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    • 9. 发明公开
    • Immunogenic peptide composition for the prevention and treatment of Alzheimer's Disease
    • 免疫原性Peptidzusammensetzung zurPräventionund Behandlung der Alzheimer-Krankheit
    • EP2123671A1
    • 2009-11-25
    • EP09168110.6
    • 2002-04-02
    • United Biomedical, Inc.
    • Wang, Chang Yi
    • C07K14/47C12N15/62A61P25/28
    • C07K14/4711A61K39/00Y10S530/806Y10S530/81
    • The present invention relates to a composition comprsing a peptide immunogen useful for the prevention and treatment of Alzheimer's Disease. More particularly, the peptide immunogen comprises a main functional/regulatory site, an N-terminal fragment of Amyloid β (Aβ) peptide linked to a helper T cell epitope (Th) having multiple class II MHC binding motifs. The peptide immunogen elicit a site-directed immune response against the main functional/regulatory site of the Aβ peptide and generate antibodies, which are highly cross-reactive to the soluble Aβ 1-42 peptide and the amyloid plaques formed in the brain of Alzheimer's Disease patients. The antibodies elicited being cross reactive to the soluble Aβ 1-42 peptide, promote fibril disaggregation and inhibit fibrillar aggregation leading to immunoneutralization of the "soluble Aβ - derived toxins"; and being cross-reactive to the amyloid plaques, accelerate the clearance of these plaques from the brain. Thus, the composition of the invention comprising the peptide immunogen is useful for the prevention and treatment of Alzheimer's Disease.
    • 本发明涉及可用于预防和治疗阿尔茨海默氏病的肽免疫原的组合物。 更具体地,肽免疫原包含主要功能/调节位点,与具有多个II类MHC结合基序的辅助T细胞表位(Th)连接的淀粉样蛋白2(A 2)肽的N-末端片段。 肽免疫原引发针对A 2肽的主要功能/调节位点的定点免疫应答,并产生与可溶性Aβ1-42肽高度交叉反应的抗体和在阿尔茨海默氏病脑中形成的淀粉样蛋白斑 耐心。 引起的抗体与可溶性Aβ1-42肽交叉反应,促进原纤维解聚并抑制纤维结合,导致“可溶性A 2衍生毒素”的免疫中和; 并且与淀粉样蛋白斑交叉反应,加速这些斑块从脑部的清除。 因此,包含肽免疫原的本发明的组合物可用于预防和治疗阿尔茨海默氏病。