人： OGASAWARA, Junki , HORIGUCHI, Hirofumi
IPC分类号： C12N9/38 , A23C9/12
CPC分类号： A23C9/12 , A23C9/1206 , B01D61/147 , B01D65/10 , C12Y302/01108
摘要： To provide a method that reduces clogging of a filter device (filter) during a filtering step prior to addition of milk to a previously formulated lactase solution, and to provide a lactase solution which is not prone to having an occurrence of clogging of the filter device. A lactase solution having a permeation rate of 5 kg/min × m 2 or more at the time of permeation of 366 kg/m 2 through a membrane filter with a pore diameter of 0.22 µm at a concentration for having an activity of 1,000 NLU/g or 2,000 ALU/g, after being subjected to a stirring treatment at 100 rpm, 10°C for 16 hours with a concentration for having an activity of 5,000 NLU/g or 10,000 ALU/g.
摘要翻译：为了提供一种方法，该方法在向先前配制的乳糖酶溶液添加牛奶之前的过滤步骤期间减少过滤装置（过滤器）的堵塞，并提供不倾向于发生过滤装置堵塞的乳糖酶溶液。通过孔径为0.22μm的膜滤器以366kg / m 2的渗透时的渗透速率为5kg / min×m 2或更高的乳糖酶溶液，其活性为1,000NLU / g或在以100rpm进行搅拌处理后，在10℃下进行16小时，并具有5,000NLU / g或10,000ALU / g的活性浓度。

3. 发明公开

EP3176259A1 METHOD FOR DECOLORIZING DYE 审中-公开
标题翻译：脱色DYE的方法
公开(公告)号：EP3176259A1
公开(公告)日：2017-06-07
申请号：EP15827983.6
申请日：2015-07-28
申请人： National University Corporation Chiba University , Godo Shusei Co., Ltd.
发明人： AMACHI, Seigo , YOSHIKAWA, Jun , HORIGUCHI, Hirofumi
IPC分类号： C12N9/02 , C02F1/00 , C02F3/34
CPC分类号： D06L4/40 , A61K8/66 , A61Q5/08 , C02F1/766 , C02F3/342 , C02F2101/308 , D06P5/137 , D06P5/158 , D21C5/025
摘要： A novel composition for decolorizing a dye is provided.
A composition for decolorizing a dye contains a multi copper oxidase and an iodide ion.
摘要翻译：提供了一种用于使染料脱色的新型组合物。用于使染料脱色的组合物含有多铜氧化酶和碘离子。

4. 发明授权

EP2687598B1 METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY 有权
标题翻译：工艺审查一个芳基硫酸酯酶活性
公开(公告)号：EP2687598B1
公开(公告)日：2017-02-15
申请号：EP12758277.3
申请日：2012-03-13
申请人： Godo Shusei Co., Ltd.
发明人： SHIOTA, Kazuma , HORIGUCHI, Hirofumi , IYOTANI, Ai , YOSHIKAWA, Jun , SATO, Tomoko
IPC分类号： C12N15/09
CPC分类号： C12Q1/34 , A23C9/1206 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12Q1/44 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108 , G01N2333/916

5. 发明授权

EP0059918B1 Physiologically active novel substance mutastein and process for its production 失效
标题翻译：生理活性的新型物质MUTASTEIN及其生产方法
公开(公告)号：EP0059918B1
公开(公告)日：1986-02-12
申请号：EP82101569.0
申请日：1982-03-01
申请人： Godo Shusei Co., Ltd.
发明人： Endo, Akira
IPC分类号： C12P1/02 , A61K37/02
CPC分类号： C12R1/66 , C12P1/02
摘要： A physiologically active novel substance designated as Mutastein is disclosed, which has the following specific physiological properties: (1) it has a molecular weight of at least 200,000, and when subjected to gel-filtration with Sephadex G-100and Sephallose 6B, it will be eluted in the void volume; (2) its ultraviolet spectrum: FIG. 1; (3) its infrared spectrum: FIG. 2; (4) it has a proteinous nature and contains about 10% of saccharide; (5) it is soluble in water and a saline solution, but it will be salted out from a saturated solution containing about 30% of ammonium salfate; and it is insoluble in acetone, ethanol, ethylacetate and benzene, (6) it dissolves in a buffer solution having a pH 7 or over, but it precipitates at a pH of from 3 to 3.5, (7) it is stable when heat-treated at pH 9, at 100 DEG C. for 10 minutes, (8) its elementary analysis: C: about 44%, H: about 7%, and N: about 12%, (9) its color reactions: Phenol-surfuric acid color reaction (orange), and Folin's color reaction (blue). This substance can be prepared by culturing the Mutastein-producing strain belonging to the genus Aspergillus, and isolating the Mutastein from the culture medium.

6. 发明公开

EP4137569A1 PACKAGED LACTASE SOLUTION 审中-实审
公开(公告)号：EP4137569A1
公开(公告)日：2023-02-22
申请号：EP21788860.1
申请日：2021-04-16
申请人： Godo Shusei Co., Ltd.
发明人： HIGA, Yumiko , OGASAWARA, Junki , SANO, Ryoko , BABA, Masahiro
IPC分类号： C12N9/38 , A23L33/195
摘要： The purpose of the present invention is to provide a packaged lactase solution that hardly causes clogging of a filter. The packaged lactase solution of the present invention, in which a lactase solution is present in a container, is characterized in that the head space volume in the container is controlled to 20% or less relative to the total volume of the container. Also, the packaged lactase solution is characterized in that the lactase solution has a lactase activity within the range of 10-100,000 NLU/g.

7. 发明公开

EP3228705A1 HEAT-RESISTANT ISOAMYLASE 审中-公开
标题翻译：耐热异构酶
公开(公告)号：EP3228705A1
公开(公告)日：2017-10-11
申请号：EP15864800.6
申请日：2015-12-04
申请人： Godo Shusei Co., Ltd.
发明人： HORIGUCHI, Hirofumi , IYOTANI, Ai , SHIOTA, Kazuma
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/44 , C12P19/12
CPC分类号： C12N9/2411 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/746 , C12N15/81 , C12P19/12 , C12P19/16 , C12P19/22 , C12Y302/01068 , C13K7/00
摘要： An isoamylase having improved heat resistance and an industrial method for producing maltose from starch.
The isoamylase is an isoamylase consisting of the amino acid sequence represented by SEQ ID NO: 1 or an isoamylase resulting from deletion, substitution, or insertion of one to several amino acid residues in the amino acid sequence represented by SEQ ID NO: 1, wherein at least valine at amino acid number 515 and methionine at amino acid number 570 are mutated to other amino acids.
摘要翻译：具有改进的耐热性的异淀粉酶和由淀粉生产麦芽糖的工业方法。异淀粉酶是由序列号1表示的氨基酸序列组成的异淀粉酶，或由序列号1表示的氨基酸序列中的1〜数个氨基酸残基的缺失，置换或插入而得到的异淀粉酶，至少氨基酸号515的缬氨酸和氨基酸号570的甲硫氨酸突变为其他氨基酸。

8. 发明公开

EP2871188A1 METHOD FOR SEPARATING CYCLIC MACROLIDE COMPOUND 有权
标题翻译：分离循环MACROLIDE化合物的方法
公开(公告)号：EP2871188A1
公开(公告)日：2015-05-13
申请号：EP13813495.2
申请日：2013-07-05
申请人： Godo Shusei Co., Ltd.
发明人： TSUKUDA, Yuya , MURAMATSU, Keita , SASAKI, Hironori , NAKAMURA, Hirohide
IPC分类号： C07H15/04 , A61K31/706 , A61P37/06 , G01N30/88
CPC分类号： A61K31/7048 , A61K31/436 , B01D15/3833 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/328 , C07H17/08 , G01N30/88 , G01N2030/884
摘要： Provided is a method capable of separating a target cyclic macrolide compound without using a silver compound even when a compound having a double bond similar to the target cyclic macrolide compound is mixed. A method for separating a cyclic macrolide compound from a mixture comprising the cyclic macrolide compound and at least one analogous compound thereof, wherein the mixture is subjected to silica gel column chromatography using an asymmetry identifying agent-immobilized silica gel.
摘要翻译：本发明提供即使混合具有与目标环状大环内酯化合物类似的双键的化合物，也能够在不使用银化合物的情况下分离目标环状大环内酯化合物的方法。从包含环状大环内酯类化合物及其至少一种类似化合物的混合物中分离环状大环内酯类化合物的方法，其中使用不对称识别剂固定化硅胶对混合物进行硅胶柱色谱。

9. 发明公开

EP2687598A1 METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY 有权
标题翻译：工艺审查一个芳基硫酸酯酶活性
公开(公告)号：EP2687598A1
公开(公告)日：2014-01-22
申请号：EP12758277.3
申请日：2012-03-13
申请人： Godo Shusei Co., Ltd.
发明人： SHIOTA, Kazuma , HORIGUCHI, Hirofumi , IYOTANI, Ai , YOSHIKAWA, Jun , SATO, Tomoko
IPC分类号： C12N15/09 , A23L1/30 , A23L1/305 , C12N9/24 , C12Q1/44 , C12N9/16 , C12R1/645
CPC分类号： C12Q1/34 , A23C9/1206 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12Q1/44 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108 , G01N2333/916
摘要： Provided is a method for assaying arylsulfatase activity in aqueous system, which comprises a step for reacting, in an aqueous reaction system with a high ionic strength, arylsulfatase with a substrate thereof, said substrate releasing a fluorophore or a chromophore when subjected to the action of arylsulfatase. Also provided are: a lactase preparation having a lactase activity of 4,000 NLU/g or greater, said lactase activity being assayed by the FCC IV method, and an arylsulfatase activity not greater than 0.1%, said arylsulfatase activity being assayed by the fluorescence method according to the present invention for assaying arylsulfatase activity in aqueous system on the basis of the lactase activity; a method for producing said preparation; and a dairy product with the use of said preparation.

10. 发明公开

EP1977742A1 PREVENTIVE/REMEDY FOR URINARY CALCULOSIS 审中-公开
标题翻译： MITTEL ZUR PRIVENTION / BEHANDLUNG VON HARNSTEINEN
公开(公告)号：EP1977742A1
公开(公告)日：2008-10-08
申请号：EP07706289.1
申请日：2007-01-30
申请人： Godo Shusei Co., Ltd.
发明人： SANAI, Kazuko , TANAKA, Yuko
IPC分类号： A61K31/191 , A23L1/30 , A61K31/365 , A61P13/04
CPC分类号： A61K31/365 , A23L33/10 , A61K31/191
摘要： The present invention relates to a prophylactic/therapeutic drug for urolithiasis containing as an active ingredient L-aldonic acid, a salt thereof, or a lactone form thereof.
摘要翻译：本发明涉及含有L-阿糖醛酸，其盐或其内酯形式作为活性成分的尿石症的预防/治疗药物。

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