专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1520587B1 ALLERGY VACCINE COMPOSITION, PRODUCTION METHOD THEREOF AND USE OF SAME IN ALLERGY TREATMENT 有权
标题翻译：过敏症疫苗组合物，工艺用于生产相同的，它们在治疗过敏
公开(公告)号：EP1520587B1
公开(公告)日：2011-06-29
申请号：EP03724819.2
申请日：2003-05-08
申请人： Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros , CENTRO NACIONAL DE BIOPREPARADOS
发明人： Lastre González, Miriam de San Juan , Pérez Martín, Oliver Germán , Labrada Rosado, Alexis , Bidot Martínez, Igor , Pérez Lastre, Jorge Ernesto , Bracho Granada, Gustavo Rafael , Del Campo Alonso, Judith Mónica , Pérez Lastre, Dainerys Aleida , Facenda Ramos, Elisa , Zayas Vignier, Caridad , Rodríguez Martínez, Claudio , Sierra Gonzàlez, Victoriano Gustavo
IPC分类号： A61K39/39 , A61K39/35
CPC分类号： A61K39/35 , A61K2039/55505 , A61K2039/55583 , A61K2039/55594 , A61K2039/57 , A61K2039/6018
摘要： The invention relates to the field of immunology, immunoallergy and, in particular, the use of adjuvants or carriers in order to modulate the immunological response to allergens. The technical objective of the invention is: to produce a therapeutic or prophylactic pharmaceutical preparation using bacterial proteoliposomes, which, when applied to allergic individuals, transforms the Th2- and IgE-dependent allergic response into a protective Th1 response; and to prevent the appearance and development of allergies in not-yet allergic individuals. The vaccine composition consists of proteoliposomes of gram-negative bacteria coupled with allergens and, optionally, other antigens or adjuvants. The invention also relates to the method of producing the inventive vaccine composition and to the two-dose schedule for immunisation with said vaccine composition.

2. 发明授权

EP1323832B1 CULTURE MEDIUM AND METHOD FOR IDENTIFYING GRAM-NEGATIVE MICROORGANISMS 有权
标题翻译：培养基和方法用于确定革兰氏阴性微生物
公开(公告)号：EP1323832B1
公开(公告)日：2006-07-05
申请号：EP01964834.4
申请日：2001-08-24
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： RODRIGUEZ MARTINEZ, Claudio , QUESADA MUNIZ, Vivian de Jesus , ZHURBENKO, Raisa
IPC分类号： C12Q1/04 , C12R1/04 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/185 , C12R1/42
CPC分类号： C12Q1/045 , Y02A50/59
摘要： The invention consists on providing a new culture medium and a method for the identification of Gram-negative organisms, based on their differentiation by the appearance of at least 10 different colors of the regular and irregular colonies and of halos of at least 5 different colors and sizes. Said medium comprises a mixture of compounds that provide the appearance of halos of different colors and sizes, constituted by siliceous earth, skimmed milk, starches and bacteriological charcoal. Said medium also comprises a mixture of nutrient bases, substances that guarantee the appearance of different colors of the colonies, substances that guarantee the inhibition of the Gram-positive organisms and substances that provide a solid matrix for the growth and development of the colonies.

3. 发明公开

EP4129318A1 PROTEIN-BASED PHARMACEUTICAL COMPOSITION WITH NEUROPROTECTIVE, IMMUNOMODULATING, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY 审中-实审
公开(公告)号：EP4129318A1
公开(公告)日：2023-02-08
申请号：EP20904540.0
申请日：2020-11-23
申请人： Centro Nacional de Biopreparados
发明人： RODRÍGUEZ MARTÍNEZ, Claudio , GARCÍA HERNÁNDEZ, Yenela , REYES ZAMORA, Mary Carmen , ESQUIVEL CRESPO, Nashelly , VIERA ORAMAS, Diana Rosa , GOVÍN RAVEIRO, Yanary , RÁBAGO CÁPIRO, Rachel , ODELÍN VERDECIA, Mayelín , PEREA MARTÍNEZ, Yoel
IPC分类号： A61K38/00 , A61P25/00 , A61P31/00 , A61P37/00
摘要： The present invention consists of a pharmaceutical composition for therapeutic purposes based on proteins and their component peptides with a total protein concentration of 0.2 to 3 mg/mL or mg/g. The proteins and peptides are combined by selecting one or more belonging to at least two groups classified by their activity on the human organism, including antioxidant activity, activity on the ubiquitin-proteosome system, anti-inflammatory and immune system modulating activity, antimicrobial activity, and activity on protein transcription and synthesis. From the combination of proteins and peptides, a pharmaceutical composition is formed for intranasal, intramuscular, intravenous, oral or sublingual administration for the treatment of diseases of the central and peripheral nervous system, autoimmune and inflammatory, infectious, primary and secondary immunodeficiencies and cancer.

4. 发明公开

EP1300471A1 NUTRITIONAL MIXTURE AND METHOD FOR EARLY IDENTIFICATION AND COUNT OF GRAM-NEGATIVE ORGANISMS 有权
标题翻译： ÄHRMIXTURUND VERFAHREN ZURFRÜHINDENTIFIZIERUNGUNDZÄHLUNGVON GRAMNEGATIVEN ORGANISMEN
公开(公告)号：EP1300471A1
公开(公告)日：2003-04-09
申请号：EP01947123.4
申请日：2001-06-29
申请人： Centro Nacional de Biopreparados
发明人： TSORAEVA, Anna , RODRIGUEZ MARTINEZ, Claudio , QUESADA MUNIZ, Vivian de Jesus
IPC分类号： C12Q1/04
CPC分类号： C12Q1/045 , Y02A50/59
摘要： The present invention is related with Microbiology and particularly with a nutrient mixture and a procedure for the identification and the early count of Gram-negative organisms. This mixture allows the development of five different colony colors in the organisms to be detected, and the appearance of three colored fluorescent emissions, the appearance of three different colors halos and zones with opaque precipitates surrounding such colonies. Those factors, together with the color changes in the medium, allow a differentiation with a high sensibility and specificity level.
The mixture include specific relations of the mixtures of tryptophan rich protein fractions, free tryptophan, organic or inorganic salts, color or fluorescence providing substances, cellulose and hemi cellulose and other components which provide from 1 to 2 layers in the composition.
摘要翻译：本发明涉及微生物学，特别是与营养物混合物以及用于鉴定和早期革兰氏阴性生物体的方法。该混合物允许检测生物体中的五种不同的菌落颜色，三色荧光发射的出现，三种不同颜色的光晕的出现以及围绕这种菌落的不透明沉淀物的区域。这些因素以及培养基中的颜色变化允许以高敏感性和特异性水平进行分化。该混合物包括富含色氨酸蛋白质部分，游离色氨酸，有机或无机盐，提供颜色或荧光的物质，纤维素和半纤维素以及在组合物中提供1至2层的其它组分的混合物的特定关系。

5. 发明公开

EP0301992A3 Vaccine against group B Neisseria meningitidis, gammaglobulin and transfer factor 失效
标题翻译：疫苗对B组脑膜炎奈瑟菌，丙种球蛋白和转移因子。
公开(公告)号：EP0301992A3
公开(公告)日：1990-02-14
申请号：EP88500077.8
申请日：1988-07-30
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： Campa Huergo, Concepcion , Sierra Gonzalez, Victoriano Gustavo , Gutierrez Vazquez, Maria Mercedes , Bisset Jorrin, Gonzalo , Garcia Imia, Luis Guillermo , Puentes Rizo, Gisela de la Caridad , Sampedro Herrera, Maria del Carmen , Sotolongo Padron, Franklin , Xochitl le Riverend Morales, Eloisa , Galguera Dominguez, Manuel Alfredo
IPC分类号： A61K39/095 , A61K39/40 , C07K2/00 , A61K35/14
CPC分类号： A61K39/095 , A61K39/00 , C07K14/22 , C07K14/52 , C07K16/1217
摘要： A method is provided for obtaining a vaccine against the different pathogenic serotypes of group B Neisseria meningitidis characterized by starting from live microorganisms of any one of the known pathogenic serotypes of the B group without inactivation, from which the extractation of the vesicles of the outer membrane and the protein antigenic complex of 65 - 95 KD molecular weight is carried out using detergent, enzyme and ultrasound combined in the treatment. The resulting product, after treatment to eliminate the nucleic acids, is purified by a dissociating treatment with detergent, ultrasonic bath and column chromatography. The multi-antigenic material so obtained is purified to obtain the protein antigenic complex of 65 - 95 KD molecular weight for HPLC chromatography (TSK 3000 SWG column) or affinity chromatography with monoclonal antibodies, or hydrophobicity chromatography, or ionic exchange chromatography or a combination of any one of them. The protein antigenic complex is then added to the fraction that contains the vesicles by ultrasound treatment so that it will be anchored on then, in a proportion of 15 por cent ± 3. The capsulr polysaccharide is also added, in a proportion of 1.1 - 1.4 with respect to the protein and the adjuvant in a relation ranging from 2 - 100 mcg/protein mcg. The different components ot the mixture may be sterilized by cobalt 60 inonizing radiations with doses from 5 - 25 Kgy and a temperature between 1 - 4 grade C before preparing the mixture or the resulting mixture may be sterilized by this procedure.

6. 发明授权

EP1970450B1 NUTRIENT MEDIUM FOR YEAST CULTURE 有权
标题翻译：对于酵母培养培养基
公开(公告)号：EP1970450B1
公开(公告)日：2010-11-17
申请号：EP06846928.7
申请日：2006-12-19
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： LOBAINA RODRÍGUEZ, Tamara , RODRÍGUEZ MARTINEZ, Claudio , ZHURBENKO, Raisa , GARCÍA MARICHAL, José Miguel , ZAYAS RUIZ, Yordania
IPC分类号： C12Q1/04 , C12N1/16 , C12R1/72
CPC分类号： C12N1/16 , C12N1/38 , C12Q1/045 , G01N2333/40
摘要： The invention relates to a novel nutrient medium which has been developed for yeast culture and in particular for the selective isolation, differentiation and simultaneous identification of yeasts, particularly species of the Candida genus of clinical or environmental interest. The invention is essentially based on the use of a combination of sweet potato extract and yeast or tomato extract in order to promote the growth of different fungal species. According to the invention, the nutrient medium is provided with specific fluorogenic and/or chromogenic substrates in order to detect the enzymatic activity of the phospholipases, aminopeptidases, hexosaminidases and glucosidases, as well as substances containing proteins in order to detect proteolytic activity present in species of the Candida genus. In addition, the medium also contains sources of carbon, salts, buffering agents, bacteria inhibitors and agar. The nutrient medium can be used to differentiate between species of Candida with the aid of the colour of the colonies, the emission of fluorescence under ultraviolet light, the formation of halos and the morphology of the colonies.

7. 发明授权

EP1196625B1 COMPOSITION AND METHOD FOR DETECTING AND EARLY AND DIFFERENTIATED COUNTING OF GRAM-NEGATIVE MICROORGANISMS 有权
标题翻译：成分和方法发现，早和革兰氏阴性微生物的差异计数用
公开(公告)号：EP1196625B1
公开(公告)日：2006-08-09
申请号：EP01925277.4
申请日：2001-04-17
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： QUESADA MUNIZ, Vivian de Jesus , RODRIGUEZ MARTINEZ, Claudio
IPC分类号： C12Q1/04 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/385 , C12R1/42
CPC分类号： C12Q1/04 , C12Q1/10 , Y02A50/59
摘要： The present invention is related with the Microbiology field and particularly with a composition and a method for early detection, identification, differentiation and count of microscopic organisms, concretely Gram-negative microorganisms. The composition described in the invention consist on a mixture of substances of protein origin with a total nitrogen content from 9 to 20% and in relationship between 2:1 to 24:1, concerning to the content of inhibitors of the Gram-positive organisms. It contains a mixture of organic and inorganic substances that facilitate the differentiation of the Gram-negative organisms, being this mixture in a relationship from 0.5:1 to 2:1 concerning to the mixture of substances of protein origin. The referred composition allows the detection and differentiated count of E. coli and other coliform organisms due to the blue-greenish color of the colonies of these microorganisms on the orange bottom of the medium; Salmonella not typhi for the red color of the centers of the colonies on rosy bottom of the medium; Salmonella typhi and Proteus for the transparency of the colonies; Citrobacter and Klebsiella for the violet color of the colonies on the pink to orange bottom of the medium and Pseudomonas aeruginosa for the orange color with darker center of the colony, taking greenish pigmentation after 24 hours and producing greenish fluorescence under low ultraviolet light.

8. 发明公开

EP2837690A2 METHOD FOR SIMULTANEOUS DETECTION, RECOVERY, IDENTIFICATION AND COUNTING OF MICROORGANISMS AND DEVICES FOR THE IMPLEMENTATION OF SAID METHOD 有权转让
标题翻译：程序对同时检测，修复，鉴定和计数微生物和三维结构FOR实施
公开(公告)号：EP2837690A2
公开(公告)日：2015-02-18
申请号：EP13767434.7
申请日：2013-03-27
申请人： Centro Nacional de Biopreparados (Biocen) , Centro Nacional De Investigaciones Cientificas (CNIC) , Rodríguez Martínez, Claudio , González Ruiz, Jesús Eduardo , Lobaina Rodríguez, Tamara , Zhurbenko, Raisa , Brito González, Anairis , López Hernández, Mónica , Aragón Fernández, Javier , Alfonso Valdés, Ivonne , Ortega Surís, Adelaida
发明人： RODRÍGUEZ MARTÍNEZ, Claudio , GONZÁLEZ RUIZ, Jesús Eduardo , LOBAINA RODRÍGUEZ, Tamara , ZHURBENKO, Raisa , BRITO GONZÁLEZ, AnaIris , LÓPEZ HERNÁNDEZ, Mónica , ARAGÓN FERNÁNDEZ, Javier , ALFONSO VALDÉS, Ivonne , ORTEGA SURÍS, Adelaida
IPC分类号： C12Q1/04 , C01B33/00
CPC分类号： C12Q1/04 , C12M25/14 , C12M41/36 , C12Q1/06 , C12Q1/10 , C12Q1/14 , G01N2333/21 , G01N2333/245 , G01N2333/315 , G01N2333/38 , G01N2333/40
摘要： Method and devices for the simultaneous detection, recovery, identification and counting of a plurality of microorganisms consisting in providing mixtures of nutrients specially selected from those that curtail the lag phase of growth in bacteria and moulds and which, together with fluorescent enzymatic, chromogenic or bioluminescent markers and other nutrient components or growth inhibitors, are embedded in three-dimensional structures or natural or artificial clays or ceramics with cavities of different dimensions and forms and specific surface areas of between 2 x 103 and 6 x 108 m 2 /m 3 .
摘要翻译：方法和用于同时检测，回收，鉴定和微生物提供营养物的混合物组成的多个计数装置特意从thosethat削减增长的细菌和霉菌，并且搁置相用荧光酶，生色或生物发光选定，一起标记物和其它营养成分或生长抑制剂，被嵌入在三维结构或天然或人造的粘土或陶瓷具有不同的尺寸和形式和2 / m 3的2和6之间×103×108个米比表面积的空腔。

9. 发明公开

EP1970450A1 NUTRIENT MEDIUM FOR YEAST CULTURE 有权
标题翻译： NÄHRMEDIUMFÜRHEFEKULTUR
公开(公告)号：EP1970450A1
公开(公告)日：2008-09-17
申请号：EP06846928.7
申请日：2006-12-19
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： LOBAINA RODRÍGUEZ, Tamara , RODRÍGUEZ MARTINEZ, Claudio , ZHURBENKO, Raisa , GARCÍA MARICHAL, José Miguel , ZAYAS RUIZ, Yordania
IPC分类号： C12Q1/04 , C12N1/16 , C12R1/72
CPC分类号： C12N1/16 , C12N1/38 , C12Q1/045 , G01N2333/40
摘要： A new nutritional medium was developed for cultivate yeast, especially intended for selective, simultaneous isolation, differentiation and identification of yeasts, particularly of species of the genus Candida of clinical or environmental relevance. The essential element of the invention lies on the use of a combination of sweet potato extract and yeast or tomato extract to promote growth of diverse fungus species. This nutritional medium incorporates specific chromogenic and/or fluorogenic substrates to detect enzymatic activity of phospholipases, aminopeptidases, hexosaminidases and glucosidases, and substances containing proteins to detect the proteolytic activity pertaining to species of the genus Candida . This medium contains also carbon sources, salts, buffering agents, bacteria inhibitors and agar. This nutritional medium allows differentiation of Candida species by coloration of the colonies, emission of fluorescence under ultraviolet light, formation of halos and morphology of the colonies.
摘要翻译：开发了用于培养酵母的新的营养培养基，特别是用于选择性，同时分离和鉴定酵母，特别是具有临床或环境相关性的假丝酵母属的物种。本发明的基本要素在于使用甘薯提取物和酵母或番茄提取物的组合来促进各种真菌物种的生长。该营养培养基含有特异的发色和/或荧光底物以检测磷脂酶，氨基肽酶，己糖胺酶和葡糖苷酶的酶活性，以及含有蛋白质的物质以检测与念珠菌属种类有关的蛋白水解活性。该介质还含有碳源，盐，缓冲剂，细菌抑制剂和琼脂。这种营养培养基允许通过菌落的着色，紫外线下的荧光发射，光晕的形成和菌落的形态来区分假丝酵母属物种。

10. 发明授权

EP1300471B1 NUTRITIONAL MIXTURE AND METHOD FOR EARLY IDENTIFICATION AND COUNT OF GRAM-NEGATIVE ORGANISMS 有权
标题翻译： NÄHRMIXTUR和方法FRÜHINDENTIFIZIERUNG及点票革兰氏阴性生物体
公开(公告)号：EP1300471B1
公开(公告)日：2007-09-12
申请号：EP01947123.4
申请日：2001-06-29
申请人： CENTRO NACIONAL DE BIOPREPARADOS
发明人： TSORAEVA, Anna , RODRIGUEZ MARTINEZ, Claudio , QUESADA MUNIZ, Vivian de Jesus
IPC分类号： C12Q1/04 , C12R1/05 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/385 , C12R1/42
CPC分类号： C12Q1/045 , Y02A50/59
摘要： The present invention is related with Microbiology and particularly with a nutrient mixture and a procedure for the identification and the early count of Gram-negative organisms. This mixture allows the development of five different colony colors in the organisms to be detected, and the appearance of three colored fluorescent emissions, the appearance of three different colors halos and zones with opaque precipitates surrounding such colonies. Those factors, together with the color changes in the medium, allow a differentiation with a high sensibility and specificity level. The mixture include specific relations of the mixtures of tryptophan rich protein fractions, free tryptophan, organic or inorganic salts, color or fluorescence providing substances, cellulose and hemi cellulose and other components which provide from 1 to 2 layers in the composition.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式