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1. 发明授权

EP2079683B1 DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译： DIFLUORHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP2079683B1
公开(公告)日：2015-01-21
申请号：EP07853752.9
申请日：2007-10-03
申请人： Virobay, Inc.
发明人： LINK, John O. , MOSSMAN, Craig J. , LIU, Jie , WOO, Soon Hyung
IPC分类号： C07C255/46 , A61K31/275 , A61P19/02 , A61P9/10
CPC分类号： C07C255/46

2. 发明授权

EP2361243B9 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译： HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP2361243B9
公开(公告)日：2014-06-11
申请号：EP09826761.0
申请日：2009-11-12
申请人： Virobay, Inc.
发明人： HART, Barry , GREEN, Michael , SETTI, Eduardo , ROEPEL, Michael
IPC分类号： C07C237/04 , C07C255/46 , C07C317/48 , C07C323/60 , C07D213/32 , A61K31/277 , A61P11/06 , A61P19/02
CPC分类号： C07C317/48 , C07C237/04 , C07C255/46 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/32

3. 发明公开

EP2215076A2 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION 审中-公开
标题翻译：组织蛋白酶S和HCV复制抑制化合物
公开(公告)号：EP2215076A2
公开(公告)日：2010-08-11
申请号：EP08841879.3
申请日：2008-10-22
申请人： Virobay, Inc.
发明人： HOLSINGER, Leslie Jean , ELROD, Kyle , LINK, John O. , GRAUPE, Michael , KIM, In Jong
IPC分类号： C07D401/12 , C07D401/02 , C07D241/02
CPC分类号： C07D403/12
摘要： The present invention is directed to compounds that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.

4. 发明公开

EP2720692A4 CATHEPSIN INHIBITORS FOR TREATING MICROGLIA-MEDIATED NEURON LOSS IN THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译： CATHEPSINHEMMER在中枢神经系统在处理小胶质细胞介导的神经元丢失
公开(公告)号：EP2720692A4
公开(公告)日：2015-05-20
申请号：EP12800202
申请日：2012-06-18
申请人： VIROBAY INC
发明人： BOOTH ROBERT
IPC分类号： A61K31/277 , A61K9/00 , A61K9/08 , A61K9/20 , A61K31/4406 , A61K47/12 , A61K47/26 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K31/277 , A61K9/0019 , A61K9/08 , A61K9/2054 , A61K31/4406 , A61K47/12 , A61K47/26

5. 发明授权

EP1663958B1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译： HALOGENALKYLHALTIGE化合物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：EP1663958B1
公开(公告)日：2015-02-25
申请号：EP04784332.1
申请日：2004-09-17
申请人： ViroBay, Inc.
发明人： LINK, John O. , MOSSMAN, Craig J. , WOO, Soon H. , ZIPFEL, Sheila M.
IPC分类号： C07C255/46 , C07C317/48 , C07C323/60 , C07D211/66 , C07D213/32 , C07D231/12 , C07D241/12 , C07D277/30 , C07D309/14 , C07D333/20 , C07D335/02 , A61K31/277 , A61K31/381 , A61K31/4402 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D333/20 , C07C255/46 , C07C317/48 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07D211/66 , C07D213/32 , C07D231/12 , C07D241/12 , C07D277/30 , C07D309/14 , C07D335/02

6. 发明授权

EP1865940B1 ALPHA KETOAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 失效转让
标题翻译： ALPHA-KETOAMID-VERBINDUNGEN ALS CYSTEINPROTEASEHEMMER
公开(公告)号：EP1865940B1
公开(公告)日：2013-02-13
申请号：EP06748476.6
申请日：2006-03-17
申请人： Virobay, Inc.
发明人： GRAUPE, Michael , LINK, John, O. , ROEPEL, Michael, G.
IPC分类号： C07C317/48 , C07D213/32
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32

7. 发明授权

EP1819667B1 SULFONAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS 有权
标题翻译：磺胺ALS抑制剂半胱氨酸
公开(公告)号：EP1819667B1
公开(公告)日：2012-10-17
申请号：EP05853104.7
申请日：2005-12-01
申请人： ViroBay, Inc.
发明人： WOO, Soon H. , VIVIAN, Randall W. , LINK, John O.
IPC分类号： C07C311/07 , C07C311/03 , C07C311/08 , C07D295/22 , C07D211/96 , C07D295/12 , C07D213/76 , C07D487/08 , C07D217/08 , C07D209/08 , C07D207/48 , C07D401/04 , C07D213/32 , A61K31/496 , A61P19/02
CPC分类号： C07D209/08 , C07C311/32 , C07C2601/02 , C07D207/48 , C07D211/96 , C07D213/32 , C07D213/76 , C07D217/08 , C07D295/13 , C07D295/26 , C07D401/04 , C07D487/08

8. 发明公开

EP2215076A4 COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION 审中-公开
标题翻译：组织蛋白酶S和HCV复制抑制化合物
公开(公告)号：EP2215076A4
公开(公告)日：2012-05-02
申请号：EP08841879
申请日：2008-10-22
申请人： VIROBAY INC
发明人： HOLSINGER LESLIE JEAN , ELROD KYLE , LINK JOHN O , GRAUPE MICHAEL , KIM IN JONG
IPC分类号： C07D401/12 , C07D241/02 , C07D401/02
CPC分类号： C07D403/12

9. 发明公开

EP2237793A1 INHIBITORS OF CATHEPSIN B 审中-公开
标题翻译：组织蛋白酶B-缝边
公开(公告)号：EP2237793A1
公开(公告)日：2010-10-13
申请号：EP09709414.8
申请日：2009-02-05
申请人： Virobay, Inc.
发明人： HOLSINGER, Leslie
IPC分类号： A61K38/00
CPC分类号： A61K38/05
摘要： The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway disease, and bone and joint disorders, including osteoporosis, osteoarthritis, rheumatoid arthritis, psoriasis, and other autoimmune disorders, liver fibrosis, including liver fibrosis associated with HCV, all types of steatosis (including non-alcoholic steatohepatitis) and alcohol-associated steatohepatitis, non-alcoholic fatty liver disease, forms of pulmonary fibrosis including idiopathic pulmonary fibrosis, pathological diagnosis of interstitial pneumonia following lung biopsy, renal fibrosis, cardiac fibrosis, retinal angiogenesis and fibrosis/gliosis in the eye, schleroderma, and systemic sclerosis. The compopunds of Formula (I) are also useful for treating subjects with both HCV and fibrosis in a mammal, particularly liver fibrosis, and subjects affirmatively diagnosed or at risk for bopth HCV and liver fibrosis.

10. 发明授权

EP2511257B1 Composition comprising an alpha ketoamide compound as cysteine protease inhibitor 有权
标题翻译：包含α-酮酰胺化合物作为半胱氨酸蛋白酶抑制剂的组合物
公开(公告)号：EP2511257B1
公开(公告)日：2015-06-17
申请号：EP12174457.7
申请日：2006-03-17
申请人： Virobay, Inc.
发明人： Graupe, Michael , Link, John, O , Roepel, Michael, G
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A61K31/00 , C07D213/32 , C07C317/48
CPC分类号： C07C317/48 , C07C2601/02 , C07D213/32

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