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1. 发明授权

EP0142009B1 Circumference measuring device 失效
标题翻译：循环测量装置
公开(公告)号：EP0142009B1
公开(公告)日：1988-08-24
申请号：EP84111937.3
申请日：1984-10-05
申请人： BEECHAM GROUP PLC
发明人： Wakeling, Fitzgerald
IPC分类号： G01B3/10 , A61B5/10
CPC分类号： G01B5/025

2. 发明授权

EP0195097B1 Arachidonic acid analogues, processes for their preparation and their use in medicine 失效
标题翻译：芳香酸类似物，其制备方法及其在医学中的应用
公开(公告)号：EP0195097B1
公开(公告)日：1987-10-28
申请号：EP85103186.4
申请日：1985-03-19
申请人： BEECHAM GROUP PLC
发明人： Buckle, Derek Richard
IPC分类号： C07C59/68 , C07C69/736 , C07C57/42 , C07C69/618 , C07C51/347 , C07C67/30 , A61K31/19 , A61K31/215
CPC分类号： C07C59/68 , C07C45/68 , C07C47/548 , C07C57/42

3. 发明公开

EP0194833A2 Erythromycin derivatives 失效
标题翻译： Erythromycinderivate。
公开(公告)号：EP0194833A2
公开(公告)日：1986-09-17
申请号：EP86301686.1
申请日：1986-03-10
申请人： BEECHAM GROUP PLC
发明人： Hunt, Eric
IPC分类号： C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： 6-ether derivatives of erythromycin 9-oximes and 9- oxime-ethers are novel antibacterially active compounds, and can be prepared by alkylation of the 6-hydroxy group.
摘要翻译：红霉素9-肟和9-肟醚的6-醚衍生物是新的抗菌活性化合物，可以通过6-羟基的烷基化制备。

4. 发明授权

EP0119088B1 Steel for use as material of cold-rolled steel sheet 无效
标题翻译：钢用作冷轧钢板材料
公开(公告)号：EP0119088B1
公开(公告)日：1986-09-03
申请号：EP84301646.0
申请日：1984-03-12
申请人： NIPPON STEEL CORPORATION
发明人： Koyama, Kazuo c/o Kimitsuseitetsusho , Hamamoto, Yasuo c/o Kimitsuseitetsusho , Katoh, Hiroshi c/o Kimitsuseitetsusho , Toyota, Hiromi c/o Kimitsuseitetsusho
IPC分类号： C22C38/12 , C22C38/00 , C21D8/04
CPC分类号： C21D8/04 , C22C38/00 , C22C38/12

5. 发明公开

EP0167050A1 Clavulanate compounds, their preparation and use and intermediates thereof 失效
标题翻译： Clavulanatverbindungen，ihre Herstellung und Verwendung sowie Zwischenprodukte。
公开(公告)号：EP0167050A1
公开(公告)日：1986-01-08
申请号：EP85107476.5
申请日：1985-06-15
申请人： BEECHAM GROUP PLC
发明人： Harbridge, John Barry , Brooks, Gerald
IPC分类号： C07D498/04 , A61K31/42
CPC分类号： C07D503/00
摘要： Compounds of the general formula I:

and their pharmaceutically acceptable salts and in-vivo hydrolysable esters,
in which

each of R' and R 2 , which may be the same or different, denotes a hydrogen atom, an aryl group, or a heterocyclyl group;
X denotes a hydrogen atom, or a hydroxy, substituted hydroxy, mercapto, substituted mercapto, azido, cyano, halo, nitro, isothiocyanato, amino, substituted amino, aryl, or heterocyclyl group, or the residue of a carbon nucleophile; and
n denotes 0, 1 or 2.
are novel compounds with (ß-lactamase inhibitory and antibacterial properties.
摘要翻译：通式I：的化合物及其药学上可接受的盐和体内可水解的酯，其中R 1和R 2各自可以相同或不同，表示氢原子，芳基或杂环基; X表示氢原子，或羟基，取代的羟基，巯基，取代的巯基，叠氮基，氰基，卤素，硝基，异硫氰酸酯基，氨基，取代的氨基，芳基或杂环基，或碳亲核试剂的残基; 并且n表示0,1或2.是具有β-内酰胺酶抑制和抗菌性质的新化合物。

6. 发明公开

EP0119088A1 Steel for use as material of cold-rolled steel sheet 无效
标题翻译： Stahlfürkaltgewalzte Feinbleche。
公开(公告)号：EP0119088A1
公开(公告)日：1984-09-19
申请号：EP84301646.0
申请日：1984-03-12
申请人： NIPPON STEEL CORPORATION
发明人： Koyama, Kazuo c/o Kimitsuseitetsusho , Hamamoto, Yasuo c/o Kimitsuseitetsusho , Katoh, Hiroshi c/o Kimitsuseitetsusho , Toyota, Hiromi c/o Kimitsuseitetsusho
IPC分类号： C22C38/12 , C22C38/00 , C21D8/04
CPC分类号： C21D8/04 , C22C38/00 , C22C38/12
摘要： A steel annealable at low temperature and suitable for use as the material of cold-rolled steel sheet having an excellent formability consists essentially, by weight, of not greater than 0.005% of C, not greater than 0.5% of Mn, not greaterthan 0.1% of P, not greater than 0.005% of N, 0.016 to 0.035% of 0, with the balance being Fe and inevitable impurities, the 0 and at least a part of the Mn existing in the form of fine oxides dispersed substantially uniformly which oxide brings about a structure which imparts the good formability to the steel. A steel sheet may be produced by a method comprising the steps of forming a steel slab from the above-mentioned components by continuous casting, subjecting the steel slab to hot rolling to form a steel sheet, subjecting the hot-rolled steel sheet to cold rolling after pickling, and subjecting the cold-rolled steel sheet to continuous annealing at a low temperature of from 600 to 770°C or to box annealing at a low temperature of from 550 to 680°C.
摘要翻译：在低温下可退火并适合用作具有优异成形性的冷轧钢板的材料的钢基本上由不大于0.005％的C，不大于0.5％的Mn，不大于0.1 P的百分比，不大于0.005的N，0.016至0.035％的O，余量为Fe和不可避免的杂质，O和至少部分以细氧化物形式存在的Mn基本均匀地分散，这种氧化物带来了赋予钢的良好成形性的结构。可以通过以下方法制造钢板：通过连续铸造从上述组分形成钢坯的方法，对钢坯进行热轧以形成钢板，对热轧钢板进行冷轧酸洗后，在600〜770℃的低温下对冷轧钢板进行连续退火，或者在550〜680℃的低温下进行框退火。

7. 发明授权

EP0016150B1 Process for the carbonylation of diolefins 失效
标题翻译：二氧化碳的制备方法
公开(公告)号：EP0016150B1
公开(公告)日：1982-07-28
申请号：EP79900887.5
申请日：1979-07-18
申请人： POLYMER SCIENCES CORPORATION
发明人： STILLE, John K.
IPC分类号： C07C67/38 , C07C51/36 , C07C51/09
CPC分类号： C07C51/09 , C07C51/36 , C07C57/13 , C07C55/14
摘要： Conjugated diolefins (e.g., 1, 3-butadiene) are carbonylated by the palladium-catalyzed addition of carbon monoxide and an alcohol of the formula ROH (e, g., benzyl alcohol) whereby polycarboxylic esters are formed in which the pair of double bonds of the conjugated diolefin has been transformed into a moiety having the formula: (FORMULA) In the process, the olefin, carbon monoxide, and alcohol are reacted in the presence of a palladium (II) salt a copper (II) salt and a base, at certain concentrations and at a pressure and temperature sufficient to effect the carbonylation. The resulting unsaturated diester can be hydrolyzed and hydrogenated or vice versa to obtain the corresponding linear diacid (e.g., adipic acid).

8. 发明授权

EP0128525B1 Auslaufsperre für Behälter, insbesondere für Tuben, und Anwendungen 有权转让
标题翻译：集装箱封闭件，特别适用于管件及其应用
公开(公告)号：EP0128525B1
公开(公告)日：1990-01-17
申请号：EP84106465.2
申请日：1984-06-06
申请人： Lingner + Fischer GmbH
发明人： Flier, Gustav, Dipl.-Phys.
IPC分类号： B65D35/46
CPC分类号： B65D35/46 , Y10T137/7781 , Y10T137/784 , Y10T137/7843 , Y10T137/788

9. 发明公开

EP0307177A3 Erythromycin derivatives 失效
标题翻译：红霉素衍生物
公开(公告)号：EP0307177A3
公开(公告)日：1989-10-25
申请号：EP88308257.0
申请日：1988-09-07
申请人： BEECHAM GROUP PLC
发明人： Brain, Edward George
IPC分类号： C07H17/08 , A61K31/00
CPC分类号： C07H17/08
摘要： 11,12-Carbonate derivatives of certain erythromycin 6-ethers are novel, antibacterially active compounds which can be prepared by treatment of an erythromycin 6-ether with a reactive carbonyl compound.
摘要翻译：某些红霉素6-醚的11,12-碳酸酯衍生物是新型的抗菌活性化合物，其可以通过用反应性羰基化合物处理红霉素6-醚来制备。

10. 发明公开

EP0321185A2 Erythromycin derivatives 失效
标题翻译：红霉素衍。
公开(公告)号：EP0321185A2
公开(公告)日：1989-06-21
申请号：EP88311785.5
申请日：1988-12-13
申请人： BEECHAM GROUP PLC
发明人： Davies, John Sidney
IPC分类号： C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： 9- N ,11- O -methylene derivatives of erythromycin-9-imine (wherein the methylene group is optionally substituted) of the general formula IA or IB:
or a pharmaceutically acceptable ester or acid addition salt thereof,
wherein
R¹ denotes hydrogen, an unsubstituted or substituted hydrocarbon group, a heterocyclyl group, or an acyl group;
R³ denotes hydrogen or hydroxy;
R⁶ denotes hydrogen or methyl;
one of R⁷ and R⁸ denotes hydrogen, hydroxy, alkoxy,alkanoyloxy, amino, substituted amino, or a group of the formula R⁹-SO₂-O-, and the other of R⁷ and R⁸ denotes hydrogen, or
R⁷ and R⁸ together denote an oxo group, an oxime group, or a substituted oxime group; and
R⁹ denotes an organic group,
possess improved acid stability, compared with erythromycin A, whilst retaining good antibacterial activity.
摘要翻译：通式IA或IB的红霉素-9-亚胺（其中亚甲基任选被取代）的9-N，11-O-亚甲基衍生物或其药学上可接受的酯或酸加成盐，其中R 1， 1>表示氢，未取代或取代的烃基，杂环基或酰基; R 3表示氢或羟基; R 6表示氢或甲基; R 7和R 8中的一个表示氢，羟基，烷氧基，烷酰氧基，氨基，取代的氨基或式R 9 -SO 2 -O-的基团，R 7和 R 8表示氢，或R 7和R 8一起表示氧代基，肟基或取代的肟基; R 9表示有机基团，与红霉素A相比具有改善的酸稳定性，同时保持良好的抗菌活性。

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