专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2155699B1 ARYLOAZOL-2-YL CYANOETHYLAMINO COMPOUNDS, METHOD OF MAKING AND METHOD OF USING THEREOF 有权转让
标题翻译： ARYLAZOL -2- YL-CYANETHYLAMINO化合物中，PROCESS FOR制造方法及使用方法
公开(公告)号：EP2155699B1
公开(公告)日：2015-07-08
申请号：EP08769452.7
申请日：2008-05-12
申请人： Merial, Inc. , Aventis Agriculture
发明人： SOLL, Mark, David , LE HIR DE FALLOIS, Loic, Patrick , HUBER, Scot, Kevin , LEE, Hyoung, Ik , WILKINSON, Douglas, Edward , JACOBS, Robert, Toms
IPC分类号： C07D249/18 , C07D231/56 , C07C253/04 , C07C255/42 , A01N43/707 , A01N37/34 , A61P33/00
CPC分类号： C07D231/56 , C07D249/18

2. 发明授权

EP2675451B1 mTOR/JAK INHIBITOR COMBINATION THERAPY 有权转让
标题翻译： KOMBINATIONSTHERAPIE AUS MTOR / JAK-HEMMER
公开(公告)号：EP2675451B1
公开(公告)日：2015-06-24
申请号：EP12705608.3
申请日：2012-02-17
申请人： Novartis Pharma AG , Incyte Corporation
发明人： VANNUCCHI, Alessandro, M. , BOGANI, Costanza , GUGLIELMELLI, Paola
IPC分类号： A61K31/436 , A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K31/436 , A61K45/06 , A61K2300/00
摘要： Provided herein is a combination therapy comprising an mTOR inhibitor and a JAK inhibitor. The combination therapy is useful for the treatment of a variety of cancers, including MPNs. The combination therapy is also useful for the treatment of any number of JAK-associated diseases.
摘要翻译：本文提供了包含mTOR抑制剂和JAK抑制剂的组合疗法。联合治疗对于治疗各种癌症（包括MPN）是有用的。联合治疗也可用于治疗任何数量的JAK相关疾病。

3. 发明公开

EP2839037A1 BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS 无效
标题翻译：生物标记识别在处理和加工患者无功病患者
公开(公告)号：EP2839037A1
公开(公告)日：2015-02-25
申请号：EP13778809.7
申请日：2013-04-19
申请人： Acetylon Pharmaceuticals, Inc.
发明人： YANG, Min , JONES, Simon, S.
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/574 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2333/71
摘要： The invention relates to methods for using biomarkers to identify cancer patients that will or are likely to respond to treatment. Specifically, the invention relates to the use of one or more of three association studies of cancer types, gene mutations, or gene expression levels in order to identify cancer patients that will or are likely to respond to treatment with a histone deacetylase (HDAC) inhibitor, alone or in combination with another cancer treatment. The methods may, optionally, further include treating such patient with an HDAC inhibitor, alone or in combination with another cancer treatment.
摘要翻译：本发明涉及一种利用生物标记来识别癌症患者thatwill或可能对治疗的反应的方法。具体而言，本发明涉及使用癌症类型，遗传突变，或者基因表达水平的一个或多个三个关联研究以鉴定癌症患者thatwill或可能对治疗与组蛋白脱乙酰酶响应（HDAC）抑制剂单独或与另一种癌症治疗组合。该方法可任选地进一步处理包括在HDAC抑制剂寻求与患者单独或与另一种癌症治疗组合。

4. 发明公开

EP2833865A1 TREATMENT OF PROLIFERATIVE DISEASES WITH PYRIMIDODIAZEPINONES 审中-公开
标题翻译：与PYRIMIDODIAZEPINONEN治疗增生性疾病
公开(公告)号：EP2833865A1
公开(公告)日：2015-02-11
申请号：EP13714992.8
申请日：2013-03-28
申请人： Cyclacel Limited
发明人： DAVIS, Susan , ZHELEVA, Daniella
IPC分类号： A61K9/00 , A61K31/5513 , A61K31/551
CPC分类号： A61K9/0019 , A61K31/551
摘要： A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in treating a proliferative disorder, wherein: X is NR
7 ; R
1 and R
2 are each independently H, alkyl or cycloalkyl; R
3 is a 6-membered heterocycloalkyi group selected from piperidinyl, piperazinyl, morpholinyl and tetrahydropyranyl, wherein said heterocycloalkyi group is optionally further substituted by one or more (CH
2 )
n R
19 groups; R
4 and R
4' are each independently H or alkyl; or R
4 and R
4' together form a spiro cycloalkyl group; Q is CH or N; R
6 is OR
8 or halogen; n is 1, 2 or 3; R
19 is H, alkyl, aryl or a cycloalkyl group; R
7 and R
8 are each independently H or alkyl; and wherein said compound is administered in accordance with a dosing regimen which: (i) maintains a plasma concentration of from about 50 to about 500 nM for a period of up to about 16 hours; or (ii) maintains a plasma concentration of from about 0.5 μΜ to about 1 μΜ for a period of up to about 6 hours; or (iii) achieves a maximum plasma concentration (Cmax) of no more than about 500 nM within a period of about 6 hours; or (iv) achieves a maximum plasma concentration (Cmax) of no more than about 200 nM within a period of about 16 hours; or (v) achieves a maximum plasma concentration (Cmax) of about 0.5 μΜ to about 1 μΜ within about 6 hours. Further claims relate to a method of treatment based on this dosing regimen, and kits relating to the same.

5. 发明公开

EP2785719A1 LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS 有权转让
标题翻译：蓝牙魔术师
公开(公告)号：EP2785719A1
公开(公告)日：2014-10-08
申请号：EP12798570.3
申请日：2012-11-30
申请人： Merial Limited
发明人： CADY, Susan, Mancini , MA, Baoqing , CHAPMAN, Robert, Clark , YANG, Chunhua , JAIN, Uday
IPC分类号： C07D493/22 , A61K31/365 , A61P33/00
CPC分类号： A61K31/365 , A61K9/0024 , A61P33/00 , C07D493/22
摘要： This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要翻译：本发明提供了莫昔克丁的新型抗寄生虫和杀虫剂形式，包括长效聚合物植入物。所得化合物可用于兽医组合物，其用于治疗，控制和预防动物体内和外寄生虫感染。

6. 发明公开

EP2741747A1 JAK P13K/mTOR COMBINATION THERAPY 审中-公开
标题翻译： JAK / P13K-MTOR联合治疗
公开(公告)号：EP2741747A1
公开(公告)日：2014-06-18
申请号：EP12748346.9
申请日：2012-08-10
申请人： Novartis Pharma AG , Incyte Corporation
发明人： VANNUCCHI, Alessandro M. , BOGANI, Costanza , BARTALUCCI, Niccolo
IPC分类号： A61K31/4188 , A61K31/7064 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/519 , A61K2300/00
摘要： Provided herein is a combination therapy comprising a JAK kinase inhibitor and a dual PBK/mTOR inhibitor, as well as methods of treating various cancers through the use of such a combination therapy.

7. 发明公开

EP2726521A1 VINYL ALCOHOL POLYMERS WITH SILANE SIDE CHAINS 审中-公开
标题翻译：乙烯醇聚乙二醇酯
公开(公告)号：EP2726521A1
公开(公告)日：2014-05-07
申请号：EP12732700.5
申请日：2012-06-29
申请人： Revolymer Limited
发明人： CASTLE, Thomas Charles , FINCH, Robert Louis , PEARS, David Alan , PRESTON, Maurice , SIVANAND, Pennadam Shanmugam , YOUNG, Brian David
IPC分类号： C08F230/08
CPC分类号： C08F230/08
摘要： The present invention relates to novel functionalised homopolymers and copolymers of vinyl alcohol comprising one or more aminosilane- and/or aminosilanol containing side chains attached to the polymer backbone via a reactive coupling group; to a process for the preparation of such copolymers, and to the use of such copolymers in coatings, inks, sealants or adhesives.
摘要翻译：本发明涉及含有一个或多个含有氨基硅烷和/或氨基硅烷醇的侧链的乙烯醇的新的官能化均聚物和共聚物，其通过反应性偶联基团连接到聚合物主链上; 涉及制备这种共聚物的方法，以及在涂料，油墨，密封剂或粘合剂中使用这些共聚物。

8. 发明授权

EP1828140B1 5-AMINOPYRAZOLE DERIVATIVES AS PESTICIDAL COMPOUNDS 无效转让
标题翻译： 5-氨基吡AS农药CONNECTIONS
公开(公告)号：EP1828140B1
公开(公告)日：2014-03-05
申请号：EP05814293.6
申请日：2005-12-02
申请人： Merial Limited
发明人： SCHNATTERER, Stefan , MAIER, Michael , PETRY, Friederike , KNAUF, Werner , SEEGER, Karl
IPC分类号： C07D231/44 , C07D405/12 , A01N43/56
CPC分类号： C07D231/44 , C07D405/12

9. 发明公开

EP2688904A1 POLYPEPTIDES WITH AFFINITY FOR HEAT SHOCK PROTEINS (HSPS) AND HSP ASSOCIATED COMPLEXES (HACS) AND THEIR USE IN DIAGNOSIS AND THERAPY 有权转让
标题翻译：随着对热休克蛋白（HSP）HSP亲和力，缔合物（HAC）和它们的诊断与治疗多肽
公开(公告)号：EP2688904A1
公开(公告)日：2014-01-29
申请号：EP12760787.7
申请日：2012-03-21
申请人： Atlantic Cancer Research Institute , New England Peptide, Inc.
发明人： GRIFFITHS, Steven, Gareth , LEWIS, Scott, Edwin
IPC分类号： C07K7/08 , A61K39/00 , A61P35/00 , A61P37/04 , C07K1/22 , C07K14/00 , C07K14/47 , C07K19/00 , C07K7/06 , C12N15/11 , G01N33/53 , G01N33/543 , G01N33/574
CPC分类号： C07K14/435 , A61K39/0011 , A61K2039/6043 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/34 , C07K2319/35 , C07K2319/70 , G01N2333/34 , G01N2333/47 , G01N2333/936
摘要： The present application is directed to a peptides comprising an a-helix forming-amino acid sequence that binds a heat shock protein. Also included is a polypeptide comprising (a) a first peptide portion that comprises an alpha-helix-forming amino acid sequence that binds a heat shock protein; and (b) at least one second peptide portion comprising an antigenic amino acid sequence and/or an a-helix-stabilizing amino acid sequence that increases the interaction of the first peptide portion with the heat shock protein. The present application also includes compositions comprising the peptides and/or polypeptides of present application and uses of the peptides and/or polypeptides of the present application for fractionating substances relevant for discovery, research or clinical analysis from a biological sample and as therapeutics.

10. 发明授权

EP1814862B1 VINYLAMINOPYRAZOLE DERIVATIVES AS PESTICIDES 无效转让
标题翻译：作为杀虫剂的乙烯基氨基吡唑衍生物
公开(公告)号：EP1814862B1
公开(公告)日：2014-01-15
申请号：EP05791711.4
申请日：2005-09-27
申请人： Merial Limited
发明人： CHOU, David, Teh-Wei , THÖNESSEN, Maria , KUHLMANN, Anke , DÖLLER, Uwe , HEMPEL, Waltraud
IPC分类号： C07D231/44 , C07D401/12 , A01N43/56
CPC分类号： C07D231/44 , A01N43/56 , C07D401/12

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式