专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2340845A3 Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions 有权
标题翻译：重复CA125基因序列及其用于诊断和治疗干预
公开(公告)号：EP2340845A3
公开(公告)日：2011-11-02
申请号：EP10012943.6
申请日：2002-04-12
申请人： The Board of Trustees of The University of Arkansas
发明人： O'Brien, Timothy , Beard, John , Underwood, Lowell
IPC分类号： A61K38/00 , A61K31/07 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences including the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. An amino terminal extension is present. The structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified. The repeat units encompass the site ofOC125 and M11 binding. Expression of the repeats was demonstrated. Any one of the repeat domains has the potential use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. The repeat domains and other domains also provide a basis for the development of a vaccine.
摘要翻译：已经克隆了CA125基因，并且已经鉴定了包括羧基末端的多个重复序列。 CA125分子包含三个主要结构域：胞外氨基末端结构域（结构域1）; 一个大的多重复域（Domain 2）; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域（结构域3）。存在氨基末端延伸。该结构主要由包含156个氨基酸重复单元的重复结构域组成，其包含表位结合位点。已经确定了60多个重复单位。重复单位包含OC125和M11结合位点。证明了重复序列的表达。任何一个重复结构域都有可能用作检测和监测CA125抗原存在的新金标准。重复域和其他域也为开发疫苗提供了基础。

2. 发明公开

EP2327715A1 Replikin peptides and uses thereof 审中-公开
公开(公告)号：EP2327715A1
公开(公告)日：2011-06-01
申请号：EP10012947.7
申请日：2002-03-26
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122 , Y02A50/412 , Y02A50/478
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

3. 发明公开

EP2320932A2 METHODS OF PREDICTING CANCER LETHALITY USING REPLIKIN COUNTS 有权
标题翻译：用于预测KREBSLETALITÄT使用复制素NUMBERS
公开(公告)号：EP2320932A2
公开(公告)日：2011-05-18
申请号：EP09791315.6
申请日：2009-08-07
申请人： Bogoch, Samuel , Bogoch, Elenore S. , Bogoch, Samuel Winston , Borsanyi, Anne Elenore
发明人： Bogoch, Samuel , Bogoch, Elenore S. , Bogoch, Samuel Winston , Borsanyi, Anne Elenore
IPC分类号： A61K38/17 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/47 , A61K39/00 , G01N33/68 , G01N33/574 , C12N15/11 , A61P35/00
CPC分类号： A61K38/08 , A61K38/10 , A61K38/1709 , A61K39/0011 , G01N33/574 , Y02A50/394
摘要： The present invention provides methods of predicting the relative growth rate, replication rate, or lethality of a first malignancy as compared to another malignancy or as compared to a plurality of malignancies, including methods of predicting the relative growth rate, replication rate, or relative lethality of a primary malignancy as compared to a metastatic malignancy, including comparing the concentration of Replikin sequences in the first malignancy with the concentration of Replikin sequences in another malignancy or malignancies and further provides Replikin peptides and Replikin Peak Genes identified within a malignancy for diagnostic, therapeutic, preventive, and predictive purposes.

4. 发明授权

EP1841866B1 NUCLEIC ACIDS FOR APOPTOSIS OF CANCER CELLS 有权
标题翻译： NUCLEIC凋亡癌细胞
公开(公告)号：EP1841866B1
公开(公告)日：2009-04-22
申请号：EP05854583.1
申请日：2005-12-19
申请人： Sky Genetics, Inc.
发明人： NORTH, Don, Adams
IPC分类号： C12N15/11
CPC分类号： C12N15/1135 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q2600/156 , G01N33/574
摘要： The disclosure relates to a nucleic acid having an Apoptotic Sequence of: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7. It also relates to a compsoition including a nucleic acid having an Apoptotic Sequence of Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7. The composition may also include a pharmaceutically acceptable carrier. The disclosure also includes a method of killing a cancer cell by administering to a cancer cell a serum including a nucleic acid having an Apoptotic Sequence of: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7 and a pharmaceutically acceptable carrier. The cancer cell may be located in a subject with cancer.

5. 发明公开

EP2027146A2 REPLIKIN PEPTIDES AND USES THEREOF 有权
标题翻译：复制素肽及其用途
公开(公告)号：EP2027146A2
公开(公告)日：2009-02-25
申请号：EP07868294.5
申请日：2007-05-30
申请人： Bogoch, Samuel, Dr. , Bogoch, Elenore, S. , Bogoch, Samuel Winston , Borsanyi, Anne-Elenore Bogoch
发明人： BOGOCH, Samuel , BOGOCH, Elenore, S. , BOGOCH, Samuel, Winston , BORSANYI, Anne-Elenore, B.
IPC分类号： C07K14/11
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/16022 , C12N2770/20022 , G01N2333/11
摘要： The present invention provides isolated influenza peptides and nucleic acid sequences and methods of identifying said influenza peptides and nucleic acid sequences having a pattern of substitution of amino acids or nucleic acids in highly conserved Replikin and Replikin Scaffold sequences that is predictive of rapid replication and virulence. Methods of predicting virulence in emerging influenza strains are provided comprising identifying peptides and nucleic acid sequences having the predictive pattern of substitution.

6. 发明公开

EP1747011A2 MITTEL UND VERFAHREN ZUR DIAGNOSE, PROPHYLAXE UND THERAPIE VON BINDEGEWEBSERKRANKUNGEN 审中-公开
标题翻译：手段与方法诊断，预防和治疗结缔组织疾病
公开(公告)号：EP1747011A2
公开(公告)日：2007-01-31
申请号：EP05739705.1
申请日：2005-05-17
申请人： Sigrist, Gerold , Lorenz, Wolfgang
发明人： Sigrist, Gerold , Lorenz, Wolfgang
IPC分类号： A61K38/39 , A61K39/02 , A61K39/04 , A61K39/108 , A61K39/112 , A61K39/095 , G01N33/564 , A61K39/395 , A61K39/40
CPC分类号： G01N33/564 , G01N2800/10
摘要： The invention relates to compositions, comprising at least one substance capable of binding to a pathogen-associated molecular patterns (PAMP) receptor and at least one tri-helical fibrous protein, a fragment or a variant thereof. According to a preferred embodiment, the tri-helical fibrous protein is pro-collagen, fragments or variants thereof. The invention further relates to pharmaceutical compositions comprising the above for prophylaxis/therapy and test kits, comprising the above for the diagnosis of connective tissue diseases. Furthermore, specific binding partners and the use thereof in pharmaceutical compositions for prophylaxis/therapy and in test kits for diagnosis are disclosed.

7. 发明授权

EP2027146B1 REPLIKIN PEPTIDES AND USES THEREOF 有权
标题翻译：复制素肽及其用途
公开(公告)号：EP2027146B1
公开(公告)日：2012-10-03
申请号：EP07868294.5
申请日：2007-05-30
申请人： Bogoch, Samuel, Dr. , Bogoch, Elenore, S. , Bogoch, Samuel Winston , Borsanyi, Anne-Elenore Bogoch
发明人： BOGOCH, Samuel , BOGOCH, Elenore, S. , BOGOCH, Samuel, Winston , BORSANYI, Anne-Elenore, B.
IPC分类号： G01N33/68 , C07K14/11
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/16022 , C12N2770/20022 , G01N2333/11

8. 发明公开

EP2345666A1 Carrier zum Targeting von Nervenzellen 无效转让
标题翻译：载体zum瞄准von Nervenzellen
公开(公告)号：EP2345666A1
公开(公告)日：2011-07-20
申请号：EP10011509.6
申请日：2006-04-26
申请人： Toxogen GmbH
发明人： Rummel, Andreas, Dr. , Weil, Tanja, Prof. Dr. , Gutcaits, Aleksandrs, Dr.
IPC分类号： C07K14/195 , C07K14/33 , A61K38/00
CPC分类号： C12N9/52 , A61K38/00 , C07K14/33 , C12Y304/24069 , Y02A50/469 , Y02A50/473
摘要： Die vorliegende Erfindung betrifft ein Transportprotein, erhältlich durch Modifizierung der schweren Kette des von Clostridium botulinum gebildeten Neurotoxins, wobei (i) das Protein an Nervenzellen mit höherer oder niedrigerer Affinität bindet als das native Neurotoxin; (ii) das Protein im Vergleich zu dem nativen Neurotoxin eine erhöhte oder verringerte Neurotoxizität aufweist; vorzugsweise wird die Neurotoxizität im Hemidiaphragma-Assay bestimmt; und/oder (iii) das Protein im Vergleich zu dem nativen Neurotoxin eine geringere Affinität gegenüber neutralisierenden Antikörpern aufweist. Ferner werden Verfahren zu dessen Herstellung und dessen Verwendung in kosmetischen und pharmazeutischen Zusammensetzungen angegeben.
摘要翻译：通过改变由肉毒梭菌产生的神经毒素的重链获得的新的转运蛋白（A）。与天然神经毒素（nNT）相比：（a）以更高或更低的亲和力结合神经细胞; （b）具有较高/较低的神经毒性，特别是在膈膜测定中测定; 和/或（c）对中和抗体具有较低的亲和力。还包括以下独立权利要求：（1）包含（A）和至少一种中间化合物的组合物（C）（2）通过标准重组方法制备（A）或（C）的方法; （3）含有编码（A）或（C）的重组表达载体（EV）的宿主细胞; 和（4）EV。活动：休闲; 偏头痛; 止痛; 伤药; 抗抑郁药; 杀病毒。没有给出这些活动的测试细节。作用机制：抑制神经递质释放的药物。

9. 发明公开

EP2345664A2 Replikin peptides and uses thereof 审中-公开
标题翻译： Replikin-Peptide和Verwendung davon
公开(公告)号：EP2345664A2
公开(公告)日：2011-07-20
申请号：EP10012944.4
申请日：2002-07-09
申请人： Bogoch, Samuel , Bogoch, Elenore S.
发明人： Bogoch, Samuel , Bogoch, Elenore S.
IPC分类号： C07K14/005
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N9/93 , C12N15/8261 , C12N2740/16022 , C12N2760/16122 , C12N2770/32122 , Y02A40/146 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译：本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

10. 发明公开

EP2281549A1 Cosmetic compositions with long lasting skin moisturizing properties 审中-公开
标题翻译： Kosmetische Zusammensetzung mit langanhaltenden Feuchtigkeit spendenden Eigenschaften
公开(公告)号：EP2281549A1
公开(公告)日：2011-02-09
申请号：EP10012158.1
申请日：2005-01-26
申请人： Alberto-Culver Company
发明人： Glover, David A. , Gurman, Natalya Y.
IPC分类号： A61K8/41 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/65 , A61K8/92 , A61K8/97 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/416 , A61K8/42 , A61K8/44 , A61K8/4913 , A61K8/65 , A61K8/922 , A61K8/97 , A61Q19/007
摘要： Cosmetic composition and related method for treating skin preferably comprising an olive oil-based compound, a quaternary ammonium salt, sodium pyrrolidone carboxylic acid, and an emulsifier.
摘要翻译：用于治疗皮肤的化妆品组合物和相关方法优选包含橄榄油基化合物，季铵盐，吡咯烷酮羧酸钠和乳化剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式