专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2314625B1 Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom 失效
标题翻译：转基因哺乳动物，人类Ig基因座包含多个包括VH和Vkappa区域，并且由此获得的抗体
公开(公告)号：EP2314625B1
公开(公告)日：2014-05-07
申请号：EP10182935.6
申请日：1997-12-03
申请人： Amgen Fremont Inc.
发明人： Green, Larry , Jakobovits, Aya , Kucherlapati, Raju , Klapholz, Sue , Mendez, Michael
IPC分类号： C07K16/24 , C07K16/00 , C07K16/28 , A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206

2. 发明授权

EP0942968B1 Fully human antibodies that bind EGFR 失效
标题翻译：全人抗体结合EGFR
公开(公告)号：EP0942968B1
公开(公告)日：2008-02-27
申请号：EP97953227.2
申请日：1997-12-03
申请人： Amgen Fremont Inc.
发明人： JAKOBOVITS, Aya , KUCHERLAPATI, Raju , KLAPHOLZ, Sue , MENDEZ, Michael , GREEN, Larry
IPC分类号： C12N15/00 , A01K67/027 , C07K16/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vλ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.

3. 发明授权

EP0923878B1 Process for making granular L-lysine feed supplement 无效
标题翻译：制备粒状L-赖氨酸饲料添加剂的方法
公开(公告)号：EP0923878B1
公开(公告)日：2004-07-14
申请号：EP98310229.4
申请日：1998-12-14
申请人： ARCHER-DANIELS-MIDLAND COMPANY
发明人： Stevens, Joseph Michael , Binder, Thomas P.
IPC分类号： A23K1/16 , C12P13/08
CPC分类号： C12P13/08 , A23K20/142

4. 发明公开

EP1287142A1 NUKLEINSAURE-MOLEKUL UMFASSEND EINE FUR EIN SDF-1 GAMMA CHEMOKIN,EINEN NEUROPEPTID-PRAKURSOR ODER MINDESTENS EIN NEUROPEPTID KODIERENDE NUKLEINSAURESEQUENZ 有权
标题翻译：核酸分子，其包含用于SDF-1 GAMMA趋化因子，神经肽PRAKURSOR或至少一种神经肽CODING核酸
公开(公告)号：EP1287142A1
公开(公告)日：2003-03-05
申请号：EP01936423.1
申请日：2001-06-01
申请人： RHEIN BIOTECH GESELLSCHAFT FÜR NEUE BIOTECHNOLOGISCHE PROZESSE UND PRODUKTE MBH
发明人： MÜLLER, Hans, Werner , BOSSE, Frank , GLEICHMANN, Marc , GILLEN, Clemens , AUER, Johannes
IPC分类号： C12N15/19 , C12N15/71 , C12N15/79 , C07K16/00 , C07K14/52 , C12Q1/68 , A61K38/19 , G01N33/53
CPC分类号： C07K14/522 , A61K38/00 , A61K48/00
摘要： The invention relates to a nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor or at least one neuropeptide, in addition to host cells containing said nucleic acid molecule. The invention also relates to a polypeptide molecule which acts as a chemokine or a neuropeptide or contains at least one neuropeptide, and to fragments thereof containing at least one neuropeptide . The invention further relates to a method for producing a polypeptide molecule or a fragment thereof. Also disclosed are antibodies, detection methods, test kits and pharmaceutical compositions. The aim of the invention is to provide novel agents which can be used specifically to diagnose and/or treat diseases which are linked to a defect in the SDF-1 factor or one of the receptors (CXCR4) thereof.

5. 发明公开

EP0979080A1 A METHOD OF MODULATING AN IMMUNE RESPONSE IN AN INFECTED MAMMAL BY TRANSMUCOSAL ADMINISTRATION OF MODULATING AGENT 失效
标题翻译：调制免疫反应的方法在哺乳动物BY INFEKTIERTEN粘膜ENTER调制MEDIUM
公开(公告)号：EP0979080A1
公开(公告)日：2000-02-16
申请号：EP98911458.2
申请日：1998-01-02
申请人： THOMAS JEFFERSON UNIVERSITY
发明人： MICHAELS, Frank , BLOCK, Timothy
IPC分类号： A61K31/505 , A61K31/52 , A61K31/655 , A61K31/557 , A61K35/12 , A61K35/66 , C07H19/073 , C07H19/173
CPC分类号： C12N15/8257 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0381 , A61K38/162 , A61K38/164 , A61K39/12 , A61K39/292 , A61K2039/517 , A61K2039/5256 , A61K2039/542 , C12N15/8509 , C12N2710/24143 , C12N2730/10134 , C12N2770/00043 , Y02A50/41 , Y02A50/414
摘要： Methods and compositions for modulating an immune response in a mammal infected with a bacterium, a virus, or a parasite are provided. The methods and compositions are useful in mammals experiencing an acute infection and in mammals experiencing a chronic infection. The methods and compositions may be used in conjunction with a known treatment for infection of a mammal by an infectious agent. Methods and compositions for transmucosal delivery of a molecule comprising an epitope located in close proximity to the immune response are provided.

6. 发明授权

EP2042596B1 Polypeptides involved in immune response 有权
标题翻译：所涉及的免疫防御新型多肽
公开(公告)号：EP2042596B1
公开(公告)日：2015-02-11
申请号：EP08171572.4
申请日：2001-11-28
申请人： Amgen Inc. , Amgen Canada Inc.
发明人： Shahinian, Arda , Bladt, Anna Tafuri , Senaldi, Giorgio , Mak, Tak Wah , Yoshinaga, Steven Kiyoshi
IPC分类号： C12N15/11 , C12N15/12 , C12N15/62 , C07K14/705 , C07K16/28 , A01K67/027 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2827 , A01K2217/05 , A01K2217/075 , C07K14/705 , C07K2319/00 , C07K2319/30

7. 发明公开

EP1261622A2 PURIFIED LH 有权
标题翻译：具有比活性和清洗过程纯化的重组HLH
公开(公告)号：EP1261622A2
公开(公告)日：2002-12-04
申请号：EP01907476.4
申请日：2001-01-22
申请人： Applied Research Systems ARS Holding N.V.
发明人： PARADISI, Gianfranco , ROSSI, Mara , SCAGLIA, Laura
IPC分类号： C07K1/36
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/00 , A61K47/26 , C07K14/59
摘要： A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high, amounting to about 25.000 IU/mg.

8. 发明公开

EP1218405A2 HÄMOCYANIN UND DAFÜR KODIERENDE NUKLEINSÄURESEQUENZ 失效
标题翻译：血蓝蛋白和核酸序列，其编码
公开(公告)号：EP1218405A2
公开(公告)日：2002-07-03
申请号：EP00918811.1
申请日：2000-03-17
申请人： Biosyn Arzneimittel GmbH
发明人： MARKL, Jürgen , ALTENHEIN, Benjamin , LIEB, Bernhard , STIEFEL, Thomas
IPC分类号： C07K14/00 , A61K39/00 , C12N15/00
CPC分类号： C07K14/43504 , A61K39/0003 , A61K2039/6081 , Y02A50/423 , Y10S530/855
摘要： The invention relates to a nucleic acid molecule comprising a nucleic acid sequence coding for a hemocyanin, a hemocyanin domain or a fragment having the immunological properties of at least one hemocyanin domain. The invention also relates to constructs containing the nucleic acid molecule and possibly a promoter suitable for controlling expression. According to a preferred embodiment the construct also contains a nucleic acid sequence coding for an antigen. The invention also relates to host cells containing the above nucleic acid molecules and/or constructs, to the recombinant expression of the nucleic acid molecules and/or constructs in the host cells, as well as to hemocyanin, a hemocyanin domain, a fragment having the immunological properties of at least one hemocyanin domain and hemocyanin fusion proteins which are coded for by the nucleic acid molecules and/or constructs. The invention also relates to pharmaceutical preparations containing the nucleic acid molecules and/or hemocyanin, a hemocyanin domain, a fragment thereof or a fusion protein, and to liposomes containing the nucleic acid molecules and/or hemocyanin, a hemocyanin domain, a fragment thereof or a fusion protein. Finally the invention relates to antibodies which can be obtained by immunization of an experimental animal with the hemocyanin, a hemocyanin domain, a fragment thereof or a fusion protein, as well to their use in screening methods for identifying tumors.

9. 发明公开

EP1186301A2 Monoclonal antibodies that recognize flk-2 receptors and the isolation of primitive hematopoietic stem cell populations 失效
标题翻译：单克隆抗体识别的Flk-2受体，而原始造血干细胞群的分离
公开(公告)号：EP1186301A2
公开(公告)日：2002-03-13
申请号：EP01122476.3
申请日：1994-09-07
申请人： IMCLONE SYSTEMS, INC.
发明人： Goldstein, Neil I. , Songsakphsan, Ratchanee , Rose, Caroline
IPC分类号： A61K39/395 , A61P35/02
CPC分类号： C07K14/71 , A61K38/00 , A61K2039/505 , C07K16/2863 , C07K16/2896 , C07K2317/34
摘要： Antibodies that bind specifically to the flk-2 tyrosine kinase receptor can be used for the preparation of a medicament for the treatment of leukaemia.
摘要翻译：抗体也特异性结合FLK-2酪氨酸激酶受体可被用于制备药物用于治疗白血病。

10. 发明公开

EP1068301A2 BAKTERIELLE TRANSGLUTAMINASEN 有权
标题翻译：细菌的转谷氨酰胺酶
公开(公告)号：EP1068301A2
公开(公告)日：2001-01-17
申请号：EP99917952.6
申请日：1999-04-01
申请人： Fuchsbauer, Hans-Lothar
发明人： FUCHSBAUER, Hans-Lothar , PASTERNACK, Ralf , DORSCH, Simone , OTTERBACH, Jens , ROBENEK, Isabella , MAINUSCH, Martina , DAUSCHER, Christine
IPC分类号： C12N9/10 , C12N15/54 , C12P21/00
CPC分类号： C12N9/1044 , C07K16/40 , C12P21/02
摘要： The invention relates to bacterial transglutaminase polypeptide molecules, bacterial transglutaminase nucleic acid molecules, expression vectors and host organisms, in addition to a method for the production of an inactive polypeptide molecule and a method for activating the same. The invention also relates to antibodies against the inventive transglutaminase polypeptide molecules. The aim of the invention is to provide a bacterial transglutaminase enzyme which can be optionally activated in a targeted manner, in addition to providing means and ways of producing and activating said enzyme. The invention further relates to a novel active or activatable bacterial transglutaminase. This is achieved by means of amino and nucleic acid sequences from streptoverticillia that are used for instance in the food, pharmaceutical and cosmetics industry, in order to polymerize substances containing protein and to improve the properties of the final products e.g. with regard to their texture resistance, gel resistance, fracture strength, viscosity, elasticity, taste and odour. The transglutaminases can also be used to immobilize enzymes and antibodies.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式