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1. 发明公开

EP0960202A1 MONOCYTE CHEMOTACTIC PROTEIN 5 (MCP-5) MOLECULES AND USES THEREFOR 失效
标题翻译：从单核细胞CHEMO战术蛋白5（MCP-5）的分子数及其用途。
公开(公告)号：EP0960202A1
公开(公告)日：1999-12-01
申请号：EP97941532.0
申请日：1997-09-11
申请人： CENTER FOR BLOOD RESEARCH, INC.
发明人： GUTIERREZ-RAMOS, Jose-Carlos , JIA, Gui-Quan , GONZALO, Jose-Angel
IPC分类号： C07K14 , C12N15 , A61K38 , A61K48
CPC分类号： C07K14/523 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to the discovery of novel genes encoding Monocyte Chemotactic Protein 5 (MCP-5) polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.

2. 发明公开

EP0956038A1 MORPHOGEN PEPTIDE-INDUCED REGENERATION OF SENSE PERCEPTORY TISSUES 无效
标题翻译： BY形态发生肽引起组织的复苏，以免意义细胞
公开(公告)号：EP0956038A1
公开(公告)日：1999-11-17
申请号：EP97948274.0
申请日：1997-11-14
申请人： CREATIVE BIOMOLECULES, INC.
发明人： SAMPATH, Kuber , RUEGER, David, C. , COHEN, Charles, M. , CHARETTE, Marc, F. , JIN, Donald, F.
IPC分类号： A61K38 , A61P27 , C07K14
CPC分类号： A61K38/1875
摘要： Disclosed are methods and compositions for the treatment and prophylaxis of sensory perception deficits. Methods involve the administration of certain morphogenic compositions.

3. 发明公开

EP0950110A1 NOVEL MORPHOGEN-RESPONSIVE SIGNAL TRANSDUCER AND METHODS OF USE THEREOF 失效
标题翻译：形态发生素敏感信号转导和应用程序的方法
公开(公告)号：EP0950110A1
公开(公告)日：1999-10-20
申请号：EP97943550.0
申请日：1997-09-24
申请人： CREATIVE BIOMOLECULES, INC.
发明人： TAKEDA, Kohsuke, The Cancer Institute, Tokyo , ICHIJO, Hidenori, The Cancer Inst. Tokyo , SAMPATH, Kuber, T.
IPC分类号： C12N15 , A61K38 , A61K48 , A61P19 , C07K14 , C12N5 , C12Q1
CPC分类号： C07K14/51 , A61K38/00
摘要： A novel gene, DD-10, and its encoded polypeptide chain, DD-10, expressed during early onset of morphogen-induced mammalian tissue morphogenesis, now has been discovered. Accordingly, the invention identifies a new gene which is a novel biological marker of cell differentiation and tissue morphogenesis, particularly of chondroblast or osteoblast cell differentiation and bone tissue morphogenesis. Disclosed are: (a) methods and compositions for screening for and producing morphogen analogs; (b) novel morphogen analogs; (c) downstream inducers of morphogenesis; (d) a novel marker for evaluating morphogen or morphogen analog dosing; and (e) therapeutic methods and compositions using these analogs and/or downstream inducers.

4. 发明公开

EP0948519A1 METHOD FOR IDENTIFYING GENES ENCODING NOVEL SECRETED OR MEMBRANE-ASSOCIATED PROTEINS 失效
标题翻译：方法识别基因分泌或膜相关的编码蛋白质的
公开(公告)号：EP0948519A1
公开(公告)日：1999-10-13
申请号：EP97950583.0
申请日：1997-11-06
申请人： Millennium Pharmaceuticals, Inc.
发明人： McCARTHY, Sean, Anthony , GEARING, David, Paul , LEVINSON, Douglas, Adam
IPC分类号： C12N15 , C12Q1
CPC分类号： C12Q1/6811 , C12N15/1034 , C12N15/1051 , C12N15/85 , C12N2800/60 , C12N2830/38
摘要： The invention features a method for identifying a cDNA nucleic acid encoding a mammalian protein having a signal sequence, which method includes the following steps: a) providing library of mammalian cDNA; b) ligating the library of mammalian cDNA to DNA encoding alkaline phosphatase lacking both a signal sequence and a membrane anchor sequence to form ligated DNA; c) transforming bacterial cells with the ligated DNA to create a bacterial cell clone library; d) isolating DNA comprising the mammalian cDNA from at least one clone in the bacterial cell clone library; e) separately transfecting DNA isolated from clones in step (d) into mammalian cells which do not express alkaline phosphatase to create a mammalian cell clone library wherein each clone in the mammalian cell clone library corresponds to a clone in the bacterial cell clone library; f) identifying a clone in the mammalian cell clone library which express alkaline phosphatase; g) identifying the clone in the bacterial cell clone library corresponding to the clone in the mammalian cell clone library identified in step (f); and h) isolating and sequencing a portion of the mammalian cDNA present in the bacterial cell library clone identified in step (g) to identify a mammalian cDNA encoding a mammalian protein having a signal sequence.

5. 发明公开

EP0942970A1 NOVEL CARBOXYLESTERASE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 失效
标题翻译：新型羧酸酯酶核酸分子，蛋白质及其用途
公开(公告)号：EP0942970A1
公开(公告)日：1999-09-22
申请号：EP97946645.0
申请日：1997-11-10
申请人： Heska Corporation
发明人： SILVER, Gary, M. , WISNEWSKI, Nancy , BRANDT, Kevin, S.
IPC分类号： G01N33 , A61K38 , A61K39 , A61K45 , A61K48 , A61P33 , C07K16 , C12N1 , C12N5 , C12N7 , C12N9 , C12N15 , C12Q1
CPC分类号： C12N9/18 , A61K38/00
摘要： The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
摘要翻译：节肢动物酯酶蛋白质本发明涉及节肢动物酯酶蛋白质; 涉及节肢动物酯酶核酸分子，包括编码此类酯酶蛋白的那些; 针对这些酯酶蛋白产生的抗体; 和抑制节肢动物酯酶活性的其他化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这样的蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这种治疗组合物用于保护动物免受食血性节肢动物侵染的用途。

6. 发明公开

EP0941245A1 PROMOTER FOR SMOOTH MUSCLE CELL EXPRESSION 失效
标题翻译：表达的平滑肌启动子
公开(公告)号：EP0941245A1
公开(公告)日：1999-09-15
申请号：EP97942457.0
申请日：1997-08-29
申请人： Arch Development Corporation
发明人： PARMACEK, Michael, S. , SOLWAY, Julian
IPC分类号： C12N15 , A61F2 , A61K31 , A61K35 , A61K38 , A61K48 , A61P9 , A61P11 , A61P43 , C07K14 , C12N5
CPC分类号： C07K14/4716 , A01K2217/05 , A61K48/00 , C12N2799/022
摘要： Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22α promoter.

7. 发明公开

EP0938487A2 2$i(R),4$i(S),$i(R),$i(S)- AND 2$i(S),4$i(R),$i(R),$i(S)-HYDROXYITRACONAZOLE- AND HYDROXYSAPERCONAZOLE DERIVATIVES 失效
标题翻译：（S），$ i（R），$ i（S） - 和2 $ i（S），4 $ i（R），$ i（R），$ i（R） S） - 羟基吡咯烷酮和羟基吡咯烷衍生物
公开(公告)号：EP0938487A2
公开(公告)日：1999-09-01
申请号：EP97946663.0
申请日：1997-11-12
申请人： SEPRACOR, INC.
发明人： MCCULLOUGH, John, R. , SENANAYAKE, Chris, H. , TANOURY, Gerald, J. , HONG, Yaping , KOCH, Patrick
IPC分类号： A61K31 , A61P31 , C07D249 , C07D405 , C07D521
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/12
摘要： A substantially pure single enantiomer of a compound of formula (1), wherein X?1 and X2¿ are independently chlorine or fluorine and R is hydrogen, -P(O)(OH)¿2? or -SO3H, or a salt thereof. A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.
摘要翻译：式（1）化合物的基本上纯的单一对映体，其中X 1和X 2独立地为氯或氟，R为氢，-P（O）（OH）2' 或-SO 3 H或其盐。公开了制备羟基依他康唑的光学纯异构体的方法，特别是仲丁基（R，S） - 异构体的两个顺式二氧戊环非对映异构体，以及其磷酸酯和硫酸酯衍生物。还公开了含有这些化合物的药物组合物及其用于治疗真菌感染的用途。

8. 发明公开

EP0938484A1 2R,4S,R,R- AND 2S,4R,R,R-HYDROXYITRACONAZOLE 失效
标题翻译： 2R，4S，R，R-和2S，4R，R，R-羟基吡咯烷酮
公开(公告)号：EP0938484A1
公开(公告)日：1999-09-01
申请号：EP97947428.0
申请日：1997-11-12
申请人： SEPRACOR, INC.
发明人： SENANAYAKE, Chris, H. , TANOURY, Gerald, J. , HONG, Yaping , KOCH, Patrick , MCCULLOUGH, John, R.
IPC分类号： C07D405 , A61K31 , A61P31 , C07D249 , C07D521
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/12
摘要： A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl R,R-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.
摘要翻译：公开了制备羟基依他康唑的光学纯异构体的方法，特别是仲丁基R，R-异构体的两个顺式二氧戊环非对映异构体，以及其磷酸酯和硫酸酯衍生物。还公开了含有这些化合物的药物组合物及其用于治疗真菌感染的用途。

9. 发明公开

EP0927052A1 BLADDER SUBMUCOSA SEEDED WITH CELLS FOR TISSUE RECONSTRUCTION 失效
标题翻译：与重建组织的细胞BLASENMUKOSA
公开(公告)号：EP0927052A1
公开(公告)日：1999-07-07
申请号：EP97938438.0
申请日：1997-08-15
申请人： The Children's Medical Center Corporation
发明人： ATALA, Anthony
IPC分类号： C12N5 , A61F2 , A61K35 , A61L27
CPC分类号： A61L27/3891 , A61K35/22 , A61K35/38 , A61L27/3604 , A61L27/3679 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882
摘要： Methods and materials for tissue reconstruction and augmentation are disclosed. The invention provides isolated bladder submucosa, optionally seeded with cells, for use in tissue reconstruction. The methods of the invention include the use of isolated bladder submucosa, optionally seeded with cells, for augmentation of bladder and other organs and tissues.

10. 发明公开

EP0918867A2 SUBSTRATE TRAPPING PROTEIN TYROSINE PHOSPHATASES 失效
标题翻译：底方END蛋白酪氨酸磷酸酶
公开(公告)号：EP0918867A2
公开(公告)日：1999-06-02
申请号：EP97937017.0
申请日：1997-07-24
申请人： COLD SPRING HARBOR LABORATORY
发明人： TONKS, Nicholas , FLINT, Andrew, J.
IPC分类号： C12N15 , A61K38 , A61P35 , C12N9 , C12Q1
CPC分类号： C12N9/16 , A61K38/00 , C12N2799/026
摘要： Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.

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