专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0956238A1 PARTITIONING DEVICE 失效
标题翻译：分区设备
公开(公告)号：EP0956238A1
公开(公告)日：1999-11-17
申请号：EP97906722.0
申请日：1997-02-24
申请人： PHARMACOPEIA, INC.
发明人： KIRK, Gregory, L. , BRZEZINSKI, Joseph, J., Jr. , CHELSKY, Daniel , NICHOLS, Thirleen, G. , RAMARAJ, T., C.
IPC分类号： G01N1 , B01J4 , B01J19 , B01L3 , C07B61 , G01N35 , C40B60
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00364 , B01J2219/00468 , B01J2219/00484 , B01J2219/005 , B01J2219/00527 , B01J2219/00659 , C40B60/14 , G01N2001/282
摘要： A device for precisely arraying small objects into a plurality of containers (9) which comprises a vessel (1) containing said objects in a fluid suspension, a tube (4), a small-objects detector (6), a drop detector (8), a means for controlling flow of said suspension (10) through said tube (4) by pressurizing said vessel (1), means for discriminating between those signals from said small-objects detector (6) caused by said small objects and those signals caused by other events, means for comparing signals from said small-objects detector (6) caused by said small objects with signals from said drop detector (8), and means for determining the number of said objects deposited into said containers (9).
摘要翻译：一种用于将小物体精确排列成多个容器（9）的装置，该容器包括容纳流体悬浮液中的所述物体的容器（1），管（4），小物体检测器（6），液滴检测器（8 ），用于通过加压所述容器（1）来控制所述悬浮液（10）通过所述管（4）的流动的装置，用于区分由所述小物体引起的来自所述小物体检测器（6）的那些信号和那些信号由其他事件引起的，用于比较由所述小物体引起的来自所述小物体检测器（6）的信号与来自所述液滴检测器（8）的信号的装置，以及用于确定存入所述容器（9）中的所述物体的数量的装置。

2. 发明公开

EP0952828A2 THERAPEUTIC USES FOR NITRIC OXIDE INHIBITORS 失效
标题翻译：治疗用于一氧化氮抑制剂
公开(公告)号：EP0952828A2
公开(公告)日：1999-11-03
申请号：EP97952182.0
申请日：1997-11-13
申请人： COLD SPRING HARBOR LABORATORY
发明人： ENIKOLOPOV, Grigori, Cold Spring Harbor Laboratory , PEUNOVA, Natalia I., Cold Spring Harbor Laboratory , KUZIN, Boris , CLINE, Hollis , MICHURINA, Tatiyana
IPC分类号： A61K31 , C12N5
CPC分类号： A61K31/00 , A61K31/155 , A61K31/17 , A61K31/198 , A61K31/216 , A61K31/223
摘要： The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells in bone marrow which are capable of undergoing normal hematopoiesis and differentiation, wherein the bone marrow is contacted with an inhibitor of NO, such as an inhibitor of nitric oxide synthase (NOS), thereby producing bone marrow having an increased population of hematopoietic stem cells which are capable of undergoing normal hematopoiesis and differentiation. The present invention also relates to a method of increasing a population of cells in S phase in a tissue of a mammal, comprising contacting the tissue with an inhibitor of NO, such as an inhibitor of NOS. The invention also pertains to a method of regenerating tissue in an adult mammal comprising contacting a selected tissue (e.g., blood, skin, bone and digestive epithelium), or precursor cells of the selected tissue, with an inhibitor of NO, thereby inhibiting differentiation and inducing proliferation of cells of the tissue.
摘要翻译：本发明基于一氧化氮（NO）是完整发育生物体中重要的生长调节剂的发现。具体而言，本发明涉及在哺乳动物中增加骨髓中能够进行正常造血和分化的造血干细胞群的方法，其中骨髓与NO抑制剂例如抑制剂的一氧化氮合酶（NOS），由此产生具有增加的造血干细胞群体的骨髓，所述造血干细胞群体能够经历正常的造血和分化。本发明还涉及增加哺乳动物组织中S期细胞群的方法，包括使组织与NO抑制剂例如NOS抑制剂接触。本发明还涉及在成年哺乳动物中再生组织的方法，其包括使选定组织（例如血液，皮肤，骨和消化上皮）或所选组织的前体细胞与NO抑制剂接触，由此抑制分化和诱导组织细胞的增殖。

3. 发明公开

EP0942907A1 2R, 4S, S, R- AND 2S, 4R, S, R-HYDROXYITRACONAZOLE 失效
标题翻译： 2R，4S，S，R-和2S，4R，S，R-羟基吡咯烷酮
公开(公告)号：EP0942907A1
公开(公告)日：1999-09-22
申请号：EP97947427.0
申请日：1997-11-12
申请人： SEPRACOR, INC.
发明人： HONG, Yaping , KOCH, Patrick , MCCULLOUGH, John, R. , SENANAYAKE, Chris, H. , TANOURY, Gerald, J.
IPC分类号： C07D405 , A61K31 , A61P31 , C07D249 , C07D521
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/12
摘要： A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,R)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.

4. 发明公开

EP0941247A2 PEPTIDE COMPOUNDS USEFUL FOR MODULATING FGF RECEPTOR ACTIVITY 失效
标题翻译：肽类化合物控制FGF受体活性的
公开(公告)号：EP0941247A2
公开(公告)日：1999-09-15
申请号：EP97950623.0
申请日：1997-11-12
申请人： Praecis Pharmaceuticals Incorporated
发明人： BENJAMIN, Howard , CHAI, Ling , FINDEIS, Mark, A. , GOODWIN, William , HUNDAL, Arvind , ISRAEL, David, I. , KELLEY, Michael , KEOUGH, Martin, P. , LU, Kuanghui , NATOLI, Farah , PETICOLAS, Alicia , SIGNER, Ethan, R. , GEFTER, Malcolm, L.
IPC分类号： A61K38 , A61P1 , A61P3 , A61P9 , A61P13 , A61P15 , A61P17 , A61P19 , A61P29 , A61P35 , A61P43 , C07K7 , C07K14
CPC分类号： C07K7/06 , A61K38/00 , C07K14/50
摘要： This invention provides peptide compounds that bind to either of fibroblast growth factor (FGF) or a fibroblast growth factor receptor (FGFR) and, accordingly, are useful for modulating FGFR activity. Preferably, the FGFR is FGFR2-IIIC. Preferably, the FGF is basic FGF. Preferably the peptide compound comprises an amino acid sequence (Y/F)-(L/F/I)-(R/D/E/S/Y/G)-(Q/L/Y)-Y-(M/L/K/R)-(L/M/D/E/N/S)-(R/L/S/T)-(L/F/M/V) (SEQ ID NO:1). The invention further comprises pharmaceutical compositions comprising the peptide compounds of the invention and a pharmaceutically acceptable carrier. The invention still further provides methods of modulating FGFR activity using the peptide compounds of the invention.

5. 发明公开

EP0939591A1 CONTACT-KILLING NON-LEACHING ANTIMICROBIAL MATERIALS 失效
标题翻译：通过以下方式联系ABSTÖTENDEAUSLAUGFESTE抗菌液体组合
公开(公告)号：EP0939591A1
公开(公告)日：1999-09-08
申请号：EP97913782.0
申请日：1997-10-28
申请人： Surfacine Development Company, LLC , Biopolymerix, Inc., c/o Biocompatibles, Ltd.
发明人： SAWAN, Samuel, P. , SHALON, Tadmor , SUBRAMANYAN, Sundar , YURKOVETSKIY, Alexander
IPC分类号： A61L27 , A01N25 , A01N47 , A01N59 , A61L29 , A61L33 , B01D39
CPC分类号： A01N47/44 , A01N59/16 , B01D39/1615 , B01D39/1623 , B01D39/2027 , B01D39/2055 , B01D2239/0442 , B01D2239/0478 , B01D2325/48 , A01N2300/00
摘要： An antimicrobial material is described which can be used to form on the surface on a substrate a non-leaching antimicrobial coating or layer which kills microorganisms on contact. The non-leaching antimicrobial coating or layer is a unique combination of an organic matrix immobilized on the surface of the substrate to having biocidal metallic materials non-leachably associated with the matrix. When a microorganism contacts the coating or layer, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it. Methods of applying the coating or layer to a substrate also are provided.

6. 发明公开

EP0932401A1 METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE USING ENANTIOMERICALLY ENRICHED (R,R)-GLYCOPYRROLATE 失效
标题翻译：使用富含赋形剂的（R，R） - 甘油酸治疗尿失禁的方法和组合物
公开(公告)号：EP0932401A1
公开(公告)日：1999-08-04
申请号：EP97931551.0
申请日：1997-06-27
申请人： SEPRACOR, INC.
发明人： FABIANO, Vincent, L. , McCULLOUGH, John, R.
IPC分类号： A61K31
CPC分类号： A61K31/40
摘要： A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R, R)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R, R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (S, S)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treament of urinary incontinence comprising enantiomerically enriched (R, R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.
摘要翻译：一种使用对映体富集的（R，R） - 格隆溴铵治疗尿失禁（例如由膀胱逼尿肌不稳定导致的失禁）的方法。该方法包括给予治疗有效量的基本上不含（S，S） - 格隆溴铵对映体的对映体富集的（R，R） - 格隆溴铵或其药学上可接受的盐。还公开了用于治疗尿失禁的药物组合物，其包含对映体富集的（R，R） - 格隆溴铵或其药学上可接受的盐和可接受的载体。

7. 发明公开

EP0929688A1 SUSTAINED DELIVERY DEVICE AND METHODS OF MAKING AND USING THE SAME 失效
标题翻译：持久供应装置及其生产和使用方法本
公开(公告)号：EP0929688A1
公开(公告)日：1999-07-21
申请号：EP97943295.0
申请日：1997-09-09
申请人： Symbiontics, Inc. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： GUEIROS-FILMO, Frederico, J. , BEVERLEY, Stephen, M. , VACCARO, Denis, E.
IPC分类号： A01K67 , A61K38 , A61K39 , A61K45 , A61K47 , A61K48 , C12N1 , C12N15 , C12P21 , C12R1
CPC分类号： C12N15/87 , A61K39/008 , A61K47/6901 , C12N1/10 , C12N15/79 , Y02A50/41
摘要： Disclosed herein are novel medical devices, particular well-suited for sustained delivery of therapeutically-significant substances. Also disclosed are methods of making and using these delivery devices. Using these devices and methods, the present invention teaches sustained, targeted and reversible delivery of immunostimulating agents, as well as therapeutic agents such as enzymes, hormones and neurotransmitters, to name but a few.

8. 发明公开

EP0927039A1 INDUCTION OF A CELLULAR STRESS RESPONSE WITH HEAVY METAL SALTS 失效
标题翻译：细胞应激反应的重金属萨尔泽RELEASE
公开(公告)号：EP0927039A1
公开(公告)日：1999-07-07
申请号：EP97910002.0
申请日：1997-10-07
申请人： Hartford Hospital
发明人： PERDRIZET, George, A.
IPC分类号： A61K33 , A61P3 , A61P9 , A61P43
CPC分类号： A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34
摘要： The present invention relates to compositions and methods of induction of a cellular stress response and a protected phenotype using heavy metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal a heavy metal in sufficient quantity and under appropriate conditions to induce a sufficient cellular stress response to provide protection (partial or complete) against injury caused by a noxious condition. The invention also relates to methods of inducing a cellular stress response in a mammal by administering a heavy metal in sufficient quantity and under appropriate conditions to induce a cellular stress response to protect the mammal against injury caused by a noxious condition. The invention also relates to compositions comprising a heavy metal, and an additional component, such as a stress protein, agents which enhance a cellular stress response, aid in the uptake of heavy metal into the tissue, or have a synergistic effect with heavy metals, stress proteins and/or other agents for the induction of the cellular stress response.

9. 发明公开

EP0920306A2 CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR 失效
标题翻译：趋化因子antagoniste和方法及其
公开(公告)号：EP0920306A2
公开(公告)日：1999-06-09
申请号：EP97933406.0
申请日：1997-07-11
申请人： Leukosite, Inc.
发明人： SCHWENDER, Charles, F. , MACKAY, Charles, R. , PINTO, Julia, C. , NEWMAN, Walter
IPC分类号： C07D295 , A61K31 , A61P1 , A61P11 , A61P17 , A61P19 , A61P37 , C07D209 , C07D211 , C07D263 , C07D277 , C07D409
CPC分类号： A61K31/496 , A61K31/05 , A61K31/137 , A61K31/14 , A61K31/216 , A61K31/222 , A61K31/404 , A61K31/423 , A61K31/428 , A61K31/451 , A61K31/4535 , A61K31/454 , A61K31/495
摘要： Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof. Z is a substituted or unsubstituted aromatic group. Y is a covalent bond, -O- or -CO-. n is an integer from one to about five. X is a covalent bond or -CO-. Ra is an aliphatic or a substituted aliphatic group; Rb is an aliphatic group substituted with an aromatic group or substituted aromatic group; and, taken together with the nitrogen atom bonded to Ra and Rb, can form a substituted or unsubstituted non-aromatic heterocyclic ring.

10. 发明公开

EP0914145A1 METHODS OF CONTROLLING AXONAL GROWTH 失效
标题翻译：方法轴突生长的管制
公开(公告)号：EP0914145A1
公开(公告)日：1999-05-12
申请号：EP97932521.0
申请日：1997-07-08
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SCHNEIDER, Gerald, E. , CHEN, Dong, Feng , TONEGOWA, Susumu , JHAVERI, Sonal
IPC分类号： C12N15 , A61K38 , A61K45 , A61K48 , A61P25 , C07K14 , C12N5 , C12Q1
CPC分类号： A61K38/1709
摘要： Agents which modulate a bcl family member to control axonal growth and regeneration are described. These bcl modulating agents promote axonal growth and regeneration in the neural cells of a subject. Compositions for promoting axonal cell growth in a subject also are described. The compositions of the present invention include an effective amount of an agent which modulates a bcl family member and in a pharmaceutically acceptable carrier. Other described aspects include packaged drugs for treating a state characterized by diminished potential for axonal growth. The packaged compounds and agents also include instructions for using the agent to promote axonal growth in a subject.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式