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4. 发明公开

EP3636278A2 CLOSTRIDIUM DIFFICILE IMMUNOGENIC COMPOSITION 审中-公开
公开(公告)号：EP3636278A2
公开(公告)日：2020-04-15
申请号：EP19192151.9
申请日：2015-06-25
申请人： GlaxoSmithKline Biologicals S.A.
发明人： CASTADO, Cindy
IPC分类号： A61K39/08 , C07K14/33
摘要： The present invention relates to immunogenic compositions comprising isolated Clostridium difficile CDTb. In particular the isolated Clostridium difficile CDTb protein has been mutated to modify pore forming ability, to modify heptamerisation ability, or is a truncated CDTb protein with the signal peptide and the prodomain removed and also the receptor binding domain removed and/or the CDTa binding domain removed.The invention also relates to fusion proteins comprising a CDTa protein and a CDTb protein. Vaccines comprising such immunogenic compositions and therapeutic uses of the same also form part of the invention.

7. 发明公开

EP2976101A1 METHOD OF TREATMENT 有权
标题翻译：治疗方法
公开(公告)号：EP2976101A1
公开(公告)日：2016-01-27
申请号：EP14711232.0
申请日：2014-03-17
申请人： GlaxoSmithKline Biologicals S.A.
发明人： BAINE, Yaela , MILLER, Jacqueline
IPC分类号： A61K39/095
摘要： The application discloses method of immunising against Neisseria meningitidis infection comprising the steps of a) immunising a human patient at a first age of between 0 and 11 months with a bacterial saccharide conjugate vaccine comprising at least one, two or three bacterial saccharide(s) separately conjugated to a carrier protein to form at least one, two or three bacterial saccharide conjugate(s); and b) immunising the human patient at a second age of between 12 and 24 months with a Neisseria meningitidis conjugate vaccine comprising at least two capsular saccharides selected from the group consisting of N. meningitidis serogroup A capsular saccharide (MenA), N. meningitidis serogroup C capsular saccharide (MenC), N. meningitidis serogroup W135 capsular saccharide (MenW135), and N. meningitidis serogroup Y capsular saccharide (MenY) conjugated separately to a carrier protein, wherein the Neisseria meningitidis conjugate vaccine is co-administered with a vaccine comprising diphtheria toxoid and tetanus toxoid.

8. 发明公开

EP2917351A1 PRODUCTION OF RECOMBINANT VACCINE IN E. COLI BY ENZYMATIC CONJUGATION 有权转让
标题翻译：大都会文艺复兴时期的HERSTELLUNG VON REKOMBINANTEM IMPFSTOFF
公开(公告)号：EP2917351A1
公开(公告)日：2015-09-16
申请号：EP13788753.5
申请日：2013-11-07
申请人： Glycovaxyn AG
发明人： WACKER, Michael , KOWARIK, Michael , WETTER, Michael , FARIDMOAYER, Amirreza
IPC分类号： C12N15/70 , A61K39/09
CPC分类号： A61K39/092 , A61K2039/523 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , C12N15/70 , C12P21/005 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/47 , Y02A50/478
摘要： Prokaryotic cells proficient to produce glycoconjugates in vivo are provided herein, as well as methods for generating these cell and methods of using these cells to produce glycoconjugates. The compositions of the mentioned glycoconjugates as well as their different uses are also included.
摘要翻译：本文提供了精细生产体内糖缀合物的原核细胞，以及产生这些细胞的方法和使用这些细胞产生糖缀合物的方法。还包括所提及的糖缀合物的组成以及它们的不同用途。

9. 发明公开

EP2719397A1 Use of alpha-toxin for treating and preventing staphylococcus infections 无效
标题翻译： Verwendung von Alpha-Toxin zur Behandlung undPräventionvon Staphylococcus-Infektionen
公开(公告)号：EP2719397A1
公开(公告)日：2014-04-16
申请号：EP13168453.2
申请日：2007-02-27
申请人： GlaxoSmithKline Biologicals SA
发明人： Taylor, Kimberly L , Fattom, Ali I
IPC分类号： A61K39/40 , A61P31/04
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , A61K2039/507 , A61K2039/55505 , A61K2039/55577 , A61K2039/6037 , A61K2039/70 , C07K2317/76
摘要： Vaccines comprising an S. aureus alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing infections. The S . aureus alpha-toxin antigen may contain at least two alterations that reduce its toxicity and/or may be conjugated to or co-administered with another bacterial antigen. The vaccines may comprise one or more other bacterial antigens.
摘要翻译：提供了包含金黄色葡萄球菌α-毒素抗原和药学上可接受的载体的疫苗，并且可用于治疗和预防感染。 S。金黄色葡萄球菌α-毒素抗原可以含有至少两种降低其毒性的改变和/或可以与另一种细菌抗原缀合或共同施用。疫苗可以包含一种或多种其它细菌抗原。

10. 发明授权

EP1790659B1 Polypeptides of pseudomonas aeruginosa 有权
标题翻译：绿脓杆菌多肽
公开(公告)号：EP1790659B1
公开(公告)日：2013-07-31
申请号：EP06022429.2
申请日：2002-11-13
申请人： ID Biomedical Corporation
发明人： Charland, Nathalie , Hamel, Josee , Brodeur, Bernard, R. , Martin, Denis , Charlebois, Isabelle , Bussiere, Diane
IPC分类号： C07K14/21 , A61K39/104 , C12N15/62 , G01N33/53
CPC分类号： C07K14/21 , A61K39/00 , A61K2039/505 , C07K2319/00

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