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1. 发明授权

EP2197489B2 B7 FAMILY MEMBER ZB7H6 AND RELATED COMPOSITIONS AND METHODS 有权
公开(公告)号：EP2197489B2
公开(公告)日：2020-04-01
申请号：EP08835652.2
申请日：2008-10-06
申请人： ZymoGenetics, Inc.
发明人： BRANDT, Cameron, S. , KENNEDY, Jacob, J. , XU, Wenfeng , YI, Eugene, C. , FOX, Brian, A. , GAO, Zeren , SIVAKUMAR, Pallavur, V.
IPC分类号： C07K16/28 , A61K47/68 , C07K14/705 , A61K39/395

2. 发明公开

EP3214095A1 COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES 有权
标题翻译：调节免疫应答的组合物和方法
公开(公告)号：EP3214095A1
公开(公告)日：2017-09-06
申请号：EP16192149.9
申请日：2006-05-12
申请人： ZymoGenetics, Inc.
发明人： LEVIN, Steven D. , BILSBOROUGH, Janine , WEST, James W. , BRANDT, Cameron , RAMSDELL, Frederick J. , HOWARD, Edward D. , CHADWICK, Eric M. , GAO, Zeren
IPC分类号： C07K14/705 , C07K16/28 , C12N15/62 , A61K38/17 , G01N33/50 , A61K38/00 , C07K14/47 , C12Q1/66 , G01N33/569 , A61K39/00
摘要： There is provided a newly identified B7 receptor, zB7R1, which functions as lymphocyte inhibitory receptor. zB7R1 is a PD-1-like molecule expressed on T cells, and is able to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signalling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic, and research purposes are also provided.
摘要翻译：提供了新发现的B7受体zB7R1，其功能为淋巴细胞抑制性受体。 zB7R1是在T细胞上表达的PD-1样分子，能够与CD155结合。还提供了用于调节zB7R1介导的负信号传导并干扰其反受体相互作用以用于治疗，诊断和研究目的的方法和组合物。

3. 发明公开

EP3103813A1 ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：抗人IL-21 MONOKLONALE抗生素
公开(公告)号：EP3103813A1
公开(公告)日：2016-12-14
申请号：EP16161751.9
申请日：2008-12-08
申请人： ZymoGenetics, Inc.
发明人： JASPERS, Stephen R. , RIXON, Mark W. , DILLON, Stacey R. , RAMSDELL, Frederick J. , KREJSA, Cecile M. , YI, Eugene C.
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S530/809
摘要： Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.
摘要翻译：提出人抗人IL-21单克隆抗体和产生它们的杂交瘤。这些抗体中的某些具有结合天然人IL-21，人IL-21的突变重组体IL-21蛋白和/或肽区的能力。这些人抗IL-21抗体可用于治疗自身免疫性和炎性疾病，特别是由T滤泡辅助细胞，B细胞TH细胞或TH17细胞介导的疾病。

4. 发明授权

EP2301969B1 IL-31 monoclonal antibodies and methods of use 有权转让
标题翻译： IL-31单克隆抗体和使用方法
公开(公告)号：EP2301969B1
公开(公告)日：2015-12-23
申请号：EP10179383.4
申请日：2006-05-08
申请人： ZymoGenetics, Inc.
发明人： Siadak, Anthony W. , Bilsborough, Janine , Florkiewicz, Elin , Haran, Aaron C. , Rene, Shirley
IPC分类号： C07K16/24 , C07K14/54 , A61P17/00 , A61P17/04
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y10S514/885 , Y10S514/886
摘要： There is provided a monoclonal antibody wherein the monoclonal antibody is produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation selected from a first group consisting of: a) ATCC Patent Deposit Designation PTA-6815; b) ATCC Patent Deposit Designation PTA-6816; c) ATCC Patent Deposit Designation PTA-6871; d) ATCC Patent Deposit Designation PTA-6829; and e) ATCC Patent Deposit Designation PTA-6830; or wherein the monoclonal antibody is selected from a second group consisting of: a) ATCC Patent Deposit Designation PTA-6831; b) ATCC Patent Deposit Designation PTA-6872; c) ATCC Patent Deposit Designation PTA-6875; and d) ATCC Patent Deposit Designation PTA-6873; for use in treating a disease selected from the group consisting of prurigo nodularis; cutaneous T cell lymphoma; atopic dermatitis; contact dermatitis; drug-induced allergic reactions; skin-tropic viruses; viral associated pruritis; vitiligo; alopecia aerata; acne rosacea; acne vulgaris; and bullous pemphigoid.
摘要翻译：提供单克隆抗体，其中单克隆抗体由保藏有美国典型培养物保藏中心的杂交瘤产生，所述杂交瘤具有选自以下的第一组的ATCC专利保藏名称：a）ATCC专利保藏名称PTA-6815; b）ATCC专利保藏号PTA-6816; c）ATCC专利保藏号PTA-6871; d）ATCC专利保藏号PTA-6829; 和e）ATCC专利保藏号PTA-6830; 或其中所述单克隆抗体选自由以下组成的第二组：a）ATCC专利保藏名称PTA-6831; b）ATCC专利保藏号PTA-6872; c）ATCC专利保藏名称PTA-6875; 和d）ATCC专利保藏号PTA-6873; 用于治疗选自结节性痒疹的疾病; 皮肤T细胞淋巴瘤; 特应性皮炎; 接触性皮炎; 药物引起的过敏反应; 皮肤热带病毒; 病毒性相关性瘙痒症白癜风; 秃头症痤疮性红斑痤疮寻常痤疮和大疱性类天疱疮。

5. 发明授权

EP2759549B1 IL-31 monoclonal antibodies and methods of use 有权
标题翻译： IL-31-monoklonaleAntikörperund Verfahren zu deren Verwendung
公开(公告)号：EP2759549B1
公开(公告)日：2015-08-19
申请号：EP14165476.4
申请日：2007-09-04
申请人： ZymoGenetics, Inc.
发明人： Siadak, Anthony W. , Bilsborough, Janine , Rene, Shirley
IPC分类号： C07K16/24 , A61K39/395 , C12N5/18 , A61P37/00 , A61P17/00
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/244 , C07K2316/96 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0602
摘要： There is provided an isolated monoclonal antibody or antigen-binding fragment thereof that competes with the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815 for binding to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:2; wherein the monoclonal antibody has a human IgG4 heavy chain immunoglobulin constant domain or wherein the antigen-binding fragment further comprises a human IgG4 heavy chain immunoglobulin constant domain; and wherein the monoclonal antibody or antigen-binding fragment inhibits signal transduction induced by the polypeptide through its heterodimeric receptor.
摘要翻译：提供了与由保藏有ATCC专利保藏号PTA-6815的美国典型培养物保藏中心的杂交瘤产生的单克隆抗体竞争的分离的单克隆抗体或其抗原结合片段，以结合由氨基酸残基27组成的多肽 -164为SEQ ID NO：2; 其中所述单克隆抗体具有人IgG4重链免疫球蛋白恒定结构域或其中所述抗原结合片段还包含人IgG4重链免疫球蛋白恒定结构域; 并且其中所述单克隆抗体或抗原结合片段通过其异二聚体受体抑制由多肽诱导的信号转导。

6. 发明授权

EP2338910B1 Cytokine receptor Zcytor17 multimers 有权
标题翻译：细胞因子Zyctor17多聚体
公开(公告)号：EP2338910B1
公开(公告)日：2015-07-08
申请号：EP11151759.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： Sprecher, Cindy A. , Gao, Zeren , Kuijper, Joseph L. , Dasovich, Maria M. , Grant, Francis J. , Presnell, Scott R. , Whitmore, Theodore E. , Hammond, Angela K. , Novak, Julia E. , Gross, Jane A. , Dillon, Stacey R.
IPC分类号： C07K14/52 , A61K38/00 , C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.

7. 发明公开

EP2759549A3 IL-31 monoclonal antibodies and methods of use 有权
标题翻译： IL-31单克隆抗体和它们的使用方法
公开(公告)号：EP2759549A3
公开(公告)日：2014-08-27
申请号：EP14165476.4
申请日：2007-09-04
申请人： ZymoGenetics, Inc.
发明人： Siadak, Anthony W. , Bilsborough, Janine , Rene, Shirley
IPC分类号： C07K16/24 , A61K39/395 , C12N5/18 , A61P37/00 , A61P17/00
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/244 , C07K2316/96 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0602
摘要： There is provided an isolated polynucleotide encoding a monoclonal antibody that binds to human IL-31, wherein said antibody is a humanized antibody derived from the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815; wherein said antibody comprises a heavy chain immunoglobulin constant domain which is a human IgG4, wherein said human IgG4 constant domain has a Ser to Pro mutation at Kabat position 241.

8. 发明公开

EP2759549A2 IL-31 monoclonal antibodies and methods of use 有权
标题翻译： IL-31单克隆抗体和使用方法
公开(公告)号：EP2759549A2
公开(公告)日：2014-07-30
申请号：EP14165476.4
申请日：2007-09-04
申请人： ZymoGenetics, Inc.
发明人： Siadak, Anthony W. , Bilsborough, Janine , Rene, Shirley
IPC分类号： C07K16/24 , A61K39/395 , C12N5/18 , A61P37/00 , A61P17/00
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/244 , C07K2316/96 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0602
摘要： There is provided an isolated polynucleotide encoding a monoclonal antibody that binds to human IL-31, wherein said antibody is a humanized antibody derived from the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815; wherein said antibody comprises a heavy chain immunoglobulin constant domain which is a human IgG4, wherein said human IgG4 constant domain has a Ser to Pro mutation at Kabat position 241.
摘要翻译：提供了编码结合人IL-31的单克隆抗体的分离的多核苷酸，其中所述抗体是衍生自由保藏于ATCC专利保藏号PTA-6815的美国典型培养物保藏中心的杂交瘤产生的单克隆抗体的人源化抗体 ; 其中所述抗体包含为人IgG4的重链免疫球蛋白恒定结构域，其中所述人IgG4恒定结构域在Kabat位置241处具有Ser至Pro突变。

9. 发明公开

EP2749571A2 Methods of treating pain and inflammation in neuronal tissue using IL-31RA and OSMRb antagonists 审中-公开
标题翻译：一种用于使用IL-31RA-和OSMRb拮抗剂神经组织治疗疼痛和炎症的方法
公开(公告)号：EP2749571A2
公开(公告)日：2014-07-02
申请号：EP14161547.6
申请日：2007-01-10
申请人： ZymoGenetics, Inc.
发明人： Yao, Yue , Bilsborough, Janine , Kresja, Cecile , Zuckerman, Linda , Rogge, Mark
IPC分类号： C07K16/24 , A61K38/20 , A61P17/02 , A61P31/12 , A61P25/00
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： There is provided a monoclonal antibody or antigen-binding fragment thereof that specifically binds to a first receptor polypeptide consisting of amino acid residues 1-662 of SEQ ID NO:8, for use in inhibiting IL-31-induced neuronal tissue inflammation in a mammal by inhibiting IL-31-induced signal transduction, wherein said IL-31 polypeptide comprises amino acid residues 27-164 of SEQ ID NO:2, and wherein said IL-31-induced signal transduction is through a heterodimeric receptor comprising said first receptor polypeptide and a second receptor polypeptide consisting of amino acid residues 1-979 of SEQ ID NO:16
摘要翻译：提供了一种单克隆抗体或其抗原结合片段，其特异性地结合到第一做受体多肽的氨基酸残基由...组成的SEQ ID NO 1-662：8，其用于抑制IL-31诱导的神经元组织中的炎症的哺乳动物通过抑制IL-31诱导的信号转导，worin所述IL-31多肽包含的氨基酸残基的SEQ ID NO 27-164：2和worin所述IL-31诱导的信号转导是通过异二聚体受体包括所述第一受体多肽和第二受体多肽的氨基酸残基由1至SEQ ID NO 979：16

10. 发明授权

EP1551426B1 METHODS OF ADMINISTERING FGF18 有权
标题翻译：方法管理FGF18作者：
公开(公告)号：EP1551426B1
公开(公告)日：2014-06-25
申请号：EP03773163.5
申请日：2003-10-07
申请人： ZymoGenetics, Inc.
发明人： ELLSWORTH, Jeff, L.
IPC分类号： A61K31/728 , A61K31/717 , A61K38/18 , C07K14/50
CPC分类号： A61K9/0019 , A61K31/728 , A61K38/1825 , A61K45/06 , A61K47/36 , C07C51/38 , C07C67/343 , C07C57/58 , C07C69/65 , A61K2300/00

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