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1. 发明授权

EP3368662B1 MOUSE LYMPHOMA CELL LINE AND ANIMAL MODEL OF HUMAN HIGH GRADE B-CELL LYMPHOMA 有权
公开(公告)号：EP3368662B1
公开(公告)日：2024-10-09
申请号：EP16815923.4
申请日：2016-10-26
IPC分类号： C12N5/09 , A01K67/027
CPC分类号： A01K67/0271 , A01K2207/1220130101 , A01K2227/10520130101 , A01K2267/033120130101 , A01K2267/038120130101 , C12N5/0694

2. 发明授权

EP3541783B1 PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VITAMIN A5 PATHWAY AND USES THEREOF 有权
公开(公告)号：EP3541783B1
公开(公告)日：2023-09-27
申请号：EP17837894.9
申请日：2017-11-17
发明人： KREZEL, Wojciech , RÜHL, Ralph , DE LERA, Angel R
IPC分类号： C07C403/02 , C07C403/10 , C07C403/20 , C07C403/24 , A61K31/07 , A61P25/00 , A61P37/00 , A61P17/00

3. 发明公开

EP3423071A1 CHONDROCYTE PROLIFERATION 审中-公开
公开(公告)号：EP3423071A1
公开(公告)日：2019-01-09
申请号：EP17760980.7
申请日：2017-03-06
申请人： Lacerta Technologies Inc.
发明人： LACZA, Zsombor , HORNYÁK, István , SIMON, Melinda , KUTÉN, Olga , JEYAKUMAR, Vivek
IPC分类号： A61K35/14 , A61K35/16 , A61K35/19

4. 发明授权

EP2414842B1 DIAGNOSIS AND TREATMENT OF GLUTEN-INDUCED AUTOIMMUNE DISEASES 有权
标题翻译：谷氨酸引起的自身免疫性疾病的诊断和治疗
公开(公告)号：EP2414842B1
公开(公告)日：2018-05-16
申请号：EP10721197.1
申请日：2010-04-01
申请人： University of Debrecen
发明人： KORPONAY-SZABÓ, Ilma , FÉSÜS, László , BAGOSSI, Péter , CSÖSZ, Éva , KIRÁLY, Róbert , SIMON-VECSEI, Zsófia , MÄKI, Markku
IPC分类号： C07K16/40 , G01N33/573
CPC分类号： G01N33/573 , C07K16/40 , G01N2800/24
摘要： The invention relates to selective diagnosis of gluten-induced autoimmune diseases by binding assays utilizing the main celiac epitope present on proteins of the transglutaminase family. The invention also relates to treatment of gluten-induced autoimmune diseases by inhibiting binding of celiac autoantibodies by therapeutic compounds.

5. 发明公开

EP3100738A1 METHOD AND PREPARATION FOR THE TREATMENT OF ARTICULAR CARTILAGE INJURY COMPRISING MESENCHYMAL STEM CELLS AND HYALURONIC ACID 审中-公开
标题翻译：程序和编写用于整形外科疾病，如关节软骨损伤，包括与骨关节炎和软骨置换整形外科和创伤性关节疾病治疗
公开(公告)号：EP3100738A1
公开(公告)日：2016-12-07
申请号：EP16020175.2
申请日：2016-05-09
申请人： DeltaBio 2000 Kft , Magyar Tudományos Akadémia SzegediBiológiai Kutatoközpont
发明人： HARACSKA, Lajos , MONOSTORI, Éva , KRISTON-PÁL, Éva , GERCSÓ, Andrásné , ILLÉSNÉ KOVÁCS, Katalin , UHER, Ferenc
IPC分类号： A61K35/28 , A61K47/00 , A61K31/728 , A61P19/02
CPC分类号： A61K35/28 , A61K9/0019 , A61K9/10 , A61K31/728 , A61K47/36 , C12N5/0667 , C12N2500/34 , A61K2300/00
摘要： The present invention relates to a composition and a therapeutic procedure for the treatment of articular cartilage injuries, preferably joint dysplasia and orthopaedic diseases (e.g. partial or complete ligament tear, patellar dislocation) in non-human, mammalian patients.
摘要翻译：本发明涉及一种组合物和关节软骨损伤，关节优选发育不良和在非人类骨科疾病（E. G.部分或完全韧带撕裂，髌骨脱位），哺乳动物患者的治疗的治疗过程。

6. 发明授权

EP2450707B1 Lung tissue model 有权转让
标题翻译：肺组织模型
公开(公告)号：EP2450707B1
公开(公告)日：2016-04-27
申请号：EP10462007.5
申请日：2010-11-04
申请人： University of Pécs
发明人： Bartis, Domokos , Pongrácz, Judit Erzsébet
IPC分类号： G01N33/50 , C12N5/071 , C07K14/475
CPC分类号： G01N33/5044 , C12N5/0688 , C12N5/0697 , C12N2501/415 , C12N2502/1323 , C12N2502/28 , C12N2503/04 , C12N2533/90 , G01N33/5088 , G01N33/57423 , G01N2500/00

7. 发明公开

EP2907875A1 A novel method to load a mammalian artificial chromosome with multiple genes 审中-公开
标题翻译：用于提供人工染色体的哺乳动物与多个基因的新方法
公开(公告)号：EP2907875A1
公开(公告)日：2015-08-19
申请号：EP13075089.6
申请日：2013-11-15
申请人： Magyar Tudományos Akadémia Szegedi Biológiai Kutatoközpont 33%
发明人： Katona, Róbert , Hadlaczky, Gyula , Fodor, Katalin , Praznovszky, Tünde , Blazsó, Péter , Udvardy, Andor , Mózesné Holló, Gyöngyi , Keresó, Judit
IPC分类号： C12N15/63 , C12Q1/68 , C12N15/85 , C12N15/90
CPC分类号： C12N15/63 , C12N15/85 , C12N15/8509 , C12N15/90 , C12N2800/20 , C12N2800/208 , C12N2800/30 , C12N2800/40
摘要： The invention provides for a system for uploading genes of interest into an artificial chromosome expression system (ACE) that has been engineered to include multiple sites for site-specific, recombination directed integration, whereby a second or further gene of interest can be loaded onto the ACE by a targeting vector, through the acceptor recombination site(s) on said ACE.
摘要翻译：本发明提供了用于上传的兴趣基因导入在人工染色体表达系统（ACE）的系统也已被工程化以包括用于位点特异性，重组定向整合，由此感兴趣的第二或另外的基因可以被装载到多个站点通过靶向载体，通过受主复合位点（一个或多个）在所述ACE ACE。

8. 发明公开

EP2893538A1 RADIATION ABSORBING COMPOSITION 审中-公开
标题翻译： STRAHLUNGSABSORBIERENDE ZUSAMMENSETZUNG
公开(公告)号：EP2893538A1
公开(公告)日：2015-07-15
申请号：EP13774827.3
申请日：2013-09-03
申请人： Helse Stavanger
发明人： HUSEBYE, Gunnar-Lasse
IPC分类号： G21F1/10
CPC分类号： G21F1/106 , G21F1/10 , G21F1/103 , G21F3/00
摘要： The invention relates to a curable radiation absorbing composition applicable in paste-like form for providing protection against x-ray and/or gamma radiation wherein said composition comprises the following ingredients: a) a radiation absorbing material comprising metal grains having an average grain size between 0.5 mm to 5 mm, b) a polymeric resin as a binder material, c) a particulate material, wherein the average particle size of the particulate material is smaller than the average grain size of the metal grains. The composition can be applied e.g. by spreading to various surfaces, preferably floors, to provide protection against x-ray or gamma radiation in a thin layer.
摘要翻译：本发明涉及适用于糊状形式的可固化辐射吸收组合物，用于提供针对x射线和/或γ辐射的保护，其中所述组合物包含以下成分：a）包含金属颗粒的辐射吸收材料，其平均粒径介于 0.5mm至5mm，b）作为粘合剂材料的聚合物树脂，c）颗粒材料，其中颗粒材料的平均粒度小于金属颗粒的平均晶粒尺寸。组合物可以例如使用。通过扩展到各种表面，优选地板，以提供防止薄层中的X射线或γ射线的保护。

9. 发明公开

EP2839293A2 QUANTITATIVE DETERMINATION OF BIOMARKERS IN THE ERYTHROCYTE CELL MEMBRANE 有权
标题翻译：生物标记的红细胞的细胞膜测定
公开(公告)号：EP2839293A2
公开(公告)日：2015-02-25
申请号：EP13766655.8
申请日：2013-04-22
申请人： Advancell Diagnosztika KFT
发明人： SARKADI, Balázs , VÁRADY, György , KASZA, Ildikó
IPC分类号： G01N33/80 , G01N33/555 , G01N15/14
CPC分类号： G01N33/6872 , G01N15/1459 , G01N21/64 , G01N33/6893 , G01N33/80 , G01N2015/1006 , G01N2015/1488 , G01N2333/705 , G01N2333/70596
摘要： This invention relates to determination of quantitative expression of plasma membrane proteins as biomarkers in the erythrocytes. The invention includes simple, quantitative assay platforms which can be made available in most diagnostic laboratories. The platform allows performing personalized, quantitative tests for the direct expression level of a wide range of membrane proteins from small volume blood samples and connecting them to individual genetic variability, disease conditions, disease stages and complications, treatment protocols, pharmacological responses, or toxic side effects.

10. 发明公开

EP2820422A1 ABCG2 TRANSPORTER ASSAY 有权
标题翻译： ABCG2转运蛋白测定
公开(公告)号：EP2820422A1
公开(公告)日：2015-01-07
申请号：EP13712598.5
申请日：2013-02-28
申请人： Cellpharma LLC
发明人： SARKADI, Balázs , TELBISZ, Ágnes
IPC分类号： G01N33/566
CPC分类号： C12Q1/34 , G01N33/566
摘要： The invention relates to membrane preparations for use in an increased sensitivity ABCG2 protein activity assay, said preparations comprising liposomes and one or more bile acid compounds wherein the bile acid compounds reduce the basal ATPase activity in said liposomes. Said membrane preparations can be cell membrane preparations or a membrane protein preparations. The invention also relates to methods for obtaining said membrane preparations, either cell membrane preparations or, preferably, membrane protein preparations comprising a reconstituted, recombinant ABCG2 protein. The invention also relates to kits comprising said membrane preparations as well as uses said kits, membrane preparations or bile acid compounds in high sensitivity ABCG2 protein activity assays.˙
摘要翻译：本发明涉及用于提高敏感性ABCG2蛋白活性测定的膜制剂，所述制剂包含脂质体和一种或多种胆汁酸化合物，其中所述胆汁酸化合物降低所述脂质体中的基础ATP酶活性。所述膜制剂可以是细胞膜制剂或膜蛋白制剂。本发明还涉及获得所述膜制剂的方法，所述膜制剂为细胞膜制剂或优选包含重构的重组ABCG2蛋白的膜蛋白制剂。本发明还涉及包含所述膜制剂的试剂盒以及在高灵敏度ABCG2蛋白活性测定中使用所述试剂盒，膜制剂或胆汁酸化合物。

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