专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3416669A1 MEANS AND METHODS FOR TREATING BACTERIAL INFECTIONS 审中-公开
公开(公告)号：EP3416669A1
公开(公告)日：2018-12-26
申请号：EP17708179.1
申请日：2017-02-16
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften , Freie Universität Berlin , Universität zu Lübeck , Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
发明人： BRANDENBURG, Klaus , HEINBOCKEL, Lena , REILING, Norbert , MARTINEZ DE TEJADA, Guillermo , SCHÜRHOLZ, Tobias , MAUSS, Karl , WEINDL, Günther
IPC分类号： A61K38/10 , C07K7/08 , C07K14/47
CPC分类号： C07K14/4723 , A61K38/00 , C07K7/08 , Y02A50/473
摘要： The present invention relates to a pharmaceutical composition comprising or consisting of a combination of (a) two or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking; or (b) one or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11 ) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking, and one or more antibiotics selected from small organic molecule antibiotics such as ceftriaxone, oxacillin, amoxicillin, amikacin, ciprofloxacin, erythromycin, imipenem and tetracycline, and peptidic antibiotics such as daptomycin and vancomycin.

2. 发明公开

EP3481392A1 ACC INHIBITORS FOR USE IN TREATING MYCOBACTERIAL DISEASES 有权
公开(公告)号：EP3481392A1
公开(公告)日：2019-05-15
申请号：EP17734362.1
申请日：2017-07-05
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： REILING, Norbert , BRANDENBURG, Julius
IPC分类号： A61K31/427 , A61K31/5377 , A61K31/00 , A61K45/06 , A61K31/133 , A61K31/4409 , A61K31/496 , A61K31/4965 , A61P31/04 , A61P31/06 , A61P31/08

3. 发明授权

EP2542286B1 VENTILATION DEVICE 有权
标题翻译：通风设备
公开(公告)号：EP2542286B1
公开(公告)日：2017-09-27
申请号：EP11704937.9
申请日：2011-02-18
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： RÜLLER, Stephan , GREVE, Susanne
IPC分类号： A61M16/00 , A61M16/20
CPC分类号： A61M16/00 , A61M16/0069 , A61M16/024 , A61M16/201 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039

4. 发明公开

EP3176175A1 METHOD FOR SYNTHETICALLY PRODUCING ARABINOGALACTAN COMPOUNDS DERIVED FROM PLANTS AND USES OF SAID COMPOUNDS FOR THE PROPHYLAXIS OF ALLERGIC REACTIONS 有权转让
标题翻译：处理综合ARABINOGALACTANVERBINDUNGEN的制剂，其来源是植物和化合物的使用过敏反应的预防
公开(公告)号：EP3176175A1
公开(公告)日：2017-06-07
申请号：EP15197381.5
申请日：2015-12-01
申请人： Protectimmun GmbH , Ruhr-Universität Bochum , Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： Peters, Marcus , Holst, Otto , Vogel, Christian , Voss, Alice
IPC分类号： C07H15/04 , A61K31/7028 , A61P29/00
CPC分类号： C07H15/04 , A61K31/7028
摘要： The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.
摘要翻译：本发明涉及-L-阿糖 - 寡糖，尤其是合成制备的L-阿拉伯 - 寡糖及其在哺乳动物过敏反应的预防用途。

5. 发明公开

EP3197461A1 NEW IMMUNOSTIMULATORY COMPOUNDS 审中-实审转让
标题翻译：新的免疫刺激化合物
公开(公告)号：EP3197461A1
公开(公告)日：2017-08-02
申请号：EP15770891.8
申请日：2015-09-28
申请人： Bernhard-Nocht-Institut für Tropenmedizin , Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： LOTTER, Hannelore , BERNIN, Hannah , TANNICH, Egbert , GONZALEZ-ROLDAN, Nestor , FUJIMOTO, Yukari , FUKASE, Koichi
IPC分类号： A61K31/683 , A61K31/7034 , C07H15/20 , C07F9/10 , A61P35/00 , A61P33/02 , A61K35/15 , A61P33/00 , A61P31/00
CPC分类号： C07F9/117 , A61K31/683 , A61K31/7034 , A61K35/15 , A61K39/0011 , A61K39/39 , A61K2039/5154 , A61K2039/54 , A61K2039/55511 , C07F9/6552 , C07F9/65586 , C07H15/207 , Y02A50/403 , Y02A50/41 , Y02A50/478 , Y02A50/486
摘要： The present invention relates to novel immunostimulatory molecules which are derived from the intestinal protozoan Entamoeba histolytica. The compounds have been found to be useful for enhancing and/or inducing an immune response in a subject in need thereof. Specifically, the compounds have been found to be useful for the treatment of cancer diseases, such as breast cancer, and parasitic diseases, such as leishmaniasis. The invention also provides pharmaceutical compositions comprising the novel compounds.
摘要翻译：本发明涉及源自肠原生动物溶组织内阿米巴的新型免疫刺激分子。已经发现该化合物可用于在有需要的受试者中增强和/或诱导免疫应答。具体而言，已经发现该化合物可用于治疗癌症疾病如乳腺癌和寄生虫病如利什曼病。本发明还提供了包含这些新化合物的药物组合物。

6. 发明公开

EP3124976A1 IMPROVED BACTERIAL ENDOTOXIN TEST FOR THE DETERMINATION OF ENDOTOXINS 有权转让
标题翻译： VERBESSERTER BKTERIELLER ENDOTOXINTEST ZUR BESTIMMUNG VON ENDOTOXINEN
公开(公告)号：EP3124976A1
公开(公告)日：2017-02-01
申请号：EP15178683.7
申请日：2015-07-28
申请人： F. Hoffmann-La Roche AG , Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： DEUTSCHMANN, Sven , LANG, Pierre , VON WINTZINGERODE, Friedrich , ALEXANDER, Christian , ZAEHRINGER, Ulrich
IPC分类号： G01N33/579
CPC分类号： G01N33/56911 , G01N1/38 , G01N33/579
摘要： Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-free aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly the limulus amoebocyte lysate assay.
摘要翻译：本文报道了在抗体（已经使用细菌细胞产生）的样品中测定低浓度的细菌内毒素的方法，包括以下顺序的以下步骤：i）向样品中加入镁离子，ii）稀释样品，iii）对无内毒素水溶液透析pH值为5.7-8.0的样品，以及iv）使用细菌内毒素试验，特别是鲎变形细胞裂解物测定法测定样品中的细菌内毒素。

7. 发明公开

EP2271356A1 NOVEL ANTIMICROBIAL PEPTIDES 有权转让
标题翻译：新的抗微生物肽
公开(公告)号：EP2271356A1
公开(公告)日：2011-01-12
申请号：EP09731331.6
申请日：2009-04-07
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： BRANDENBURG, Klaus
IPC分类号： A61K38/04 , C07K7/00
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention relates to a peptide of linear, non-cyclic structure consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1 ) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking (23) G or lacking. Further, the invention relates to a nucleic acid molecule encoding the peptide of the invention, an expression vector comprising the nucleic acid molecule of the invention, a host cell which may be grown in cell culture comprising the vector of the invention, and a method of producing the peptide of the invention comprising culturing the host cell of the invention and collecting the peptide produced. Also, the present invention relates to a pharmaceutical composition comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention and a kit comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention.
摘要翻译：本发明涉及由17至23个氨基酸组成或包含17至23个氨基酸的线性非环状结构的肽，其中从N端计数的1至23位的氨基酸如下（1）G，S 或缺乏; （2）C或缺乏; （3）K或R; （4）K或R; （5）Y，W或F; （6）K或R; （7）K或R; （8）F，W或L; （9）K或R; （10）K或L或缺乏; （11）W，L或F; （12）K或R; （13）F，Y或C; （14）K或R; （15）G或Q; （16）K或R; （17）F，L或W; （18）F或W; （19）F，L或W; （20）W或F; （21）C或缺乏; （22）F或G或缺乏（23）G或缺乏。此外，本发明涉及编码本发明的肽的核酸分子，包含本发明的核酸分子的表达载体，可以在包含本发明的载体的细胞培养物中生长的宿主细胞，以及产生本发明的肽，包括培养本发明的宿主细胞并收集产生的肽。而且，本发明涉及药物组合物，其包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞和试剂盒，其包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞。

8. 发明公开

EP2261662A1 Novel synthetic blocking reagents 有权
标题翻译： Neuartige合成Blockierlösungen
公开(公告)号：EP2261662A1
公开(公告)日：2010-12-15
申请号：EP09007701.7
申请日：2009-06-10
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： Fujimoto, Naho , Röckendorf, Niels , Bade, Steffen , Ramaker, Katrin , Frey, Andreas
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/54393 , Y10T436/143333
摘要： The present invention concerns novel synthetic blocking reagents for the reduction of non-specific bindings in solid phase assays that rely on biological and specific recognition, e.g., in enzyme-linked immunosorbent assays (ELISAs). The invention provides the use of compounds as blocking reagents as well as kits comprising these compounds. The compounds comprise one or more poly(ethylene glycol) moieties, one or more alkyl- or aminoalkyl groups and another unit bridging the aforementioned groups, wherein the compound comprises at least one amino group.
摘要翻译：本发明涉及用于在固相测定中减少非特异性结合的新型合成阻断试剂，其依赖于生物学和特异性识别，例如在酶联免疫吸附测定（ELISA）中。本发明提供化合物作为封闭试剂的用途以及包含这些化合物的试剂盒。化合物包含一个或多个聚（乙二醇）部分，一个或多个烷基 - 或氨基烷基基团和另一个桥接上述基团的单元，其中该化合物包含至少一个氨基。

9. 发明公开

EP3266454A1 ACC INHIBITORS FOR USE IN TREATING MYCOBACTERIAL DISEASES 审中-公开
标题翻译： ACC抑制剂用于治疗菌血症
公开(公告)号：EP3266454A1
公开(公告)日：2018-01-10
申请号：EP16178441.8
申请日：2016-07-07
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： Reiling, Norbert , Brandenburg, Julius
IPC分类号： A61K31/427 , A61K31/5377 , A61K31/00 , A61K45/06 , A61K31/133 , A61K31/4409 , A61K31/496 , A61K31/4965 , A61P31/04 , A61P31/06 , A61P31/08
CPC分类号： A61K31/427 , A61K31/00 , A61K31/133 , A61K31/4409 , A61K31/496 , A61K31/4965 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention relates to acetyl-CoA-carboxylase (ACC) inhibitors and to pharmaceutical compositions containing such compounds, for use in treating mycobacterial diseases. The invention further relates to a kit of parts comprising a pharmaceutical composition containing such compounds and at least one additional pharmaceutically active compound, selected from antbiotics, antifungals or anti-HIV compounds.
摘要翻译：本发明涉及乙酰-CoA-羧化酶（ACC）抑制剂和含有这些化合物的药物组合物，用于治疗分枝杆菌疾病。本发明还涉及包含含有这些化合物和至少一种选自抗生素，抗真菌剂或抗HIV化合物的另外的药物活性化合物的药物组合物的试剂盒。

10. 发明授权

EP2271356B1 NOVEL ANTIMICROBIAL PEPTIDES 有权转让
标题翻译：新抗菌肽
公开(公告)号：EP2271356B1
公开(公告)日：2015-01-28
申请号：EP09731331.6
申请日：2009-04-07
申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften
发明人： BRANDENBURG, Klaus
IPC分类号： C07K7/08 , C07K14/435 , A61K38/00
CPC分类号： C07K14/43509 , A61K38/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式